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The map label for this gene is gyrB [H]

Identifier: 148827759

GI number: 148827759

Start: 1111054

End: 1113474

Strand: Reverse

Name: gyrB [H]

Synonym: CGSHiGG_06110

Alternate gene names: 148827759

Gene position: 1113474-1111054 (Counterclockwise)

Preceding gene: 148827760

Following gene: 148827758

Centisome position: 59.0

GC content: 41.22

Gene sequence:

>2421_bases
ATGTCAGAAACGACCAATGATAACTATGGTGCATCAAGCATTAAAGTATTAAAAGGCCTTGATGCGGTGCGTAAGCGTCC
TGGTATGTATATCGGCGATACCGATGACGGTACTGGTTTGCACCATATGGTATTTGAAGTGGTGGATAATGCCATTGATG
AAGCCCTCGCTGGCCATTGTTCCGATATTATCGTGACAATTCACGATGATAATTCTGTATCGGTGCAAGATGATGGGCGC
GGGATTCCTGTGGATATTCATCCTGAAGAAGGCGTTTCTGCAGCGGAAGTGATTATGACTGTGCTTCACGCAGGCGGTAA
ATTTGACGATAACTCTTATAAAGTATCGGGCGGTTTACACGGCGTGGGCGTATCTGTAGTGAATGCGCTTTCTGATAAGT
TACAATTAACCATTCGTCGTCAAGGTCACGTTCACGAGCAGTTTTATCATTTAGGGGAGCCTCAATCGCCATTAACAGTG
ATTGGCGAAACAGAGGCAACGGGGACAACGGTTCGTTTCTGGCCAAGCTCAGATATTTTTGCTATCACAACCTTTGATTA
CAAAATCTTAGCAAAACGCTTACGTGAGCTTTCTTTCTTGAATTCTGGCGTATCTATTCGTTTAATCGATAAACGTGATG
GATCTGAAGATCATTTCCATTATGAAGGCGGTATTCAAGCATTCGTAGAATATTTGAACAAAAATAAAAACCCAATTCAT
CCAAAGCCATTTTATTTTACCGCTGAGAAAGATGGCATCGGCGTAGAAGTCGCCTTGCAGTGGAATGATGGTGTAAATGA
AAACGTGTATTGCTTTACCAATAACATTCCTCAACGTGATGGCGGTACTCACTTAGCTGGTTTCCGTGGGGCTTTAACCC
GTAGCTTAAATAGCTATATGGAAAACGAAGGCATGCTGAAAAAAGAAAAAGTGGCGACTTCAGGCGATGATGCACGTGAA
GGTTTAGTGGCGATTATTTCAGTTAAAGTGCCAGATCCAAAATTCTCATCGCAAACGAAAGACAAACTCGTGTCTTCAGA
AGTTAAAAGTGCGGTGGAATCTGCGATGAATGAAAAAATGCAGGAATATTTATTAGAAAATCCTGCAGATGCAAAAATCA
TTGTAAATCAAATTATTATGGCTGCTCGTGCGCGTGAAGCAGCACGTAAAGCGCGTGAAATGACTCGCCGTAAAGGGGCA
TTAGATATTGCAGGTTTACCGGGTAAACTTGCAGACTGCCAAGAAAAAGATCCTGCGCTTTCTGAACTTTACTTGGTGGA
GGGGGACTCCGCTGGTGGTTCTGCAAAAGTTGGTCGTGATCGTAAAACTCAAGCAATTTTGCCATTGAAAGGTAAAATCT
TAAACGTAGAAAAAGCACGTTTCGACAAAATGTTGTCTTCCCAAGAAGTGGGCACATTAATTACTGCTTTAGGCTGCGGC
ATTGGTCGTGATGAATATAATCCAGATAAATTACGTTATCATCATATCATTATTATGACCGATGCTGATGTGGATGGTTC
TCACATCCGTACGTTGCTTTTAACCTTCTTCTATCGTCAAATGCCTGAGCTGATTGAGCGTGGTTATGTTTACATTGCTC
AGCCGCCACTTTACAAAGTGAAAAAAGGAAAACAAGAACGCTACATTAAAGATGCGGATGAAATGGAGCAATATGAATTA
ACCCTTGCGTTAGATGGCGCAGAATTACATATCAGCGCAAATGCACCAGCAATGAATGCCCTTGTATTTGAAAAATTGGT
GGCAGAATATAACAGCGTACAAAAACTTATCGGTCGCTTAAGCCGTCATTACCCAGTGCCTGTATTGCAAGGATTAATTT
ATCAGTCGCCAATTTCTATTGAAATGATGAAAGAGGAAAGTGCGGTGGAAAATTGGGGTAAATCTTTTGTTGAACAACTG
ACTGCAAAAGAAACAGAAGCACATCAATATTCAGTGCGTACACAATTTAATGCGGAACGCCAAGTGTATGAAGCGGTGAT
TACTGTTCGCAAACACGGTATTGATACCGATTATTTCTTGAATTTTGATTTTGTTCACGGCAATGAATACGCGAAAATTG
TTTCTCTTAATAAACAACTCAATGGTTTATTAGAAGAGGGTGCTTATGTTATTCGTGGCGAAAAAGTACAACCAGTACGT
AGTTTTGAACAAGCCGTTGAATGGCTAGTGAAAGAATCTCGTAAAGGCCTTGAAGTACAACGTTATAAAGGACTTGGGGA
AATGAATGCAGATCAACTTTGGGAAACCACAATGGATCCAAATTCACGTCGTATGTTGAAAGTTTCTATTAAGGATGCTG
TTGCAGCAGATCAACTCTTCACGACCTTAATGGGAGATGAAGTTGAGCCACGTCGTGAGTTCATTGAGCTGAATGCGTTA
AGAGCAAATTTAGACGTGTAA

Upstream 100 bases:

>100_bases
CCTTTTTTTATCGTTTTCCTTTCCCGAAAAGCATCGCCAAAACGGCGATTTTTTGCTATAATCTCGCCCAATTTTTATTT
ACAAAAGAATGAGATAAATT

Downstream 100 bases:

>100_bases
ATTTTCGTCTATTTATATTCAATTCATGACTGAAAGGGCACCAAAGTGCCCTTTCTTTGTTTATCTTGTTATTTCATATA
AGGATTACTATTGGTTTTTT

Product: DNA gyrase subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 806; Mature: 805

Protein sequence:

>806_residues
MSETTNDNYGASSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCSDIIVTIHDDNSVSVQDDGR
GIPVDIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSDKLQLTIRRQGHVHEQFYHLGEPQSPLTV
IGETEATGTTVRFWPSSDIFAITTFDYKILAKRLRELSFLNSGVSIRLIDKRDGSEDHFHYEGGIQAFVEYLNKNKNPIH
PKPFYFTAEKDGIGVEVALQWNDGVNENVYCFTNNIPQRDGGTHLAGFRGALTRSLNSYMENEGMLKKEKVATSGDDARE
GLVAIISVKVPDPKFSSQTKDKLVSSEVKSAVESAMNEKMQEYLLENPADAKIIVNQIIMAARAREAARKAREMTRRKGA
LDIAGLPGKLADCQEKDPALSELYLVEGDSAGGSAKVGRDRKTQAILPLKGKILNVEKARFDKMLSSQEVGTLITALGCG
IGRDEYNPDKLRYHHIIIMTDADVDGSHIRTLLLTFFYRQMPELIERGYVYIAQPPLYKVKKGKQERYIKDADEMEQYEL
TLALDGAELHISANAPAMNALVFEKLVAEYNSVQKLIGRLSRHYPVPVLQGLIYQSPISIEMMKEESAVENWGKSFVEQL
TAKETEAHQYSVRTQFNAERQVYEAVITVRKHGIDTDYFLNFDFVHGNEYAKIVSLNKQLNGLLEEGAYVIRGEKVQPVR
SFEQAVEWLVKESRKGLEVQRYKGLGEMNADQLWETTMDPNSRRMLKVSIKDAVAADQLFTTLMGDEVEPRREFIELNAL
RANLDV

Sequences:

>Translated_806_residues
MSETTNDNYGASSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCSDIIVTIHDDNSVSVQDDGR
GIPVDIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSDKLQLTIRRQGHVHEQFYHLGEPQSPLTV
IGETEATGTTVRFWPSSDIFAITTFDYKILAKRLRELSFLNSGVSIRLIDKRDGSEDHFHYEGGIQAFVEYLNKNKNPIH
PKPFYFTAEKDGIGVEVALQWNDGVNENVYCFTNNIPQRDGGTHLAGFRGALTRSLNSYMENEGMLKKEKVATSGDDARE
GLVAIISVKVPDPKFSSQTKDKLVSSEVKSAVESAMNEKMQEYLLENPADAKIIVNQIIMAARAREAARKAREMTRRKGA
LDIAGLPGKLADCQEKDPALSELYLVEGDSAGGSAKVGRDRKTQAILPLKGKILNVEKARFDKMLSSQEVGTLITALGCG
IGRDEYNPDKLRYHHIIIMTDADVDGSHIRTLLLTFFYRQMPELIERGYVYIAQPPLYKVKKGKQERYIKDADEMEQYEL
TLALDGAELHISANAPAMNALVFEKLVAEYNSVQKLIGRLSRHYPVPVLQGLIYQSPISIEMMKEESAVENWGKSFVEQL
TAKETEAHQYSVRTQFNAERQVYEAVITVRKHGIDTDYFLNFDFVHGNEYAKIVSLNKQLNGLLEEGAYVIRGEKVQPVR
SFEQAVEWLVKESRKGLEVQRYKGLGEMNADQLWETTMDPNSRRMLKVSIKDAVAADQLFTTLMGDEVEPRREFIELNAL
RANLDV
>Mature_805_residues
SETTNDNYGASSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCSDIIVTIHDDNSVSVQDDGRG
IPVDIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSDKLQLTIRRQGHVHEQFYHLGEPQSPLTVI
GETEATGTTVRFWPSSDIFAITTFDYKILAKRLRELSFLNSGVSIRLIDKRDGSEDHFHYEGGIQAFVEYLNKNKNPIHP
KPFYFTAEKDGIGVEVALQWNDGVNENVYCFTNNIPQRDGGTHLAGFRGALTRSLNSYMENEGMLKKEKVATSGDDAREG
LVAIISVKVPDPKFSSQTKDKLVSSEVKSAVESAMNEKMQEYLLENPADAKIIVNQIIMAARAREAARKAREMTRRKGAL
DIAGLPGKLADCQEKDPALSELYLVEGDSAGGSAKVGRDRKTQAILPLKGKILNVEKARFDKMLSSQEVGTLITALGCGI
GRDEYNPDKLRYHHIIIMTDADVDGSHIRTLLLTFFYRQMPELIERGYVYIAQPPLYKVKKGKQERYIKDADEMEQYELT
LALDGAELHISANAPAMNALVFEKLVAEYNSVQKLIGRLSRHYPVPVLQGLIYQSPISIEMMKEESAVENWGKSFVEQLT
AKETEAHQYSVRTQFNAERQVYEAVITVRKHGIDTDYFLNFDFVHGNEYAKIVSLNKQLNGLLEEGAYVIRGEKVQPVRS
FEQAVEWLVKESRKGLEVQRYKGLGEMNADQLWETTMDPNSRRMLKVSIKDAVAADQLFTTLMGDEVEPRREFIELNALR
ANLDV

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=604, Percent_Identity=25.1655629139073, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI19913406, Length=566, Percent_Identity=25.4416961130742, Blast_Score=130, Evalue=5e-30,
Organism=Escherichia coli, GI48994957, Length=803, Percent_Identity=75.2179327521793, Blast_Score=1247, Evalue=0.0,
Organism=Escherichia coli, GI1789408, Length=555, Percent_Identity=41.6216216216216, Blast_Score=396, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17535065, Length=539, Percent_Identity=25.974025974026, Blast_Score=145, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI212645845, Length=514, Percent_Identity=24.124513618677, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI212645657, Length=155, Percent_Identity=34.8387096774194, Blast_Score=78, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=571, Percent_Identity=25.569176882662, Blast_Score=126, Evalue=1e-29,
Organism=Drosophila melanogaster, GI17136538, Length=543, Percent_Identity=25.9668508287293, Blast_Score=138, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011557
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 89956; Mature: 89825

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETTNDNYGASSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHC
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHCCC
SDIIVTIHDDNSVSVQDDGRGIPVDIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLH
CEEEEEEECCCEEEECCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCC
GVGVSVVNALSDKLQLTIRRQGHVHEQFYHLGEPQSPLTVIGETEATGTTVRFWPSSDIF
HHHHHHHHHHHHHHEEEEECCCCHHHHHHHCCCCCCCEEEEECCCCCCCEEEECCCCCEE
AITTFDYKILAKRLRELSFLNSGVSIRLIDKRDGSEDHFHYEGGIQAFVEYLNKNKNPIH
EEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEECCHHHHHHHHHHCCCCCCC
PKPFYFTAEKDGIGVEVALQWNDGVNENVYCFTNNIPQRDGGTHLAGFRGALTRSLNSYM
CCCEEEEECCCCCEEEEEEEECCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
ENEGMLKKEKVATSGDDAREGLVAIISVKVPDPKFSSQTKDKLVSSEVKSAVESAMNEKM
HCCCCCCHHHCCCCCCCHHCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QEYLLENPADAKIIVNQIIMAARAREAARKAREMTRRKGALDIAGLPGKLADCQEKDPAL
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCC
SELYLVEGDSAGGSAKVGRDRKTQAILPLKGKILNVEKARFDKMLSSQEVGTLITALGCG
EEEEEEECCCCCCCCCCCCCCCCEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHHHCC
IGRDEYNPDKLRYHHIIIMTDADVDGSHIRTLLLTFFYRQMPELIERGYVYIAQPPLYKV
CCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHH
KKGKQERYIKDADEMEQYELTLALDGAELHISANAPAMNALVFEKLVAEYNSVQKLIGRL
HCCCHHHHHCCHHHHHHEEEEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
SRHYPVPVLQGLIYQSPISIEMMKEESAVENWGKSFVEQLTAKETEAHQYSVRTQFNAER
HCCCCCHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHH
QVYEAVITVRKHGIDTDYFLNFDFVHGNEYAKIVSLNKQLNGLLEEGAYVIRGEKVQPVR
HHHHHHHHHHHCCCCCEEEEEEEEEECCCEEEEEEHHHHHHHHHHCCEEEEECCCCCHHH
SFEQAVEWLVKESRKGLEVQRYKGLGEMNADQLWETTMDPNSRRMLKVSIKDAVAADQLF
HHHHHHHHHHHHHHCCCEEHHHCCCCCCCHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHH
TTLMGDEVEPRREFIELNALRANLDV
HHHHCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SETTNDNYGASSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHC
CCCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHCCC
SDIIVTIHDDNSVSVQDDGRGIPVDIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLH
CEEEEEEECCCEEEECCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCC
GVGVSVVNALSDKLQLTIRRQGHVHEQFYHLGEPQSPLTVIGETEATGTTVRFWPSSDIF
HHHHHHHHHHHHHHEEEEECCCCHHHHHHHCCCCCCCEEEEECCCCCCCEEEECCCCCEE
AITTFDYKILAKRLRELSFLNSGVSIRLIDKRDGSEDHFHYEGGIQAFVEYLNKNKNPIH
EEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEECCHHHHHHHHHHCCCCCCC
PKPFYFTAEKDGIGVEVALQWNDGVNENVYCFTNNIPQRDGGTHLAGFRGALTRSLNSYM
CCCEEEEECCCCCEEEEEEEECCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
ENEGMLKKEKVATSGDDAREGLVAIISVKVPDPKFSSQTKDKLVSSEVKSAVESAMNEKM
HCCCCCCHHHCCCCCCCHHCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QEYLLENPADAKIIVNQIIMAARAREAARKAREMTRRKGALDIAGLPGKLADCQEKDPAL
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCC
SELYLVEGDSAGGSAKVGRDRKTQAILPLKGKILNVEKARFDKMLSSQEVGTLITALGCG
EEEEEEECCCCCCCCCCCCCCCCEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHHHCC
IGRDEYNPDKLRYHHIIIMTDADVDGSHIRTLLLTFFYRQMPELIERGYVYIAQPPLYKV
CCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHH
KKGKQERYIKDADEMEQYELTLALDGAELHISANAPAMNALVFEKLVAEYNSVQKLIGRL
HCCCHHHHHCCHHHHHHEEEEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
SRHYPVPVLQGLIYQSPISIEMMKEESAVENWGKSFVEQLTAKETEAHQYSVRTQFNAER
HCCCCCHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHH
QVYEAVITVRKHGIDTDYFLNFDFVHGNEYAKIVSLNKQLNGLLEEGAYVIRGEKVQPVR
HHHHHHHHHHHCCCCCEEEEEEEEEECCCEEEEEEHHHHHHHHHHCCEEEEECCCCCHHH
SFEQAVEWLVKESRKGLEVQRYKGLGEMNADQLWETTMDPNSRRMLKVSIKDAVAADQLF
HHHHHHHHHHHHHHCCCEEHHHCCCCCCCHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHH
TTLMGDEVEPRREFIELNALRANLDV
HHHHCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]