Click here to switch to the map view.

The map label for this gene is guaB

Identifier: 148824618

GI number: 148824618

Start: 3841222

End: 3842811

Strand: Reverse

Name: guaB

Synonym: TBFG_13445

Alternate gene names: 148824618

Gene position: 3842811-3841222 (Counterclockwise)

Preceding gene: 148824620

Following gene: 148824617

Centisome position: 86.85

GC content: 67.8

Gene sequence:

>1590_bases
ATGTCCCGTGGCATGTCCGGCCTGGAAGACAGCTCCGACCTGGTGGTCAGCCCGTACGTTCGCATGGGCGGCCTGACTAC
TGACCCGGTGCCCACCGGCGGCGACGACCCGCACAAGGTGGCGATGCTGGGGCTGACATTCGACGACGTCTTGTTGTTGC
CGGCGGCTTCCGACGTGGTGCCCGCCACCGCGGATACCTCCAGCCAGCTCACCAAGAAGATCAGGCTCAAGGTGCCACTG
GTCAGCTCGGCGATGGACACCGTCACCGAGTCGCGTATGGCCATCGCGATGGCACGGGCGGGTGGCATGGGGGTGTTGCA
CCGCAACCTGCCCGTTGCCGAGCAAGCCGGCCAGGTCGAGATGGTGAAGCGATCCGAGGCCGGCATGGTCACCGATCCCG
TCACCTGCCGGCCGGACAACACCTTGGCCCAGGTCGATGCGCTGTGCGCCCGGTTCCGGATCTCCGGGTTGCCGGTGGTC
GACGACGACGGTGCGCTGGTGGGCATCATCACCAACCGTGACATGCGGTTTGAGGTCGACCAGTCCAAGCAGGTCGCCGA
GGTGATGACCAAAGCCCCGCTGATCACCGCTCAAGAGGGTGTCAGTGCGTCCGCGGCGCTGGGCCTGTTGCGCCGCAACA
AGATCGAGAAGCTGCCCGTGGTCGACGGCCGCGGCCGGCTGACCGGGCTGATCACCGTCAAGGACTTCGTCAAGACCGAG
CAACACCCGCTGGCCACCAAGGACAGCGACGGCCGGCTGCTGGTGGGGGCGGCCGTCGGCGTCGGCGGCGATGCCTGGGT
GCGCGCCATGATGTTGGTCGACGCTGGGGTCGACGTGCTGGTCGTGGACACCGCGCACGCGCACAACCGGTTGGTGCTCG
ACATGGTGGGCAAACTCAAGTCCGAAGTCGGCGACCGGGTTGAGGTGGTAGGCGGCAACGTCGCCACCAGGTCCGCGGCC
GCGGCCCTGGTCGACGCCGGAGCCGACGCGGTGAAAGTCGGCGTGGGGCCGGGGTCGATCTGCACGACGAGGGTGGTGGC
CGGGGTGGGCGCGCCGCAGATCACGGCGATCTTGGAAGCTGTAGCGGCTTGTCGTCCTGCTGGCGTGCCGGTGATCGCCG
ACGGCGGACTGCAGTACTCCGGCGACATCGCCAAGGCGCTGGCCGCCGGTGCGTCGACGGCCATGCTGGGCTCGCTGCTG
GCCGGCACAGCCGAGGCGCCCGGTGAGCTGATCTTCGTGAACGGCAAGCAGTACAAGAGTTATCGCGGCATGGGATCACT
GGGTGCCATGCGAGGGCGTGGGGGGGCGACGTCGTATTCCAAGGATCGCTACTTCGCCGACGACGCGCTGTCGGAAGACA
AACTGGTGCCGGAAGGGATCGAGGGGCGGGTGCCGTTCCGTGGTCCGCTGTCGTCGGTGATCCACCAGTTGACCGGTGGC
CTGCGCGCCGCGATGGGCTACACCGGGTCGCCCACCATCGAGGTGCTACAGCAGGCGCAATTCGTCCGGATCACACCCGC
GGGCCTCAAGGAGAGTCATCCCCACGACGTCGCGATGACCGTCGAGGCGCCCAACTACTACGCGCGCTAA

Upstream 100 bases:

>100_bases
GTTCTTCTCGGCCAGCGCTGCGGCGCGCATCGTCACCGGGCGGTTACGAGCCGATAGGATGCGCTTCTCACTGAAAACAT
GCGTATGGAGGGCCCCACCG

Downstream 100 bases:

>100_bases
CGGCGACCTGGATATCTAGATGGTCGAGATCGGCATGGGCCGCACCGCCCGCCGCACCTATGAACTCAGCGAGATTAGCA
TCGTGCCGTCGCGGCGCACC

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH

Number of amino acids: Translated: 529; Mature: 528

Protein sequence:

>529_residues
MSRGMSGLEDSSDLVVSPYVRMGGLTTDPVPTGGDDPHKVAMLGLTFDDVLLLPAASDVVPATADTSSQLTKKIRLKVPL
VSSAMDTVTESRMAIAMARAGGMGVLHRNLPVAEQAGQVEMVKRSEAGMVTDPVTCRPDNTLAQVDALCARFRISGLPVV
DDDGALVGIITNRDMRFEVDQSKQVAEVMTKAPLITAQEGVSASAALGLLRRNKIEKLPVVDGRGRLTGLITVKDFVKTE
QHPLATKDSDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLVVDTAHAHNRLVLDMVGKLKSEVGDRVEVVGGNVATRSAA
AALVDAGADAVKVGVGPGSICTTRVVAGVGAPQITAILEAVAACRPAGVPVIADGGLQYSGDIAKALAAGASTAMLGSLL
AGTAEAPGELIFVNGKQYKSYRGMGSLGAMRGRGGATSYSKDRYFADDALSEDKLVPEGIEGRVPFRGPLSSVIHQLTGG
LRAAMGYTGSPTIEVLQQAQFVRITPAGLKESHPHDVAMTVEAPNYYAR

Sequences:

>Translated_529_residues
MSRGMSGLEDSSDLVVSPYVRMGGLTTDPVPTGGDDPHKVAMLGLTFDDVLLLPAASDVVPATADTSSQLTKKIRLKVPL
VSSAMDTVTESRMAIAMARAGGMGVLHRNLPVAEQAGQVEMVKRSEAGMVTDPVTCRPDNTLAQVDALCARFRISGLPVV
DDDGALVGIITNRDMRFEVDQSKQVAEVMTKAPLITAQEGVSASAALGLLRRNKIEKLPVVDGRGRLTGLITVKDFVKTE
QHPLATKDSDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLVVDTAHAHNRLVLDMVGKLKSEVGDRVEVVGGNVATRSAA
AALVDAGADAVKVGVGPGSICTTRVVAGVGAPQITAILEAVAACRPAGVPVIADGGLQYSGDIAKALAAGASTAMLGSLL
AGTAEAPGELIFVNGKQYKSYRGMGSLGAMRGRGGATSYSKDRYFADDALSEDKLVPEGIEGRVPFRGPLSSVIHQLTGG
LRAAMGYTGSPTIEVLQQAQFVRITPAGLKESHPHDVAMTVEAPNYYAR
>Mature_528_residues
SRGMSGLEDSSDLVVSPYVRMGGLTTDPVPTGGDDPHKVAMLGLTFDDVLLLPAASDVVPATADTSSQLTKKIRLKVPLV
SSAMDTVTESRMAIAMARAGGMGVLHRNLPVAEQAGQVEMVKRSEAGMVTDPVTCRPDNTLAQVDALCARFRISGLPVVD
DDGALVGIITNRDMRFEVDQSKQVAEVMTKAPLITAQEGVSASAALGLLRRNKIEKLPVVDGRGRLTGLITVKDFVKTEQ
HPLATKDSDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLVVDTAHAHNRLVLDMVGKLKSEVGDRVEVVGGNVATRSAAA
ALVDAGADAVKVGVGPGSICTTRVVAGVGAPQITAILEAVAACRPAGVPVIADGGLQYSGDIAKALAAGASTAMLGSLLA
GTAEAPGELIFVNGKQYKSYRGMGSLGAMRGRGGATSYSKDRYFADDALSEDKLVPEGIEGRVPFRGPLSSVIHQLTGGL
RAAMGYTGSPTIEVLQQAQFVRITPAGLKESHPHDVAMTVEAPNYYAR

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains

Homologues:

Organism=Homo sapiens, GI217035146, Length=490, Percent_Identity=41.0204081632653, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI34328928, Length=503, Percent_Identity=40.5566600397614, Blast_Score=333, Evalue=3e-91,
Organism=Homo sapiens, GI156616279, Length=490, Percent_Identity=41.0204081632653, Blast_Score=332, Evalue=4e-91,
Organism=Homo sapiens, GI66933016, Length=484, Percent_Identity=41.7355371900826, Blast_Score=332, Evalue=4e-91,
Organism=Homo sapiens, GI34328930, Length=490, Percent_Identity=41.0204081632653, Blast_Score=332, Evalue=5e-91,
Organism=Homo sapiens, GI217035152, Length=460, Percent_Identity=41.7391304347826, Blast_Score=324, Evalue=1e-88,
Organism=Homo sapiens, GI217035148, Length=490, Percent_Identity=40.4081632653061, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI217035150, Length=490, Percent_Identity=38.9795918367347, Blast_Score=302, Evalue=6e-82,
Organism=Homo sapiens, GI50541954, Length=275, Percent_Identity=32.7272727272727, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI50541952, Length=275, Percent_Identity=32.7272727272727, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI50541948, Length=275, Percent_Identity=32.7272727272727, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI50541956, Length=275, Percent_Identity=32.7272727272727, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI156104880, Length=230, Percent_Identity=34.3478260869565, Blast_Score=135, Evalue=1e-31,
Organism=Escherichia coli, GI1788855, Length=490, Percent_Identity=53.8775510204082, Blast_Score=460, Evalue=1e-130,
Organism=Escherichia coli, GI1786293, Length=239, Percent_Identity=33.4728033472803, Blast_Score=139, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI71994385, Length=489, Percent_Identity=35.1738241308793, Blast_Score=265, Evalue=5e-71,
Organism=Caenorhabditis elegans, GI71994389, Length=449, Percent_Identity=36.0801781737194, Blast_Score=258, Evalue=8e-69,
Organism=Caenorhabditis elegans, GI17560440, Length=284, Percent_Identity=33.0985915492958, Blast_Score=147, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6323585, Length=459, Percent_Identity=40.3050108932462, Blast_Score=335, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6322012, Length=459, Percent_Identity=39.2156862745098, Blast_Score=325, Evalue=8e-90,
Organism=Saccharomyces cerevisiae, GI6323464, Length=459, Percent_Identity=39.8692810457516, Blast_Score=325, Evalue=1e-89,
Organism=Saccharomyces cerevisiae, GI6319352, Length=339, Percent_Identity=37.7581120943953, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6319353, Length=116, Percent_Identity=40.5172413793103, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24641071, Length=485, Percent_Identity=41.0309278350515, Blast_Score=333, Evalue=2e-91,
Organism=Drosophila melanogaster, GI24641073, Length=485, Percent_Identity=41.0309278350515, Blast_Score=333, Evalue=2e-91,
Organism=Drosophila melanogaster, GI28571163, Length=444, Percent_Identity=40.3153153153153, Blast_Score=294, Evalue=8e-80,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): IMDH_MYCBO (P65168)

Other databases:

- EMBL:   BX248346
- RefSeq:   NP_857085.1
- ProteinModelPortal:   P65168
- SMR:   P65168
- EnsemblBacteria:   EBMYCT00000018010
- GeneID:   1091016
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb3445c
- GeneTree:   EBGT00050000017422
- HOGENOM:   HBG298985
- OMA:   CVGLITV
- ProtClustDB:   PRK05567
- BioCyc:   MBOV233413:MB3445C-MONOMER
- BRENDA:   1.1.1.205
- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000130
- SMART:   SM00116
- TIGRFAMs:   TIGR01302

Pfam domain/function: PF00571 CBS; PF00478 IMPDH

EC number: =1.1.1.205

Molecular weight: Translated: 54868; Mature: 54737

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS51371 CBS; PS00487 IMP_DH_GMP_RED

Important sites: ACT_SITE 341-341 BINDING 374-374 BINDING 421-421

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRGMSGLEDSSDLVVSPYVRMGGLTTDPVPTGGDDPHKVAMLGLTFDDVLLLPAASDVV
CCCCCCCCCCCCCEEEECHHHHCCCCCCCCCCCCCCCCEEEEEEECHHHEEEECCCCCCC
PATADTSSQLTKKIRLKVPLVSSAMDTVTESRMAIAMARAGGMGVLHRNLPVAEQAGQVE
CCCCCCHHHHHHHHEEECCHHHHHHHHHHHHHHHEEECCCCCCEEEECCCCCHHHCCCEE
MVKRSEAGMVTDPVTCRPDNTLAQVDALCARFRISGLPVVDDDGALVGIITNRDMRFEVD
EEECCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCEECCCCCEEEEEECCCEEEECC
QSKQVAEVMTKAPLITAQEGVSASAALGLLRRNKIEKLPVVDGRGRLTGLITVKDFVKTE
CHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHCCCCCCCEECCCCCEEEEEEEHHHHCCC
QHPLATKDSDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLVVDTAHAHNRLVLDMVGKLK
CCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHH
SEVGDRVEVVGGNVATRSAAAALVDAGADAVKVGVGPGSICTTRVVAGVGAPQITAILEA
HHHCCEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHHH
VAACRPAGVPVIADGGLQYSGDIAKALAAGASTAMLGSLLAGTAEAPGELIFVNGKQYKS
HHHCCCCCCCEEECCCCEECCHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEECCHHHH
YRGMGSLGAMRGRGGATSYSKDRYFADDALSEDKLVPEGIEGRVPFRGPLSSVIHQLTGG
HCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCC
LRAAMGYTGSPTIEVLQQAQFVRITPAGLKESHPHDVAMTVEAPNYYAR
HHHHCCCCCCHHHHHHHCCCEEEECCCCCCCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure 
SRGMSGLEDSSDLVVSPYVRMGGLTTDPVPTGGDDPHKVAMLGLTFDDVLLLPAASDVV
CCCCCCCCCCCCEEEECHHHHCCCCCCCCCCCCCCCCEEEEEEECHHHEEEECCCCCCC
PATADTSSQLTKKIRLKVPLVSSAMDTVTESRMAIAMARAGGMGVLHRNLPVAEQAGQVE
CCCCCCHHHHHHHHEEECCHHHHHHHHHHHHHHHEEECCCCCCEEEECCCCCHHHCCCEE
MVKRSEAGMVTDPVTCRPDNTLAQVDALCARFRISGLPVVDDDGALVGIITNRDMRFEVD
EEECCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCEECCCCCEEEEEECCCEEEECC
QSKQVAEVMTKAPLITAQEGVSASAALGLLRRNKIEKLPVVDGRGRLTGLITVKDFVKTE
CHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHCCCCCCCEECCCCCEEEEEEEHHHHCCC
QHPLATKDSDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLVVDTAHAHNRLVLDMVGKLK
CCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHH
SEVGDRVEVVGGNVATRSAAAALVDAGADAVKVGVGPGSICTTRVVAGVGAPQITAILEA
HHHCCEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHHH
VAACRPAGVPVIADGGLQYSGDIAKALAAGASTAMLGSLLAGTAEAPGELIFVNGKQYKS
HHHCCCCCCCEEECCCCEECCHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEECCHHHH
YRGMGSLGAMRGRGGATSYSKDRYFADDALSEDKLVPEGIEGRVPFRGPLSSVIHQLTGG
HCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCC
LRAAMGYTGSPTIEVLQQAQFVRITPAGLKESHPHDVAMTVEAPNYYAR
HHHHCCCCCCHHHHHHHCCCEEEECCCCCCCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972