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The map label for this gene is guaB [C]

Identifier: 148824617

GI number: 148824617

Start: 3840075

End: 3841202

Strand: Reverse

Name: guaB [C]

Synonym: TBFG_13444

Alternate gene names: 148824617

Gene position: 3841202-3840075 (Counterclockwise)

Preceding gene: 148824618

Following gene: 148824616

Centisome position: 86.82

GC content: 70.48

Gene sequence:

>1128_bases
ATGGTCGAGATCGGCATGGGCCGCACCGCCCGCCGCACCTATGAACTCAGCGAGATTAGCATCGTGCCGTCGCGGCGCAC
CCGCTCGTCGAAGGACGTCTCCACGGCCTGGCAGCTGGACGCCTACCGGTTCGAGATCCCGGTGGTGGCACACCCCACCG
ATGCCCTGGTGTCCCCGGAGTTCGCGATCGAGCTCGGCCGGCTGGGCGGGCTGGGCGTGCTCAACGGCGAGGGGCTGATC
GGCCGCCACCTCGATGTCGAGGCAAAAATCGCCCAACTCTTGGAAGCTGCAGCGGCCGACCCCGAACCGTCGACGGCGAT
CCGGTTGCTGCAGGAGCTGCACGCGGCACCGCTAAATCCCGACCTGTTGGGTGCCGCGGTGGCTCGCATCCGCGAGGCCG
GGGTGACCACCGCGGTGCGGGTGAGCCCGCAAAACGCCCAGTGGCTGACACCGGTACTGGTTGCGGCCGGTATTGACTTG
CTGGTCATCCAGGGGACCATCGTCTCCGCCGAGCGCGTCGCCAGCGACGGCGAGCCGCTCAACCTGAAGACCTTCATCTC
CGAGCTCGACATACCGGTCGTCGCCGGCGGGGTGCTCGACCACCGCACCGCGCTGCATCTGATGCGCACCGGCGCCGCCG
GCGTCATCGTTGGCTACGGCTCCACCCAGGGGGTGACGACGACCGACGAGGTGCTGGGCATCAGCGTGCCGATGGCGACC
GCGATCGCCGACGCTGCCGCCGCGCGGCGCGACTACCTCGACGAGACGGGCGGCCGCTACGTGCACGTGTTGGCCGACGG
CGACATCCACACTTCCGGCGAGTTGGCCAAGGCCATCGCCTGCGGCGCCGACGCGGTGGTGCTGGGTACCCCGTTAGCCG
AATCGGCCGAGGCGCTCGGCGAGGGATGGTTCTGGCCGGCCGCGGCGGCGCACCCGTCGTTGCCGCGGGGGGCGTTGCTG
CAGATCGCGGTCGGCGAGCGGCCGCCGCTGGCGCGGGTGCTGGGCGGGCCGTCGGACGACCCGTTCGGCGGCCTGAATCT
GGTCGGTGGGCTACGCCGATCGATGGCCAAGGCCGGGTATTGCGACCTCAAGGAGTTCCAGAAGGTCGGCCTGACCGTTG
GGGGCTGA

Upstream 100 bases:

>100_bases
ATCACACCCGCGGGCCTCAAGGAGAGTCATCCCCACGACGTCGCGATGACCGTCGAGGCGCCCAACTACTACGCGCGCTA
ACGGCGACCTGGATATCTAG

Downstream 100 bases:

>100_bases
CGCCACCTGAGAGACTGATTAACTGGCCCGATGTAAAGGGGGTCATACTGCAGCGATGAAGCCGGATTACGACGTCCTGA
TTATTGGATCGGGTTTCGGG

Product: inosine 5-monophosphate dehydrogenase

Products: xanthosine 5'-phosphate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MVEIGMGRTARRTYELSEISIVPSRRTRSSKDVSTAWQLDAYRFEIPVVAHPTDALVSPEFAIELGRLGGLGVLNGEGLI
GRHLDVEAKIAQLLEAAAADPEPSTAIRLLQELHAAPLNPDLLGAAVARIREAGVTTAVRVSPQNAQWLTPVLVAAGIDL
LVIQGTIVSAERVASDGEPLNLKTFISELDIPVVAGGVLDHRTALHLMRTGAAGVIVGYGSTQGVTTTDEVLGISVPMAT
AIADAAAARRDYLDETGGRYVHVLADGDIHTSGELAKAIACGADAVVLGTPLAESAEALGEGWFWPAAAAHPSLPRGALL
QIAVGERPPLARVLGGPSDDPFGGLNLVGGLRRSMAKAGYCDLKEFQKVGLTVGG

Sequences:

>Translated_375_residues
MVEIGMGRTARRTYELSEISIVPSRRTRSSKDVSTAWQLDAYRFEIPVVAHPTDALVSPEFAIELGRLGGLGVLNGEGLI
GRHLDVEAKIAQLLEAAAADPEPSTAIRLLQELHAAPLNPDLLGAAVARIREAGVTTAVRVSPQNAQWLTPVLVAAGIDL
LVIQGTIVSAERVASDGEPLNLKTFISELDIPVVAGGVLDHRTALHLMRTGAAGVIVGYGSTQGVTTTDEVLGISVPMAT
AIADAAAARRDYLDETGGRYVHVLADGDIHTSGELAKAIACGADAVVLGTPLAESAEALGEGWFWPAAAAHPSLPRGALL
QIAVGERPPLARVLGGPSDDPFGGLNLVGGLRRSMAKAGYCDLKEFQKVGLTVGG
>Mature_375_residues
MVEIGMGRTARRTYELSEISIVPSRRTRSSKDVSTAWQLDAYRFEIPVVAHPTDALVSPEFAIELGRLGGLGVLNGEGLI
GRHLDVEAKIAQLLEAAAADPEPSTAIRLLQELHAAPLNPDLLGAAVARIREAGVTTAVRVSPQNAQWLTPVLVAAGIDL
LVIQGTIVSAERVASDGEPLNLKTFISELDIPVVAGGVLDHRTALHLMRTGAAGVIVGYGSTQGVTTTDEVLGISVPMAT
AIADAAAARRDYLDETGGRYVHVLADGDIHTSGELAKAIACGADAVVLGTPLAESAEALGEGWFWPAAAAHPSLPRGALL
QIAVGERPPLARVLGGPSDDPFGGLNLVGGLRRSMAKAGYCDLKEFQKVGLTVGG

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family [H]

Homologues:

Organism=Caenorhabditis elegans, GI71994385, Length=162, Percent_Identity=31.4814814814815, Blast_Score=64, Evalue=1e-10,
Organism=Drosophila melanogaster, GI28571163, Length=158, Percent_Identity=32.9113924050633, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641071, Length=158, Percent_Identity=32.9113924050633, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641073, Length=158, Percent_Identity=32.9113924050633, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001093
- InterPro:   IPR005992 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: 1.1.1.205

Molecular weight: Translated: 38991; Mature: 38991

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEIGMGRTARRTYELSEISIVPSRRTRSSKDVSTAWQLDAYRFEIPVVAHPTDALVSPE
CEEECCCCCHHHEEEEEEEEEECCCCCCCCCCCCHHEEECEEEEEEEEEECCCCCCCCCH
FAIELGRLGGLGVLNGEGLIGRHLDVEAKIAQLLEAAAADPEPSTAIRLLQELHAAPLNP
HHHEECCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCH
DLLGAAVARIREAGVTTAVRVSPQNAQWLTPVLVAAGIDLLVIQGTIVSAERVASDGEPL
HHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCEEEEEECEEEEHHHHCCCCCCC
NLKTFISELDIPVVAGGVLDHRTALHLMRTGAAGVIVGYGSTQGVTTTDEVLGISVPMAT
CHHHHHHHCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHEEECCHHHH
AIADAAAARRDYLDETGGRYVHVLADGDIHTSGELAKAIACGADAVVLGTPLAESAEALG
HHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHC
EGWFWPAAAAHPSLPRGALLQIAVGERPPLARVLGGPSDDPFGGLNLVGGLRRSMAKAGY
CCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCC
CDLKEFQKVGLTVGG
CCHHHHHHCCCCCCC
>Mature Secondary Structure
MVEIGMGRTARRTYELSEISIVPSRRTRSSKDVSTAWQLDAYRFEIPVVAHPTDALVSPE
CEEECCCCCHHHEEEEEEEEEECCCCCCCCCCCCHHEEECEEEEEEEEEECCCCCCCCCH
FAIELGRLGGLGVLNGEGLIGRHLDVEAKIAQLLEAAAADPEPSTAIRLLQELHAAPLNP
HHHEECCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCH
DLLGAAVARIREAGVTTAVRVSPQNAQWLTPVLVAAGIDLLVIQGTIVSAERVASDGEPL
HHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCEEEEEECEEEEHHHHCCCCCCC
NLKTFISELDIPVVAGGVLDHRTALHLMRTGAAGVIVGYGSTQGVTTTDEVLGISVPMAT
CHHHHHHHCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHEEECCHHHH
AIADAAAARRDYLDETGGRYVHVLADGDIHTSGELAKAIACGADAVVLGTPLAESAEALG
HHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHC
EGWFWPAAAAHPSLPRGALLQIAVGERPPLARVLGGPSDDPFGGLNLVGGLRRSMAKAGY
CCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCC
CDLKEFQKVGLTVGG
CCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: inosine 5'-phosphate; NAD+; H2O

Specific reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA