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The map label for this gene is mtrB

Identifier: 148824447

GI number: 148824447

Start: 3636688

End: 3638391

Strand: Reverse

Name: mtrB

Synonym: TBFG_13274

Alternate gene names: 148824447

Gene position: 3638391-3636688 (Counterclockwise)

Preceding gene: 148824448

Following gene: 148824446

Centisome position: 82.23

GC content: 66.61

Gene sequence:

>1704_bases
ATGATCTTCGGCTCGCGCCGACGCATTCGGGGTCGCCGGGGTCGCTCTGGCCCGATGACACGGGGCCTCAGTGCGTTGAG
TCGAGCCGTAGCTGTCGCGTGGCGCCGATCGCTGCAGCTGCGGGTCGTGGCGCTGACCCTTGGACTGTCGCTAGCCGTCA
TCCTGGCGCTTGGCTTTGTGCTGACCAGCCAGGTCACCAATCGTGTCCTCGACATCAAGGTCAGGGCGGCGATCGACCAG
ATCGAGCGGGCACGCACCACCGTCAGCGGGATCGTCAACGGTGAGGAGACGCGCTCACTGGACAGTAGCCTGCAGCTTGC
GCGCAACACTCTGACGTCGAAAACCGACCCCGCTTCGGGGGCTGGCCTCGCCGGTGCGTTCGATGCGGTGCTGATGGTGC
CGGGTGATGGGCCGCGCGCTGCCTCTACTGCCGGACCCGTCGATCAGGTGCCCAACGCGCTGCGCGGCTTCGTCAAGGCC
GGGCAGGCCGCCTACCAGTACGCCACGGTGCAGACCGAAGGTTTCTCCGGGCCGGCCCTGATCATCGGGACTCCGACGTT
GTCGCGGGTGGCCAACCTGGAGCTATACCTGATCTTTCCGCTGGCGAGCGAGCAAGCCACGATCACGCTGGTGCGTGGCA
CGATGGCCACCGGCGGCCTGGTACTGCTAGTCCTGCTCGCCGGCATTGCGCTGCTGGTGTCGCGTCAGGTGGTGGTGCCG
GTGCGGTCGGCGTCGCGGATCGCCGAACGTTTCGCCGAGGGACATCTGTCCGAACGCATGCCGGTGCGCGGCGAGGACGA
CATGGCCAGGCTGGCGGTGTCGTTCAACGACATGGCCGAGAGCCTGTCCCGACAGATCGCCCAGCTGGAGGAGTTCGGCA
ACCTACAGCGCCGGTTCACCTCCGACGTCAGCCACGAACTGCGTACGCCGCTGACCACGGTGCGGATGGCGGCCGACTTG
ATCTATGACCACAGCGCCGACCTCGACCCCACGCTGCGGCGGTCCACCGAGTTGATGGTTAGCGAGCTGGACCGATTCGA
GACGTTGCTCAACGACCTGCTGGAGATCTCGCGGCATGACGCCGGGGTGGCCGAGTTGTCGGTTGAGGCGGTCGACTTGC
GCACAACGGTCAACAACGCGCTCGGCAATGTGGGCCACCTGGCCGAGGAGGCCGGTATCGAGTTGCTGGTGGATCTGCCC
GCCGAGCAGGTGATCGCGGAGGTCGATGCGCGTCGGGTAGAACGGATCCTGCGCAATCTGATTGCCAATGCCATCGACCA
CGCCGAACACAAACCGGTGCGGATCCGGATGGCCGCCGACGAAGACACGGTCGCCGTCACCGTGCGTGACTACGGGGTTG
GGCTGCGGCCTGGTGAGGAGAAGCTGGTGTTTAGCCGGTTCTGGCGCTCGGATCCCTCACGGGTACGTCGGTCCGGCGGC
ACCGGGCTGGGTTTGGCGATCAGCGTCGAGGATGCCCGATTGCACCAGGGTCGGCTTGAGGCGTGGGGCGAACCCGGCGA
GGGCGCCTGCTTCCGGCTGACGCTTCCGCTGGTGCGCGGCCACAAGGTCACCACCAGCCCGCTGCCCATGAAACCGATCC
CGCAGCCAGTTCTGCAACCGGTCGCGCAACCGAATCCGCAACCGATGCCACCGGAATACAAGGAACGTCAGCGCCCACGT
GAGCACGCGGAGTGGAGCGGTTGA

Upstream 100 bases:

>100_bases
ACTGTGGTGCTGACCGTTCGAGGAGTGGGGTACAAGGCCGGACCTCCGTGATCCGCGCCGGCGACGATGCAGAGCGCAGC
GATGCTAAGGAGCGGCGCCG

Downstream 100 bases:

>100_bases
TGCGGCTGACAATTTTGTTGTTCCTTGGTGCAGTGCTGGCCGGCTGTGCCAGTGTGCCCAGCACGTCGGCCCCGCAAGCC
ATCGGAACCGTCGAACGTCC

Product: two component system sensor transduction histidine kinase mtrB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 567; Mature: 567

Protein sequence:

>567_residues
MIFGSRRRIRGRRGRSGPMTRGLSALSRAVAVAWRRSLQLRVVALTLGLSLAVILALGFVLTSQVTNRVLDIKVRAAIDQ
IERARTTVSGIVNGEETRSLDSSLQLARNTLTSKTDPASGAGLAGAFDAVLMVPGDGPRAASTAGPVDQVPNALRGFVKA
GQAAYQYATVQTEGFSGPALIIGTPTLSRVANLELYLIFPLASEQATITLVRGTMATGGLVLLVLLAGIALLVSRQVVVP
VRSASRIAERFAEGHLSERMPVRGEDDMARLAVSFNDMAESLSRQIAQLEEFGNLQRRFTSDVSHELRTPLTTVRMAADL
IYDHSADLDPTLRRSTELMVSELDRFETLLNDLLEISRHDAGVAELSVEAVDLRTTVNNALGNVGHLAEEAGIELLVDLP
AEQVIAEVDARRVERILRNLIANAIDHAEHKPVRIRMAADEDTVAVTVRDYGVGLRPGEEKLVFSRFWRSDPSRVRRSGG
TGLGLAISVEDARLHQGRLEAWGEPGEGACFRLTLPLVRGHKVTTSPLPMKPIPQPVLQPVAQPNPQPMPPEYKERQRPR
EHAEWSG

Sequences:

>Translated_567_residues
MIFGSRRRIRGRRGRSGPMTRGLSALSRAVAVAWRRSLQLRVVALTLGLSLAVILALGFVLTSQVTNRVLDIKVRAAIDQ
IERARTTVSGIVNGEETRSLDSSLQLARNTLTSKTDPASGAGLAGAFDAVLMVPGDGPRAASTAGPVDQVPNALRGFVKA
GQAAYQYATVQTEGFSGPALIIGTPTLSRVANLELYLIFPLASEQATITLVRGTMATGGLVLLVLLAGIALLVSRQVVVP
VRSASRIAERFAEGHLSERMPVRGEDDMARLAVSFNDMAESLSRQIAQLEEFGNLQRRFTSDVSHELRTPLTTVRMAADL
IYDHSADLDPTLRRSTELMVSELDRFETLLNDLLEISRHDAGVAELSVEAVDLRTTVNNALGNVGHLAEEAGIELLVDLP
AEQVIAEVDARRVERILRNLIANAIDHAEHKPVRIRMAADEDTVAVTVRDYGVGLRPGEEKLVFSRFWRSDPSRVRRSGG
TGLGLAISVEDARLHQGRLEAWGEPGEGACFRLTLPLVRGHKVTTSPLPMKPIPQPVLQPVAQPNPQPMPPEYKERQRPR
EHAEWSG
>Mature_567_residues
MIFGSRRRIRGRRGRSGPMTRGLSALSRAVAVAWRRSLQLRVVALTLGLSLAVILALGFVLTSQVTNRVLDIKVRAAIDQ
IERARTTVSGIVNGEETRSLDSSLQLARNTLTSKTDPASGAGLAGAFDAVLMVPGDGPRAASTAGPVDQVPNALRGFVKA
GQAAYQYATVQTEGFSGPALIIGTPTLSRVANLELYLIFPLASEQATITLVRGTMATGGLVLLVLLAGIALLVSRQVVVP
VRSASRIAERFAEGHLSERMPVRGEDDMARLAVSFNDMAESLSRQIAQLEEFGNLQRRFTSDVSHELRTPLTTVRMAADL
IYDHSADLDPTLRRSTELMVSELDRFETLLNDLLEISRHDAGVAELSVEAVDLRTTVNNALGNVGHLAEEAGIELLVDLP
AEQVIAEVDARRVERILRNLIANAIDHAEHKPVRIRMAADEDTVAVTVRDYGVGLRPGEEKLVFSRFWRSDPSRVRRSGG
TGLGLAISVEDARLHQGRLEAWGEPGEGACFRLTLPLVRGHKVTTSPLPMKPIPQPVLQPVAQPNPQPMPPEYKERQRPR
EHAEWSG

Specific function: Member of the two-component regulatory system mtrA/mtrB. Seems to function as a membrane-associated protein kinase that phosphorylates mtrA in response to environmental signals

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain

Homologues:

Organism=Escherichia coli, GI1790346, Length=330, Percent_Identity=30, Blast_Score=132, Evalue=6e-32,
Organism=Escherichia coli, GI1788393, Length=286, Percent_Identity=29.7202797202797, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1787894, Length=305, Percent_Identity=28.5245901639344, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1789149, Length=341, Percent_Identity=25.8064516129032, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI1786783, Length=345, Percent_Identity=26.9565217391304, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1786912, Length=340, Percent_Identity=28.8235294117647, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI87081816, Length=355, Percent_Identity=27.6056338028169, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI87082128, Length=307, Percent_Identity=26.7100977198697, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI145693157, Length=242, Percent_Identity=27.2727272727273, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1788549, Length=254, Percent_Identity=27.9527559055118, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1788713, Length=238, Percent_Identity=26.4705882352941, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1786600, Length=237, Percent_Identity=27.4261603375527, Blast_Score=83, Evalue=6e-17,
Organism=Escherichia coli, GI1788279, Length=301, Percent_Identity=26.578073089701, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1790436, Length=223, Percent_Identity=26.9058295964126, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI48994928, Length=225, Percent_Identity=29.3333333333333, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1789403, Length=225, Percent_Identity=29.7777777777778, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790551, Length=277, Percent_Identity=25.2707581227437, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789808, Length=300, Percent_Identity=25, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTRB_MYCBO (P59963)

Other databases:

- EMBL:   BX248345
- RefSeq:   NP_856918.1
- ProteinModelPortal:   P59963
- EnsemblBacteria:   EBMYCT00000017500
- GeneID:   1093997
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb3273c
- GeneTree:   EBGT00050000014826
- HOGENOM:   HBG428949
- OMA:   MVNELDR
- ProtClustDB:   CLSK792375
- BioCyc:   MBOV233413:MB3273C-MONOMER
- BRENDA:   2.7.13.3
- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- Gene3D:   G3DSA:3.30.565.10
- PRINTS:   PR00344
- SMART:   SM00304
- SMART:   SM00387
- SMART:   SM00388

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; SSF55874 ATP_bd_ATPase; SSF47384 His_kin_homodim

EC number: =2.7.13.3

Molecular weight: Translated: 61620; Mature: 61620

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: PS50885 HAMP; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1d860898)-; HASH(0x1d5ffb4c)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFGSRRRIRGRRGRSGPMTRGLSALSRAVAVAWRRSLQLRVVALTLGLSLAVILALGFV
CCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHH
LTSQVTNRVLDIKVRAAIDQIERARTTVSGIVNGEETRSLDSSLQLARNTLTSKTDPASG
HHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
AGLAGAFDAVLMVPGDGPRAASTAGPVDQVPNALRGFVKAGQAAYQYATVQTEGFSGPAL
CCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHEEEEEEECCCCCCEE
IIGTPTLSRVANLELYLIFPLASEQATITLVRGTMATGGLVLLVLLAGIALLVSRQVVVP
EEECCHHHHHHCCEEEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEE
VRSASRIAERFAEGHLSERMPVRGEDDMARLAVSFNDMAESLSRQIAQLEEFGNLQRRFT
CHHHHHHHHHHHHCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SDVSHELRTPLTTVRMAADLIYDHSADLDPTLRRSTELMVSELDRFETLLNDLLEISRHD
HHHHHHHHCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AGVAELSVEAVDLRTTVNNALGNVGHLAEEAGIELLVDLPAEQVIAEVDARRVERILRNL
CCHHHEEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHH
IANAIDHAEHKPVRIRMAADEDTVAVTVRDYGVGLRPGEEKLVFSRFWRSDPSRVRRSGG
HHHHHHHCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHCCC
TGLGLAISVEDARLHQGRLEAWGEPGEGACFRLTLPLVRGHKVTTSPLPMKPIPQPVLQP
CCEEEEEEECHHHHHCCHHHHCCCCCCCCEEEEEEEHHCCCEECCCCCCCCCCCHHHHHH
VAQPNPQPMPPEYKERQRPREHAEWSG
HCCCCCCCCCCCHHHHCCCHHCCCCCH
>Mature Secondary Structure
MIFGSRRRIRGRRGRSGPMTRGLSALSRAVAVAWRRSLQLRVVALTLGLSLAVILALGFV
CCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHH
LTSQVTNRVLDIKVRAAIDQIERARTTVSGIVNGEETRSLDSSLQLARNTLTSKTDPASG
HHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
AGLAGAFDAVLMVPGDGPRAASTAGPVDQVPNALRGFVKAGQAAYQYATVQTEGFSGPAL
CCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHEEEEEEECCCCCCEE
IIGTPTLSRVANLELYLIFPLASEQATITLVRGTMATGGLVLLVLLAGIALLVSRQVVVP
EEECCHHHHHHCCEEEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEE
VRSASRIAERFAEGHLSERMPVRGEDDMARLAVSFNDMAESLSRQIAQLEEFGNLQRRFT
CHHHHHHHHHHHHCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SDVSHELRTPLTTVRMAADLIYDHSADLDPTLRRSTELMVSELDRFETLLNDLLEISRHD
HHHHHHHHCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AGVAELSVEAVDLRTTVNNALGNVGHLAEEAGIELLVDLPAEQVIAEVDARRVERILRNL
CCHHHEEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHH
IANAIDHAEHKPVRIRMAADEDTVAVTVRDYGVGLRPGEEKLVFSRFWRSDPSRVRRSGG
HHHHHHHCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHCCC
TGLGLAISVEDARLHQGRLEAWGEPGEGACFRLTLPLVRGHKVTTSPLPMKPIPQPVLQP
CCEEEEEEECHHHHHCCHHHHCCCCCCCCEEEEEEEHHCCCEECCCCCCCCCCCHHHHHH
VAQPNPQPMPPEYKERQRPREHAEWSG
HCCCCCCCCCCCHHHHCCCHHCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972