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The map label for this gene is ribBA [H]

Identifier: 150395740

GI number: 150395740

Start: 559679

End: 560779

Strand: Direct

Name: ribBA [H]

Synonym: Smed_0516

Alternate gene names: 150395740

Gene position: 559679-560779 (Clockwise)

Preceding gene: 150395739

Following gene: 150395742

Centisome position: 14.8

GC content: 61.85

Gene sequence:

>1101_bases
ATGTCCTACGACCAAAAGCGCGTCGTCGAAGCCATTCGCGCATTTGAAGCGGGAGAGATCGTCGTCGTCACCGACGACGG
AGGTCGCGAGAACGAGGGCGACCTGATCGTCGCGGCGGTACACTGCACGCCTGAGAAGATGGCGTTTATCGTGCGCCATA
CGTCCGGCATCGTCTGCACGCCGATGCCGCGCGAGGAGGCGAAGCGCCTGAATCTGAATGCGATGGTTGCCGAGAACGAC
TCCGCTCACACCACGGCCTTCACCGTGTCGGTTGATTTCAAGCACGGGACCACGACCGGCATTTCCGCGGACGATCGTAC
GCTGACGGCCAGAAACCTTGCAAATCCGAATGTCGGGCCGACGGATTTCGTCCGGCCGGGCCATATATTCCCTCTGGTCG
CCCGCGAGGGTGGAGTGCTGATGCGCTCCGGTCATACCGAGGCCGCGGTCGATCTCTGCCGGCTTGCAAGCCTGCCGCCT
ATCGGGGTCATCTGCGAGCTCGTCAACGATGACGGCACGGTCATGCGCGGTCCACAGGTCGAAACCTTCGCCGAAGCACA
CGGCCTCAAGCAGGTCTCCGTGGCCGATCTCATCGCCTACCGTCAGCGCAAGGAGACCTTGATCGAGAAGGGGCATTCCT
TCGAGATGAATACGCCCTGCGGCAAGGCCGTGGGCCACACCTATTCGCTTCCATGGGATCCGATGCAGCACCTGGCGGTG
GTCTTCGGCGACGTCAGGGACGGTGTCGACATTCCGGTTCGCCTCCATCTCGAAAATGTCGGAGCAGACGTCTTCGGAAA
CGGCCGCCAGATCGACGAGATCATGAAACGCATCGCGGCAGAGGGCAGGGGCGTCATCGTCTACCTGCGCGAGGGTTCGG
TAGGCGTCGGCGTTTCACAGACCGCGCGTAAGGGCAAACACGAACGGGAAGCGCATTCGGAGGCGCAGACGCGCGAAAGC
GAGTGGCTGGAGATCGGCCTCGGAGCGCAGATCCTGAAAGATCTGGGCATTACCTCCATTCGCCTTCTTTCGACGCGCGA
ACGGCACTATGTCGGCCTGGAGGGTTTCGGCATCAAGATCGCCGCCACCGAGATTTTGTGA

Upstream 100 bases:

>100_bases
CGCAATCGCCGACCATTACCTGCGTGATCGCGGCCAGACAGGCCGGCTGAAGTAACAAGGCAGTGCAATTGCGGTGAAAC
AACACGTCGCGGAGATAAAA

Downstream 100 bases:

>100_bases
TCAGCCCCTCATGAAAAAAGCCGCGTCAAAGGCGCGGCTTGGTCGCTTCTCCGGGAATGCCGCTGTCAGGGAAGCGCGTC
GTAGCCCTCGTCGAAGCCCT

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MSYDQKRVVEAIRAFEAGEIVVVTDDGGRENEGDLIVAAVHCTPEKMAFIVRHTSGIVCTPMPREEAKRLNLNAMVAEND
SAHTTAFTVSVDFKHGTTTGISADDRTLTARNLANPNVGPTDFVRPGHIFPLVAREGGVLMRSGHTEAAVDLCRLASLPP
IGVICELVNDDGTVMRGPQVETFAEAHGLKQVSVADLIAYRQRKETLIEKGHSFEMNTPCGKAVGHTYSLPWDPMQHLAV
VFGDVRDGVDIPVRLHLENVGADVFGNGRQIDEIMKRIAAEGRGVIVYLREGSVGVGVSQTARKGKHEREAHSEAQTRES
EWLEIGLGAQILKDLGITSIRLLSTRERHYVGLEGFGIKIAATEIL

Sequences:

>Translated_366_residues
MSYDQKRVVEAIRAFEAGEIVVVTDDGGRENEGDLIVAAVHCTPEKMAFIVRHTSGIVCTPMPREEAKRLNLNAMVAEND
SAHTTAFTVSVDFKHGTTTGISADDRTLTARNLANPNVGPTDFVRPGHIFPLVAREGGVLMRSGHTEAAVDLCRLASLPP
IGVICELVNDDGTVMRGPQVETFAEAHGLKQVSVADLIAYRQRKETLIEKGHSFEMNTPCGKAVGHTYSLPWDPMQHLAV
VFGDVRDGVDIPVRLHLENVGADVFGNGRQIDEIMKRIAAEGRGVIVYLREGSVGVGVSQTARKGKHEREAHSEAQTRES
EWLEIGLGAQILKDLGITSIRLLSTRERHYVGLEGFGIKIAATEIL
>Mature_365_residues
SYDQKRVVEAIRAFEAGEIVVVTDDGGRENEGDLIVAAVHCTPEKMAFIVRHTSGIVCTPMPREEAKRLNLNAMVAENDS
AHTTAFTVSVDFKHGTTTGISADDRTLTARNLANPNVGPTDFVRPGHIFPLVAREGGVLMRSGHTEAAVDLCRLASLPPI
GVICELVNDDGTVMRGPQVETFAEAHGLKQVSVADLIAYRQRKETLIEKGHSFEMNTPCGKAVGHTYSLPWDPMQHLAVV
FGDVRDGVDIPVRLHLENVGADVFGNGRQIDEIMKRIAAEGRGVIVYLREGSVGVGVSQTARKGKHEREAHSEAQTRESE
WLEIGLGAQILKDLGITSIRLLSTRERHYVGLEGFGIKIAATEIL

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=200, Percent_Identity=49, Blast_Score=191, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6320695, Length=202, Percent_Identity=49.009900990099, Blast_Score=197, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 39814; Mature: 39683

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYDQKRVVEAIRAFEAGEIVVVTDDGGRENEGDLIVAAVHCTPEKMAFIVRHTSGIVCT
CCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEEECCHHHEEEEEEECCCEEEC
PMPREEAKRLNLNAMVAENDSAHTTAFTVSVDFKHGTTTGISADDRTLTARNLANPNVGP
CCCHHHHHHCCCEEEEECCCCCCEEEEEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCC
TDFVRPGHIFPLVAREGGVLMRSGHTEAAVDLCRLASLPPIGVICELVNDDGTVMRGPQV
CCCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCCHHEEEEEECCCCCEEECCCH
ETFAEAHGLKQVSVADLIAYRQRKETLIEKGHSFEMNTPCGKAVGHTYSLPWDPMQHLAV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHCCCCCCCCCCHHHHHHH
VFGDVRDGVDIPVRLHLENVGADVFGNGRQIDEIMKRIAAEGRGVIVYLREGSVGVGVSQ
HHHHHCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCHH
TARKGKHEREAHSEAQTRESEWLEIGLGAQILKDLGITSIRLLSTRERHYVGLEGFGIKI
HHHCCCHHHHHHHHHHHCCCHHEEECCCHHHHHHCCCCEEEEEECCCCEEEEECCCCEEE
AATEIL
EEEECC
>Mature Secondary Structure 
SYDQKRVVEAIRAFEAGEIVVVTDDGGRENEGDLIVAAVHCTPEKMAFIVRHTSGIVCT
CCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEEECCHHHEEEEEEECCCEEEC
PMPREEAKRLNLNAMVAENDSAHTTAFTVSVDFKHGTTTGISADDRTLTARNLANPNVGP
CCCHHHHHHCCCEEEEECCCCCCEEEEEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCC
TDFVRPGHIFPLVAREGGVLMRSGHTEAAVDLCRLASLPPIGVICELVNDDGTVMRGPQV
CCCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCCHHEEEEEECCCCCEEECCCH
ETFAEAHGLKQVSVADLIAYRQRKETLIEKGHSFEMNTPCGKAVGHTYSLPWDPMQHLAV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHCCCCCCCCCCHHHHHHH
VFGDVRDGVDIPVRLHLENVGADVFGNGRQIDEIMKRIAAEGRGVIVYLREGSVGVGVSQ
HHHHHCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCHH
TARKGKHEREAHSEAQTRESEWLEIGLGAQILKDLGITSIRLLSTRERHYVGLEGFGIKI
HHHCCCHHHHHHHHHHHCCCHHEEECCCHHHHHHCCCCEEEEEECCCCEEEEECCCCEEE
AATEIL
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA