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The map label for this gene is hldE [H]

Identifier: 148826814

GI number: 148826814

Start: 56145

End: 57575

Strand: Direct

Name: hldE [H]

Synonym: CGSHiGG_00330

Alternate gene names: 148826814

Gene position: 56145-57575 (Clockwise)

Preceding gene: 148826810

Following gene: 148826817

Centisome position: 2.98

GC content: 39.97

Gene sequence:

>1431_bases
ATGGCTCAATATTCAGCAGAATTTAAGCAAGCAAAAGTACTTGTATTAGGCGATGTTATGCTTGATCGTTATTGGTTCGG
TGCAACCAACCGTATTTCACCAGAAGCACCAGTGCCAGTGGTTCGTGTACAAGAAAATGAAGAACGCGCGGGCGGTGCTG
CAAATGTAGCGATGAATATTGCGTCACTCAATGTACCCGTTCAGTTAATGGGATTGATTGGACAAGATGAAACTGGTTCT
GCACTTTCCCTCTTATTAGAAAAACAAAAAATTGATTGTAATTTTGTTGCATTAGAAACCCATCCAACTATTACTAAATT
ACGTATTTTATCTCGTCACCAACAGTTACTTCGCCTTGATTTTGAAGAAGATTTCAATAATGTAGATTGCAAGGATTTAT
TAGCGAAGTTAGAAAGTGCGGTGAAAAATTACGGTGCTTTGATTCTTTCTGATTACGGCAAAGGCACGCTTAAAGATGTT
CAGAAAATGATTCAAATTGCACGCAAAGCGAATGTGCCTGTGTTGATCGATCCAAAGGGAACTGATTTTGAACGTTATTG
TGGGGCTACATTATTGACACCCAATATGTCTGAATTTGAAGCCGTTGTAGGTAAATGTAATACAGAAGAAGAGATTATTA
AGAAGGGTTTAAAATTAATTTCTGATATTGAATTAACCGCGCTTTTGGTGACGCGTTCTGAAAAAGGCATGACATTATTA
CGCCCAAATCAAGAACCCTATCATTTGCCAACCGTTGCAAAAGAAGTGTTTGATGTGACGGGAGCGGGGGACACTGTCAT
TAGCGTATTAGCAACCGCATTAGCAGATGGACGTTCTTTCGAAGAATCTTGTTACCTAGCCAATGTTGCCGCTGGAATTG
TGGTGGGTAAATTGGGGACTTCAACGGTTTCGACCGTGGAACTTGAAAATGCGATTCATGCTCGCCCTGAAACGGGATTT
GGCATTATGAGTGAAGCAGAATTAAAAGATGCTGTCGCACAAGCGAAAGCGCGCGGTGAAAAAATTGTGATGACTAATGG
CTGTTTCGATATTTTGCATCCCGGGCATATTTCTTATTTAGAAAATGCACGCAAATTGGGCGATCGTTTAATTGTTGCGG
TAAACAGCGACGATTCTGTTAAACGCTTAAAAGGCGAAAGTCGTCCAATTAATAATCTTGAAAATCGTATGGCGGTACTG
GCTGGTTTGGCATCCGTGGACTGGTTGGTACCTTTCACTGAAGATACACCACAACATTTAATCGGCGAAATTCTACCAGA
TCTTTTAGTCAAAGGTGGAGATTACAAACCCGAAGAGATTGCAGGCAGTAAAGAAGTTTGGGCAAACGGTGGCGATGTTA
AAGTGCTAAACTTTGAAAATGGTTGTTCAACAACAAATGTGATTGAAAAAATTAAATTATTAAAAGATTAA

Upstream 100 bases:

>100_bases
TCATTGTTCTTTCCACGTAAGTTAGGGGCGTAGTTTATCGTAAATTTGAGTTGTGGTAAAATCGCCACAATTTTGGTTAT
TCAAATAGAGAGATTTTAAA

Downstream 100 bases:

>100_bases
GTGAAAGGTTAGGGACAACTTGTTTATCATAAAAAACAACGAAATATAATGGGAAGTGGGATATAACCAGATGGTTATCC
ACAGTTTCGTGGATTAAAAT

Product: bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase [H]

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MAQYSAEFKQAKVLVLGDVMLDRYWFGATNRISPEAPVPVVRVQENEERAGGAANVAMNIASLNVPVQLMGLIGQDETGS
ALSLLLEKQKIDCNFVALETHPTITKLRILSRHQQLLRLDFEEDFNNVDCKDLLAKLESAVKNYGALILSDYGKGTLKDV
QKMIQIARKANVPVLIDPKGTDFERYCGATLLTPNMSEFEAVVGKCNTEEEIIKKGLKLISDIELTALLVTRSEKGMTLL
RPNQEPYHLPTVAKEVFDVTGAGDTVISVLATALADGRSFEESCYLANVAAGIVVGKLGTSTVSTVELENAIHARPETGF
GIMSEAELKDAVAQAKARGEKIVMTNGCFDILHPGHISYLENARKLGDRLIVAVNSDDSVKRLKGESRPINNLENRMAVL
AGLASVDWLVPFTEDTPQHLIGEILPDLLVKGGDYKPEEIAGSKEVWANGGDVKVLNFENGCSTTNVIEKIKLLKD

Sequences:

>Translated_476_residues
MAQYSAEFKQAKVLVLGDVMLDRYWFGATNRISPEAPVPVVRVQENEERAGGAANVAMNIASLNVPVQLMGLIGQDETGS
ALSLLLEKQKIDCNFVALETHPTITKLRILSRHQQLLRLDFEEDFNNVDCKDLLAKLESAVKNYGALILSDYGKGTLKDV
QKMIQIARKANVPVLIDPKGTDFERYCGATLLTPNMSEFEAVVGKCNTEEEIIKKGLKLISDIELTALLVTRSEKGMTLL
RPNQEPYHLPTVAKEVFDVTGAGDTVISVLATALADGRSFEESCYLANVAAGIVVGKLGTSTVSTVELENAIHARPETGF
GIMSEAELKDAVAQAKARGEKIVMTNGCFDILHPGHISYLENARKLGDRLIVAVNSDDSVKRLKGESRPINNLENRMAVL
AGLASVDWLVPFTEDTPQHLIGEILPDLLVKGGDYKPEEIAGSKEVWANGGDVKVLNFENGCSTTNVIEKIKLLKD
>Mature_475_residues
AQYSAEFKQAKVLVLGDVMLDRYWFGATNRISPEAPVPVVRVQENEERAGGAANVAMNIASLNVPVQLMGLIGQDETGSA
LSLLLEKQKIDCNFVALETHPTITKLRILSRHQQLLRLDFEEDFNNVDCKDLLAKLESAVKNYGALILSDYGKGTLKDVQ
KMIQIARKANVPVLIDPKGTDFERYCGATLLTPNMSEFEAVVGKCNTEEEIIKKGLKLISDIELTALLVTRSEKGMTLLR
PNQEPYHLPTVAKEVFDVTGAGDTVISVLATALADGRSFEESCYLANVAAGIVVGKLGTSTVSTVELENAIHARPETGFG
IMSEAELKDAVAQAKARGEKIVMTNGCFDILHPGHISYLENARKLGDRLIVAVNSDDSVKRLKGESRPINNLENRMAVLA
GLASVDWLVPFTEDTPQHLIGEILPDLLVKGGDYKPEEIAGSKEVWANGGDVKVLNFENGCSTTNVIEKIKLLKD

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose [H]

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789432, Length=466, Percent_Identity=70.3862660944206, Blast_Score=684, Evalue=0.0,
Organism=Drosophila melanogaster, GI45550975, Length=209, Percent_Identity=29.6650717703349, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45550974, Length=214, Percent_Identity=28.9719626168224, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19921220, Length=142, Percent_Identity=28.8732394366197, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI45550973, Length=64, Percent_Identity=50, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB [H]

EC number: 2.7.-.-

Molecular weight: Translated: 51873; Mature: 51742

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQYSAEFKQAKVLVLGDVMLDRYWFGATNRISPEAPVPVVRVQENEERAGGAANVAMNI
CCCCCCCHHHCEEEEEHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCHHHEEEEE
ASLNVPVQLMGLIGQDETGSALSLLLEKQKIDCNFVALETHPTITKLRILSRHQQLLRLD
EECCCCCEEHEECCCCCCCHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHCC
FEEDFNNVDCKDLLAKLESAVKNYGALILSDYGKGTLKDVQKMIQIARKANVPVLIDPKG
HHHCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEECCCC
TDFERYCGATLLTPNMSEFEAVVGKCNTEEEIIKKGLKLISDIELTALLVTRSEKGMTLL
CCHHHHCCCEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCEEE
RPNQEPYHLPTVAKEVFDVTGAGDTVISVLATALADGRSFEESCYLANVAAGIVVGKLGT
CCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEECCCC
STVSTVELENAIHARPETGFGIMSEAELKDAVAQAKARGEKIVMTNGCFDILHPGHISYL
CCEEEEEHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHCCCCHHHHH
ENARKLGDRLIVAVNSDDSVKRLKGESRPINNLENRMAVLAGLASVDWLVPFTEDTPQHL
HHHHHCCCEEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHCEEEECCCCCHHHH
IGEILPDLLVKGGDYKPEEIAGSKEVWANGGDVKVLNFENGCSTTNVIEKIKLLKD
HHHHHHHHHHCCCCCCHHHHCCCHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
AQYSAEFKQAKVLVLGDVMLDRYWFGATNRISPEAPVPVVRVQENEERAGGAANVAMNI
CCCCCCHHHCEEEEEHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCHHHEEEEE
ASLNVPVQLMGLIGQDETGSALSLLLEKQKIDCNFVALETHPTITKLRILSRHQQLLRLD
EECCCCCEEHEECCCCCCCHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHCC
FEEDFNNVDCKDLLAKLESAVKNYGALILSDYGKGTLKDVQKMIQIARKANVPVLIDPKG
HHHCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEECCCC
TDFERYCGATLLTPNMSEFEAVVGKCNTEEEIIKKGLKLISDIELTALLVTRSEKGMTLL
CCHHHHCCCEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCEEE
RPNQEPYHLPTVAKEVFDVTGAGDTVISVLATALADGRSFEESCYLANVAAGIVVGKLGT
CCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEECCCC
STVSTVELENAIHARPETGFGIMSEAELKDAVAQAKARGEKIVMTNGCFDILHPGHISYL
CCEEEEEHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHCCCCHHHHH
ENARKLGDRLIVAVNSDDSVKRLKGESRPINNLENRMAVLAGLASVDWLVPFTEDTPQHL
HHHHHCCCEEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHCEEEECCCCCHHHH
IGEILPDLLVKGGDYKPEEIAGSKEVWANGGDVKVLNFENGCSTTNVIEKIKLLKD
HHHHHHHHHHCCCCCCHHHHCCCHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA