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The map label for this gene is moeA [H]

Identifier: 150396625

GI number: 150396625

Start: 1492201

End: 1493421

Strand: Direct

Name: moeA [H]

Synonym: Smed_1411

Alternate gene names: 150396625

Gene position: 1492201-1493421 (Clockwise)

Preceding gene: 150396624

Following gene: 150396635

Centisome position: 39.46

GC content: 62.41

Gene sequence:

>1221_bases
ATGTCGCTTCTTTCGGTCGAGGAGGCGCTGAAGAGAATTTTGGCAAAAGCGCGACCGCCGCAACGGGTGGAACGCGTGGC
GCTCCATGATTGCCTCGGGCGGGTACTCGCCGAAGATGTCGCAGCCCGTCTAACCCACCCTCCCTTCGACAATTCCGCCA
TGGACGGCTATGCCGTTCGCTACGAGGATATTGCCGCAATCGGAACGGAGCTCACCGTCATCGGGCAATCCGCCGCCGGA
AGCGGTTTTCGCGGTCAAATCAGATCCGGCGAGGCTGTGCGGATCTTTACCGGAGCACCTGTGCCTGCAGGGGCTGACAC
CGTAATCATTCAAGAAGATACGGAAAACCTGCCGGAGGGACGCATTCGCACGCTGTTTGCGCCGTCCAAAGGCCGGCACA
TCCGCCTGGCGGGCCAGGACTTTCTCGCGGATGACATAGCACTCACGGCCGGAACCGCGCTCGATGCCGGCCGGTTGACG
CTTGCTGCCGGGATGAACCATCCGGAGTTGCCGGTTCTTGCACGACCCAGAATCGCAATCCTCGCCACAGGCGACGAATT
GCTGCCGCCGGGGAGCGCTCCCGGGGTTGACCAGATCATCGCCTCCAACAGTTTCGGGGTGGCCGCGATCGCCCGGGAGA
ACGGCGCCGAAGTTCTTGATCTTGGCATTGTCGGTGATGAGCCCGCGGCAATCGCCGCGGCCGTCTCCAAAGCGCACGCG
GCTGAAGCGGATGTGCTTGTCACCCTCGGTGGTGCCTCGGTCGGCGATCACGATCTCGTCCAATCGACGCTGCTCGGCTG
CGGCATGACGCTCGATTTCTGGCGTATTGCAATGCGCCCGGGAAAGCCGCTGATGGTCGGCGATCTCGACGGTATGACGG
TTCTGGGTTTGCCCGGAAATCCCGTTTCCAGCCTTGTTTGCGCCTTGCTCTTCCTCGAACCATTGACGCGAAAGCTTGCT
TATCTTCCGGCCCGTTCACGACTGTCCCAGGCACGACTTGCCACCCCGCTGCCGGCCAATGACCGGCGCCAGGACTATAT
ACGTGCCCGCCTGACCCGGGAGGCCGACGGATCGTTCCTGGCCCACCCGTTCCCGCGCCAGGATTCGTCGATGGTCAGCG
TTTTCGCCCAGTCCGATGGCCTGATCGTAAGGCCGCCTGGTGCCCCCGAGGCCAAGATCGGAGAGGCATGCAGTGTTTTC
AAGTTGAGGGATTCAGTCTGA

Upstream 100 bases:

>100_bases
CCAAGGCCGCGGACCGGGACATGGAAATCGGCGGGGTGCGGCTGGTCAGTAAATCGGGCGGGCGTTCCGGCGACTATCGT
CGCGAGGGAGACATGCGCTG

Downstream 100 bases:

>100_bases
CCTAAAGCTGCGACCGGGAGGGCGTGCGCACCCGCGCCGCTTGCCGGAACAATGAGGCCGATGCGAGCCATAGCGCGACA
AACAACGCATTGACCCCAAG

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MSLLSVEEALKRILAKARPPQRVERVALHDCLGRVLAEDVAARLTHPPFDNSAMDGYAVRYEDIAAIGTELTVIGQSAAG
SGFRGQIRSGEAVRIFTGAPVPAGADTVIIQEDTENLPEGRIRTLFAPSKGRHIRLAGQDFLADDIALTAGTALDAGRLT
LAAGMNHPELPVLARPRIAILATGDELLPPGSAPGVDQIIASNSFGVAAIARENGAEVLDLGIVGDEPAAIAAAVSKAHA
AEADVLVTLGGASVGDHDLVQSTLLGCGMTLDFWRIAMRPGKPLMVGDLDGMTVLGLPGNPVSSLVCALLFLEPLTRKLA
YLPARSRLSQARLATPLPANDRRQDYIRARLTREADGSFLAHPFPRQDSSMVSVFAQSDGLIVRPPGAPEAKIGEACSVF
KLRDSV

Sequences:

>Translated_406_residues
MSLLSVEEALKRILAKARPPQRVERVALHDCLGRVLAEDVAARLTHPPFDNSAMDGYAVRYEDIAAIGTELTVIGQSAAG
SGFRGQIRSGEAVRIFTGAPVPAGADTVIIQEDTENLPEGRIRTLFAPSKGRHIRLAGQDFLADDIALTAGTALDAGRLT
LAAGMNHPELPVLARPRIAILATGDELLPPGSAPGVDQIIASNSFGVAAIARENGAEVLDLGIVGDEPAAIAAAVSKAHA
AEADVLVTLGGASVGDHDLVQSTLLGCGMTLDFWRIAMRPGKPLMVGDLDGMTVLGLPGNPVSSLVCALLFLEPLTRKLA
YLPARSRLSQARLATPLPANDRRQDYIRARLTREADGSFLAHPFPRQDSSMVSVFAQSDGLIVRPPGAPEAKIGEACSVF
KLRDSV
>Mature_405_residues
SLLSVEEALKRILAKARPPQRVERVALHDCLGRVLAEDVAARLTHPPFDNSAMDGYAVRYEDIAAIGTELTVIGQSAAGS
GFRGQIRSGEAVRIFTGAPVPAGADTVIIQEDTENLPEGRIRTLFAPSKGRHIRLAGQDFLADDIALTAGTALDAGRLTL
AAGMNHPELPVLARPRIAILATGDELLPPGSAPGVDQIIASNSFGVAAIARENGAEVLDLGIVGDEPAAIAAAVSKAHAA
EADVLVTLGGASVGDHDLVQSTLLGCGMTLDFWRIAMRPGKPLMVGDLDGMTVLGLPGNPVSSLVCALLFLEPLTRKLAY
LPARSRLSQARLATPLPANDRRQDYIRARLTREADGSFLAHPFPRQDSSMVSVFAQSDGLIVRPPGAPEAKIGEACSVFK
LRDSV

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=398, Percent_Identity=33.6683417085427, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI66932975, Length=398, Percent_Identity=33.6683417085427, Blast_Score=175, Evalue=7e-44,
Organism=Escherichia coli, GI1787049, Length=386, Percent_Identity=39.3782383419689, Blast_Score=247, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI25147659, Length=375, Percent_Identity=31.7333333333333, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17562606, Length=361, Percent_Identity=26.5927977839335, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI17136978, Length=406, Percent_Identity=27.5862068965517, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24638841, Length=406, Percent_Identity=27.5862068965517, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 42697; Mature: 42565

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLSVEEALKRILAKARPPQRVERVALHDCLGRVLAEDVAARLTHPPFDNSAMDGYAVR
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEE
YEDIAAIGTELTVIGQSAAGSGFRGQIRSGEAVRIFTGAPVPAGADTVIIQEDTENLPEG
HHHHHHCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCC
RIRTLFAPSKGRHIRLAGQDFLADDIALTAGTALDAGRLTLAAGMNHPELPVLARPRIAI
CEEEEECCCCCCEEEEECCCHHHHHHHEECCCCCCCCCEEEEECCCCCCCCEEECCCEEE
LATGDELLPPGSAPGVDQIIASNSFGVAAIARENGAEVLDLGIVGDEPAAIAAAVSKAHA
EECCCCCCCCCCCCCHHHHHHCCCCCEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHC
AEADVLVTLGGASVGDHDLVQSTLLGCGMTLDFWRIAMRPGKPLMVGDLDGMTVLGLPGN
CCCCEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCCCEEEEECCCC
PVSSLVCALLFLEPLTRKLAYLPARSRLSQARLATPLPANDRRQDYIRARLTREADGSFL
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEE
AHPFPRQDSSMVSVFAQSDGLIVRPPGAPEAKIGEACSVFKLRDSV
ECCCCCCCCCEEEEEECCCCEEECCCCCCCCCCCCHHEEEEECCCC
>Mature Secondary Structure 
SLLSVEEALKRILAKARPPQRVERVALHDCLGRVLAEDVAARLTHPPFDNSAMDGYAVR
CCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEE
YEDIAAIGTELTVIGQSAAGSGFRGQIRSGEAVRIFTGAPVPAGADTVIIQEDTENLPEG
HHHHHHCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCC
RIRTLFAPSKGRHIRLAGQDFLADDIALTAGTALDAGRLTLAAGMNHPELPVLARPRIAI
CEEEEECCCCCCEEEEECCCHHHHHHHEECCCCCCCCCEEEEECCCCCCCCEEECCCEEE
LATGDELLPPGSAPGVDQIIASNSFGVAAIARENGAEVLDLGIVGDEPAAIAAAVSKAHA
EECCCCCCCCCCCCCHHHHHHCCCCCEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHC
AEADVLVTLGGASVGDHDLVQSTLLGCGMTLDFWRIAMRPGKPLMVGDLDGMTVLGLPGN
CCCCEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCCCEEEEECCCC
PVSSLVCALLFLEPLTRKLAYLPARSRLSQARLATPLPANDRRQDYIRARLTREADGSFL
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEE
AHPFPRQDSSMVSVFAQSDGLIVRPPGAPEAKIGEACSVFKLRDSV
ECCCCCCCCCEEEEEECCCCEEECCCCCCCCCCCCHHEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]