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The map label for this gene is ctaC [H]

Identifier: 150395742

GI number: 150395742

Start: 561807

End: 562691

Strand: Direct

Name: ctaC [H]

Synonym: Smed_0518

Alternate gene names: 150395742

Gene position: 561807-562691 (Clockwise)

Preceding gene: 150395740

Following gene: 150395743

Centisome position: 14.86

GC content: 58.87

Gene sequence:

>885_bases
GTGAAAAACAAGGCCTATGCAGTTCTGGCAGCGCTTGCCTGTCTGCTTTTTGCTTCGAGCGCCTTTGCTGACAAGCCTGT
CGACTGGCAGACGAATTTTCAGCCGGCTGCTACTGGCATAATGGAAGAAATCACGTGGTTTGAGCATTATACCCTGTGGT
TCATCATTCCGATCACACTTTTCGTTCTTCTTCTGCTGGTCGTCGTGGTCGTCAAGTTTCGCGAGAGTGCCAATCCGGTT
CCGTCGAGGACCAGCCACAATACGCTGATCGAAGTCGTCTGGACCGTGGGTCCGGTCATCGTGCTTCTTTTCCTGGCGGT
TCCTTCCTTCCAGCTCCTGACCGCGCAACTCACGCCTCCGGAAAATCCGGACCTGACGGTCAAGGCGACCGGCAACCAAT
GGTACTGGTCCTATGAATACGAAGTCGGCGAAAACCCGCTGTCCTTCGACAGCCTGCTTCTGAAGGACGAGGACAGGGCC
GGGCTCGGCAAGGAGGACAAGGGGCAATATCCGCGTCTTCTCGCGGTCGACAACGAGGTGGTCGTGCCGGTCGGCAAGAC
GGTTCGCCTGCTCGTCACCGCGGCTGACGTGATCCATGCCTTCGCCATGCCTGCTTTCGGTGTCAAGATCGACGCGGTTC
CAGGCCGCCTCAACGAGACCTGGTTCAAGGCCGATCGCGAAGGCCTCTATTACGGCCAGTGTTCCGAGCTCTGCGGCAAG
GATCACGCCTATATGCCGATCGCCGTCCGCGTTGTTGCGCAGGATAAATACGACGCCTGGCTCGCCGCCGCCGCAACCAA
TATCGGCGAAGCGAACAAGGCGCTCATGGCGTCCGTCGACGGCGCGGCCAAGGCCGTTGACGTCGCCGAAAACGCCGCAC
AGTAA

Upstream 100 bases:

>100_bases
GTTGCGGCGCTGGTCAAACTGTGGTTTGAAGCGCTTCAGCATCGCAGGGATTCTGCGTTCCGGGTTTGATCCTGATCAAG
CGCATTGGGGAGACGTAATT

Downstream 100 bases:

>100_bases
TCGGAAGTGGAGCTTGACCATGGCTGGAACAGCCGTTCATCACGATCAACGCCATGATCATTCCGATCATGGCCACGCGG
AACACGCGCACAAGCCGCTG

Product: cytochrome c oxidase subunit II

Products: NA

Alternate protein names: Cytochrome aa3 subunit 2; Cytochrome c oxidase polypeptide II; Oxidase aa(3) subunit 2 [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MKNKAYAVLAALACLLFASSAFADKPVDWQTNFQPAATGIMEEITWFEHYTLWFIIPITLFVLLLLVVVVVKFRESANPV
PSRTSHNTLIEVVWTVGPVIVLLFLAVPSFQLLTAQLTPPENPDLTVKATGNQWYWSYEYEVGENPLSFDSLLLKDEDRA
GLGKEDKGQYPRLLAVDNEVVVPVGKTVRLLVTAADVIHAFAMPAFGVKIDAVPGRLNETWFKADREGLYYGQCSELCGK
DHAYMPIAVRVVAQDKYDAWLAAAATNIGEANKALMASVDGAAKAVDVAENAAQ

Sequences:

>Translated_294_residues
MKNKAYAVLAALACLLFASSAFADKPVDWQTNFQPAATGIMEEITWFEHYTLWFIIPITLFVLLLLVVVVVKFRESANPV
PSRTSHNTLIEVVWTVGPVIVLLFLAVPSFQLLTAQLTPPENPDLTVKATGNQWYWSYEYEVGENPLSFDSLLLKDEDRA
GLGKEDKGQYPRLLAVDNEVVVPVGKTVRLLVTAADVIHAFAMPAFGVKIDAVPGRLNETWFKADREGLYYGQCSELCGK
DHAYMPIAVRVVAQDKYDAWLAAAATNIGEANKALMASVDGAAKAVDVAENAAQ
>Mature_294_residues
MKNKAYAVLAALACLLFASSAFADKPVDWQTNFQPAATGIMEEITWFEHYTLWFIIPITLFVLLLLVVVVVKFRESANPV
PSRTSHNTLIEVVWTVGPVIVLLFLAVPSFQLLTAQLTPPENPDLTVKATGNQWYWSYEYEVGENPLSFDSLLLKDEDRA
GLGKEDKGQYPRLLAVDNEVVVPVGKTVRLLVTAADVIHAFAMPAFGVKIDAVPGRLNETWFKADREGLYYGQCSELCGK
DHAYMPIAVRVVAQDKYDAWLAAAATNIGEANKALMASVDGAAKAVDVAENAAQ

Specific function: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) [H]

COG id: COG1622

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 2

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome c oxidase subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831110, Length=223, Percent_Identity=38.5650224215247, Blast_Score=159, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6226540, Length=244, Percent_Identity=40.5737704918033, Blast_Score=169, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001505
- InterPro:   IPR008972
- InterPro:   IPR014222
- InterPro:   IPR015964
- InterPro:   IPR002429
- InterPro:   IPR011759 [H]

Pfam domain/function: PF00116 COX2; PF02790 COX2_TM [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 32263; Mature: 32263

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00078 COX2 ; PS50999 COX2_TM ; PS50857 COX2_CUA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKAYAVLAALACLLFASSAFADKPVDWQTNFQPAATGIMEEITWFEHYTLWFIIPITL
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FVLLLLVVVVVKFRESANPVPSRTSHNTLIEVVWTVGPVIVLLFLAVPSFQLLTAQLTPP
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCC
ENPDLTVKATGNQWYWSYEYEVGENPLSFDSLLLKDEDRAGLGKEDKGQYPRLLAVDNEV
CCCCEEEEECCCEEEEEEEEEECCCCCCHHHEEEECCCCCCCCCCCCCCCCEEEEECCEE
VVPVGKTVRLLVTAADVIHAFAMPAFGVKIDAVPGRLNETWFKADREGLYYGQCSELCGK
EEECCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHCCCCCEECCHHHHHCC
DHAYMPIAVRVVAQDKYDAWLAAAATNIGEANKALMASVDGAAKAVDVAENAAQ
CCCCCEEEEEEEECCCHHHHHHHHHHCCCCCCHHHEEECCCHHHHHHHHHHCCC
>Mature Secondary Structure
MKNKAYAVLAALACLLFASSAFADKPVDWQTNFQPAATGIMEEITWFEHYTLWFIIPITL
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FVLLLLVVVVVKFRESANPVPSRTSHNTLIEVVWTVGPVIVLLFLAVPSFQLLTAQLTPP
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCC
ENPDLTVKATGNQWYWSYEYEVGENPLSFDSLLLKDEDRAGLGKEDKGQYPRLLAVDNEV
CCCCEEEEECCCEEEEEEEEEECCCCCCHHHEEEECCCCCCCCCCCCCCCCEEEEECCEE
VVPVGKTVRLLVTAADVIHAFAMPAFGVKIDAVPGRLNETWFKADREGLYYGQCSELCGK
EEECCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHCCCCCEECCHHHHHCC
DHAYMPIAVRVVAQDKYDAWLAAAATNIGEANKALMASVDGAAKAVDVAENAAQ
CCCCCEEEEEEEECCCHHHHHHHHHHCCCCCCHHHEEECCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2820725; 7651515; 9380672 [H]