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The map label for this gene is ilvD

Identifier: 150008683

GI number: 150008683

Start: 2450108

End: 2451943

Strand: Reverse

Name: ilvD

Synonym: BDI_2073

Alternate gene names: 150008683

Gene position: 2451943-2450108 (Counterclockwise)

Preceding gene: 150008694

Following gene: 150008682

Centisome position: 50.96

GC content: 53.21

Gene sequence:

>1836_bases
ATGAAGAATCCGTTAAGAAGCTCATTTAGCACCGAAGGTCGTAGGATGGCCGGAGCCCGTGCGCTATGGCGTGCCAACGG
GATGAAAGAGGAACAGTTCGGCAAGCCTATTATCGCTATCGTAAATTCATTTACCCAGTTCGTGCCGGGGCATACGCATT
TGCATGAGATCGGGCAACTGGTCAAGGCCGAGATCGAGAAACAAGGTTGTTTCGCCGCTGAATTTAATACGATCGCTATC
GATGACGGTATCGCTATGGGGCACGATGGGATGCTTTACTCGCTTCCTTCACGCGACATTATCGCGGACAGCGTGGAATA
TATGGTAAATGCCCATAAGGCGGACGCTATGGTTTGCATCAGCAATTGCGATAAGATCACGCCGGGTATGCTTATGGCTT
CCATGCGATTAAATATCCCGACGGTGTTCGTGTCCGGTGGCCCGATGGAGGCAGGTGAGCTGGATGGCCGCCATCTGGAT
TTGATCGACGCGATGATTGAGTCCGCCGATACATCGGTAAGCGATGAGCGTATCGAGCAGGTGGAACGCCATGCGTGTCC
GGGTTGCGGTTGTTGTTCCGGTATGTTTACCGCTAACTCTATGAACTGCTTGAACGAGGCGATCGGTCTGGCGCTTCCGG
GGAACGGGACGATCGTGGCTACCCATAAGAACCGTATCCAACTTTTCCGTGATGCGGCTAAGCAAATCGTTGAGAACGCT
TACAAATACTATCGTGACGGGGATGATTCCGTGTTACCTCGCAACATCGCTACCCGTCAGGCTTTCTTGAACGCCATGTC
GCTGGATATCGCCATGGGGGGGTCTACCAATACGGTGCTTCACTTATTGGCCGTGGCACAAGAAGCCGGCGCCGATTTTC
ATATGGAGGATATCGATATGTTATCCCGCAAGACACCTTGCCTGTGTAAGGTAGCCCCGAATACGCACACTTATCATGTA
CAAGACGTAAACCGTGCCGGTGGAATCCTCGGTATCATGAACGAGTTGATGAAAGCCGGGCTTGTGGATGGCAGCACGAG
ACGTGCGGACGGCCTGACCTTGGCCGAGGCTGTTGATAAATACGCCGTCACTTCCCCGAACGTAACGGAGGAGGCGATCC
GTAAATACAAGAGCGCTCCCGCTCATCGGTTCAGTATCCAGATGGGTTCCCAAGAATCTTATTATAAGGAATTAGATACG
GATCGTGCCGAAGGTTGTATCCGTGACGTGGAGCACGCTTATTCCAAGGATGGCGGCTTGGCTGTTTTGAGAGGGAATAT
CGCCTTGGACGGATGTGTCGTAAAAACCGCCGGCGTGGATGAGAGTATTTGGAAATTCTCCGGCCCGGCGAAAGTCTTCG
ATTCACAGGATGCCGCTTGCGAGGGCATTTTAGGAGGCAAGGTCGTTTCAGGCGATGTGGTCGTCATCACGTATGAGGGT
CCGAAAGGAGGGCCGGGAATGCAAGAGATGTTATATCCTACCTCTTATATAAAGAGCCGTCACTTAGGTAAGGAGTGCGC
CTTGATCACGGATGGTCGTTTCAGTGGCGGTACGTCCGGTCTTTCTATCGGGCATATCTCTCCTGAGGCCGCTTCCGGTG
GCGCTATCGGACTGGTGAGAGACGGGGATATCATCGAGATCAATATCCCGGAACGTTCCATCAACGTGCGGCTGAGCGAC
GAGGAGTTGGCCGAGCGCCGTAAAGCGGAAGAGGCGCGTGGAAAGAAAGCCTTTACGCCGCCGACGCGTCAGCGTGAGGT
CTCGAAAGCGTTGAGAGCGTACGGGAAGATGGTTAGCTCCGCCGATAAGGGAGGTGTAAGGATTGTTGAAGATTAA

Upstream 100 bases:

>100_bases
TCTTAAGCCTTTCTCCATATAGGGAAAGGCTTTTTTTATTATAAATAATTCAAGGTAGAGGCGTGGATAAAGCGCTCTAC
GAACAAAAAATAGGAAAGAG

Downstream 100 bases:

>100_bases
AGCCAATAATATACATTAAACACGTTATTTCTTATGGAGAAACAAAAGATAACCGGTTCGGAAGCTTTGCTGAAAGCGTT
GATTGCTGAAGGAGTAGATA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 611; Mature: 611

Protein sequence:

>611_residues
MKNPLRSSFSTEGRRMAGARALWRANGMKEEQFGKPIIAIVNSFTQFVPGHTHLHEIGQLVKAEIEKQGCFAAEFNTIAI
DDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHKADAMVCISNCDKITPGMLMASMRLNIPTVFVSGGPMEAGELDGRHLD
LIDAMIESADTSVSDERIEQVERHACPGCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATHKNRIQLFRDAAKQIVENA
YKYYRDGDDSVLPRNIATRQAFLNAMSLDIAMGGSTNTVLHLLAVAQEAGADFHMEDIDMLSRKTPCLCKVAPNTHTYHV
QDVNRAGGILGIMNELMKAGLVDGSTRRADGLTLAEAVDKYAVTSPNVTEEAIRKYKSAPAHRFSIQMGSQESYYKELDT
DRAEGCIRDVEHAYSKDGGLAVLRGNIALDGCVVKTAGVDESIWKFSGPAKVFDSQDAACEGILGGKVVSGDVVVITYEG
PKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGGTSGLSIGHISPEAASGGAIGLVRDGDIIEINIPERSINVRLSD
EELAERRKAEEARGKKAFTPPTRQREVSKALRAYGKMVSSADKGGVRIVED

Sequences:

>Translated_611_residues
MKNPLRSSFSTEGRRMAGARALWRANGMKEEQFGKPIIAIVNSFTQFVPGHTHLHEIGQLVKAEIEKQGCFAAEFNTIAI
DDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHKADAMVCISNCDKITPGMLMASMRLNIPTVFVSGGPMEAGELDGRHLD
LIDAMIESADTSVSDERIEQVERHACPGCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATHKNRIQLFRDAAKQIVENA
YKYYRDGDDSVLPRNIATRQAFLNAMSLDIAMGGSTNTVLHLLAVAQEAGADFHMEDIDMLSRKTPCLCKVAPNTHTYHV
QDVNRAGGILGIMNELMKAGLVDGSTRRADGLTLAEAVDKYAVTSPNVTEEAIRKYKSAPAHRFSIQMGSQESYYKELDT
DRAEGCIRDVEHAYSKDGGLAVLRGNIALDGCVVKTAGVDESIWKFSGPAKVFDSQDAACEGILGGKVVSGDVVVITYEG
PKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGGTSGLSIGHISPEAASGGAIGLVRDGDIIEINIPERSINVRLSD
EELAERRKAEEARGKKAFTPPTRQREVSKALRAYGKMVSSADKGGVRIVED
>Mature_611_residues
MKNPLRSSFSTEGRRMAGARALWRANGMKEEQFGKPIIAIVNSFTQFVPGHTHLHEIGQLVKAEIEKQGCFAAEFNTIAI
DDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHKADAMVCISNCDKITPGMLMASMRLNIPTVFVSGGPMEAGELDGRHLD
LIDAMIESADTSVSDERIEQVERHACPGCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATHKNRIQLFRDAAKQIVENA
YKYYRDGDDSVLPRNIATRQAFLNAMSLDIAMGGSTNTVLHLLAVAQEAGADFHMEDIDMLSRKTPCLCKVAPNTHTYHV
QDVNRAGGILGIMNELMKAGLVDGSTRRADGLTLAEAVDKYAVTSPNVTEEAIRKYKSAPAHRFSIQMGSQESYYKELDT
DRAEGCIRDVEHAYSKDGGLAVLRGNIALDGCVVKTAGVDESIWKFSGPAKVFDSQDAACEGILGGKVVSGDVVVITYEG
PKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGGTSGLSIGHISPEAASGGAIGLVRDGDIIEINIPERSINVRLSD
EELAERRKAEEARGKKAFTPPTRQREVSKALRAYGKMVSSADKGGVRIVED

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=607, Percent_Identity=66.7215815485997, Blast_Score=833, Evalue=0.0,
Organism=Escherichia coli, GI2367371, Length=513, Percent_Identity=31.7738791423002, Blast_Score=193, Evalue=3e-50,
Organism=Escherichia coli, GI1788157, Length=534, Percent_Identity=28.0898876404494, Blast_Score=185, Evalue=7e-48,
Organism=Escherichia coli, GI1786464, Length=519, Percent_Identity=31.0211946050096, Blast_Score=178, Evalue=8e-46,
Organism=Saccharomyces cerevisiae, GI6322476, Length=607, Percent_Identity=36.0790774299835, Blast_Score=340, Evalue=3e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_PARD8 (A6LDP0)

Other databases:

- EMBL:   CP000140
- RefSeq:   YP_001303426.1
- STRING:   A6LDP0
- GeneID:   5307222
- GenomeReviews:   CP000140_GR
- KEGG:   pdi:BDI_2073
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- ProtClustDB:   PRK12448
- BioCyc:   PDIS435591:BDI_2073-MONOMER
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 65860; Mature: 65860

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNPLRSSFSTEGRRMAGARALWRANGMKEEQFGKPIIAIVNSFTQFVPGHTHLHEIGQL
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHH
VKAEIEKQGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHKADAMVCI
HHHHHHHCCCEEECCCEEEEECCEEECCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEE
SNCDKITPGMLMASMRLNIPTVFVSGGPMEAGELDGRHLDLIDAMIESADTSVSDERIEQ
CCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHH
VERHACPGCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATHKNRIQLFRDAAKQIVENA
HHHHCCCCCCCCCCCCCCCHHHHHHHHHCEEECCCCEEEEECHHHHHHHHHHHHHHHHHH
YKYYRDGDDSVLPRNIATRQAFLNAMSLDIAMGGSTNTVLHLLAVAQEAGADFHMEDIDM
HHHHCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHH
LSRKTPCLCKVAPNTHTYHVQDVNRAGGILGIMNELMKAGLVDGSTRRADGLTLAEAVDK
HHCCCCEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
YAVTSPNVTEEAIRKYKSAPAHRFSIQMGSQESYYKELDTDRAEGCIRDVEHAYSKDGGL
HCCCCCCCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCE
AVLRGNIALDGCVVKTAGVDESIWKFSGPAKVFDSQDAACEGILGGKVVSGDVVVITYEG
EEEECCEEECCEEEEECCCCHHHHHCCCCCHHCCCCCHHHCCCCCCEEEECCEEEEEECC
PKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGGTSGLSIGHISPEAASGGAIGLVR
CCCCCCHHHHHCCHHHHHHHCCCCCEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEEEE
DGDIIEINIPERSINVRLSDEELAERRKAEEARGKKAFTPPTRQREVSKALRAYGKMVSS
CCCEEEEECCCCEEEEEECHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHC
ADKGGVRIVED
CCCCCEEEECC
>Mature Secondary Structure
MKNPLRSSFSTEGRRMAGARALWRANGMKEEQFGKPIIAIVNSFTQFVPGHTHLHEIGQL
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHH
VKAEIEKQGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHKADAMVCI
HHHHHHHCCCEEECCCEEEEECCEEECCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEE
SNCDKITPGMLMASMRLNIPTVFVSGGPMEAGELDGRHLDLIDAMIESADTSVSDERIEQ
CCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHH
VERHACPGCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATHKNRIQLFRDAAKQIVENA
HHHHCCCCCCCCCCCCCCCHHHHHHHHHCEEECCCCEEEEECHHHHHHHHHHHHHHHHHH
YKYYRDGDDSVLPRNIATRQAFLNAMSLDIAMGGSTNTVLHLLAVAQEAGADFHMEDIDM
HHHHCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHH
LSRKTPCLCKVAPNTHTYHVQDVNRAGGILGIMNELMKAGLVDGSTRRADGLTLAEAVDK
HHCCCCEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
YAVTSPNVTEEAIRKYKSAPAHRFSIQMGSQESYYKELDTDRAEGCIRDVEHAYSKDGGL
HCCCCCCCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCE
AVLRGNIALDGCVVKTAGVDESIWKFSGPAKVFDSQDAACEGILGGKVVSGDVVVITYEG
EEEECCEEECCEEEEECCCCHHHHHCCCCCHHCCCCCHHHCCCCCCEEEECCEEEEEECC
PKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGGTSGLSIGHISPEAASGGAIGLVR
CCCCCCHHHHHCCHHHHHHHCCCCCEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEEEE
DGDIIEINIPERSINVRLSDEELAERRKAEEARGKKAFTPPTRQREVSKALRAYGKMVSS
CCCEEEEECCCCEEEEEECHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHC
ADKGGVRIVED
CCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA