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The map label for this gene is folB

Identifier: 148825456

GI number: 148825456

Start: 325221

End: 325577

Strand: Direct

Name: folB

Synonym: CGSHiEE_01730

Alternate gene names: 148825456

Gene position: 325221-325577 (Clockwise)

Preceding gene: 148825450

Following gene: 148825460

Centisome position: 17.94

GC content: 36.97

Gene sequence:

>357_bases
ATGGATCGTGTTTTTATTGAAGAATTGACTGTTTTTGCACAAATCGGTGTATATGATTGGGAACAGCAAATAAAGCAAAA
ACTTGTGTTTGATTTAGAAATGGCTTGGGATTGCAAACAAGCGGCAGAAACGGATGATGTTGTATATTGTTTAAATTATG
CTGAAGTGAGTCAAGCGATTATTGATTATGTGGAAAGCAAACCTTTCTTGCTGATTGAGCGAGTGGCTTATGAAGTGGCG
GATTTGCTTGAGTCACGTTATCAACTTCAAGGATTAAAAATTAAACTGAGTAAACCAAAAGCCGTCGCGCAAGCTCGAAA
TGTTGGCGTATTGATTGTTCGTGGTTGTTTAAAATAA

Upstream 100 bases:

>100_bases
AAGGGCGAAAAGGCTCATTTTGCACTCCAGCAAGAAAAACTGTTCGTTATTCTACCCAAAATTGATAGCATACGCCTACA
ATAATTTTAGAGGAAACCTT

Downstream 100 bases:

>100_bases
TGTAACGATAGTGGCTATTAATAAATCTGACAGGCATGCAATTTAATTGGTGCCTGTCAGATTGGCTTTATGCTTTTACT
TTGTGTTCTGAATAGTTATT

Product: dihydroneopterin aldolase

Products: NA

Alternate protein names: DHNA

Number of amino acids: Translated: 118; Mature: 118

Protein sequence:

>118_residues
MDRVFIEELTVFAQIGVYDWEQQIKQKLVFDLEMAWDCKQAAETDDVVYCLNYAEVSQAIIDYVESKPFLLIERVAYEVA
DLLESRYQLQGLKIKLSKPKAVAQARNVGVLIVRGCLK

Sequences:

>Translated_118_residues
MDRVFIEELTVFAQIGVYDWEQQIKQKLVFDLEMAWDCKQAAETDDVVYCLNYAEVSQAIIDYVESKPFLLIERVAYEVA
DLLESRYQLQGLKIKLSKPKAVAQARNVGVLIVRGCLK
>Mature_118_residues
MDRVFIEELTVFAQIGVYDWEQQIKQKLVFDLEMAWDCKQAAETDDVVYCLNYAEVSQAIIDYVESKPFLLIERVAYEVA
DLLESRYQLQGLKIKLSKPKAVAQARNVGVLIVRGCLK

Specific function: Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin

COG id: COG1539

COG function: function code H; Dihydroneopterin aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHNA family

Homologues:

Organism=Escherichia coli, GI87082204, Length=115, Percent_Identity=59.1304347826087, Blast_Score=144, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FOLB_HAEIN (P46362)

Other databases:

- EMBL:   L42023
- RefSeq:   NP_438434.1
- ProteinModelPortal:   P46362
- SMR:   P46362
- GeneID:   949403
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0265
- NMPDR:   fig|71421.1.peg.250
- TIGR:   HI_0265
- HOGENOM:   HBG635896
- OMA:   LITEKPI
- ProtClustDB:   CLSK870577
- BioCyc:   HINF71421:HI_0265-MONOMER
- BRENDA:   4.1.2.25
- InterPro:   IPR006156
- InterPro:   IPR006157
- PANTHER:   PTHR20941:SF3
- SMART:   SM00905
- TIGRFAMs:   TIGR00525
- TIGRFAMs:   TIGR00526

Pfam domain/function: PF02152 FolB

EC number: =4.1.2.25

Molecular weight: Translated: 13577; Mature: 13577

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRVFIEELTVFAQIGVYDWEQQIKQKLVFDLEMAWDCKQAAETDDVVYCLNYAEVSQAI
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCEEEEECHHHHHHHH
IDYVESKPFLLIERVAYEVADLLESRYQLQGLKIKLSKPKAVAQARNVGVLIVRGCLK
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHCCCCEEEEECCCC
>Mature Secondary Structure
MDRVFIEELTVFAQIGVYDWEQQIKQKLVFDLEMAWDCKQAAETDDVVYCLNYAEVSQAI
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCEEEEECHHHHHHHH
IDYVESKPFLLIERVAYEVADLLESRYQLQGLKIKLSKPKAVAQARNVGVLIVRGCLK
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800