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The map label for this gene is uvrD [H]

Identifier: 148826205

GI number: 148826205

Start: 1215062

End: 1215949

Strand: Direct

Name: uvrD [H]

Synonym: CGSHiEE_06120

Alternate gene names: 148826205

Gene position: 1215062-1215949 (Clockwise)

Preceding gene: 148826204

Following gene: 148826206

Centisome position: 67.02

GC content: 41.89

Gene sequence:

>888_bases
ATGTCTGACACGCCTTCAACTTTCGCGCCGAAAACGCCCTTGCAAGAATTTTGGTTTTACTTCAAACAAAACCGTGGTGC
GCTAATTGGTTTAATTTTTATTTTGATTGTTGCCTTAATCAGCATTCTTGCGCCTTATATTGCGCCTTTTGATCCAACAG
AGCAAAATCGTACCGCACTTTTACTTCCCCCTGCTTGGTATGATGGTGGCAATCCTGCCTATTTACTCGGAACAGATGAT
ATTGGGCGAGATATTCTTTCTCGCATCATTTACGGAACACGAATTTCCGTCTTTGCGGGATTTGTTATTGTATTGCTATC
TTGTGCCTTTGGTACCAGTCTTGGCTTGGTTTCTGGCTATTATGGCGGCATGCTAGATACAATTATCATTCGCCTAATTG
ATATTATGCTCGCGATTCCAAACTTACTCTTGACGATTGTGGTCGTCTCTATTTTAGAGCCATCACTCGCCAACGCCACT
TTAGCTATCGCCGTTGTATCAATTCCTAGCTATGTGCGTTTAACTCGAGCAGCAGTGATGAATGAAAAAAATCGTGATTA
TGTGACTTCATCTAAAGTGGCTGGTGCAGGTATTTTACGCCTAATGTTTATTGTGATTTTACCGAACTGTTTAGCCCCTT
TAATTGTGCAAATGACAATGGGTATTTCCAATGCGATCTTAGAACTTGCAACACTTGGTTTCTTAGGCATTGGTGCAAAA
CCGCCAACACCTGAACTTGGCACAATGCTTTCAGAAGCACGTGGTTTTATGCAAGCGGCAAACTGGTTGGTTACAATTCC
CGGTTTAGTGATTTTATCTTTGGTATTAGCTTTCAACTTAATGGGCGATGGCTTGCGTGATGCCCTTGATCCAAAACTCA
AACAATAG

Upstream 100 bases:

>100_bases
TACTGATTATTGCAACAATTATTGTTGTGGTAAATTTAACTGTCGATTTACTTTACGGCGTGGTCAATCCGCGTATCCGT
CATTAATTGTAGGAGAAATT

Downstream 100 bases:

>100_bases
GAAAACAGAATGGCATTATTAGACGTAAAAGAACTTTCTGTTCACTTTGGCGACAAAAAAACGCCATTTAAAGCAGTGGA
TCGCATCAGCTATCAAGTCG

Product: DNA-dependent helicase II

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MSDTPSTFAPKTPLQEFWFYFKQNRGALIGLIFILIVALISILAPYIAPFDPTEQNRTALLLPPAWYDGGNPAYLLGTDD
IGRDILSRIIYGTRISVFAGFVIVLLSCAFGTSLGLVSGYYGGMLDTIIIRLIDIMLAIPNLLLTIVVVSILEPSLANAT
LAIAVVSIPSYVRLTRAAVMNEKNRDYVTSSKVAGAGILRLMFIVILPNCLAPLIVQMTMGISNAILELATLGFLGIGAK
PPTPELGTMLSEARGFMQAANWLVTIPGLVILSLVLAFNLMGDGLRDALDPKLKQ

Sequences:

>Translated_295_residues
MSDTPSTFAPKTPLQEFWFYFKQNRGALIGLIFILIVALISILAPYIAPFDPTEQNRTALLLPPAWYDGGNPAYLLGTDD
IGRDILSRIIYGTRISVFAGFVIVLLSCAFGTSLGLVSGYYGGMLDTIIIRLIDIMLAIPNLLLTIVVVSILEPSLANAT
LAIAVVSIPSYVRLTRAAVMNEKNRDYVTSSKVAGAGILRLMFIVILPNCLAPLIVQMTMGISNAILELATLGFLGIGAK
PPTPELGTMLSEARGFMQAANWLVTIPGLVILSLVLAFNLMGDGLRDALDPKLKQ
>Mature_294_residues
SDTPSTFAPKTPLQEFWFYFKQNRGALIGLIFILIVALISILAPYIAPFDPTEQNRTALLLPPAWYDGGNPAYLLGTDDI
GRDILSRIIYGTRISVFAGFVIVLLSCAFGTSLGLVSGYYGGMLDTIIIRLIDIMLAIPNLLLTIVVVSILEPSLANATL
AIAVVSIPSYVRLTRAAVMNEKNRDYVTSSKVAGAGILRLMFIVILPNCLAPLIVQMTMGISNAILELATLGFLGIGAKP
PTPELGTMLSEARGFMQAANWLVTIPGLVILSLVLAFNLMGDGLRDALDPKLKQ

Specific function: Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG1173

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1789964, Length=286, Percent_Identity=63.986013986014, Blast_Score=338, Evalue=2e-94,
Organism=Escherichia coli, GI1787054, Length=284, Percent_Identity=40.4929577464789, Blast_Score=224, Evalue=7e-60,
Organism=Escherichia coli, GI1787760, Length=261, Percent_Identity=44.0613026819923, Blast_Score=215, Evalue=3e-57,
Organism=Escherichia coli, GI1787549, Length=287, Percent_Identity=36.5853658536585, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1789889, Length=251, Percent_Identity=34.2629482071713, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1787498, Length=297, Percent_Identity=30.6397306397306, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1788505, Length=218, Percent_Identity=33.4862385321101, Blast_Score=113, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 31772; Mature: 31641

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTPSTFAPKTPLQEFWFYFKQNRGALIGLIFILIVALISILAPYIAPFDPTEQNRTAL
CCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
LLPPAWYDGGNPAYLLGTDDIGRDILSRIIYGTRISVFAGFVIVLLSCAFGTSLGLVSGY
EECCCEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGGMLDTIIIRLIDIMLAIPNLLLTIVVVSILEPSLANATLAIAVVSIPSYVRLTRAAVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
NEKNRDYVTSSKVAGAGILRLMFIVILPNCLAPLIVQMTMGISNAILELATLGFLGIGAK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PPTPELGTMLSEARGFMQAANWLVTIPGLVILSLVLAFNLMGDGLRDALDPKLKQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC
>Mature Secondary Structure 
SDTPSTFAPKTPLQEFWFYFKQNRGALIGLIFILIVALISILAPYIAPFDPTEQNRTAL
CCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
LLPPAWYDGGNPAYLLGTDDIGRDILSRIIYGTRISVFAGFVIVLLSCAFGTSLGLVSGY
EECCCEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGGMLDTIIIRLIDIMLAIPNLLLTIVVVSILEPSLANATLAIAVVSIPSYVRLTRAAVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
NEKNRDYVTSSKVAGAGILRLMFIVILPNCLAPLIVQMTMGISNAILELATLGFLGIGAK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PPTPELGTMLSEARGFMQAANWLVTIPGLVILSLVLAFNLMGDGLRDALDPKLKQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800; 8550458 [H]