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The map label for this gene is uvrD [H]

Identifier: 148826204

GI number: 148826204

Start: 1211775

End: 1213955

Strand: Direct

Name: uvrD [H]

Synonym: CGSHiEE_06105

Alternate gene names: 148826204

Gene position: 1211775-1213955 (Clockwise)

Preceding gene: 148826203

Following gene: 148826205

Centisome position: 66.84

GC content: 40.03

Gene sequence:

>2181_bases
ATGGATATTTCTGAATTACTTGACGGACTCAACGATAAACAACGCGAAGCCGTAGCTGCTCCTCTTGGTAATCACTTAGT
GCTAGCTGGTGCAGGCTCGGGCAAAACGCGTGTATTGACGCACCGTATTGCTTGGTTAATTGCGGTCGAAAATATTTCTG
AAGGCAGCATTATGGCGGTGACCTTTACCAATAAAGCCGCAGCAGAAATGCGTCATCGTATTCAATCTACCCTTGCCAAA
CACGCACAACATCAATTATTTGGTATGTGGATTGGCACCTTCCATAGCATTGCTCATCGTTTGTTGCGAGCTCATCATTT
AGATGTGGGATTGCCACAAGATTTCCAAATTTTAGATTCAGAAGATCAACGTCGTTTAATTAAACGATTATTAAAATTAC
ATAATTTTGATGAAAAAGCTTTTCCGCCTAAACAGGCTTGTTGGTACATCAATAACAAAAAAGATGAAGGCTTGCGACCA
AATGATATTGAAGATTTTAATGATCGCCAAGAACGTGAATGGATTAAAATTTATCAGATCTATCAAGACACTTGCGATCG
CGCAGGGTTGGTCGATTTTGCTGAATTATTAATTCGGGTCTATGAATTATTTGAGAAAAAACCATTAATTTTGCAACGTT
ATCAACAACGTTTTCAGCATATTTTGGTGGATGAGTTTCAAGACACCAATAAAATTCAATATAAGTGGATTAAAATTCTT
GCTGGAAAAACAGGCAAAGTCATGATCGTAGGCGATGATGATCAATCTATATACGGTTGGCGTGGCGCACAAATTGAAAA
TATCCAAAAATTCTTGAAAGATTTCAAAGCCGAAACAATTCGCCTTGAACAAAACTACCGTTCTACCGCCAATATCCTAA
ACAGCGCAAATGAATTAATTGCAAACAATAGTGATCGTCTTGGTAAAAATTTATGGACAGAGGGTGAGAAAGGCGATCCT
GTGGGCATCTATTCTGCCTTTAATGAATTAGATGAAGCAAAATTTGTCGCTTCACAAATTCAGGATTGGGTAGAACATGG
CGGAAAACTTGATGATTGCGCTGTACTTTATCGTAGTAATAGCCAATCACGGGTTATTGAAGAAGCTTTAATTCGTTGTC
AAATTCCATACCGTATTTATGGCGGTATGCGTTTCTTCGAACGTCAAGAAATTAAAGATGCGTTAGCCTATCTTCGTTTG
ATTAATAATCGTCAAGATGATGCGGCTTTTGAGCGTGTAATTAATACGCCAACCCGTGGCATTGGCGACCGCACTTTAGA
TATATTGCGTAACTTAACACGCGAACGCCAAATTACCTTATGGCAAGCAGTACAAGTCGCAACACAAGAAAATATGTTGG
CAGGGCGAGCCTCAACAGCCTTATTACGTTTCCAAGAATTAATTAATTCACTACAACTTGATACCGCAGAAATGCCGCTT
TTCGCACAAACTGATTTTGTGATTAAACATTCGGGCTTATATGAAATGTATCAACAAGAAAAAGGCGAAAAAGGCGAAGT
GCGGATTGAAAATTTGGAAGAATTAGTTACCGCAACCCGTGAATTTATCAAACCTGATGATGCGGAAGAAATGACCGAAC
TCACTGCCTTTTTAACTCATGCCTCTTTAGAAGCTGGTGAAGAACAAGCCTCGCCGCATCAATCTTGTGTAGAAATGATG
ACGTTGCACTCTGCGAAAGGCTTAGAATTTCCTCGTGTATTTATGGTGGGCGTAGAAGAAGGATTATTCCCAAGTTTTCG
TTCTTTTGAAGAACCCGGACGTTTAGAAGAAGAGCGTCGTTTAGCTTATGTCGGTATTACTCGCGCACAGAAAAAACTGA
CCATCTCTTATGCGGAAAGCCGTCGATTATATGCCAAAGAAGAACGCCATTTGCCATCACGGTTTATCGCAGAATTACCG
AGAGAATGTATCCAAGAAATTCGTTTACGAGGGACAGTCACGCGTGCGATGAACCTAGCAAAAGTCGGTTCATTGTCGAA
TACCAGTGCGGTCGAAAATGAATGGAAAATGGGTCAAAAAGTTAAACACGAAAAATTTGGTTTCGGCACAGTGATTAATG
TGGAAGGATCTGAAAATAACACACGTTTACAAATAGCGTTCCAAGCTCAAGGCATTAAATGGTTGATTGCGCATTTGGCA
ACATTGGAAAAAGTGCGGTAG

Upstream 100 bases:

>100_bases
TGTTCTACCCTACTTTTGATATACTCACAAATCTTATTGTTTCACAAGATAGATGGGACTATAATAACTGTAAATTTAAA
CAGATTAAAGATAGTTTATG

Downstream 100 bases:

>100_bases
AATTCAAGAGTATTATATTTTTTACCGATTAATTTCTTTGAAAAGTGCGGTGAATTTTTACCGCACTTTTATTATCTACG
AGTGATGGAATGTTTAAATT

Product: DNA-dependent helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 726; Mature: 726

Protein sequence:

>726_residues
MDISELLDGLNDKQREAVAAPLGNHLVLAGAGSGKTRVLTHRIAWLIAVENISEGSIMAVTFTNKAAAEMRHRIQSTLAK
HAQHQLFGMWIGTFHSIAHRLLRAHHLDVGLPQDFQILDSEDQRRLIKRLLKLHNFDEKAFPPKQACWYINNKKDEGLRP
NDIEDFNDRQEREWIKIYQIYQDTCDRAGLVDFAELLIRVYELFEKKPLILQRYQQRFQHILVDEFQDTNKIQYKWIKIL
AGKTGKVMIVGDDDQSIYGWRGAQIENIQKFLKDFKAETIRLEQNYRSTANILNSANELIANNSDRLGKNLWTEGEKGDP
VGIYSAFNELDEAKFVASQIQDWVEHGGKLDDCAVLYRSNSQSRVIEEALIRCQIPYRIYGGMRFFERQEIKDALAYLRL
INNRQDDAAFERVINTPTRGIGDRTLDILRNLTRERQITLWQAVQVATQENMLAGRASTALLRFQELINSLQLDTAEMPL
FAQTDFVIKHSGLYEMYQQEKGEKGEVRIENLEELVTATREFIKPDDAEEMTELTAFLTHASLEAGEEQASPHQSCVEMM
TLHSAKGLEFPRVFMVGVEEGLFPSFRSFEEPGRLEEERRLAYVGITRAQKKLTISYAESRRLYAKEERHLPSRFIAELP
RECIQEIRLRGTVTRAMNLAKVGSLSNTSAVENEWKMGQKVKHEKFGFGTVINVEGSENNTRLQIAFQAQGIKWLIAHLA
TLEKVR

Sequences:

>Translated_726_residues
MDISELLDGLNDKQREAVAAPLGNHLVLAGAGSGKTRVLTHRIAWLIAVENISEGSIMAVTFTNKAAAEMRHRIQSTLAK
HAQHQLFGMWIGTFHSIAHRLLRAHHLDVGLPQDFQILDSEDQRRLIKRLLKLHNFDEKAFPPKQACWYINNKKDEGLRP
NDIEDFNDRQEREWIKIYQIYQDTCDRAGLVDFAELLIRVYELFEKKPLILQRYQQRFQHILVDEFQDTNKIQYKWIKIL
AGKTGKVMIVGDDDQSIYGWRGAQIENIQKFLKDFKAETIRLEQNYRSTANILNSANELIANNSDRLGKNLWTEGEKGDP
VGIYSAFNELDEAKFVASQIQDWVEHGGKLDDCAVLYRSNSQSRVIEEALIRCQIPYRIYGGMRFFERQEIKDALAYLRL
INNRQDDAAFERVINTPTRGIGDRTLDILRNLTRERQITLWQAVQVATQENMLAGRASTALLRFQELINSLQLDTAEMPL
FAQTDFVIKHSGLYEMYQQEKGEKGEVRIENLEELVTATREFIKPDDAEEMTELTAFLTHASLEAGEEQASPHQSCVEMM
TLHSAKGLEFPRVFMVGVEEGLFPSFRSFEEPGRLEEERRLAYVGITRAQKKLTISYAESRRLYAKEERHLPSRFIAELP
RECIQEIRLRGTVTRAMNLAKVGSLSNTSAVENEWKMGQKVKHEKFGFGTVINVEGSENNTRLQIAFQAQGIKWLIAHLA
TLEKVR
>Mature_726_residues
MDISELLDGLNDKQREAVAAPLGNHLVLAGAGSGKTRVLTHRIAWLIAVENISEGSIMAVTFTNKAAAEMRHRIQSTLAK
HAQHQLFGMWIGTFHSIAHRLLRAHHLDVGLPQDFQILDSEDQRRLIKRLLKLHNFDEKAFPPKQACWYINNKKDEGLRP
NDIEDFNDRQEREWIKIYQIYQDTCDRAGLVDFAELLIRVYELFEKKPLILQRYQQRFQHILVDEFQDTNKIQYKWIKIL
AGKTGKVMIVGDDDQSIYGWRGAQIENIQKFLKDFKAETIRLEQNYRSTANILNSANELIANNSDRLGKNLWTEGEKGDP
VGIYSAFNELDEAKFVASQIQDWVEHGGKLDDCAVLYRSNSQSRVIEEALIRCQIPYRIYGGMRFFERQEIKDALAYLRL
INNRQDDAAFERVINTPTRGIGDRTLDILRNLTRERQITLWQAVQVATQENMLAGRASTALLRFQELINSLQLDTAEMPL
FAQTDFVIKHSGLYEMYQQEKGEKGEVRIENLEELVTATREFIKPDDAEEMTELTAFLTHASLEAGEEQASPHQSCVEMM
TLHSAKGLEFPRVFMVGVEEGLFPSFRSFEEPGRLEEERRLAYVGITRAQKKLTISYAESRRLYAKEERHLPSRFIAELP
RECIQEIRLRGTVTRAMNLAKVGSLSNTSAVENEWKMGQKVKHEKFGFGTVINVEGSENNTRLQIAFQAQGIKWLIAHLA
TLEKVR

Specific function: May process damage occurring in non-replicating regions of DNA to produce recombinational intermediates for sister strand recombinational exchange [H]

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=728, Percent_Identity=67.3076923076923, Blast_Score=1021, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=643, Percent_Identity=39.3468118195956, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI1789183, Length=518, Percent_Identity=23.7451737451737, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322369, Length=731, Percent_Identity=28.3173734610123, Blast_Score=186, Evalue=9e-48,
Organism=Saccharomyces cerevisiae, GI6324477, Length=653, Percent_Identity=22.052067381317, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 83514; Mature: 83514

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDISELLDGLNDKQREAVAAPLGNHLVLAGAGSGKTRVLTHRIAWLIAVENISEGSIMAV
CCHHHHHHCCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHEECCCCCCCEEEE
TFTNKAAAEMRHRIQSTLAKHAQHQLFGMWIGTFHSIAHRLLRAHHLDVGLPQDFQILDS
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
EDQRRLIKRLLKLHNFDEKAFPPKQACWYINNKKDEGLRPNDIEDFNDRQEREWIKIYQI
HHHHHHHHHHHHHCCCCCCCCCCCHHEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
YQDTCDRAGLVDFAELLIRVYELFEKKPLILQRYQQRFQHILVDEFQDTNKIQYKWIKIL
HHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEEE
AGKTGKVMIVGDDDQSIYGWRGAQIENIQKFLKDFKAETIRLEQNYRSTANILNSANELI
ECCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHH
ANNSDRLGKNLWTEGEKGDPVGIYSAFNELDEAKFVASQIQDWVEHGGKLDDCAVLYRSN
CCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEECC
SQSRVIEEALIRCQIPYRIYGGMRFFERQEIKDALAYLRLINNRQDDAAFERVINTPTRG
CHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCC
IGDRTLDILRNLTRERQITLWQAVQVATQENMLAGRASTALLRFQELINSLQLDTAEMPL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
FAQTDFVIKHSGLYEMYQQEKGEKGEVRIENLEELVTATREFIKPDDAEEMTELTAFLTH
EECCCEEEECCCHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
ASLEAGEEQASPHQSCVEMMTLHSAKGLEFPRVFMVGVEEGLFPSFRSFEEPGRLEEERR
HHHHCCHHCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHCCCCCCCCCHHHC
LAYVGITRAQKKLTISYAESRRLYAKEERHLPSRFIAELPRECIQEIRLRGTVTRAMNLA
EEEEEEHHHHHEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KVGSLSNTSAVENEWKMGQKVKHEKFGFGTVINVEGSENNTRLQIAFQAQGIKWLIAHLA
HHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEECCCHHHHHHHHH
TLEKVR
HHHHCC
>Mature Secondary Structure
MDISELLDGLNDKQREAVAAPLGNHLVLAGAGSGKTRVLTHRIAWLIAVENISEGSIMAV
CCHHHHHHCCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHEECCCCCCCEEEE
TFTNKAAAEMRHRIQSTLAKHAQHQLFGMWIGTFHSIAHRLLRAHHLDVGLPQDFQILDS
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
EDQRRLIKRLLKLHNFDEKAFPPKQACWYINNKKDEGLRPNDIEDFNDRQEREWIKIYQI
HHHHHHHHHHHHHCCCCCCCCCCCHHEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
YQDTCDRAGLVDFAELLIRVYELFEKKPLILQRYQQRFQHILVDEFQDTNKIQYKWIKIL
HHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEEE
AGKTGKVMIVGDDDQSIYGWRGAQIENIQKFLKDFKAETIRLEQNYRSTANILNSANELI
ECCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHH
ANNSDRLGKNLWTEGEKGDPVGIYSAFNELDEAKFVASQIQDWVEHGGKLDDCAVLYRSN
CCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEECC
SQSRVIEEALIRCQIPYRIYGGMRFFERQEIKDALAYLRLINNRQDDAAFERVINTPTRG
CHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCC
IGDRTLDILRNLTRERQITLWQAVQVATQENMLAGRASTALLRFQELINSLQLDTAEMPL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
FAQTDFVIKHSGLYEMYQQEKGEKGEVRIENLEELVTATREFIKPDDAEEMTELTAFLTH
EECCCEEEECCCHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
ASLEAGEEQASPHQSCVEMMTLHSAKGLEFPRVFMVGVEEGLFPSFRSFEEPGRLEEERR
HHHHCCHHCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHCCCCCCCCCHHHC
LAYVGITRAQKKLTISYAESRRLYAKEERHLPSRFIAELPRECIQEIRLRGTVTRAMNLA
EEEEEEHHHHHEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KVGSLSNTSAVENEWKMGQKVKHEKFGFGTVINVEGSENNTRLQIAFQAQGIKWLIAHLA
HHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEECCCHHHHHHHHH
TLEKVR
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8294031; 7542800; 3259573 [H]