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The map label for this gene is aroB [H]

Identifier: 150395597

GI number: 150395597

Start: 398129

End: 399658

Strand: Direct

Name: aroB [H]

Synonym: Smed_0372

Alternate gene names: 150395597

Gene position: 398129-399658 (Clockwise)

Preceding gene: 150395596

Following gene: 150395598

Centisome position: 10.53

GC content: 67.78

Gene sequence:

>1530_bases
GTGCGCACAGGCGCGTCACGAAGCGGCAAGGGCAAACGGAGGCGGCGCAGGCCGTCCGGTTCGCCGTCTGCAATTGCCAG
CCAATCCGGCCCGTCCGGAGAAGCAGGGCGTCCCGCAGCACTGAATGAGGCGGAGCCGTCGCGCAAGCGAAAACGGCGCC
GGCGCTCGAAATCAGCAAAACCAGAGGACTCATCTGCCGCATCAGGTGCACGCGCGCCGGAGCCGGATGCTGCCGCCGGC
GACAAAAAGAACAATAAACGCAACAGGAAGGCGCGTCATCGGCGTGGCCTTCAAGGGCGGCCGCTGGCTTCCACGAATAC
GCCCCCCGCAACTGTGCGGGCTGGCGAAGCTGTGCGCTCGCGCAGTGGCGACAGCGCAGCACCGCGTCAGCAGCAGTCGC
GCGCGGAGCGGCCGGGCGGTCAACCCGGTGCGCCCTTCGTCGCGCCAAGCGAACCGCCCGCGCCGCTTTACGCGGCGCTC
GACCTTGGCACCAACAATTGCCGGCTGCTCATCGCGCAGCCGACCCGGCCGGGGCAGTTCCGTGTGGTCGATGCGTTTTC
GAGGATCGTCCGGCTGGGCGAGGGGCTCGGTGCAAGCGGACGGCTTTCGGACGACGCAATGGAGCGTTCGGTCGAAGCGC
TCAAGGTCTGCGCGGCCAAGCTCGGCGCCCGCTCGATCCGCCGTCATCGGCTGATCGCGACGGAGGCTGCGCGCGCGGCC
GCCAATGGCGAGGCCTTCATGCGGCGCGTCGCCGAGGAAACCGGCCTGGATCTCGAAATCATCGACCGGGAGACGGAGGC
ACGGCTTGCGGTATCCGGCTGCTCGTCGCTCGTCGACCGGGAAACCAAGTCCGTCGTCCTCTTCGATATCGGCGGCGGCT
CTTCGGAAATCGCCGTCATTCGCATAGGTGAAAATCGTTCCAGCCGGCTTGCCAATCACATCACCCATTGGACGTCGCTG
CCCGTCGGCGTCGTCACCCTTTCCGAGCGCCATGGCGGCGAGCATGTGACGCCTCAAAGCTTCGAGGTGATGGTGCGCGA
GGTCGAGGCCATGCTCGCCGGCTTCGAGTGCCCCTCCGTCGATGTCCTGGCAAGCGGCTCCTATAGCGATGGCTTCCATC
TGATCGGAACTTCGGGAACCGTCACGACGCTCGCCGGCGTGCATCTCGACCTGCCGCGCTACGACCGTCGCCGTGTCGAT
GGCCTATGGCTTTCGGACGACGAGGTTTCCGCCATGCAGGCGCGCCTCCTCTCCTGGGATTTTGCCGCGCGTGCCGCCAA
TCCCTGCATTGGGCCCGACCGGGCAGACCTGGTGCTTGCCGGATGCGCGATCCTCGAGGCGATCCGTCGCCGCTGGCCGT
CGACCCGCATGCGCGTTGCCGATCGGGGGCTTCGCGAAGGGTTGCTGACCGACATGATGGCGGATGACGGGGCCTGGCGC
CGGGCGCGTCCACGCCGCCACCAACGCAGCTTCGGTCCCCCGCAGGCGGGGGAGGAGTGCGCGAAGCGCCATGAAGGAAC
CGACGCATGA

Upstream 100 bases:

>100_bases
CGTAAGGCTTCGCGCGGCGCCATGGTTGAGACAAGTGAAAGACCCCGATCACGGCGAGAAGCCGTCTGAATCCGGGGCGT
CGGCAGCAGGTCGCGGCGAG

Downstream 100 bases:

>100_bases
CGAAACCCCCGGTCGGCAGCAACCGCAGCGGCCGAAAGCTCGGTCAGAAGGTCAAGAAGGGCAAGCTCAAGGCATCCTCG
CGCCGCTGGATCGAGCGCCA

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: 3-dehydroquinate synthase; Unknown phosphatase [H]

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MRTGASRSGKGKRRRRRPSGSPSAIASQSGPSGEAGRPAALNEAEPSRKRKRRRRSKSAKPEDSSAASGARAPEPDAAAG
DKKNNKRNRKARHRRGLQGRPLASTNTPPATVRAGEAVRSRSGDSAAPRQQQSRAERPGGQPGAPFVAPSEPPAPLYAAL
DLGTNNCRLLIAQPTRPGQFRVVDAFSRIVRLGEGLGASGRLSDDAMERSVEALKVCAAKLGARSIRRHRLIATEAARAA
ANGEAFMRRVAEETGLDLEIIDRETEARLAVSGCSSLVDRETKSVVLFDIGGGSSEIAVIRIGENRSSRLANHITHWTSL
PVGVVTLSERHGGEHVTPQSFEVMVREVEAMLAGFECPSVDVLASGSYSDGFHLIGTSGTVTTLAGVHLDLPRYDRRRVD
GLWLSDDEVSAMQARLLSWDFAARAANPCIGPDRADLVLAGCAILEAIRRRWPSTRMRVADRGLREGLLTDMMADDGAWR
RARPRRHQRSFGPPQAGEECAKRHEGTDA

Sequences:

>Translated_509_residues
MRTGASRSGKGKRRRRRPSGSPSAIASQSGPSGEAGRPAALNEAEPSRKRKRRRRSKSAKPEDSSAASGARAPEPDAAAG
DKKNNKRNRKARHRRGLQGRPLASTNTPPATVRAGEAVRSRSGDSAAPRQQQSRAERPGGQPGAPFVAPSEPPAPLYAAL
DLGTNNCRLLIAQPTRPGQFRVVDAFSRIVRLGEGLGASGRLSDDAMERSVEALKVCAAKLGARSIRRHRLIATEAARAA
ANGEAFMRRVAEETGLDLEIIDRETEARLAVSGCSSLVDRETKSVVLFDIGGGSSEIAVIRIGENRSSRLANHITHWTSL
PVGVVTLSERHGGEHVTPQSFEVMVREVEAMLAGFECPSVDVLASGSYSDGFHLIGTSGTVTTLAGVHLDLPRYDRRRVD
GLWLSDDEVSAMQARLLSWDFAARAANPCIGPDRADLVLAGCAILEAIRRRWPSTRMRVADRGLREGLLTDMMADDGAWR
RARPRRHQRSFGPPQAGEECAKRHEGTDA
>Mature_509_residues
MRTGASRSGKGKRRRRRPSGSPSAIASQSGPSGEAGRPAALNEAEPSRKRKRRRRSKSAKPEDSSAASGARAPEPDAAAG
DKKNNKRNRKARHRRGLQGRPLASTNTPPATVRAGEAVRSRSGDSAAPRQQQSRAERPGGQPGAPFVAPSEPPAPLYAAL
DLGTNNCRLLIAQPTRPGQFRVVDAFSRIVRLGEGLGASGRLSDDAMERSVEALKVCAAKLGARSIRRHRLIATEAARAA
ANGEAFMRRVAEETGLDLEIIDRETEARLAVSGCSSLVDRETKSVVLFDIGGGSSEIAVIRIGENRSSRLANHITHWTSL
PVGVVTLSERHGGEHVTPQSFEVMVREVEAMLAGFECPSVDVLASGSYSDGFHLIGTSGTVTTLAGVHLDLPRYDRRRVD
GLWLSDDEVSAMQARLLSWDFAARAANPCIGPDRADLVLAGCAILEAIRRRWPSTRMRVADRGLREGLLTDMMADDGAWR
RARPRRHQRSFGPPQAGEECAKRHEGTDA

Specific function: Degradation Of Inorganic Polyphosphates. Orthophosphate Is Released Progressively From The Ends Of Polyphosphate Of Circa 500 Residues Long, While Chains Of Circa 15 Residues Compete Poorly With Polyphosphate As Substrate. [C]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=321, Percent_Identity=25.2336448598131, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI48994966, Length=319, Percent_Identity=27.5862068965517, Blast_Score=81, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002658
- InterPro:   IPR016037
- InterPro:   IPR003695 [H]

Pfam domain/function: PF01761 DHQ_synthase; PF02541 Ppx-GppA [H]

EC number: =4.2.3.4 [H]

Molecular weight: Translated: 54841; Mature: 54841

Theoretical pI: Translated: 11.19; Mature: 11.19

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTGASRSGKGKRRRRRPSGSPSAIASQSGPSGEAGRPAALNEAEPSRKRKRRRRSKSAK
CCCCCCCCCCCHHHHCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCC
PEDSSAASGARAPEPDAAAGDKKNNKRNRKARHRRGLQGRPLASTNTPPATVRAGEAVRS
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEECCHHHHH
RSGDSAAPRQQQSRAERPGGQPGAPFVAPSEPPAPLYAALDLGTNNCRLLIAQPTRPGQF
CCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCE
RVVDAFSRIVRLGEGLGASGRLSDDAMERSVEALKVCAAKLGARSIRRHRLIATEAARAA
EHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANGEAFMRRVAEETGLDLEIIDRETEARLAVSGCSSLVDRETKSVVLFDIGGGSSEIAVI
CCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEE
RIGENRSSRLANHITHWTSLPVGVVTLSERHGGEHVTPQSFEVMVREVEAMLAGFECPSV
EECCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
DVLASGSYSDGFHLIGTSGTVTTLAGVHLDLPRYDRRRVDGLWLSDDEVSAMQARLLSWD
EEEECCCCCCCEEEEECCCCEEHHCCEEECCCCHHHHHCCCEEECCCHHHHHHHHHHHHH
FAARAANPCIGPDRADLVLAGCAILEAIRRRWPSTRMRVADRGLREGLLTDMMADDGAWR
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
RARPRRHQRSFGPPQAGEECAKRHEGTDA
HCCCHHHHHCCCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MRTGASRSGKGKRRRRRPSGSPSAIASQSGPSGEAGRPAALNEAEPSRKRKRRRRSKSAK
CCCCCCCCCCCHHHHCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCC
PEDSSAASGARAPEPDAAAGDKKNNKRNRKARHRRGLQGRPLASTNTPPATVRAGEAVRS
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEECCHHHHH
RSGDSAAPRQQQSRAERPGGQPGAPFVAPSEPPAPLYAALDLGTNNCRLLIAQPTRPGQF
CCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCE
RVVDAFSRIVRLGEGLGASGRLSDDAMERSVEALKVCAAKLGARSIRRHRLIATEAARAA
EHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANGEAFMRRVAEETGLDLEIIDRETEARLAVSGCSSLVDRETKSVVLFDIGGGSSEIAVI
CCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEE
RIGENRSSRLANHITHWTSLPVGVVTLSERHGGEHVTPQSFEVMVREVEAMLAGFECPSV
EECCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
DVLASGSYSDGFHLIGTSGTVTTLAGVHLDLPRYDRRRVDGLWLSDDEVSAMQARLLSWD
EEEECCCCCCCEEEEECCCCEEHHCCEEECCCCHHHHHCCCEEECCCHHHHHHHHHHHHH
FAARAANPCIGPDRADLVLAGCAILEAIRRRWPSTRMRVADRGLREGLLTDMMADDGAWR
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
RARPRRHQRSFGPPQAGEECAKRHEGTDA
HCCCHHHHHCCCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11889109 [H]