Click here to switch to the map view.

The map label for this gene is folK [H]

Identifier: 150009008

GI number: 150009008

Start: 2817517

End: 2817975

Strand: Reverse

Name: folK [H]

Synonym: BDI_2404

Alternate gene names: 150009008

Gene position: 2817975-2817517 (Counterclockwise)

Preceding gene: 150009009

Following gene: 150009007

Centisome position: 58.57

GC content: 48.37

Gene sequence:

>459_bases
ATGGCGACAGCTTACCTTGGATTAGGTACGAACGTAGGTAATAAACGAGGAAATTTGGTGACAGCGGCGGCGCTGCTGGC
TGAAAGGGTGGGAGATGTTCTTGCCCTTTCTGATATGTATGAGACGGAGCCTTGGGGATTTGAATCGGACAACACTTTCT
TGAACGCCGTGATCGTCATGACGACGGAACTTTCCCCTATGGAATTATTAGATGCTACCCGTTTGATCGAGATCGAGATG
GGACGTATCGAAAAAAGTGACGGTGCGTATCATGACCGTATCATCGATATCGATCTGTTAATGGTGGATGAGCAAATCCT
GCATACGGAGCGGCTGACGCTACCGCACCCTCTGATGCACAAACGGTCGTTTGTAATGGAACCGTTGGCAGAAGTAGCTC
CGTCGGTGAAACATCCTGTGTTTGGCAAGACGATGCGTGAACTTTTATCCGAATTATAA

Upstream 100 bases:

>100_bases
GGTTATGAGTTGATCATGGACGCTTACGATATCGCTTTGAAAGAGAAATATCGTTTCGGTGCTTACGGCGACGCTATGCT
AATCCTTTAATCCGGTTTCT

Downstream 100 bases:

>100_bases
GTTTTAATTATGAACTACGAGATTTGAGTTATGAATAAAGAAATTAATAAAGCGATGACGCAAGGGATCGTCTTCAAGAA
AGCGAAAGGCGAAGCGGAAG

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 152; Mature: 151

Protein sequence:

>152_residues
MATAYLGLGTNVGNKRGNLVTAAALLAERVGDVLALSDMYETEPWGFESDNTFLNAVIVMTTELSPMELLDATRLIEIEM
GRIEKSDGAYHDRIIDIDLLMVDEQILHTERLTLPHPLMHKRSFVMEPLAEVAPSVKHPVFGKTMRELLSEL

Sequences:

>Translated_152_residues
MATAYLGLGTNVGNKRGNLVTAAALLAERVGDVLALSDMYETEPWGFESDNTFLNAVIVMTTELSPMELLDATRLIEIEM
GRIEKSDGAYHDRIIDIDLLMVDEQILHTERLTLPHPLMHKRSFVMEPLAEVAPSVKHPVFGKTMRELLSEL
>Mature_151_residues
ATAYLGLGTNVGNKRGNLVTAAALLAERVGDVLALSDMYETEPWGFESDNTFLNAVIVMTTELSPMELLDATRLIEIEMG
RIEKSDGAYHDRIIDIDLLMVDEQILHTERLTLPHPLMHKRSFVMEPLAEVAPSVKHPVFGKTMRELLSEL

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=150, Percent_Identity=33.3333333333333, Blast_Score=95, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324073, Length=157, Percent_Identity=32.484076433121, Blast_Score=83, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 16964; Mature: 16833

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATAYLGLGTNVGNKRGNLVTAAALLAERVGDVLALSDMYETEPWGFESDNTFLNAVIVM
CCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEE
TTELSPMELLDATRLIEIEMGRIEKSDGAYHDRIIDIDLLMVDEQILHTERLTLPHPLMH
ECCCCHHHHHHHHHEEEEECCCEECCCCCCCCEEEEEHEEEHHHHHHHHHHCCCCCHHHH
KRSFVMEPLAEVAPSVKHPVFGKTMRELLSEL
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
>Mature Secondary Structure 
ATAYLGLGTNVGNKRGNLVTAAALLAERVGDVLALSDMYETEPWGFESDNTFLNAVIVM
CEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEE
TTELSPMELLDATRLIEIEMGRIEKSDGAYHDRIIDIDLLMVDEQILHTERLTLPHPLMH
ECCCCHHHHHHHHHEEEEECCCEECCCCCCCCEEEEEHEEEHHHHHHHHHHCCCCCHHHH
KRSFVMEPLAEVAPSVKHPVFGKTMRELLSEL
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA