| Definition | Haemophilus influenzae PittEE chromosome, complete genome. |
|---|---|
| Accession | NC_009566 |
| Length | 1,813,033 |
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The map label for this gene is lepA [H]
Identifier: 148825703
GI number: 148825703
Start: 649403
End: 651199
Strand: Direct
Name: lepA [H]
Synonym: CGSHiEE_03230
Alternate gene names: 148825703
Gene position: 649403-651199 (Clockwise)
Preceding gene: 148825702
Following gene: 148825704
Centisome position: 35.82
GC content: 40.46
Gene sequence:
>1797_bases ATGAAGAATATTCGCAACTTTTCTATTATTGCCCATATTGACCACGGTAAATCGACACTTTCTGACCGTTTGATTCAAAC TTGTGGTGGACTTTCGGATCGTGAAATGGAAGCGCAAGTGCTAGATTCAATGGATCTTGAGCGTGAGCGTGGAATTACCA TCAAAGCACAAAGTGTGACTTTAAATTATAAAGCCAAAGATGGCGAAACTTATCAATTAAACTTTATCGATACCCCAGGA CACGTGGACTTTTCCTATGAAGTGTCTCGCTCTCTTGCTGCTTGTGAAGGGGCATTGTTAGTTGTGGATGCAGGACAAGG AGTCGAAGCCCAAACTCTAGCAAACTGTTATACCGCAATCGAAATGGATTTAGAAGTAGTGCCGATTTTGAATAAAATCG ACTTGCCTGCCGCAGATCCTGAACGTGTAGCGGAAGAAATTGAAGATATTGTTGGAATTGATGCGATGGAAGCGGTTCGA TGCTCAGCTAAAACGGGTGTGGGTATCGAAGATGTATTAGAAGAAATCGTGGCAAAAATTCCCGCACCAGAAGGCGATCC TAATGCGCCATTACAAGCATTGATTATTGATTCTTGGTTCGATAACTATTTGGGCGTGGTATCTTTAGTGCGTATTAAAA ATGGGGTATTACGTAAAGGCGATAAAATTAAAGTGATGTCCACAGGGCAAACTTACAACGTAGATCGTTTAGGGATTTTT ACGCCAAAACAAGAAGATACGACTGTTTTAGAATGTGGCGAAGTGGGTTGGGTTGTTTGTGCGATTAAAGATATTCTAGG TGCGCCAGTGGGCGATACCTTAACCCATCAACATAATTCTGCAACTGAAGTATTACCAGGCTTTAAAAAAGTAAAACCAC AGGTTTATGCTGGGCTTTTTCCTGTAAGTTCTGATGATTATGAAGCGTTTCGTGATGCGCTTGGTAAATTAAGTTTAAAC GATGCATCACTTTTCTATGAACCAGAAACTTCGACCGCACTTGGTTTTGGTTTCCGTTGTGGTTTCCTTGGACTTCTGCA TATGGAAATCATTCAAGAGCGTCTAGAGCGTGAGTATGATTTAGATCTTATCACAACTGCCCCAACGGTAATTTACGAAG TGCAATTAACGAATGGCGAGGTTGTTTATGTGGATAGTCCTGCAAAATTGCCTCCACTTAATAATATTGCTGAAATTCGC GAGCCAATCGCAGAATGTAATATGCTGGTGCCGCAAGAATATTTAGGTAACGTTATTACCCTTTGCGTTGAAAAACGTGG CGTGCAAACCAATATGGTATATCACGGTAATCAGATTGCGCTGACTTATGAAATTCCAATGGGCGAAGTGGTTTTAGATT TCTTTGATCGTTTAAAATCAACCTCGCGTGGTTATGCTTCGTTAGATTACGGTTTTAAACGTTTCCAAGCGGCAGATATG GTTCGCGTGGATATTATGATTAACAGCGAACGAGTAGATGCGTTGGCTTTAATCGTTCATAAAGATAATTCACAATATCG TGGCCGTGAATTGGTTGAAAAAATGCGTGAGTTAATTCCTCGTCAGCAATTTGATATCGCTATTCAAGCAGCGATTGGAA ACCATATTATTGCTCGTTCTACGGTGAAACAATTACGTAAAAACGTATTAGCAAAATGTTATGGTGGTGACGTGAGCCGT AAGAAAAAACTCTTACAGAAGCAGAAAGAAGGGAAAAAACGTATGAAGTCTTTAGGTAACGTAGAAGTGCCGCAAGAGGC GTTTTTAGCAATTTTACACGTAGGAAAAGATAAATAA
Upstream 100 bases:
>100_bases AATTTGACCGCACTTTTCCTTTTCATCTCTAGCGATTTCCGCACTTTTCAGGTACAATCCGCCAGTTAAATTTAATGATT TTTGAGAAAAACTATCTTTT
Downstream 100 bases:
>100_bases GGAAAATTATGTCAAATTTATTTTTTGTGATTTTATTGGCTGTCGGCTTTGGTGTGTGGAAAGTTTTAGATTATTTTCAG TTGCCAAATACTTTTAGTAT
Product: GTP-binding protein LepA
Products: NA
Alternate protein names: EF-4; Ribosomal back-translocase LepA [H]
Number of amino acids: Translated: 598; Mature: 598
Protein sequence:
>598_residues MKNIRNFSIIAHIDHGKSTLSDRLIQTCGGLSDREMEAQVLDSMDLERERGITIKAQSVTLNYKAKDGETYQLNFIDTPG HVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAIEMDLEVVPILNKIDLPAADPERVAEEIEDIVGIDAMEAVR CSAKTGVGIEDVLEEIVAKIPAPEGDPNAPLQALIIDSWFDNYLGVVSLVRIKNGVLRKGDKIKVMSTGQTYNVDRLGIF TPKQEDTTVLECGEVGWVVCAIKDILGAPVGDTLTHQHNSATEVLPGFKKVKPQVYAGLFPVSSDDYEAFRDALGKLSLN DASLFYEPETSTALGFGFRCGFLGLLHMEIIQERLEREYDLDLITTAPTVIYEVQLTNGEVVYVDSPAKLPPLNNIAEIR EPIAECNMLVPQEYLGNVITLCVEKRGVQTNMVYHGNQIALTYEIPMGEVVLDFFDRLKSTSRGYASLDYGFKRFQAADM VRVDIMINSERVDALALIVHKDNSQYRGRELVEKMRELIPRQQFDIAIQAAIGNHIIARSTVKQLRKNVLAKCYGGDVSR KKKLLQKQKEGKKRMKSLGNVEVPQEAFLAILHVGKDK
Sequences:
>Translated_598_residues MKNIRNFSIIAHIDHGKSTLSDRLIQTCGGLSDREMEAQVLDSMDLERERGITIKAQSVTLNYKAKDGETYQLNFIDTPG HVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAIEMDLEVVPILNKIDLPAADPERVAEEIEDIVGIDAMEAVR CSAKTGVGIEDVLEEIVAKIPAPEGDPNAPLQALIIDSWFDNYLGVVSLVRIKNGVLRKGDKIKVMSTGQTYNVDRLGIF TPKQEDTTVLECGEVGWVVCAIKDILGAPVGDTLTHQHNSATEVLPGFKKVKPQVYAGLFPVSSDDYEAFRDALGKLSLN DASLFYEPETSTALGFGFRCGFLGLLHMEIIQERLEREYDLDLITTAPTVIYEVQLTNGEVVYVDSPAKLPPLNNIAEIR EPIAECNMLVPQEYLGNVITLCVEKRGVQTNMVYHGNQIALTYEIPMGEVVLDFFDRLKSTSRGYASLDYGFKRFQAADM VRVDIMINSERVDALALIVHKDNSQYRGRELVEKMRELIPRQQFDIAIQAAIGNHIIARSTVKQLRKNVLAKCYGGDVSR KKKLLQKQKEGKKRMKSLGNVEVPQEAFLAILHVGKDK >Mature_598_residues MKNIRNFSIIAHIDHGKSTLSDRLIQTCGGLSDREMEAQVLDSMDLERERGITIKAQSVTLNYKAKDGETYQLNFIDTPG HVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAIEMDLEVVPILNKIDLPAADPERVAEEIEDIVGIDAMEAVR CSAKTGVGIEDVLEEIVAKIPAPEGDPNAPLQALIIDSWFDNYLGVVSLVRIKNGVLRKGDKIKVMSTGQTYNVDRLGIF TPKQEDTTVLECGEVGWVVCAIKDILGAPVGDTLTHQHNSATEVLPGFKKVKPQVYAGLFPVSSDDYEAFRDALGKLSLN DASLFYEPETSTALGFGFRCGFLGLLHMEIIQERLEREYDLDLITTAPTVIYEVQLTNGEVVYVDSPAKLPPLNNIAEIR EPIAECNMLVPQEYLGNVITLCVEKRGVQTNMVYHGNQIALTYEIPMGEVVLDFFDRLKSTSRGYASLDYGFKRFQAADM VRVDIMINSERVDALALIVHKDNSQYRGRELVEKMRELIPRQQFDIAIQAAIGNHIIARSTVKQLRKNVLAKCYGGDVSR KKKLLQKQKEGKKRMKSLGNVEVPQEAFLAILHVGKDK
Specific function: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- transloc
COG id: COG0481
COG function: function code M; Membrane GTPase LepA
Gene ontology:
Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the GTP-binding elongation factor family. LepA subfamily [H]
Homologues:
Organism=Homo sapiens, GI157426893, Length=607, Percent_Identity=47.6112026359143, Blast_Score=605, Evalue=1e-173, Organism=Homo sapiens, GI94966754, Length=133, Percent_Identity=45.8646616541353, Blast_Score=114, Evalue=3e-25, Organism=Homo sapiens, GI4503483, Length=144, Percent_Identity=43.75, Blast_Score=110, Evalue=5e-24, Organism=Homo sapiens, GI25306283, Length=175, Percent_Identity=40, Blast_Score=105, Evalue=1e-22, Organism=Homo sapiens, GI19923640, Length=152, Percent_Identity=42.1052631578947, Blast_Score=104, Evalue=2e-22, Organism=Homo sapiens, GI25306287, Length=152, Percent_Identity=42.1052631578947, Blast_Score=104, Evalue=2e-22, Organism=Homo sapiens, GI18390331, Length=182, Percent_Identity=34.0659340659341, Blast_Score=100, Evalue=4e-21, Organism=Homo sapiens, GI310132016, Length=110, Percent_Identity=44.5454545454545, Blast_Score=95, Evalue=2e-19, Organism=Homo sapiens, GI310110807, Length=110, Percent_Identity=44.5454545454545, Blast_Score=95, Evalue=2e-19, Organism=Homo sapiens, GI310123363, Length=110, Percent_Identity=44.5454545454545, Blast_Score=95, Evalue=2e-19, Organism=Homo sapiens, GI53729339, Length=239, Percent_Identity=32.6359832635983, Blast_Score=90, Evalue=6e-18, Organism=Homo sapiens, GI53729337, Length=239, Percent_Identity=32.6359832635983, Blast_Score=90, Evalue=6e-18, Organism=Homo sapiens, GI217272892, Length=133, Percent_Identity=37.593984962406, Blast_Score=84, Evalue=5e-16, Organism=Homo sapiens, GI217272894, Length=133, Percent_Identity=37.593984962406, Blast_Score=84, Evalue=5e-16, Organism=Homo sapiens, GI4503471, Length=170, Percent_Identity=30, Blast_Score=67, Evalue=4e-11, Organism=Homo sapiens, GI4503475, Length=118, Percent_Identity=34.7457627118644, Blast_Score=67, Evalue=4e-11, Organism=Homo sapiens, GI34147630, Length=251, Percent_Identity=27.0916334661355, Blast_Score=66, Evalue=8e-11, Organism=Escherichia coli, GI1788922, Length=597, Percent_Identity=88.7772194304858, Blast_Score=1071, Evalue=0.0, Organism=Escherichia coli, GI48994988, Length=479, Percent_Identity=30.062630480167, Blast_Score=171, Evalue=1e-43, Organism=Escherichia coli, GI1789738, Length=155, Percent_Identity=35.4838709677419, Blast_Score=91, Evalue=2e-19, Organism=Escherichia coli, GI1790835, Length=156, Percent_Identity=32.6923076923077, Blast_Score=86, Evalue=7e-18, Organism=Escherichia coli, GI1789559, Length=228, Percent_Identity=30.2631578947368, Blast_Score=80, Evalue=3e-16, Organism=Escherichia coli, GI1790412, Length=249, Percent_Identity=26.5060240963855, Blast_Score=63, Evalue=5e-11, Organism=Escherichia coli, GI1789737, Length=249, Percent_Identity=26.5060240963855, Blast_Score=63, Evalue=5e-11, Organism=Caenorhabditis elegans, GI17557151, Length=610, Percent_Identity=40, Blast_Score=484, Evalue=1e-137, Organism=Caenorhabditis elegans, GI17556745, Length=463, Percent_Identity=25.0539956803456, Blast_Score=112, Evalue=4e-25, Organism=Caenorhabditis elegans, GI17506493, Length=170, Percent_Identity=36.4705882352941, Blast_Score=99, Evalue=9e-21, Organism=Caenorhabditis elegans, GI17533571, Length=146, Percent_Identity=36.3013698630137, Blast_Score=95, Evalue=1e-19, Organism=Caenorhabditis elegans, GI71988819, Length=134, Percent_Identity=36.5671641791045, Blast_Score=88, Evalue=2e-17, Organism=Caenorhabditis elegans, GI71988811, Length=134, Percent_Identity=36.5671641791045, Blast_Score=88, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17552882, Length=145, Percent_Identity=35.8620689655172, Blast_Score=86, Evalue=5e-17, Organism=Caenorhabditis elegans, GI25141371, Length=240, Percent_Identity=27.5, Blast_Score=69, Evalue=5e-12, Organism=Caenorhabditis elegans, GI32566303, Length=244, Percent_Identity=27.0491803278689, Blast_Score=67, Evalue=3e-11, Organism=Caenorhabditis elegans, GI71994658, Length=223, Percent_Identity=27.3542600896861, Blast_Score=67, Evalue=4e-11, Organism=Saccharomyces cerevisiae, GI6323320, Length=601, Percent_Identity=46.2562396006656, Blast_Score=547, Evalue=1e-156, Organism=Saccharomyces cerevisiae, GI6323098, Length=201, Percent_Identity=35.8208955223881, Blast_Score=112, Evalue=2e-25, Organism=Saccharomyces cerevisiae, GI6324707, Length=144, Percent_Identity=42.3611111111111, Blast_Score=112, Evalue=2e-25, Organism=Saccharomyces cerevisiae, GI6320593, Length=144, Percent_Identity=42.3611111111111, Blast_Score=112, Evalue=2e-25, Organism=Saccharomyces cerevisiae, GI6322359, Length=115, Percent_Identity=38.2608695652174, Blast_Score=94, Evalue=8e-20, Organism=Saccharomyces cerevisiae, GI6324166, Length=144, Percent_Identity=38.8888888888889, Blast_Score=84, Evalue=5e-17, Organism=Saccharomyces cerevisiae, GI6324761, Length=246, Percent_Identity=26.4227642276423, Blast_Score=73, Evalue=1e-13, Organism=Saccharomyces cerevisiae, GI6325337, Length=284, Percent_Identity=25, Blast_Score=73, Evalue=1e-13, Organism=Saccharomyces cerevisiae, GI6319594, Length=284, Percent_Identity=25, Blast_Score=73, Evalue=1e-13, Organism=Drosophila melanogaster, GI78706572, Length=601, Percent_Identity=43.261231281198, Blast_Score=528, Evalue=1e-150, Organism=Drosophila melanogaster, GI24582462, Length=161, Percent_Identity=35.4037267080745, Blast_Score=101, Evalue=1e-21, Organism=Drosophila melanogaster, GI24585709, Length=162, Percent_Identity=36.4197530864198, Blast_Score=101, Evalue=2e-21, Organism=Drosophila melanogaster, GI28574573, Length=138, Percent_Identity=43.4782608695652, Blast_Score=100, Evalue=2e-21, Organism=Drosophila melanogaster, GI24585711, Length=162, Percent_Identity=36.4197530864198, Blast_Score=100, Evalue=2e-21, Organism=Drosophila melanogaster, GI24585713, Length=162, Percent_Identity=36.4197530864198, Blast_Score=100, Evalue=2e-21, Organism=Drosophila melanogaster, GI221458488, Length=149, Percent_Identity=38.9261744966443, Blast_Score=94, Evalue=2e-19, Organism=Drosophila melanogaster, GI21357743, Length=133, Percent_Identity=36.0902255639098, Blast_Score=84, Evalue=2e-16, Organism=Drosophila melanogaster, GI28572034, Length=227, Percent_Identity=29.5154185022026, Blast_Score=75, Evalue=9e-14, Organism=Drosophila melanogaster, GI281363316, Length=238, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=1e-11, Organism=Drosophila melanogaster, GI17864358, Length=238, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=1e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR009022 - InterPro: IPR006297 - InterPro: IPR013842 - InterPro: IPR000795 - InterPro: IPR005225 - InterPro: IPR000640 - InterPro: IPR004161 - InterPro: IPR009000 [H]
Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF06421 LepA_C [H]
EC number: NA
Molecular weight: Translated: 66315; Mature: 66315
Theoretical pI: Translated: 4.94; Mature: 4.94
Prosite motif: PS00301 EFACTOR_GTP
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.7 %Cys (Translated Protein) 2.3 %Met (Translated Protein) 4.0 %Cys+Met (Translated Protein) 1.7 %Cys (Mature Protein) 2.3 %Met (Mature Protein) 4.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKNIRNFSIIAHIDHGKSTLSDRLIQTCGGLSDREMEAQVLDSMDLERERGITIKAQSVT CCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHCCCEEEEEEEE LNYKAKDGETYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAI EEEEECCCCEEEEEEECCCCCEEEEHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHH EMDLEVVPILNKIDLPAADPERVAEEIEDIVGIDAMEAVRCSAKTGVGIEDVLEEIVAKI CCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHC PAPEGDPNAPLQALIIDSWFDNYLGVVSLVRIKNGVLRKGDKIKVMSTGQTYNVDRLGIF CCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEECCCEEEEE TPKQEDTTVLECGEVGWVVCAIKDILGAPVGDTLTHQHNSATEVLPGFKKVKPQVYAGLF CCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCHHCCCCCHHHHCCCHHHCCCHHHEEEE PVSSDDYEAFRDALGKLSLNDASLFYEPETSTALGFGFRCGFLGLLHMEIIQERLEREYD CCCCCHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC LDLITTAPTVIYEVQLTNGEVVYVDSPAKLPPLNNIAEIREPIAECNMLVPQEYLGNVIT CEEEECCCEEEEEEEECCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHH LCVEKRGVQTNMVYHGNQIALTYEIPMGEVVLDFFDRLKSTSRGYASLDYGFKRFQAADM HHHHHCCCEEEEEEECCEEEEEEECCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCE VRVDIMINSERVDALALIVHKDNSQYRGRELVEKMRELIPRQQFDIAIQAAIGNHIIARS EEEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCHHCEEEEEECCCHHHHHH TVKQLRKNVLAKCYGGDVSRKKKLLQKQKEGKKRMKSLGNVEVPQEAFLAILHVGKDK HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCC >Mature Secondary Structure MKNIRNFSIIAHIDHGKSTLSDRLIQTCGGLSDREMEAQVLDSMDLERERGITIKAQSVT CCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHCCCEEEEEEEE LNYKAKDGETYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAI EEEEECCCCEEEEEEECCCCCEEEEHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHH EMDLEVVPILNKIDLPAADPERVAEEIEDIVGIDAMEAVRCSAKTGVGIEDVLEEIVAKI CCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHC PAPEGDPNAPLQALIIDSWFDNYLGVVSLVRIKNGVLRKGDKIKVMSTGQTYNVDRLGIF CCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEECCCEEEEE TPKQEDTTVLECGEVGWVVCAIKDILGAPVGDTLTHQHNSATEVLPGFKKVKPQVYAGLF CCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCHHCCCCCHHHHCCCHHHCCCHHHEEEE PVSSDDYEAFRDALGKLSLNDASLFYEPETSTALGFGFRCGFLGLLHMEIIQERLEREYD CCCCCHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC LDLITTAPTVIYEVQLTNGEVVYVDSPAKLPPLNNIAEIREPIAECNMLVPQEYLGNVIT CEEEECCCEEEEEEEECCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHH LCVEKRGVQTNMVYHGNQIALTYEIPMGEVVLDFFDRLKSTSRGYASLDYGFKRFQAADM HHHHHCCCEEEEEEECCEEEEEEECCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCE VRVDIMINSERVDALALIVHKDNSQYRGRELVEKMRELIPRQQFDIAIQAAIGNHIIARS EEEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCHHCEEEEEECCCHHHHHH TVKQLRKNVLAKCYGGDVSRKKKLLQKQKEGKKRMKSLGNVEVPQEAFLAILHVGKDK HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: NA