| Definition | Bacteroides vulgatus ATCC 8482 chromosome, complete genome. |
|---|---|
| Accession | NC_009614 |
| Length | 5,163,189 |
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The map label for this gene is uxuB [H]
Identifier: 150004713
GI number: 150004713
Start: 2809263
End: 2810078
Strand: Direct
Name: uxuB [H]
Synonym: BVU_2174
Alternate gene names: 150004713
Gene position: 2809263-2810078 (Clockwise)
Preceding gene: 150004712
Following gene: 150004714
Centisome position: 54.41
GC content: 47.92
Gene sequence:
>816_bases ATGAATGAATTATTTGGAATTGCAGGAAAAGTAGCCGTTATCACTGGAGCCGGTGGAGTTTTAGGCGGTAATATCGCAAA ACATTTTATGCGGCAGGGTGCAAAAGTCGTTGCAGTTGATATCCGTCAGGAACAACTGGACAAGCGGGTTTCCGAACTGA AACAATATGGAAATGAGGTGATTGGCGTTGTTGGCGACGTACTTGATGTGGCAAGCCTGGGAAAACTGGCCGGACAAGTA CTTTCTCAATGGGGGAAGATTGATATACTTCTGAATATTGCAGGGGGGAATATGCCGGGAGCCACACTTGAACCGGAGCA ACACTTTTATGATATGGATATAGCCTGCTGGGAGAAGGTGACCGGCCTGAATATGAACGGTACTGTGTATCCGTCAATGG TCTTCGGCAAAGTGATGGCGGAACAAAAGAAAGGTTGTATTGTCAATGTATCTTCGATGGCCGCTTATAGTGCCATTACC CGTGTACCCGGCTATTCGGCTGCAAAATCTGCAGTTGCTAATTTTACCCAATGGCTTGCCTCTGAAATGGCTTTGAAATA TGGTGACAGCATTCGTGTCAATGCCATCGCTCCCGGTTTCTTTATCGGCGACCAGAACCGGAGGGTATTAATTAATCCTG ACGGATCTTTGACGGAACGAAGCCGCAAGGTACTGGCCAAAACCCCGATGGGACGCTTTGGGGACATTACCGAACTCAAC GGTGCGGTTCAGTTCCTATGCAGTGATGCGGCAAGTTTTATAACCGGTGCATTACTGCCTGTTGACGGCGGATTCAGTGC TTACAGTGGAGTGTGA
Upstream 100 bases:
>100_bases GAAGGGATGATGTCCGTTGTGCAGGATGAATTGCAGGAACAGCGAATGAGATTTTAAATAGTAATATGGATTATACCGAT TAAATTATATGCCGATTGAA
Downstream 100 bases:
>100_bases AGGGGGATATGGAGGCTGACCGGGTGATAATGGGGTGACTCATTTGTTGCCCGGTTGTGTATGTCGGCTTGTTGGTCGTA CTTTTAGCTGTACATATATT
Product: D-mannonate oxidoreductase
Products: 3alpha12alpha-dihydroxy-oxobeta-cholanate; NADH [C]
Alternate protein names: NA
Number of amino acids: Translated: 271; Mature: 271
Protein sequence:
>271_residues MNELFGIAGKVAVITGAGGVLGGNIAKHFMRQGAKVVAVDIRQEQLDKRVSELKQYGNEVIGVVGDVLDVASLGKLAGQV LSQWGKIDILLNIAGGNMPGATLEPEQHFYDMDIACWEKVTGLNMNGTVYPSMVFGKVMAEQKKGCIVNVSSMAAYSAIT RVPGYSAAKSAVANFTQWLASEMALKYGDSIRVNAIAPGFFIGDQNRRVLINPDGSLTERSRKVLAKTPMGRFGDITELN GAVQFLCSDAASFITGALLPVDGGFSAYSGV
Sequences:
>Translated_271_residues MNELFGIAGKVAVITGAGGVLGGNIAKHFMRQGAKVVAVDIRQEQLDKRVSELKQYGNEVIGVVGDVLDVASLGKLAGQV LSQWGKIDILLNIAGGNMPGATLEPEQHFYDMDIACWEKVTGLNMNGTVYPSMVFGKVMAEQKKGCIVNVSSMAAYSAIT RVPGYSAAKSAVANFTQWLASEMALKYGDSIRVNAIAPGFFIGDQNRRVLINPDGSLTERSRKVLAKTPMGRFGDITELN GAVQFLCSDAASFITGALLPVDGGFSAYSGV >Mature_271_residues MNELFGIAGKVAVITGAGGVLGGNIAKHFMRQGAKVVAVDIRQEQLDKRVSELKQYGNEVIGVVGDVLDVASLGKLAGQV LSQWGKIDILLNIAGGNMPGATLEPEQHFYDMDIACWEKVTGLNMNGTVYPSMVFGKVMAEQKKGCIVNVSSMAAYSAIT RVPGYSAAKSAVANFTQWLASEMALKYGDSIRVNAIAPGFFIGDQNRRVLINPDGSLTERSRKVLAKTPMGRFGDITELN GAVQFLCSDAASFITGALLPVDGGFSAYSGV
Specific function: 7-Alpha-Dehydroxylation Of Cholic Acid, Yielding Deoxycholic Acid And Lithocholic Acid, Respectively. Highest Affinity With Taurochenodeoxycholic Acid. [C]
COG id: COG1028
COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI5031737, Length=260, Percent_Identity=29.2307692307692, Blast_Score=105, Evalue=6e-23, Organism=Homo sapiens, GI32483357, Length=261, Percent_Identity=29.8850574712644, Blast_Score=98, Evalue=9e-21, Organism=Homo sapiens, GI7705925, Length=266, Percent_Identity=30.0751879699248, Blast_Score=98, Evalue=9e-21, Organism=Homo sapiens, GI10190704, Length=259, Percent_Identity=32.4324324324324, Blast_Score=97, Evalue=2e-20, Organism=Homo sapiens, GI33667109, Length=237, Percent_Identity=29.957805907173, Blast_Score=92, Evalue=5e-19, Organism=Homo sapiens, GI19923817, Length=270, Percent_Identity=30, Blast_Score=89, Evalue=3e-18, Organism=Homo sapiens, GI66933014, Length=259, Percent_Identity=30.1158301158301, Blast_Score=89, Evalue=4e-18, Organism=Homo sapiens, GI4503301, Length=260, Percent_Identity=29.6153846153846, Blast_Score=86, Evalue=2e-17, Organism=Homo sapiens, GI126723750, Length=264, Percent_Identity=26.1363636363636, Blast_Score=79, Evalue=3e-15, Organism=Homo sapiens, GI40254992, Length=185, Percent_Identity=32.972972972973, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI15277342, Length=265, Percent_Identity=25.2830188679245, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI31542939, Length=204, Percent_Identity=28.921568627451, Blast_Score=69, Evalue=4e-12, Organism=Homo sapiens, GI4503817, Length=212, Percent_Identity=27.3584905660377, Blast_Score=65, Evalue=5e-11, Organism=Homo sapiens, GI59889578, Length=241, Percent_Identity=26.1410788381743, Blast_Score=65, Evalue=7e-11, Organism=Homo sapiens, GI142976729, Length=215, Percent_Identity=25.5813953488372, Blast_Score=65, Evalue=9e-11, Organism=Escherichia coli, GI1787905, Length=256, Percent_Identity=34.375, Blast_Score=118, Evalue=5e-28, Organism=Escherichia coli, GI1789208, Length=264, Percent_Identity=30.3030303030303, Blast_Score=117, Evalue=1e-27, Organism=Escherichia coli, GI1790717, Length=265, Percent_Identity=30.5660377358491, Blast_Score=114, Evalue=8e-27, Organism=Escherichia coli, GI87082160, Length=263, Percent_Identity=30.4182509505703, Blast_Score=109, Evalue=2e-25, Organism=Escherichia coli, GI87082100, Length=269, Percent_Identity=33.457249070632, Blast_Score=101, Evalue=5e-23, Organism=Escherichia coli, GI1787335, Length=258, Percent_Identity=29.4573643410853, Blast_Score=100, Evalue=7e-23, Organism=Escherichia coli, GI1788459, Length=265, Percent_Identity=29.4339622641509, Blast_Score=84, Evalue=1e-17, Organism=Escherichia coli, GI1786812, Length=267, Percent_Identity=28.4644194756554, Blast_Score=80, Evalue=2e-16, Organism=Escherichia coli, GI1787820, Length=220, Percent_Identity=28.6363636363636, Blast_Score=78, Evalue=6e-16, Organism=Caenorhabditis elegans, GI115534694, Length=263, Percent_Identity=30.4182509505703, Blast_Score=100, Evalue=1e-21, Organism=Caenorhabditis elegans, GI17561402, Length=260, Percent_Identity=29.6153846153846, Blast_Score=98, Evalue=5e-21, Organism=Caenorhabditis elegans, GI17560676, Length=264, Percent_Identity=29.1666666666667, Blast_Score=96, Evalue=1e-20, Organism=Caenorhabditis elegans, GI25147288, Length=268, Percent_Identity=30.2238805970149, Blast_Score=94, Evalue=7e-20, Organism=Caenorhabditis elegans, GI17555706, Length=260, Percent_Identity=28.8461538461538, Blast_Score=92, Evalue=3e-19, Organism=Caenorhabditis elegans, GI71994604, Length=261, Percent_Identity=29.5019157088123, Blast_Score=86, Evalue=3e-17, Organism=Caenorhabditis elegans, GI17551412, Length=275, Percent_Identity=30.1818181818182, Blast_Score=86, Evalue=3e-17, Organism=Caenorhabditis elegans, GI17536025, Length=268, Percent_Identity=29.1044776119403, Blast_Score=81, Evalue=5e-16, Organism=Caenorhabditis elegans, GI17559104, Length=276, Percent_Identity=29.3478260869565, Blast_Score=80, Evalue=8e-16, Organism=Caenorhabditis elegans, GI17563726, Length=276, Percent_Identity=30.4347826086957, Blast_Score=80, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17561272, Length=261, Percent_Identity=32.5670498084291, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17560220, Length=280, Percent_Identity=28.2142857142857, Blast_Score=79, Evalue=3e-15, Organism=Caenorhabditis elegans, GI17538480, Length=273, Percent_Identity=30.03663003663, Blast_Score=79, Evalue=3e-15, Organism=Caenorhabditis elegans, GI17560150, Length=266, Percent_Identity=27.4436090225564, Blast_Score=78, Evalue=4e-15, Organism=Caenorhabditis elegans, GI71994600, Length=262, Percent_Identity=27.8625954198473, Blast_Score=78, Evalue=5e-15, Organism=Caenorhabditis elegans, GI17562908, Length=271, Percent_Identity=28.7822878228782, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17562990, Length=271, Percent_Identity=27.3062730627306, Blast_Score=72, Evalue=4e-13, Organism=Caenorhabditis elegans, GI193203117, Length=197, Percent_Identity=28.9340101522843, Blast_Score=72, Evalue=4e-13, Organism=Caenorhabditis elegans, GI17562906, Length=276, Percent_Identity=25, Blast_Score=71, Evalue=5e-13, Organism=Caenorhabditis elegans, GI72000259, Length=275, Percent_Identity=27.2727272727273, Blast_Score=71, Evalue=5e-13, Organism=Caenorhabditis elegans, GI17565030, Length=270, Percent_Identity=30, Blast_Score=71, Evalue=7e-13, Organism=Caenorhabditis elegans, GI193203115, Length=194, Percent_Identity=29.3814432989691, Blast_Score=70, Evalue=8e-13, Organism=Caenorhabditis elegans, GI17560332, Length=194, Percent_Identity=31.4432989690722, Blast_Score=70, Evalue=9e-13, Organism=Caenorhabditis elegans, GI17536651, Length=259, Percent_Identity=27.7992277992278, Blast_Score=70, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17562910, Length=279, Percent_Identity=27.5985663082437, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17562904, Length=288, Percent_Identity=29.1666666666667, Blast_Score=69, Evalue=3e-12, Organism=Caenorhabditis elegans, GI17544670, Length=280, Percent_Identity=27.5, Blast_Score=68, Evalue=4e-12, Organism=Caenorhabditis elegans, GI71997099, Length=250, Percent_Identity=26.4, Blast_Score=65, Evalue=3e-11, Organism=Caenorhabditis elegans, GI17531453, Length=271, Percent_Identity=25.4612546125461, Blast_Score=65, Evalue=4e-11, Organism=Caenorhabditis elegans, GI17538486, Length=265, Percent_Identity=27.5471698113208, Blast_Score=64, Evalue=7e-11, Organism=Caenorhabditis elegans, GI17564282, Length=196, Percent_Identity=25.5102040816327, Blast_Score=64, Evalue=7e-11, Organism=Caenorhabditis elegans, GI17538182, Length=280, Percent_Identity=26.7857142857143, Blast_Score=64, Evalue=8e-11, Organism=Saccharomyces cerevisiae, GI6324126, Length=261, Percent_Identity=26.4367816091954, Blast_Score=70, Evalue=4e-13, Organism=Saccharomyces cerevisiae, GI6322226, Length=219, Percent_Identity=29.2237442922374, Blast_Score=62, Evalue=9e-11, Organism=Drosophila melanogaster, GI23397609, Length=259, Percent_Identity=33.5907335907336, Blast_Score=120, Evalue=1e-27, Organism=Drosophila melanogaster, GI21355319, Length=262, Percent_Identity=31.2977099236641, Blast_Score=112, Evalue=3e-25, Organism=Drosophila melanogaster, GI28571526, Length=265, Percent_Identity=31.6981132075472, Blast_Score=111, Evalue=6e-25, Organism=Drosophila melanogaster, GI24644339, Length=269, Percent_Identity=32.3420074349442, Blast_Score=107, Evalue=7e-24, Organism=Drosophila melanogaster, GI24644337, Length=261, Percent_Identity=32.9501915708812, Blast_Score=106, Evalue=2e-23, Organism=Drosophila melanogaster, GI24639444, Length=263, Percent_Identity=33.0798479087452, Blast_Score=105, Evalue=4e-23, Organism=Drosophila melanogaster, GI21357041, Length=265, Percent_Identity=29.0566037735849, Blast_Score=96, Evalue=2e-20, Organism=Drosophila melanogaster, GI24643142, Length=263, Percent_Identity=27.3764258555133, Blast_Score=75, Evalue=5e-14, Organism=Drosophila melanogaster, GI24649181, Length=197, Percent_Identity=26.9035532994924, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI116007236, Length=199, Percent_Identity=28.1407035175879, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI17737361, Length=267, Percent_Identity=25.8426966292135, Blast_Score=68, Evalue=6e-12, Organism=Drosophila melanogaster, GI21358495, Length=201, Percent_Identity=27.8606965174129, Blast_Score=65, Evalue=6e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.159 [C]
Molecular weight: Translated: 28716; Mature: 28716
Theoretical pI: Translated: 8.03; Mature: 8.03
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.1 %Cys (Translated Protein) 3.7 %Met (Translated Protein) 4.8 %Cys+Met (Translated Protein) 1.1 %Cys (Mature Protein) 3.7 %Met (Mature Protein) 4.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNELFGIAGKVAVITGAGGVLGGNIAKHFMRQGAKVVAVDIRQEQLDKRVSELKQYGNEV CCCCCCCCCEEEEEECCCCHHCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHH IGVVGDVLDVASLGKLAGQVLSQWGKIDILLNIAGGNMPGATLEPEQHFYDMDIACWEKV HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHCCCCHHHHHHH TGLNMNGTVYPSMVFGKVMAEQKKGCIVNVSSMAAYSAITRVPGYSAAKSAVANFTQWLA CCCCCCCEECHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH SEMALKYGDSIRVNAIAPGFFIGDQNRRVLINPDGSLTERSRKVLAKTPMGRFGDITELN HHHHHHCCCCEEEEEECCEEEECCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCHHHHH GAVQFLCSDAASFITGALLPVDGGFSAYSGV HHHHHHHHHHHHHHHCCCEECCCCCHHCCCC >Mature Secondary Structure MNELFGIAGKVAVITGAGGVLGGNIAKHFMRQGAKVVAVDIRQEQLDKRVSELKQYGNEV CCCCCCCCCEEEEEECCCCHHCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHH IGVVGDVLDVASLGKLAGQVLSQWGKIDILLNIAGGNMPGATLEPEQHFYDMDIACWEKV HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHCCCCHHHHHHH TGLNMNGTVYPSMVFGKVMAEQKKGCIVNVSSMAAYSAITRVPGYSAAKSAVANFTQWLA CCCCCCCEECHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH SEMALKYGDSIRVNAIAPGFFIGDQNRRVLINPDGSLTERSRKVLAKTPMGRFGDITELN HHHHHHCCCCEEEEEECCEEEECCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCHHHHH GAVQFLCSDAASFITGALLPVDGGFSAYSGV HHHHHHHHHHHHHHHCCCEECCCCCHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: 2-Mercaptoethanol; Dithiothreitol; NAD+; NADH [C]
Metal ions: CaCl2; KCl; MnCl2; NaCl [C]
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): 0.8 {cholic} 0.24 {taurochenodeoxycholic} 0.085 {glycochenodeoxycholic} 1 {glycocholic} 0.06 {chenodeoxycholic} [C]
Substrates: @ALPH01.txt*3alpha7alpha12alpha-Trihydroxybeta-cholanate!; NAD [C]
Specific reaction: @ALPH01.txt*3alpha7alpha12alpha-Trihydroxybeta-cholanate! + NAD+ = 3alpha12alpha-dihydroxy-oxobeta-cholanate + NADH [C]
General reaction: Redox reaction [C]
Inhibitor: Ascorbicacid; BaCl2; CoCl2; CuCl2; EDTA; FeCl3; HgCl2; MgCl2; NH4Cl; Potassiumoxalate; Sodiumcitrate; Sodiumlaurylsulfate; Sodiumperchlorate; Sodiumperiodate; Sodiumpersulfate; TritonX-100; Tween; ZnCl2 [C]
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9579062; 9384377 [H]