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The map label for this gene is betA [C]

Identifier: 150395596

GI number: 150395596

Start: 395655

End: 397283

Strand: Direct

Name: betA [C]

Synonym: Smed_0371

Alternate gene names: 150395596

Gene position: 395655-397283 (Clockwise)

Preceding gene: 150395595

Following gene: 150395597

Centisome position: 10.46

GC content: 58.81

Gene sequence:

>1629_bases
GTGGATCAGAATAAGCCTGACCTAAAGCGACATGAAAATCCGGCACCAACACATCATGAGGTTTCAGACGATTTTGACTT
TATCGTATGTGGAGCCGGCTCCAGTGGTTCAGTCATTGCCGCTCGACTGGCACAATGCGGAAGCGCCCGCGTCTTGCTTC
TTGAGGCAGGCGGCGATGACGTAGCCGAGTCTGTTAGAGACCCGGCCCAATGGCCACTCAATCTCGGCACGAGCCGTGAC
TGGGGTTTCGTTGGAGAGCCGGCGCCTGAGCTCTACGGTAGGCGGCTACCTCTCAGCATGGGCAAGGGTTTGGGCGGCGG
ATCGAGCATCAACGTGATGGTCTGGGCGCGGGGCCACATGGAAGACTGGAATTATTTCGCTGCCGAAGCGGGCGATGAAG
CCTGGGGCTATGAATCGGTTCTCGGTTACTATCGGCGAATTGAAGACTGGCGCGGCACGCCAGATACTGTACGCCGCGGC
GCTGGAGGGCCGGTATATGTCGCCCAGCCACGTTCGCCGCAGCCTATCGCAGAGGCTTTGCTGAACGCTGCGTCGGCGAT
AGGAATTCCGGTATTCGACACTCCAAACGGCGAACTGATGGAAAGTGGAGGAGGTGCATCGATCGCAGAACTGCGCATCC
GGGATGGCAAGCGGGAGTCCGTATTCGGATCTTATGTTCGTCCGCTCATGTCACGACCAAACCTAACGGTCCTAACCGAC
GCGTTGGTCACGCGCATCATCTTCGATGGCATACGGGCGACAGGCGTCGACGTTCTCGTCAACGGTCAACGGTGCGCGTT
CACTGCGCGATGCGAAACGGTATTGTCGCTGGGTGCTATCAACACGCCAAAGGTGCTGATGCAGTCAGGCATTGGCCCGA
GGGACGAGCTGAAGGCCCACGGGATATCTGTCGTGCAGCATCTTCCGGGTGTGGGTCGAAACCATCAGGATCATCTCGCG
TTCGGCTGCACGTGGGCATATCGAAAGCCGGAAGGCATCGGCGGGGGAGGCTGCGAAGCAAAACTCTATTGGAAAAGCGA
CTCCCGCCTCTCTCAGCCGGACATTCTTCAGTGCCAGTTGGAGTTCGCCGTACCTTCGCCGGTGGAGACAGGTCTGGAAA
CCCCGGCGCATGGCTGGACGATGTTTTCAGGGCTTGCGCAGCCGAAAAGCCGTGGCCGGCTGAGGCTCTCCGGCCCCAAT
ACAAACGACCCTATCCTGATTGAACCAAACTCTCTCAGTGAGCCGGAAGACGTGGCTGCAGCCTTGGCAGCGGTTGAGCT
GTGTCGCGAACTCGGAAATAGCGACGCCTTCACGCCGCTGGTCGCGTGCGAAGCAGTGCCGGGCACGCGAGACCGGGCAG
GGATGATCGATTTCATCCGAAAGTCGGCCGTCACTTACTGGCACCAGTCCTGCACGGCCAAAATGGGACGCGACAGCATG
TCCGTGGTCAATAACGAGCTCAAGGTCTACGGGGTTGAAAGTCTTCGTATCGCAGATGCCTCTATCATGCCGCGTATCAC
CACCGGAAACACGATGGCACCGTGTGTCGTCATCGGAGAGCGCGCAGGCGATTTGATCAGAAAGACGCATGGTCTTGCTG
ACTCGAGTGGTGTCGCTCCATTCGCCTGA

Upstream 100 bases:

>100_bases
AAACCGTCGATCTCCCATGGAGATCGATCGCGCCTTTGAGCCGTTAGCGCTCACCGCCATTTCTCACAATCGAAGCTCTT
CAATTCACAAAGGTAATCCA

Downstream 100 bases:

>100_bases
AGATGCTTTAGAAGAGCTCGGCGGTCAGCATACACCGGCGGTCGAGCTCTTTGCGCCCTTTTTGGGTCAACCGTTCGGCT
TGTTTCAAGACCTTCTACTA

Product: glucose-methanol-choline oxidoreductase

Products: NA

Alternate protein names: SDH [H]

Number of amino acids: Translated: 542; Mature: 542

Protein sequence:

>542_residues
MDQNKPDLKRHENPAPTHHEVSDDFDFIVCGAGSSGSVIAARLAQCGSARVLLLEAGGDDVAESVRDPAQWPLNLGTSRD
WGFVGEPAPELYGRRLPLSMGKGLGGGSSINVMVWARGHMEDWNYFAAEAGDEAWGYESVLGYYRRIEDWRGTPDTVRRG
AGGPVYVAQPRSPQPIAEALLNAASAIGIPVFDTPNGELMESGGGASIAELRIRDGKRESVFGSYVRPLMSRPNLTVLTD
ALVTRIIFDGIRATGVDVLVNGQRCAFTARCETVLSLGAINTPKVLMQSGIGPRDELKAHGISVVQHLPGVGRNHQDHLA
FGCTWAYRKPEGIGGGGCEAKLYWKSDSRLSQPDILQCQLEFAVPSPVETGLETPAHGWTMFSGLAQPKSRGRLRLSGPN
TNDPILIEPNSLSEPEDVAAALAAVELCRELGNSDAFTPLVACEAVPGTRDRAGMIDFIRKSAVTYWHQSCTAKMGRDSM
SVVNNELKVYGVESLRIADASIMPRITTGNTMAPCVVIGERAGDLIRKTHGLADSSGVAPFA

Sequences:

>Translated_542_residues
MDQNKPDLKRHENPAPTHHEVSDDFDFIVCGAGSSGSVIAARLAQCGSARVLLLEAGGDDVAESVRDPAQWPLNLGTSRD
WGFVGEPAPELYGRRLPLSMGKGLGGGSSINVMVWARGHMEDWNYFAAEAGDEAWGYESVLGYYRRIEDWRGTPDTVRRG
AGGPVYVAQPRSPQPIAEALLNAASAIGIPVFDTPNGELMESGGGASIAELRIRDGKRESVFGSYVRPLMSRPNLTVLTD
ALVTRIIFDGIRATGVDVLVNGQRCAFTARCETVLSLGAINTPKVLMQSGIGPRDELKAHGISVVQHLPGVGRNHQDHLA
FGCTWAYRKPEGIGGGGCEAKLYWKSDSRLSQPDILQCQLEFAVPSPVETGLETPAHGWTMFSGLAQPKSRGRLRLSGPN
TNDPILIEPNSLSEPEDVAAALAAVELCRELGNSDAFTPLVACEAVPGTRDRAGMIDFIRKSAVTYWHQSCTAKMGRDSM
SVVNNELKVYGVESLRIADASIMPRITTGNTMAPCVVIGERAGDLIRKTHGLADSSGVAPFA
>Mature_542_residues
MDQNKPDLKRHENPAPTHHEVSDDFDFIVCGAGSSGSVIAARLAQCGSARVLLLEAGGDDVAESVRDPAQWPLNLGTSRD
WGFVGEPAPELYGRRLPLSMGKGLGGGSSINVMVWARGHMEDWNYFAAEAGDEAWGYESVLGYYRRIEDWRGTPDTVRRG
AGGPVYVAQPRSPQPIAEALLNAASAIGIPVFDTPNGELMESGGGASIAELRIRDGKRESVFGSYVRPLMSRPNLTVLTD
ALVTRIIFDGIRATGVDVLVNGQRCAFTARCETVLSLGAINTPKVLMQSGIGPRDELKAHGISVVQHLPGVGRNHQDHLA
FGCTWAYRKPEGIGGGGCEAKLYWKSDSRLSQPDILQCQLEFAVPSPVETGLETPAHGWTMFSGLAQPKSRGRLRLSGPN
TNDPILIEPNSLSEPEDVAAALAAVELCRELGNSDAFTPLVACEAVPGTRDRAGMIDFIRKSAVTYWHQSCTAKMGRDSM
SVVNNELKVYGVESLRIADASIMPRITTGNTMAPCVVIGERAGDLIRKTHGLADSSGVAPFA

Specific function: Can Catalyze The Oxidation Of Choline To Betaine Aldehyde And Betaine Aldehyde To Glycine Betaine At The Same Rate. [C]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=553, Percent_Identity=35.8047016274864, Blast_Score=285, Evalue=1e-76,
Organism=Escherichia coli, GI1786503, Length=544, Percent_Identity=34.5588235294118, Blast_Score=260, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17532301, Length=556, Percent_Identity=32.7338129496403, Blast_Score=261, Evalue=7e-70,
Organism=Drosophila melanogaster, GI24642048, Length=588, Percent_Identity=33.3333333333333, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI24642042, Length=573, Percent_Identity=31.9371727748691, Blast_Score=241, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24650267, Length=581, Percent_Identity=31.4974182444062, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI45549471, Length=575, Percent_Identity=30.9565217391304, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI45551458, Length=585, Percent_Identity=31.1111111111111, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24642059, Length=579, Percent_Identity=31.7789291882556, Blast_Score=225, Evalue=6e-59,
Organism=Drosophila melanogaster, GI17137792, Length=557, Percent_Identity=31.2387791741472, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24642039, Length=574, Percent_Identity=31.7073170731707, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24642037, Length=571, Percent_Identity=32.5744308231173, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI18859995, Length=575, Percent_Identity=31.304347826087, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24642035, Length=572, Percent_Identity=32.1678321678322, Blast_Score=208, Evalue=9e-54,
Organism=Drosophila melanogaster, GI24642055, Length=329, Percent_Identity=36.7781155015198, Blast_Score=193, Evalue=3e-49,
Organism=Drosophila melanogaster, GI18859993, Length=573, Percent_Identity=29.4938917975567, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24642051, Length=573, Percent_Identity=28.4467713787086, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24642057, Length=332, Percent_Identity=28.6144578313253, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24645930, Length=169, Percent_Identity=31.3609467455621, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.32 [H]

Molecular weight: Translated: 58101; Mature: 58101

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQNKPDLKRHENPAPTHHEVSDDFDFIVCGAGSSGSVIAARLAQCGSARVLLLEAGGDD
CCCCCCCHHHCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHCCCCEEEEEECCCCH
VAESVRDPAQWPLNLGTSRDWGFVGEPAPELYGRRLPLSMGKGLGGGSSINVMVWARGHM
HHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCHHHCCCCCCCCEEEEEEEECCCC
EDWNYFAAEAGDEAWGYESVLGYYRRIEDWRGTPDTVRRGAGGPVYVAQPRSPQPIAEAL
CCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCEEEECCCCCCHHHHHH
LNAASAIGIPVFDTPNGELMESGGGASIAELRIRDGKRESVFGSYVRPLMSRPNLTVLTD
HHHHHHCCCCEEECCCCHHEECCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEHHH
ALVTRIIFDGIRATGVDVLVNGQRCAFTARCETVLSLGAINTPKVLMQSGIGPRDELKAH
HHHHHHHHHCHHHCCEEEEECCCEEEEHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHH
GISVVQHLPGVGRNHQDHLAFGCTWAYRKPEGIGGGGCEAKLYWKSDSRLSQPDILQCQL
HHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEE
EFAVPSPVETGLETPAHGWTMFSGLAQPKSRGRLRLSGPNTNDPILIEPNSLSEPEDVAA
EECCCCCHHHCCCCCCCCHHHHHHHCCHHHCCEEEECCCCCCCCEEECCCCCCCHHHHHH
ALAAVELCRELGNSDAFTPLVACEAVPGTRDRAGMIDFIRKSAVTYWHQSCTAKMGRDSM
HHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHH
SVVNNELKVYGVESLRIADASIMPRITTGNTMAPCVVIGERAGDLIRKTHGLADSSGVAP
HHHCCCEEEEEECEEEEECHHHCCEECCCCCCCCEEEEECHHHHHHHHHCCCCCCCCCCC
FA
CC
>Mature Secondary Structure
MDQNKPDLKRHENPAPTHHEVSDDFDFIVCGAGSSGSVIAARLAQCGSARVLLLEAGGDD
CCCCCCCHHHCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHCCCCEEEEEECCCCH
VAESVRDPAQWPLNLGTSRDWGFVGEPAPELYGRRLPLSMGKGLGGGSSINVMVWARGHM
HHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCHHHCCCCCCCCEEEEEEEECCCC
EDWNYFAAEAGDEAWGYESVLGYYRRIEDWRGTPDTVRRGAGGPVYVAQPRSPQPIAEAL
CCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCEEEECCCCCCHHHHHH
LNAASAIGIPVFDTPNGELMESGGGASIAELRIRDGKRESVFGSYVRPLMSRPNLTVLTD
HHHHHHCCCCEEECCCCHHEECCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEHHH
ALVTRIIFDGIRATGVDVLVNGQRCAFTARCETVLSLGAINTPKVLMQSGIGPRDELKAH
HHHHHHHHHCHHHCCEEEEECCCEEEEHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHH
GISVVQHLPGVGRNHQDHLAFGCTWAYRKPEGIGGGGCEAKLYWKSDSRLSQPDILQCQL
HHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEE
EFAVPSPVETGLETPAHGWTMFSGLAQPKSRGRLRLSGPNTNDPILIEPNSLSEPEDVAA
EECCCCCHHHCCCCCCCCHHHHHHHCCHHHCCEEEECCCCCCCCEEECCCCCCCHHHHHH
ALAAVELCRELGNSDAFTPLVACEAVPGTRDRAGMIDFIRKSAVTYWHQSCTAKMGRDSM
HHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHH
SVVNNELKVYGVESLRIADASIMPRITTGNTMAPCVVIGERAGDLIRKTHGLADSSGVAP
HHHCCCEEEEEECEEEEECHHHCCEECCCCCCCCEEEEECHHHHHHHHHCCCCCCCCCCC
FA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9023923 [H]