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The map label for this gene is lpxD [H]

Identifier: 150396358

GI number: 150396358

Start: 1208600

End: 1209664

Strand: Direct

Name: lpxD [H]

Synonym: Smed_1139

Alternate gene names: 150396358

Gene position: 1208600-1209664 (Clockwise)

Preceding gene: 150396357

Following gene: 150396359

Centisome position: 31.96

GC content: 61.78

Gene sequence:

>1065_bases
ATGGAAAAGAATTGGTTTTTCCCGCCCCATGACGGGATTCGTTTGGGCGACCTTGCGGATCAGATTGGGGCGGAATTGCT
GGATGCTACCGCCGCCGACCGCGCAGTGCGTGCGGTCGCGCCGGTCTATCGCGCCAAGGCCGGCGACGTCTGTTACATGC
TGTCGCGCAAAAGCCGCGAGGAATTGCAGACCTGCAGCGCCACTGCGATCATCTGCGACAAGGCGATATCGTCGCTCGTT
CCCGATACCATTCCCGTATTATTGACCGCGAAGCCGCATACCGCCTTTGCGCTTGCAGGCACCTTGCTTCATGAAAGGGC
CATGCGGCCATCCTATAATACGAGTGAGAGAGGCGTATCTCCGGGAGCCTTCGTCGATTCCACGGCGCGCCTGGAGGCAG
GCGTAGAGGTCGAGCCGATGGCGGTGATCGGTGCCGGCGCTGAAATCGGAAGCGGCACGCGAATCGCTGCGGGCGCCATG
ATAGGACCCGGTGTGCGGATCGGCCGCGATTGCACCATCTCCGCGGGTGTGAGCATTCTTTGCGCGCTGATCGGCAACAA
CGTCATCATTCACCCTGGAACGCGCATCGGCCAGGACGGGTTCGGCTATGCGCCTGGTCCGACGGGCGGGATGATCAAAA
TCGTCCAGGTCGGACGGGTGATCATACAGGATCACGTTGAGATCGGTGCCAACACGACGATCGATCGTGGCACCATGGAC
GACACGGTGATCGGCGAGGGGACGAAGATCGACAATCTCGTGCAGATCGGCCACAACGTGCGCATTGGCCGCTATTGCGG
CATCGTCAGTCAGGTCGGCATTGCCGGCAGCGCCCAGATCGGCGACGGAGTGATGATCGGCGGAGGCGTCGGGGTCAACG
GGCATACCAGCATCGGAAGTGGTGCGCAGATCGCAGCAATGAGTGGCGTGGCAAGCGATGTGCCGGCCGGCGAACGCTAC
GGCGGTATTCCGGCGCGGCCGATGCGCGACTTTCTCCGCGATGTCGCTGAAATGGCGCTGAGGTCGAGCGAGAGGCAGAA
GAAGAAGGGTGGCAAGGATGAATGA

Upstream 100 bases:

>100_bases
AAGGAAGACTTCGACGAAATTCAGAACTTCAAGTTCGGAATCAACTCGTCGTTCTGATAAGAGCAGTCCAGAACTGCCAG
AAAATCGTTCTGGAGTGTCC

Downstream 100 bases:

>100_bases
AGCTGCAACGGTCCTCGGAACCGCGGACATACAGGAAATCCTGAAGCTTCTTCCCCATCGTTATCCCTTCTTGCTCGTGG
ATCGCATCATCGAGATCGAT

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MEKNWFFPPHDGIRLGDLADQIGAELLDATAADRAVRAVAPVYRAKAGDVCYMLSRKSREELQTCSATAIICDKAISSLV
PDTIPVLLTAKPHTAFALAGTLLHERAMRPSYNTSERGVSPGAFVDSTARLEAGVEVEPMAVIGAGAEIGSGTRIAAGAM
IGPGVRIGRDCTISAGVSILCALIGNNVIIHPGTRIGQDGFGYAPGPTGGMIKIVQVGRVIIQDHVEIGANTTIDRGTMD
DTVIGEGTKIDNLVQIGHNVRIGRYCGIVSQVGIAGSAQIGDGVMIGGGVGVNGHTSIGSGAQIAAMSGVASDVPAGERY
GGIPARPMRDFLRDVAEMALRSSERQKKKGGKDE

Sequences:

>Translated_354_residues
MEKNWFFPPHDGIRLGDLADQIGAELLDATAADRAVRAVAPVYRAKAGDVCYMLSRKSREELQTCSATAIICDKAISSLV
PDTIPVLLTAKPHTAFALAGTLLHERAMRPSYNTSERGVSPGAFVDSTARLEAGVEVEPMAVIGAGAEIGSGTRIAAGAM
IGPGVRIGRDCTISAGVSILCALIGNNVIIHPGTRIGQDGFGYAPGPTGGMIKIVQVGRVIIQDHVEIGANTTIDRGTMD
DTVIGEGTKIDNLVQIGHNVRIGRYCGIVSQVGIAGSAQIGDGVMIGGGVGVNGHTSIGSGAQIAAMSGVASDVPAGERY
GGIPARPMRDFLRDVAEMALRSSERQKKKGGKDE
>Mature_354_residues
MEKNWFFPPHDGIRLGDLADQIGAELLDATAADRAVRAVAPVYRAKAGDVCYMLSRKSREELQTCSATAIICDKAISSLV
PDTIPVLLTAKPHTAFALAGTLLHERAMRPSYNTSERGVSPGAFVDSTARLEAGVEVEPMAVIGAGAEIGSGTRIAAGAM
IGPGVRIGRDCTISAGVSILCALIGNNVIIHPGTRIGQDGFGYAPGPTGGMIKIVQVGRVIIQDHVEIGANTTIDRGTMD
DTVIGEGTKIDNLVQIGHNVRIGRYCGIVSQVGIAGSAQIGDGVMIGGGVGVNGHTSIGSGAQIAAMSGVASDVPAGERY
GGIPARPMRDFLRDVAEMALRSSERQKKKGGKDE

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=354, Percent_Identity=36.1581920903955, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1786378, Length=249, Percent_Identity=29.3172690763052, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 36666; Mature: 36666

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKNWFFPPHDGIRLGDLADQIGAELLDATAADRAVRAVAPVYRAKAGDVCYMLSRKSRE
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHCCHH
ELQTCSATAIICDKAISSLVPDTIPVLLTAKPHTAFALAGTLLHERAMRPSYNTSERGVS
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHCCCC
PGAFVDSTARLEAGVEVEPMAVIGAGAEIGSGTRIAAGAMIGPGVRIGRDCTISAGVSIL
CCCCCCCHHHHHCCCCCCCEEEEECCCCCCCCCEEEECCEECCCCEECCCCCHHHHHHHH
CALIGNNVIIHPGTRIGQDGFGYAPGPTGGMIKIVQVGRVIIQDHVEIGANTTIDRGTMD
HHHHCCCEEECCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCC
DTVIGEGTKIDNLVQIGHNVRIGRYCGIVSQVGIAGSAQIGDGVMIGGGVGVNGHTSIGS
CCCCCCCCCHHHHHHHCCCEEEHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCC
GAQIAAMSGVASDVPAGERYGGIPARPMRDFLRDVAEMALRSSERQKKKGGKDE
CCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MEKNWFFPPHDGIRLGDLADQIGAELLDATAADRAVRAVAPVYRAKAGDVCYMLSRKSRE
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHCCHH
ELQTCSATAIICDKAISSLVPDTIPVLLTAKPHTAFALAGTLLHERAMRPSYNTSERGVS
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHCCCC
PGAFVDSTARLEAGVEVEPMAVIGAGAEIGSGTRIAAGAMIGPGVRIGRDCTISAGVSIL
CCCCCCCHHHHHCCCCCCCEEEEECCCCCCCCCEEEECCEECCCCEECCCCCHHHHHHHH
CALIGNNVIIHPGTRIGQDGFGYAPGPTGGMIKIVQVGRVIIQDHVEIGANTTIDRGTMD
HHHHCCCEEECCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCC
DTVIGEGTKIDNLVQIGHNVRIGRYCGIVSQVGIAGSAQIGDGVMIGGGVGVNGHTSIGS
CCCCCCCCCHHHHHHHCCCEEEHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCC
GAQIAAMSGVASDVPAGERYGGIPARPMRDFLRDVAEMALRSSERQKKKGGKDE
CCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]