Click here to switch to the map view.

The map label for this gene is patB [H]

Identifier: 150008690

GI number: 150008690

Start: 2463508

End: 2464683

Strand: Direct

Name: patB [H]

Synonym: BDI_2080

Alternate gene names: 150008690

Gene position: 2463508-2464683 (Clockwise)

Preceding gene: 150008689

Following gene: 150008691

Centisome position: 51.2

GC content: 47.53

Gene sequence:

>1176_bases
ATGAAACACTACAACTTCGACGAAGTTATCGAACGGCATGGGACGAGTTGCGTGAAATTCGACCGTTTGAAAGAGATGTT
CGGTGACGAGAATCTGATACCACTATGGGTGGCGGATATGGATTTCCGCACACCGGACTTTATTGTAGAGGCCCTGAAGA
AACGTTGTGAGCACGAGATATTCGGCTATACATTCGGCTCCGACGAGTATTACGAGAGTATCATCAATTGGGTACACTAC
AAACATAACTGGAAAATACAACGGGAATGGATCAGCTATATCCCGGGAATCGTAAAGGGAATCGCTTTCGCTATCCAATG
CTTTACGCAAAAAGGAGATAAGGTCATCATCCAGCCCCCTGTTTATCACCCGTTCCGCATCGTTCCGGAGAAAATGAAGC
GCGAGGTCGTTTATAATCCGCTAAAGATGGTAGACGGCATCTATGAGATGGATTTTGATCATCTTGAATCTATTATAGAT
GATAAATGCAAGGTATTGATCCTCTGCAACCCTCACAATCCGGGTGGGATCGTCTGGAAAAAGGAAACCTTGGTCCGATT
GGCCGAGATTTGCGCCAAGCACAATATTTTGGTTATCTCCGATGAGATTCATGCGGAAATGGCCTATCCTCAGTACACGC
ATTACCCGTTCGCCTCCGTATCGGATACCGCCGCTTCCTGCAGCGTGACTTTCATGGCACCGAGCAAGACGTTCAATATC
GCCGGTATCGTGACTTCCTACGCAATCGTACCCAATGATCGCATCCGGGAAGAATTTTACTCTTTCCTTGAGGCCGGAGA
GTTTGGCGATGGCACGATCTTCGCTTATACGGCGACAACCGCCGCTTACACCTATGGCGCCGAATGGTTGCAACAAATGC
GAATGTATATCATGGAGAATGTACGTTTCGTGGAAGAGTTCATGAAACTACATCTCCCCAAGATAAAAGTTTACCAGCCC
CAAGCCTCCTTCCTCGTTTGGTTGGATTGCAGGGAACTGGAATTAAGTCAAGATGAACTCGTACACCTGTTCAAAGACAA
AGCCGGACTAGCGCTGAACGACGGAAGTATCTTCGGCCCCGGGGGAGAAGGCCATATGCGTTTGAACATTGGCTGCCCCC
GCTCTGTTTTAGATAAAGCGATGAACGCTCTTAAAAAGGCGGTGGATAAGAAATAA

Upstream 100 bases:

>100_bases
TACAAAAACATCATCTTTATACATATTTTGCTTTAAAATCGCAGTTTTTTATGTAAGTTTGACCCCTAAAACAATTAAGA
AACTGATCGTTAATAAAAAT

Downstream 100 bases:

>100_bases
AATCGTATCTTTGCGAGCATTTCTATACATATTTAAAATACAAGACAAATGAAAATTACAGCAAACAAATACGTTGCGGT
TACATACGACCTGAACGTTG

Product: putative aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MKHYNFDEVIERHGTSCVKFDRLKEMFGDENLIPLWVADMDFRTPDFIVEALKKRCEHEIFGYTFGSDEYYESIINWVHY
KHNWKIQREWISYIPGIVKGIAFAIQCFTQKGDKVIIQPPVYHPFRIVPEKMKREVVYNPLKMVDGIYEMDFDHLESIID
DKCKVLILCNPHNPGGIVWKKETLVRLAEICAKHNILVISDEIHAEMAYPQYTHYPFASVSDTAASCSVTFMAPSKTFNI
AGIVTSYAIVPNDRIREEFYSFLEAGEFGDGTIFAYTATTAAYTYGAEWLQQMRMYIMENVRFVEEFMKLHLPKIKVYQP
QASFLVWLDCRELELSQDELVHLFKDKAGLALNDGSIFGPGGEGHMRLNIGCPRSVLDKAMNALKKAVDKK

Sequences:

>Translated_391_residues
MKHYNFDEVIERHGTSCVKFDRLKEMFGDENLIPLWVADMDFRTPDFIVEALKKRCEHEIFGYTFGSDEYYESIINWVHY
KHNWKIQREWISYIPGIVKGIAFAIQCFTQKGDKVIIQPPVYHPFRIVPEKMKREVVYNPLKMVDGIYEMDFDHLESIID
DKCKVLILCNPHNPGGIVWKKETLVRLAEICAKHNILVISDEIHAEMAYPQYTHYPFASVSDTAASCSVTFMAPSKTFNI
AGIVTSYAIVPNDRIREEFYSFLEAGEFGDGTIFAYTATTAAYTYGAEWLQQMRMYIMENVRFVEEFMKLHLPKIKVYQP
QASFLVWLDCRELELSQDELVHLFKDKAGLALNDGSIFGPGGEGHMRLNIGCPRSVLDKAMNALKKAVDKK
>Mature_391_residues
MKHYNFDEVIERHGTSCVKFDRLKEMFGDENLIPLWVADMDFRTPDFIVEALKKRCEHEIFGYTFGSDEYYESIINWVHY
KHNWKIQREWISYIPGIVKGIAFAIQCFTQKGDKVIIQPPVYHPFRIVPEKMKREVVYNPLKMVDGIYEMDFDHLESIID
DKCKVLILCNPHNPGGIVWKKETLVRLAEICAKHNILVISDEIHAEMAYPQYTHYPFASVSDTAASCSVTFMAPSKTFNI
AGIVTSYAIVPNDRIREEFYSFLEAGEFGDGTIFAYTATTAAYTYGAEWLQQMRMYIMENVRFVEEFMKLHLPKIKVYQP
QASFLVWLDCRELELSQDELVHLFKDKAGLALNDGSIFGPGGEGHMRLNIGCPRSVLDKAMNALKKAVDKK

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=161, Percent_Identity=29.1925465838509, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI56713254, Length=161, Percent_Identity=29.1925465838509, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1787909, Length=389, Percent_Identity=33.1619537275064, Blast_Score=252, Evalue=3e-68,
Organism=Escherichia coli, GI1788627, Length=288, Percent_Identity=20.8333333333333, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786816, Length=237, Percent_Identity=21.9409282700422, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71994472, Length=226, Percent_Identity=26.5486725663717, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71994476, Length=226, Percent_Identity=26.5486725663717, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322401, Length=334, Percent_Identity=25.1497005988024, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28573069, Length=156, Percent_Identity=30.7692307692308, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24646114, Length=156, Percent_Identity=30.7692307692308, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573067, Length=156, Percent_Identity=30.7692307692308, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573065, Length=156, Percent_Identity=30.7692307692308, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI18859735, Length=236, Percent_Identity=22.8813559322034, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 45153; Mature: 45153

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHYNFDEVIERHGTSCVKFDRLKEMFGDENLIPLWVADMDFRTPDFIVEALKKRCEHEI
CCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHCHHH
FGYTFGSDEYYESIINWVHYKHNWKIQREWISYIPGIVKGIAFAIQCFTQKGDKVIIQPP
CEEECCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
VYHPFRIVPEKMKREVVYNPLKMVDGIYEMDFDHLESIIDDKCKVLILCNPHNPGGIVWK
CCCCHHHCCHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHCCCCEEEEEECCCCCCCEEEC
KETLVRLAEICAKHNILVISDEIHAEMAYPQYTHYPFASVSDTAASCSVTFMAPSKTFNI
HHHHHHHHHHHHCCCEEEEECHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEE
AGIVTSYAIVPNDRIREEFYSFLEAGEFGDGTIFAYTATTAAYTYGAEWLQQMRMYIMEN
EEHHHHEEECCCHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHH
VRFVEEFMKLHLPKIKVYQPQASFLVWLDCRELELSQDELVHLFKDKAGLALNDGSIFGP
HHHHHHHHHHCCCCEEEECCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEECCCCEECC
GGEGHMRLNIGCPRSVLDKAMNALKKAVDKK
CCCCEEEEECCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKHYNFDEVIERHGTSCVKFDRLKEMFGDENLIPLWVADMDFRTPDFIVEALKKRCEHEI
CCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHCHHH
FGYTFGSDEYYESIINWVHYKHNWKIQREWISYIPGIVKGIAFAIQCFTQKGDKVIIQPP
CEEECCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
VYHPFRIVPEKMKREVVYNPLKMVDGIYEMDFDHLESIIDDKCKVLILCNPHNPGGIVWK
CCCCHHHCCHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHCCCCEEEEEECCCCCCCEEEC
KETLVRLAEICAKHNILVISDEIHAEMAYPQYTHYPFASVSDTAASCSVTFMAPSKTFNI
HHHHHHHHHHHHCCCEEEEECHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEE
AGIVTSYAIVPNDRIREEFYSFLEAGEFGDGTIFAYTATTAAYTYGAEWLQQMRMYIMEN
EEHHHHEEECCCHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHH
VRFVEEFMKLHLPKIKVYQPQASFLVWLDCRELELSQDELVHLFKDKAGLALNDGSIFGP
HHHHHHHHHHCCCCEEEECCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEECCCCEECC
GGEGHMRLNIGCPRSVLDKAMNALKKAVDKK
CCCCEEEEECCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]