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The map label for this gene is 148823807

Identifier: 148823807

GI number: 148823807

Start: 2953926

End: 2954513

Strand: Reverse

Name: 148823807

Synonym: TBFG_12632

Alternate gene names: NA

Gene position: 2954513-2953926 (Counterclockwise)

Preceding gene: 148823808

Following gene: 148823806

Centisome position: 66.78

GC content: 63.78

Gene sequence:

>588_bases
GTGAGTGACGAGGACCGCACGGATCGGGCCACCGAGGACCACACCATCTTCGATCGGGGTGTCGGCCAGCGCGACCAGCT
GCAGCGGTTATGGACCCCCTACCGGATGAACTACCTGGCCGAAGCGCCAGTGAAGCGTGACCCCAATTCCTCGGCCAGCC
CTGCGCAGCCGTTCACCGAGATCCCGCAGCTGTCCGACGAAGAGGGTCTGGTGGTCGCTCGTGGCAAGCTGGTCTACGCC
GTGCTCAACCTGTACCCGTACAACCCCGGGCACTTGATGGTGGTGCCCTATCGTCGGGTATCCGAACTCGAGGATCTCAC
CGATTTGGAGAGCGCCGAGTTGATGGCGTTCACCCAGAAGGCGATTCGCGTGATCAAGAACGTGTCGCGTCCGCACGGCT
TCAATGTCGGCCTGAACCTAGGGACATCGGCGGGCGGGTCGCTGGCCGAGCACCTGCACGTGCATGTGGTGCCACGGTGG
GGTGGCGATGCGAATTTCATCACCATCATCGGGGGCTCCAAGGTGATTCCGCAGCTGCTGCGCGACACCCGTCGGCTGCT
TGCCACCGAGTGGGCTCGGCAACCATGA

Upstream 100 bases:

>100_bases
AACGGTGTGGCCCGTGACGATGCGGTGGCGGCCATTGTCGCCTGGATCGCTGACCGCGAAAATGCGGTTCCTACAGCGGA
ACTGGTGAAAGTGGCCGGTC

Downstream 100 bases:

>100_bases
GCAAGCTGCCCTTCCTGTCCCGGGCGGCGTTCGCCCGGATTACCACCCCGATCGCCAGGGGACTGCTGCGGGTCGGCCTC
ACGCCGGACGTCGTCACCAT

Product: hypothetical protein

Products: NA

Alternate protein names: ATP adenylyltransferase; Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase; AP,A phosphorylase

Number of amino acids: Translated: 195; Mature: 194

Protein sequence:

>195_residues
MSDEDRTDRATEDHTIFDRGVGQRDQLQRLWTPYRMNYLAEAPVKRDPNSSASPAQPFTEIPQLSDEEGLVVARGKLVYA
VLNLYPYNPGHLMVVPYRRVSELEDLTDLESAELMAFTQKAIRVIKNVSRPHGFNVGLNLGTSAGGSLAEHLHVHVVPRW
GGDANFITIIGGSKVIPQLLRDTRRLLATEWARQP

Sequences:

>Translated_195_residues
MSDEDRTDRATEDHTIFDRGVGQRDQLQRLWTPYRMNYLAEAPVKRDPNSSASPAQPFTEIPQLSDEEGLVVARGKLVYA
VLNLYPYNPGHLMVVPYRRVSELEDLTDLESAELMAFTQKAIRVIKNVSRPHGFNVGLNLGTSAGGSLAEHLHVHVVPRW
GGDANFITIIGGSKVIPQLLRDTRRLLATEWARQP
>Mature_194_residues
SDEDRTDRATEDHTIFDRGVGQRDQLQRLWTPYRMNYLAEAPVKRDPNSSASPAQPFTEIPQLSDEEGLVVARGKLVYAV
LNLYPYNPGHLMVVPYRRVSELEDLTDLESAELMAFTQKAIRVIKNVSRPHGFNVGLNLGTSAGGSLAEHLHVHVVPRWG
GDANFITIIGGSKVIPQLLRDTRRLLATEWARQP

Specific function: Catabolizes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) into ADP and ATP. It does not catalyze the reverse phosphorolysis reaction. The optimum substrates are dinucleoside polyphosphates containing four or five phosphate residues

COG id: COG0537

COG function: function code FGR; Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HIT domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AP4A_MYCTU (O06201)

Other databases:

- EMBL:   AE000516
- EMBL:   BX842580
- PIR:   D70571
- RefSeq:   NP_217129.1
- RefSeq:   NP_337190.1
- HSSP:   P49789
- ProteinModelPortal:   O06201
- SMR:   O06201
- EnsemblBacteria:   EBMYCT00000001225
- EnsemblBacteria:   EBMYCT00000072357
- GeneID:   888193
- GeneID:   925619
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2688
- KEGG:   mtu:Rv2613c
- TIGR:   MT2688
- TubercuList:   Rv2613c
- GeneTree:   EBGT00050000015502
- HOGENOM:   HBG743217
- OMA:   GHLLVCP
- ProtClustDB:   CLSK791952
- GO:   GO:0040007
- InterPro:   IPR011146
- InterPro:   IPR011151
- InterPro:   IPR001310
- Gene3D:   G3DSA:3.30.428.10
- PANTHER:   PTHR23089

Pfam domain/function: PF01230 HIT; SSF54197 His_triad-like_motif

EC number: =2.7.7.53

Molecular weight: Translated: 21869; Mature: 21738

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00892 HIT_1; PS51084 HIT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDEDRTDRATEDHTIFDRGVGQRDQLQRLWTPYRMNYLAEAPVKRDPNSSASPAQPFTE
CCCCCCCCCCCCCCHHHHCCCCCHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCHHH
IPQLSDEEGLVVARGKLVYAVLNLYPYNPGHLMVVPYRRVSELEDLTDLESAELMAFTQK
CCCCCCCCCEEEECCHHEEHHHHHCCCCCCCEEEECCHHHHHHHHHHCCCHHHHHHHHHH
AIRVIKNVSRPHGFNVGLNLGTSAGGSLAEHLHVHVVPRWGGDANFITIIGGSKVIPQLL
HHHHHHHCCCCCCCEEEEECCCCCCCHHHHCEEEEEEECCCCCCCEEEEECCCHHHHHHH
RDTRRLLATEWARQP
HHHHHHHHHHHCCCC
>Mature Secondary Structure 
SDEDRTDRATEDHTIFDRGVGQRDQLQRLWTPYRMNYLAEAPVKRDPNSSASPAQPFTE
CCCCCCCCCCCCCHHHHCCCCCHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCHHH
IPQLSDEEGLVVARGKLVYAVLNLYPYNPGHLMVVPYRRVSELEDLTDLESAELMAFTQK
CCCCCCCCCEEEECCHHEEHHHHHCCCCCCCEEEECCHHHHHHHHHHCCCHHHHHHHHHH
AIRVIKNVSRPHGFNVGLNLGTSAGGSLAEHLHVHVVPRWGGDANFITIIGGSKVIPQLL
HHHHHHHCCCCCCCEEEEECCCCCCCHHHHCEEEEEEECCCCCCCEEEEECCCHHHHHHH
RDTRRLLATEWARQP
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12368430; 12218036