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The map label for this gene is ptpA [H]

Identifier: 150004541

GI number: 150004541

Start: 2576645

End: 2578846

Strand: Reverse

Name: ptpA [H]

Synonym: BVU_1991

Alternate gene names: 150004541

Gene position: 2578846-2576645 (Counterclockwise)

Preceding gene: 150004544

Following gene: 150004540

Centisome position: 49.95

GC content: 40.55

Gene sequence:

>2202_bases
ATGAGAAAATTAAGTATATTTATTATTTTATTCTTCTGCTTGCTGACAGTCGGAGCTCAACAAGTAAGCTTGCAAGACGT
AGCAAACAGAACGTATCATGCCGAAGGAATCAGAGGTATCAAACCGATGTTGGATGGAGAACATTATACCCAAATGAGTG
CCGATGGCAAAAAAATCATACAGTATTCTTTCAAGACCGGCAAAGAAACAGGTACCATCTTCGATGTAAATACGGCCCGT
GACTGTAGCATCAAGTCATTTGATGACTATATCATGTCACCCGATGAAAAACTGATTCTAATACAGACTGAAACCAAACC
TATTTATCGTCGTTCGTTTACCGCCAATTACTATATTTTCAACGTAAAAAACAATAAAATGGAACCGCTCTCAGAAAACG
GTCCACAACAGGTTCCTTTATTCTCGCCGGATGGCAATCAGATAGCTTTTGTACGTGATAATAATATCTATCTGGTAAAA
TTATTGTTTGGCAACAGTGAATCACAAGTAACCAAAGACGGCAAATTCAACGAAGTGCTAAATGGTATTCCCGACTGGGT
ATATGAAGAGGAATTCGGCTTCAACCGTGCTTTCGACTTCAGTGCAGACAGCCAGATGCTTGCCTATATCCGTTTTGATG
AGAGTCAAGTACCTATGTATTCTTTTCCACTATACAAAGGTATGGTTCCCGCATTAGAGAAATTCAGCACTTATCCGGGA
GAATATGAATACAAATACCCTATGCCAGGAATTGACAATTCCAAAGTAACCGTTCATACTTTTGATATAAAAAGTAAGGT
AACCCGCAAGATGGACTTGCCTCTAGATGCAGACGGTTATATCCCTCGCATCAAGTTTACGGATGATGAAAATGCGTTGG
CAATCACGACTTTGAACCGTCATCAAAACCGTTTCGACCTCTATTTTGCCAATCCACGAAGTACATTGTGTAAACTGATG
GTACGTGATGAAGCTCCCCAATACATTAAAGAAGAAGCCTACTCCAACATCGTTTTCTATCCAAAAAACTTTGTGGTGAT
GAGTGAAAAAGACGGTTATAACCATCTCTATCTTTACACTAGCGGAGGAAACCTGGTTAAGCAAATCACAAAAGGGAACT
TCGAAGTGAAAGATTTCCTGGGATGGGATGAAGCTACCAACACATTCTATTTTGAAAGCAATGAAGGTAGTCCGCTACGC
ACCGCTATCTACAAAGTGGACGGCAAAGGTAAAAAGACCAAACTATCCAAACAGGAAGGAACTCATAAAGCTATTTTCAG
TAACAATATGAAGTATTACATCAATACTTTCTCTAATATCAACACCCCTCCTGTCATTACCCTTAATGACAATAATGGTA
AAGAATTGGCAACCTTAGTAGATAATAACACATTGAAACACCAAGTTTCACGTCTGAATATGCCAAATAAAGAACTATTT
AGTTTCAAGACCAATGACGGTGTGGAATTGAATGGTTGGATAATGAAACCCGCAAATTTCAATCCGAACAAAAAATATCC
TGTTATCATGCACCAATATAGTGGACCGGGTTCACAAGAAGTTGCAGACAAATGGGGAATTGGAGCCCGTAGAGATGGCG
GCATGTTCGAAGCTTATATGGCCGGTCAAGGCTTCATCATGGCTTGTGTAGACGGACGCGGAACCGGTGGCCGAGGGTCT
GATTTTGAAAAATGCACCTACTTGAGTTTAGGAGTAAAAGAATCGAAAGATCAAGTAGAAGCCGCCAAATACTTAAGTAC
ACTACCCTATGTAGATGGTAACCGTATCGGTATATGGGGATGGAGCTATGGAGGTTACAATACATTAATGTCCATGAGTG
AAGGAACACCGATATTCAAAGCTGGAGTAGCTGTTGCAGCTCCTACAGACTGGCGTTTCTACGATTCGGTATATACAGAG
CGCTTCATGCGTACCCCCAAAGAAAACATGGAAGGTTACAATGCTGCATCTGCTATTAACCGTGCCAACAAACTGAACGG
TGAATTGTTGCTGATCCACGGCACAGCAGATGATAATGTACACTTACGTAACAACGCAGAATACAGTGAAGCATTGGTAC
AGGCCGACAAGCAATTTGACATGCAAATCTATACCAACCGCAACCATGGAATCAGTGGAGGCAACACAACTAAACATTTA
CTGACTCGCGTAGCCAATTTCTTTATTGATAATTTAAAATAA

Upstream 100 bases:

>100_bases
ATCTCTCTGTTCATGAACTTATTTTGCGGGACAAAGATACGTATTTTCAAACAAAAGTTTTACCTTTGTCTTTGATTATC
ATTTAAAGAATTTATCTATT

Downstream 100 bases:

>100_bases
AAAACCATTCACCACAGATTATACAATTTTACATAAAAACCGAATGAAAACAATTTGCATTGGTATAATCTGTGGTGAAT
TATAAATCTAATATCATCAT

Product: dipeptidyl peptidase IV

Products: NA

Alternate protein names: PTP; Prolyl tripeptidyl peptidase A [H]

Number of amino acids: Translated: 733; Mature: 733

Protein sequence:

>733_residues
MRKLSIFIILFFCLLTVGAQQVSLQDVANRTYHAEGIRGIKPMLDGEHYTQMSADGKKIIQYSFKTGKETGTIFDVNTAR
DCSIKSFDDYIMSPDEKLILIQTETKPIYRRSFTANYYIFNVKNNKMEPLSENGPQQVPLFSPDGNQIAFVRDNNIYLVK
LLFGNSESQVTKDGKFNEVLNGIPDWVYEEEFGFNRAFDFSADSQMLAYIRFDESQVPMYSFPLYKGMVPALEKFSTYPG
EYEYKYPMPGIDNSKVTVHTFDIKSKVTRKMDLPLDADGYIPRIKFTDDENALAITTLNRHQNRFDLYFANPRSTLCKLM
VRDEAPQYIKEEAYSNIVFYPKNFVVMSEKDGYNHLYLYTSGGNLVKQITKGNFEVKDFLGWDEATNTFYFESNEGSPLR
TAIYKVDGKGKKTKLSKQEGTHKAIFSNNMKYYINTFSNINTPPVITLNDNNGKELATLVDNNTLKHQVSRLNMPNKELF
SFKTNDGVELNGWIMKPANFNPNKKYPVIMHQYSGPGSQEVADKWGIGARRDGGMFEAYMAGQGFIMACVDGRGTGGRGS
DFEKCTYLSLGVKESKDQVEAAKYLSTLPYVDGNRIGIWGWSYGGYNTLMSMSEGTPIFKAGVAVAAPTDWRFYDSVYTE
RFMRTPKENMEGYNAASAINRANKLNGELLLIHGTADDNVHLRNNAEYSEALVQADKQFDMQIYTNRNHGISGGNTTKHL
LTRVANFFIDNLK

Sequences:

>Translated_733_residues
MRKLSIFIILFFCLLTVGAQQVSLQDVANRTYHAEGIRGIKPMLDGEHYTQMSADGKKIIQYSFKTGKETGTIFDVNTAR
DCSIKSFDDYIMSPDEKLILIQTETKPIYRRSFTANYYIFNVKNNKMEPLSENGPQQVPLFSPDGNQIAFVRDNNIYLVK
LLFGNSESQVTKDGKFNEVLNGIPDWVYEEEFGFNRAFDFSADSQMLAYIRFDESQVPMYSFPLYKGMVPALEKFSTYPG
EYEYKYPMPGIDNSKVTVHTFDIKSKVTRKMDLPLDADGYIPRIKFTDDENALAITTLNRHQNRFDLYFANPRSTLCKLM
VRDEAPQYIKEEAYSNIVFYPKNFVVMSEKDGYNHLYLYTSGGNLVKQITKGNFEVKDFLGWDEATNTFYFESNEGSPLR
TAIYKVDGKGKKTKLSKQEGTHKAIFSNNMKYYINTFSNINTPPVITLNDNNGKELATLVDNNTLKHQVSRLNMPNKELF
SFKTNDGVELNGWIMKPANFNPNKKYPVIMHQYSGPGSQEVADKWGIGARRDGGMFEAYMAGQGFIMACVDGRGTGGRGS
DFEKCTYLSLGVKESKDQVEAAKYLSTLPYVDGNRIGIWGWSYGGYNTLMSMSEGTPIFKAGVAVAAPTDWRFYDSVYTE
RFMRTPKENMEGYNAASAINRANKLNGELLLIHGTADDNVHLRNNAEYSEALVQADKQFDMQIYTNRNHGISGGNTTKHL
LTRVANFFIDNLK
>Mature_733_residues
MRKLSIFIILFFCLLTVGAQQVSLQDVANRTYHAEGIRGIKPMLDGEHYTQMSADGKKIIQYSFKTGKETGTIFDVNTAR
DCSIKSFDDYIMSPDEKLILIQTETKPIYRRSFTANYYIFNVKNNKMEPLSENGPQQVPLFSPDGNQIAFVRDNNIYLVK
LLFGNSESQVTKDGKFNEVLNGIPDWVYEEEFGFNRAFDFSADSQMLAYIRFDESQVPMYSFPLYKGMVPALEKFSTYPG
EYEYKYPMPGIDNSKVTVHTFDIKSKVTRKMDLPLDADGYIPRIKFTDDENALAITTLNRHQNRFDLYFANPRSTLCKLM
VRDEAPQYIKEEAYSNIVFYPKNFVVMSEKDGYNHLYLYTSGGNLVKQITKGNFEVKDFLGWDEATNTFYFESNEGSPLR
TAIYKVDGKGKKTKLSKQEGTHKAIFSNNMKYYINTFSNINTPPVITLNDNNGKELATLVDNNTLKHQVSRLNMPNKELF
SFKTNDGVELNGWIMKPANFNPNKKYPVIMHQYSGPGSQEVADKWGIGARRDGGMFEAYMAGQGFIMACVDGRGTGGRGS
DFEKCTYLSLGVKESKDQVEAAKYLSTLPYVDGNRIGIWGWSYGGYNTLMSMSEGTPIFKAGVAVAAPTDWRFYDSVYTE
RFMRTPKENMEGYNAASAINRANKLNGELLLIHGTADDNVHLRNNAEYSEALVQADKQFDMQIYTNRNHGISGGNTTKHL
LTRVANFFIDNLK

Specific function: Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI16933540, Length=749, Percent_Identity=30.4405874499332, Blast_Score=317, Evalue=3e-86,
Organism=Homo sapiens, GI18765694, Length=701, Percent_Identity=31.9543509272468, Blast_Score=289, Evalue=7e-78,
Organism=Homo sapiens, GI86792863, Length=771, Percent_Identity=25.810635538262, Blast_Score=253, Evalue=3e-67,
Organism=Homo sapiens, GI86792778, Length=771, Percent_Identity=25.810635538262, Blast_Score=253, Evalue=4e-67,
Organism=Homo sapiens, GI86792774, Length=771, Percent_Identity=25.810635538262, Blast_Score=253, Evalue=4e-67,
Organism=Homo sapiens, GI295849272, Length=685, Percent_Identity=28.6131386861314, Blast_Score=251, Evalue=2e-66,
Organism=Homo sapiens, GI85787627, Length=685, Percent_Identity=28.6131386861314, Blast_Score=251, Evalue=2e-66,
Organism=Homo sapiens, GI52426756, Length=685, Percent_Identity=28.6131386861314, Blast_Score=251, Evalue=2e-66,
Organism=Homo sapiens, GI295842359, Length=685, Percent_Identity=28.6131386861314, Blast_Score=251, Evalue=2e-66,
Organism=Homo sapiens, GI295842403, Length=685, Percent_Identity=28.6131386861314, Blast_Score=251, Evalue=3e-66,
Organism=Homo sapiens, GI18450280, Length=709, Percent_Identity=27.6445698166432, Blast_Score=213, Evalue=4e-55,
Organism=Homo sapiens, GI37577089, Length=709, Percent_Identity=27.6445698166432, Blast_Score=213, Evalue=5e-55,
Organism=Homo sapiens, GI194394146, Length=726, Percent_Identity=25.6198347107438, Blast_Score=188, Evalue=2e-47,
Organism=Homo sapiens, GI37577091, Length=708, Percent_Identity=24.5762711864407, Blast_Score=148, Evalue=2e-35,
Organism=Homo sapiens, GI18450278, Length=509, Percent_Identity=23.9685658153242, Blast_Score=83, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17564632, Length=621, Percent_Identity=25.4428341384863, Blast_Score=171, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17564634, Length=621, Percent_Identity=25.7648953301127, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17550672, Length=677, Percent_Identity=26.1447562776957, Blast_Score=165, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17508019, Length=264, Percent_Identity=32.5757575757576, Blast_Score=149, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17508017, Length=264, Percent_Identity=32.5757575757576, Blast_Score=149, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6321817, Length=674, Percent_Identity=30.7121661721068, Blast_Score=263, Evalue=7e-71,
Organism=Saccharomyces cerevisiae, GI6324793, Length=685, Percent_Identity=26.8613138686131, Blast_Score=225, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24582032, Length=666, Percent_Identity=29.4294294294294, Blast_Score=258, Evalue=9e-69,
Organism=Drosophila melanogaster, GI17933704, Length=721, Percent_Identity=29.2649098474341, Blast_Score=250, Evalue=3e-66,
Organism=Drosophila melanogaster, GI161083744, Length=721, Percent_Identity=29.2649098474341, Blast_Score=249, Evalue=5e-66,
Organism=Drosophila melanogaster, GI221331178, Length=721, Percent_Identity=29.2649098474341, Blast_Score=249, Evalue=5e-66,
Organism=Drosophila melanogaster, GI45550825, Length=704, Percent_Identity=26.2784090909091, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI45553511, Length=704, Percent_Identity=26.2784090909091, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI45551969, Length=704, Percent_Identity=26.2784090909091, Blast_Score=193, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24582257, Length=287, Percent_Identity=34.1463414634146, Blast_Score=179, Evalue=7e-45,
Organism=Drosophila melanogaster, GI221372266, Length=685, Percent_Identity=23.5036496350365, Blast_Score=156, Evalue=5e-38,
Organism=Drosophila melanogaster, GI221372263, Length=685, Percent_Identity=23.5036496350365, Blast_Score=155, Evalue=7e-38,
Organism=Drosophila melanogaster, GI45551475, Length=685, Percent_Identity=23.5036496350365, Blast_Score=155, Evalue=8e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001375
- InterPro:   IPR002469 [H]

Pfam domain/function: PF00930 DPPIV_N; PF00326 Peptidase_S9 [H]

EC number: =3.4.14.12 [H]

Molecular weight: Translated: 83269; Mature: 83269

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKLSIFIILFFCLLTVGAQQVSLQDVANRTYHAEGIRGIKPMLDGEHYTQMSADGKKII
CCEEHHHHHHHHHHHHCCCCCEEHHHHHCCCEECCCCCCCCCCCCCCHHEECCCCCCEEE
QYSFKTGKETGTIFDVNTARDCSIKSFDDYIMSPDEKLILIQTETKPIYRRSFTANYYIF
EEEECCCCCCCCEEECCCCCCCCCCCCHHHHCCCCCEEEEEEECCCCEEEEEEEEEEEEE
NVKNNKMEPLSENGPQQVPLFSPDGNQIAFVRDNNIYLVKLLFGNSESQVTKDGKFNEVL
EECCCCCCCCCCCCCCCCEEECCCCCEEEEEECCCEEEEEEEECCCCCCCCCCCCHHHHH
NGIPDWVYEEEFGFNRAFDFSADSQMLAYIRFDESQVPMYSFPLYKGMVPALEKFSTYPG
HCCCCHHEHHCCCCCEEECCCCCCEEEEEEEECCCCCCEEECCHHHHHHHHHHHHCCCCC
EYEYKYPMPGIDNSKVTVHTFDIKSKVTRKMDLPLDADGYIPRIKFTDDENALAITTLNR
CEEEECCCCCCCCCEEEEEEEECHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEEEECC
HQNRFDLYFANPRSTLCKLMVRDEAPQYIKEEAYSNIVFYPKNFVVMSEKDGYNHLYLYT
CCCEEEEEEECCHHHHHHHHHHCCCHHHHHHHHCCCEEEECCCEEEEECCCCCCEEEEEE
SGGNLVKQITKGNFEVKDFLGWDEATNTFYFESNEGSPLRTAIYKVDGKGKKTKLSKQEG
CCCHHHHHHHCCCCEEEHHCCCCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCCCC
THKAIFSNNMKYYINTFSNINTPPVITLNDNNGKELATLVDNNTLKHQVSRLNMPNKELF
CEEEEHCCCCEEEEEECCCCCCCCEEEEECCCCCEEEEEECCCHHHHHHHHCCCCCHHHE
SFKTNDGVELNGWIMKPANFNPNKKYPVIMHQYSGPGSQEVADKWGIGARRDGGMFEAYM
EEECCCCEEEEEEEEECCCCCCCCCCCEEEEECCCCCCHHHHHHHCCCCCCCCCEEEEEE
AGQGFIMACVDGRGTGGRGSDFEKCTYLSLGVKESKDQVEAAKYLSTLPYVDGNRIGIWG
CCCCEEEEEECCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEE
WSYGGYNTLMSMSEGTPIFKAGVAVAAPTDWRFYDSVYTERFMRTPKENMEGYNAASAIN
ECCCCHHHHEECCCCCCEEECCEEEECCCCCHHHHHHHHHHHHCCCHHHCCCCCHHHHHH
RANKLNGELLLIHGTADDNVHLRNNAEYSEALVQADKQFDMQIYTNRNHGISGGNTTKHL
HHHCCCCEEEEEECCCCCCEEECCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHH
LTRVANFFIDNLK
HHHHHHHHHHCCC
>Mature Secondary Structure
MRKLSIFIILFFCLLTVGAQQVSLQDVANRTYHAEGIRGIKPMLDGEHYTQMSADGKKII
CCEEHHHHHHHHHHHHCCCCCEEHHHHHCCCEECCCCCCCCCCCCCCHHEECCCCCCEEE
QYSFKTGKETGTIFDVNTARDCSIKSFDDYIMSPDEKLILIQTETKPIYRRSFTANYYIF
EEEECCCCCCCCEEECCCCCCCCCCCCHHHHCCCCCEEEEEEECCCCEEEEEEEEEEEEE
NVKNNKMEPLSENGPQQVPLFSPDGNQIAFVRDNNIYLVKLLFGNSESQVTKDGKFNEVL
EECCCCCCCCCCCCCCCCEEECCCCCEEEEEECCCEEEEEEEECCCCCCCCCCCCHHHHH
NGIPDWVYEEEFGFNRAFDFSADSQMLAYIRFDESQVPMYSFPLYKGMVPALEKFSTYPG
HCCCCHHEHHCCCCCEEECCCCCCEEEEEEEECCCCCCEEECCHHHHHHHHHHHHCCCCC
EYEYKYPMPGIDNSKVTVHTFDIKSKVTRKMDLPLDADGYIPRIKFTDDENALAITTLNR
CEEEECCCCCCCCCEEEEEEEECHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEEEECC
HQNRFDLYFANPRSTLCKLMVRDEAPQYIKEEAYSNIVFYPKNFVVMSEKDGYNHLYLYT
CCCEEEEEEECCHHHHHHHHHHCCCHHHHHHHHCCCEEEECCCEEEEECCCCCCEEEEEE
SGGNLVKQITKGNFEVKDFLGWDEATNTFYFESNEGSPLRTAIYKVDGKGKKTKLSKQEG
CCCHHHHHHHCCCCEEEHHCCCCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCCCC
THKAIFSNNMKYYINTFSNINTPPVITLNDNNGKELATLVDNNTLKHQVSRLNMPNKELF
CEEEEHCCCCEEEEEECCCCCCCCEEEEECCCCCEEEEEECCCHHHHHHHHCCCCCHHHE
SFKTNDGVELNGWIMKPANFNPNKKYPVIMHQYSGPGSQEVADKWGIGARRDGGMFEAYM
EEECCCCEEEEEEEEECCCCCCCCCCCEEEEECCCCCCHHHHHHHCCCCCCCCCEEEEEE
AGQGFIMACVDGRGTGGRGSDFEKCTYLSLGVKESKDQVEAAKYLSTLPYVDGNRIGIWG
CCCCEEEEEECCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEE
WSYGGYNTLMSMSEGTPIFKAGVAVAAPTDWRFYDSVYTERFMRTPKENMEGYNAASAIN
ECCCCHHHHEECCCCCCEEECCEEEECCCCCHHHHHHHHHHHHCCCHHHCCCCCHHHHHH
RANKLNGELLLIHGTADDNVHLRNNAEYSEALVQADKQFDMQIYTNRNHGISGGNTTKHL
HHHCCCCEEEEEECCCCCCEEECCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHH
LTRVANFFIDNLK
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA