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The map label for this gene is kefBC [H]

Identifier: 150396430

GI number: 150396430

Start: 1294901

End: 1296712

Strand: Direct

Name: kefBC [H]

Synonym: Smed_1212

Alternate gene names: 150396430

Gene position: 1294901-1296712 (Clockwise)

Preceding gene: 150396429

Following gene: 150396431

Centisome position: 34.24

GC content: 56.9

Gene sequence:

>1812_bases
ATGGCAGTTGAATCTCACGGACCAGACCTCCTACCAGTCATCGCGCTACTCGGCGCGGGGGTTGTTGCGGCCACGGTCTT
CAAGCGATCTGGACTTGGCTCCGTCCTGGGTTATCTCGCCGCGGGCGTCGTCATCGGTCCATTCGGGCTTCGGGTATTTC
AAGAGCCGGCATCCATTCTCCATTTCGCTGAGCTGGGCGTCGTAATGTTTCTCTTCCTGATAGGCCTTGAGATGAGGCCT
TCACGACTTTGGGGTTTGCGCAGGCAGATTTTTGGCCTGGGAGTCCTTCAGGTCGGCGTCTGCATTCTTTGTCTCACGGC
AGTCGGTATGGCGACTGGTTTCCCGGTGGCGCCGTCCTTCGTTGCGGGGACGGGATTCGTGCTTACATCGACGGCAATTG
TGATGCAGCTCCTTGAGGAGCGAGGTACGATCTCTACGCCACCTGGCCAGCGCATCGTAGCCATCCTGCTCCTTGAGGAT
TTAGCGATCGTACCGCTCCTCGCGTTGGTCGCCTTTCTGGCCCCCATCGTTCCTGGCACGACTTCGAGTGCTCAAGGAAT
CGACTGGATTGCAATAGGCGTGGGCGTCGCCGCGATAGCGGGAGTCGTAGTCTCCGGCTTGTATCTCCTAAACCCTCTCT
TTGGGCTTATAGCCGGCGCACAGGCGCGTGAGGTTATGACGGCCGCAGCGTTGCTCGTCGTACTTGGCGCCGCTTATGTG
ATGCAGCTTGGCGGGCTGTCCATGGCGATGGGCGCGTTCCTTGCAGGCGTTCTCCTGTCCGAGTCAACGTTCCGACACCA
GCTAGAAGTCGATATCGAACCCTTTCGCGGTATCCTCCTGGGTCTCTTCTTCCTCGCTGTCGGTATGTCTCTTGAGTTGG
GTGTCGTGGCGGCCGACTGGGAGCTGATTGCGTTCTATGTTGCCGCATTCATGATCGTGAAAGGGCTAGCAGTTTACGGC
TGTGCTCGCCTTCTTAAAAGTACGCACTGGGAAGCCGCCGAGCGAGCCGTTCTTATGGCCCAGGGTGGGGAATTTGCCTT
CGTACTCTATGCATCGGCTCTCTCATTCGGGATCATCTCTTCCGACCAGAATGCTGTTCTGACAGCAATCGTCATCCTGT
CGATGGTTCTCACGCCGCTTCTAGTCTTGATCTTGAAGCGGTTCGAAGGAGCGAGTTCTTCACGGGTCGATGGCTACGCA
ATTTCCGGCAATTTAAGAGGTACGGTTCTGATCATCGGCTTCGGCCGGGTCGGACAGATAGTCAGTCAGCTTCTGCTATC
CCGAGGTCACGAGATTTCCATCATCGACACCGATGTCGAGATGATCAACATAGCTCGTGAATTTCAGTTCGACGTCTACT
ACGGCGACGGCACACGTCTCGATATCCTTGAGACGGCGGGTGCTGGTGAGGCGAAGGTGATAGCTGTGTGCGTGGACAAC
GGCGACGACGTCACAGCTATTGTACGCCTGCTCAAAGCTGAATTTCCTCTGGCAACAATTGTCGCCCGAGCAACGGATCG
GCGGCATGCACTCGACCTGGTCAGATCGGGTGCCGATGTCCAGATCCGAGAAACCTTTGAGTCCGCGATGGCGCTGGGCA
ACAAGGCGCTTGAAATTCTTGGGGCCACGCCGGAAGAAATGTCGAATCTGGCGAAGGGATTTCGGGAGCGTGATGGCGCG
CGGCTTGAACTCGAATTGGTTGGAGGGATGTATGCTGGCCGCGAATTCTTCAGTGGAAGGACTCACGCATCGAAAATCAC
GGCGGAGATTGATGCTTCCGAGAAAATGCGGGACTTCAGGTCGACCCCGTAG

Upstream 100 bases:

>100_bases
ACGAGATTGCACTTGGAGACAGCGAGGAAGCCTATCTGATCGCCTCCGGCGACGCGGAGGGTGACGCTGAGATACAAAGG
TTAGAAGTCGGAGCAGTTCG

Downstream 100 bases:

>100_bases
AGCGAGTTGAGAATGTTCAATGCCTATAGACCTCGAAAAGGTTAGATCAGAGACACCGGGTATCCGGAACCGAATCCACC
TGAACAACGCTGGGGCAGCT

Product: potassium efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 603; Mature: 602

Protein sequence:

>603_residues
MAVESHGPDLLPVIALLGAGVVAATVFKRSGLGSVLGYLAAGVVIGPFGLRVFQEPASILHFAELGVVMFLFLIGLEMRP
SRLWGLRRQIFGLGVLQVGVCILCLTAVGMATGFPVAPSFVAGTGFVLTSTAIVMQLLEERGTISTPPGQRIVAILLLED
LAIVPLLALVAFLAPIVPGTTSSAQGIDWIAIGVGVAAIAGVVVSGLYLLNPLFGLIAGAQAREVMTAAALLVVLGAAYV
MQLGGLSMAMGAFLAGVLLSESTFRHQLEVDIEPFRGILLGLFFLAVGMSLELGVVAADWELIAFYVAAFMIVKGLAVYG
CARLLKSTHWEAAERAVLMAQGGEFAFVLYASALSFGIISSDQNAVLTAIVILSMVLTPLLVLILKRFEGASSSRVDGYA
ISGNLRGTVLIIGFGRVGQIVSQLLLSRGHEISIIDTDVEMINIAREFQFDVYYGDGTRLDILETAGAGEAKVIAVCVDN
GDDVTAIVRLLKAEFPLATIVARATDRRHALDLVRSGADVQIRETFESAMALGNKALEILGATPEEMSNLAKGFRERDGA
RLELELVGGMYAGREFFSGRTHASKITAEIDASEKMRDFRSTP

Sequences:

>Translated_603_residues
MAVESHGPDLLPVIALLGAGVVAATVFKRSGLGSVLGYLAAGVVIGPFGLRVFQEPASILHFAELGVVMFLFLIGLEMRP
SRLWGLRRQIFGLGVLQVGVCILCLTAVGMATGFPVAPSFVAGTGFVLTSTAIVMQLLEERGTISTPPGQRIVAILLLED
LAIVPLLALVAFLAPIVPGTTSSAQGIDWIAIGVGVAAIAGVVVSGLYLLNPLFGLIAGAQAREVMTAAALLVVLGAAYV
MQLGGLSMAMGAFLAGVLLSESTFRHQLEVDIEPFRGILLGLFFLAVGMSLELGVVAADWELIAFYVAAFMIVKGLAVYG
CARLLKSTHWEAAERAVLMAQGGEFAFVLYASALSFGIISSDQNAVLTAIVILSMVLTPLLVLILKRFEGASSSRVDGYA
ISGNLRGTVLIIGFGRVGQIVSQLLLSRGHEISIIDTDVEMINIAREFQFDVYYGDGTRLDILETAGAGEAKVIAVCVDN
GDDVTAIVRLLKAEFPLATIVARATDRRHALDLVRSGADVQIRETFESAMALGNKALEILGATPEEMSNLAKGFRERDGA
RLELELVGGMYAGREFFSGRTHASKITAEIDASEKMRDFRSTP
>Mature_602_residues
AVESHGPDLLPVIALLGAGVVAATVFKRSGLGSVLGYLAAGVVIGPFGLRVFQEPASILHFAELGVVMFLFLIGLEMRPS
RLWGLRRQIFGLGVLQVGVCILCLTAVGMATGFPVAPSFVAGTGFVLTSTAIVMQLLEERGTISTPPGQRIVAILLLEDL
AIVPLLALVAFLAPIVPGTTSSAQGIDWIAIGVGVAAIAGVVVSGLYLLNPLFGLIAGAQAREVMTAAALLVVLGAAYVM
QLGGLSMAMGAFLAGVLLSESTFRHQLEVDIEPFRGILLGLFFLAVGMSLELGVVAADWELIAFYVAAFMIVKGLAVYGC
ARLLKSTHWEAAERAVLMAQGGEFAFVLYASALSFGIISSDQNAVLTAIVILSMVLTPLLVLILKRFEGASSSRVDGYAI
SGNLRGTVLIIGFGRVGQIVSQLLLSRGHEISIIDTDVEMINIAREFQFDVYYGDGTRLDILETAGAGEAKVIAVCVDNG
DDVTAIVRLLKAEFPLATIVARATDRRHALDLVRSGADVQIRETFESAMALGNKALEILGATPEEMSNLAKGFRERDGAR
LELELVGGMYAGREFFSGRTHASKITAEIDASEKMRDFRSTP

Specific function: Transport system that facilitate potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=358, Percent_Identity=25.1396648044693, Blast_Score=74, Evalue=5e-13,
Organism=Escherichia coli, GI1789749, Length=602, Percent_Identity=40.3654485049834, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1786232, Length=568, Percent_Identity=40.1408450704225, Blast_Score=376, Evalue=1e-105,
Organism=Escherichia coli, GI1786685, Length=530, Percent_Identity=26.9811320754717, Blast_Score=140, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 63744; Mature: 63613

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVESHGPDLLPVIALLGAGVVAATVFKRSGLGSVLGYLAAGVVIGPFGLRVFQEPASIL
CCCCCCCCCHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
HFAELGVVMFLFLIGLEMRPSRLWGLRRQIFGLGVLQVGVCILCLTAVGMATGFPVAPSF
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHH
VAGTGFVLTSTAIVMQLLEERGTISTPPGQRIVAILLLEDLAIVPLLALVAFLAPIVPGT
HCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TSSAQGIDWIAIGVGVAAIAGVVVSGLYLLNPLFGLIAGAQAREVMTAAALLVVLGAAYV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
MQLGGLSMAMGAFLAGVLLSESTFRHQLEVDIEPFRGILLGLFFLAVGMSLELGVVAADW
HHHCCHHHHHHHHHHHHHHHCHHHHHEEEECCCHHHHHHHHHHHHHHCCCCEEEEEECCH
ELIAFYVAAFMIVKGLAVYGCARLLKSTHWEAAERAVLMAQGGEFAFVLYASALSFGIIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCEEEEECCCCEEEHHHHHHHHHHCCC
SDQNAVLTAIVILSMVLTPLLVLILKRFEGASSSRVDGYAISGNLRGTVLIIGFGRVGQI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCEEEEEEECCHHHHH
VSQLLLSRGHEISIIDTDVEMINIAREFQFDVYYGDGTRLDILETAGAGEAKVIAVCVDN
HHHHHHHCCCEEEEEECCHHHHHHHHHHEEEEEECCCCEEEEEECCCCCCCEEEEEEECC
GDDVTAIVRLLKAEFPLATIVARATDRRHALDLVRSGADVQIRETFESAMALGNKALEIL
CCCHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHCCCCEEHHHHHHHHHHHCHHHHHHH
GATPEEMSNLAKGFRERDGARLELELVGGMYAGREFFSGRTHASKITAEIDASEKMRDFR
CCCHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHCCCCHHHHHEEECCCHHHHHHHC
STP
CCC
>Mature Secondary Structure 
AVESHGPDLLPVIALLGAGVVAATVFKRSGLGSVLGYLAAGVVIGPFGLRVFQEPASIL
CCCCCCCCHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
HFAELGVVMFLFLIGLEMRPSRLWGLRRQIFGLGVLQVGVCILCLTAVGMATGFPVAPSF
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHH
VAGTGFVLTSTAIVMQLLEERGTISTPPGQRIVAILLLEDLAIVPLLALVAFLAPIVPGT
HCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TSSAQGIDWIAIGVGVAAIAGVVVSGLYLLNPLFGLIAGAQAREVMTAAALLVVLGAAYV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
MQLGGLSMAMGAFLAGVLLSESTFRHQLEVDIEPFRGILLGLFFLAVGMSLELGVVAADW
HHHCCHHHHHHHHHHHHHHHCHHHHHEEEECCCHHHHHHHHHHHHHHCCCCEEEEEECCH
ELIAFYVAAFMIVKGLAVYGCARLLKSTHWEAAERAVLMAQGGEFAFVLYASALSFGIIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCEEEEECCCCEEEHHHHHHHHHHCCC
SDQNAVLTAIVILSMVLTPLLVLILKRFEGASSSRVDGYAISGNLRGTVLIIGFGRVGQI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCEEEEEEECCHHHHH
VSQLLLSRGHEISIIDTDVEMINIAREFQFDVYYGDGTRLDILETAGAGEAKVIAVCVDN
HHHHHHHCCCEEEEEECCHHHHHHHHHHEEEEEECCCCEEEEEECCCCCCCEEEEEEECC
GDDVTAIVRLLKAEFPLATIVARATDRRHALDLVRSGADVQIRETFESAMALGNKALEIL
CCCHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHCCCCEEHHHHHHHHHHHCHHHHHHH
GATPEEMSNLAKGFRERDGARLELELVGGMYAGREFFSGRTHASKITAEIDASEKMRDFR
CCCHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHCCCCHHHHHEEECCCHHHHHHHC
STP
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]