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The map label for this gene is menB [H]

Identifier: 150004954

GI number: 150004954

Start: 3102703

End: 3103524

Strand: Reverse

Name: menB [H]

Synonym: BVU_2417

Alternate gene names: 150004954

Gene position: 3103524-3102703 (Counterclockwise)

Preceding gene: 150004955

Following gene: 150004953

Centisome position: 60.11

GC content: 51.95

Gene sequence:

>822_bases
ATGGAAACAAGAGAATGGAAAACCATCAAAGAATATCAGGATATTCTGTTTGACTTTTACAACGGAATAGCGAAAATCAC
CATCAACCGTCCGCGTTACCGCAACGCGTTCACCCCCACCACCACTTCGGAAATCAGCGACGCCCTGTATTACTGCCGCG
AGTGCCAGGATATCAATGTAGTGGTTCTGACCGGAGCAGGCGACAAAGCCTTCTGCAGCGGGGGAGATATGCACGTAAAA
GGTCATGGCGGCTATATCGGCACGGATGGAGTTCCCCGTCTGAATGTGCTGGACGTACAAAAGCAAATCCGGTCACTGCC
TAAACCGGTCATCGCCATGGTAAACGGTTACGCCATCGGCGGCGGTCATGTGCTGCATGTGGTATGCGATCTGACCATTG
CCTCAGAGAATGCCATTTTCGGACAGACAGGTCCCAAGGTAGGCAGCTTCGACGCCGGATTCGGCTCTTCCTATCTGGCA
CGCATCGTAGGGCAGAAGAAAGCCCGTGAAATATGGTTCCTTTGCCGTCAATACTCCGCACAGGAAGCACTGGAAATGGG
ATTGGTCAATACAGTCGTTCCTTTCTACCGCCTGGAAGACGAAACCGTGGCATGGGCAGAAAAGATGATGGAGCACAGCC
CGCTCGCTCTTCGTATGATCAAAGCCGGACTGAATGCCGAACTGGACGGACAAGCCGGCATACAAGAACTTGCCGGAGAT
GCCACCATGCTGTATTACATGACAGAGGAAGCACAGGAAGGAGGAAAGGCATTTTTGGAAAAACGCAAGCCACGGTTCCA
GGATTATCCGAAGTTCCCATAA

Upstream 100 bases:

>100_bases
CACGGATGCAACCCATGCTGCTGGAGGTGTTTACCGACAAGGAAAAAGACACCACCCTGTTAAGAGAATATTATCACGGA
CTTAAAAATAAAAATGAATA

Downstream 100 bases:

>100_bases
TCAGTGGTTCATTTTTCCGGTGGAGGACAACCCAATAGTCCTCCTTGCTTCCCATTAACCACTAATCACTAATAAGAATG
TTCCAAACCCGAATTATAAA

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
METREWKTIKEYQDILFDFYNGIAKITINRPRYRNAFTPTTTSEISDALYYCRECQDINVVVLTGAGDKAFCSGGDMHVK
GHGGYIGTDGVPRLNVLDVQKQIRSLPKPVIAMVNGYAIGGGHVLHVVCDLTIASENAIFGQTGPKVGSFDAGFGSSYLA
RIVGQKKAREIWFLCRQYSAQEALEMGLVNTVVPFYRLEDETVAWAEKMMEHSPLALRMIKAGLNAELDGQAGIQELAGD
ATMLYYMTEEAQEGGKAFLEKRKPRFQDYPKFP

Sequences:

>Translated_273_residues
METREWKTIKEYQDILFDFYNGIAKITINRPRYRNAFTPTTTSEISDALYYCRECQDINVVVLTGAGDKAFCSGGDMHVK
GHGGYIGTDGVPRLNVLDVQKQIRSLPKPVIAMVNGYAIGGGHVLHVVCDLTIASENAIFGQTGPKVGSFDAGFGSSYLA
RIVGQKKAREIWFLCRQYSAQEALEMGLVNTVVPFYRLEDETVAWAEKMMEHSPLALRMIKAGLNAELDGQAGIQELAGD
ATMLYYMTEEAQEGGKAFLEKRKPRFQDYPKFP
>Mature_273_residues
METREWKTIKEYQDILFDFYNGIAKITINRPRYRNAFTPTTTSEISDALYYCRECQDINVVVLTGAGDKAFCSGGDMHVK
GHGGYIGTDGVPRLNVLDVQKQIRSLPKPVIAMVNGYAIGGGHVLHVVCDLTIASENAIFGQTGPKVGSFDAGFGSSYLA
RIVGQKKAREIWFLCRQYSAQEALEMGLVNTVVPFYRLEDETVAWAEKMMEHSPLALRMIKAGLNAELDGQAGIQELAGD
ATMLYYMTEEAQEGGKAFLEKRKPRFQDYPKFP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=251, Percent_Identity=34.2629482071713, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI31542718, Length=262, Percent_Identity=32.4427480916031, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI45643119, Length=213, Percent_Identity=29.1079812206573, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI260275230, Length=213, Percent_Identity=29.1079812206573, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI260274832, Length=213, Percent_Identity=29.1079812206573, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI4502327, Length=275, Percent_Identity=27.2727272727273, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4757966, Length=218, Percent_Identity=27.0642201834862, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI51538581, Length=218, Percent_Identity=27.0642201834862, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI25453481, Length=218, Percent_Identity=27.0642201834862, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI51538573, Length=218, Percent_Identity=27.0642201834862, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI70995211, Length=219, Percent_Identity=30.1369863013699, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI37594469, Length=155, Percent_Identity=27.0967741935484, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI37594471, Length=155, Percent_Identity=27.0967741935484, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI116235487, Length=220, Percent_Identity=27.7272727272727, Blast_Score=68, Evalue=7e-12,
Organism=Escherichia coli, GI1788597, Length=272, Percent_Identity=64.7058823529412, Blast_Score=362, Evalue=1e-101,
Organism=Escherichia coli, GI1787659, Length=246, Percent_Identity=33.739837398374, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87082183, Length=261, Percent_Identity=30.6513409961686, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI221142681, Length=250, Percent_Identity=30.8, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787660, Length=265, Percent_Identity=30.188679245283, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI1788682, Length=202, Percent_Identity=27.2277227722772, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790281, Length=222, Percent_Identity=27.027027027027, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17554946, Length=249, Percent_Identity=32.5301204819277, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI25145438, Length=254, Percent_Identity=33.8582677165354, Blast_Score=124, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17540714, Length=205, Percent_Identity=30.2439024390244, Blast_Score=97, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17549921, Length=216, Percent_Identity=26.8518518518519, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17536985, Length=263, Percent_Identity=25.8555133079848, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17535521, Length=248, Percent_Identity=26.2096774193548, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17560910, Length=194, Percent_Identity=28.3505154639175, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17534483, Length=222, Percent_Identity=30.1801801801802, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI25144157, Length=162, Percent_Identity=27.7777777777778, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25144160, Length=162, Percent_Identity=27.7777777777778, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI20129971, Length=245, Percent_Identity=34.2857142857143, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24653477, Length=245, Percent_Identity=34.2857142857143, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24653139, Length=256, Percent_Identity=30.46875, Blast_Score=107, Evalue=6e-24,
Organism=Drosophila melanogaster, GI19922422, Length=254, Percent_Identity=27.5590551181102, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI21357171, Length=189, Percent_Identity=32.2751322751323, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24654903, Length=227, Percent_Identity=29.9559471365639, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24650670, Length=186, Percent_Identity=29.0322580645161, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 30386; Mature: 30386

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METREWKTIKEYQDILFDFYNGIAKITINRPRYRNAFTPTTTSEISDALYYCRECQDINV
CCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCE
VVLTGAGDKAFCSGGDMHVKGHGGYIGTDGVPRLNVLDVQKQIRSLPKPVIAMVNGYAIG
EEEECCCCCCEECCCCEEEEECCCEECCCCCCCCHHHHHHHHHHHCCHHHHHHHCCEEEC
GGHVLHVVCDLTIASENAIFGQTGPKVGSFDAGFGSSYLARIVGQKKAREIWFLCRQYSA
CCCEEEEEEEEEECCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QEALEMGLVNTVVPFYRLEDETVAWAEKMMEHSPLALRMIKAGLNAELDGQAGIQELAGD
HHHHHHHHHHHHHHHHEECCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHCCC
ATMLYYMTEEAQEGGKAFLEKRKPRFQDYPKFP
CEEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
METREWKTIKEYQDILFDFYNGIAKITINRPRYRNAFTPTTTSEISDALYYCRECQDINV
CCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCE
VVLTGAGDKAFCSGGDMHVKGHGGYIGTDGVPRLNVLDVQKQIRSLPKPVIAMVNGYAIG
EEEECCCCCCEECCCCEEEEECCCEECCCCCCCCHHHHHHHHHHHCCHHHHHHHCCEEEC
GGHVLHVVCDLTIASENAIFGQTGPKVGSFDAGFGSSYLARIVGQKKAREIWFLCRQYSA
CCCEEEEEEEEEECCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QEALEMGLVNTVVPFYRLEDETVAWAEKMMEHSPLALRMIKAGLNAELDGQAGIQELAGD
HHHHHHHHHHHHHHHHEECCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHCCC
ATMLYYMTEEAQEGGKAFLEKRKPRFQDYPKFP
CEEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629163; 8566759; 9387221; 9384377 [H]