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The map label for this gene is relA

Identifier: 148823778

GI number: 148823778

Start: 2921143

End: 2923515

Strand: Reverse

Name: relA

Synonym: TBFG_12603

Alternate gene names: 148823778

Gene position: 2923515-2921143 (Counterclockwise)

Preceding gene: 148823779

Following gene: 148823777

Centisome position: 66.08

GC content: 65.19

Gene sequence:

>2373_bases
GTGGCCGAGGACCAGCTCACGGCGCAAGCGGTTGCACCGCCCACGGAGGCTTCTGCGGCTCTCGAGCCCGCTCTCGAGAC
GCCCGAGTCGCCGGTCGAGACTCTTAAGACCAGCATCAGCGCGTCGCGTCGGGTGCGGGCCCGATTGGCCCGGCGGATGA
CCGCCCAGCGCAGCACCACCAATCCGGTGCTCGAGCCGTTGGTGGCGGTGCACCGGGAGATCTATCCCAAGGCCGACCTG
TCGATCTTGCAGCGAGCCTACGAGGTCGCTGACCAAAGGCATGCCAGCCAGTTGCGGCAGTCCGGTGATCCCTACATCAC
CCACCCGTTGGCCGTTGCCAACATTCTGGCCGAGTTGGGCATGGACACCACCACTTTGGTGGCCGCGCTGCTGCACGACA
CCGTCGAGGACACCGGTTACACCCTGGAGGCGTTGACCGAGGAATTCGGCGAAGAGGTGGGCCATCTCGTCGACGGGGTG
ACCAAGCTGGATCGGGTGGTGTTGGGCAGCGCCGCCGAAGGCGAGACTATTCGCAAGATGATCACCGCGATGGCCCGCGA
TCCGCGGGTGCTGGTGATAAAGGTGGCTGACCGGTTACACAACATGCGCACCATGCGCTTCTTGCCGCCGGAGAAGCAGG
CCCGCAAGGCCCGTGAGACGTTGGAAGTCATTGCACCCCTGGCGCATCGGCTGGGCATGGCCAGCGTCAAGTGGGAGTTG
GAGGACCTGTCCTTCGCGATCCTGCATCCCAAGAAGTACGAGGAGATCGTCCGGCTGGTCGCCGGTCGCGCGCCGTCCCG
GGACACCTACCTGGCCAAGGTGCGTGCCGAAATCGTCAACACGCTGACCGCGTCGAAGATCAAGGCGACGGTGGAGGGCC
GCCCCAAGCACTATTGGTCGATCTACCAGAAGATGATCGTTAAGGGCCGCGACTTCGACGACATCCACGACCTGGTCGGT
GTGCGCATCCTGTGCGACGAAATCCGGGACTGCTACGCGGCTGTCGGCGTAGTGCATTCGCTATGGCAGCCGATGGCGGG
TCGGTTCAAGGACTACATCGCCCAGCCCAGATACGGTGTGTACCAGTCACTGCACACCACTGTGGTCGGGCCTGAGGGCA
AGCCGCTGGAAGTGCAGATCCGTACCCGCGACATGCACCGCACCGCCGAATACGGCATCGCCGCGCATTGGCGCTACAAA
GAAGCCAAGGGCCGCAACGGTGTTCTTCATCCGCATGCCGCCGCGGAGATCGACGACATGGCCTGGATGCGTCAGCTGCT
CGACTGGCAACGTGAGGCGGCCGACCCCGGTGAGTTCTTGGAATCATTGCGCTACGACCTTGCGGTGCAAGAGATTTTCG
TGTTTACCCCCAAGGGCGACGTGATCACGCTGCCAACCGGTTCGACGCCGGTGGACTTCGCTTACGCGGTGCACACAGAG
GTGGGCCACCGCTGCATCGGCGCCCGAGTGAACGGCCGGTTGGTAGCGCTGGAACGCAAGCTGGAAAACGGAGAAGTTGT
CGAGGTTTTCACGTCCAAGGCGCCGAACGCCGGGCCGTCGCGGGACTGGCAGCAGTTCGTGGTGTCGCCGCGCGCAAAGA
CGAAGATCCGCCAGTGGTTCGCCAAGGAGCGGCGTGAGGAGGCGTTGGAGACCGGTAAGGATGCGATGGCCCGCGAGGTG
CGCCGCGGTGGACTTCCGTTGCAGCGCTTGGTCAATGGTGAGTCCATGGCGGCGGTGGCCCGCGAGCTGCACTACGCGGA
CGTGTCAGCACTCTATACCGCCATCGGTGAGGGGCACGTGTCGGCGAAACACGTCGTGCAGCGGTTGTTGGCCGAGCTCG
GCGGTATCGACCAGGCGGAAGAGGAACTCGCCGAGCGGTCCACGCCGGCGACCATGCCGCGGCGCCCACGCAGCACCGAC
GATGTCGGGGTCTCCGTCCCCGGCGCCCCGGGCGTGCTGACCAAGCTGGCCAAGTGCTGCACGCCGGTTCCGGGCGATGT
GATTATGGGGTTCGTCACCCGTGGCGGCGGGGTCAGTGTGCACCGCACCGACTGCACCAACGCCGCATCGCTGCAGCAGC
AGGCCGAGCGCATCATCGAGGTGCTATGGGCGCCGTCGCCGTCGTCGGTGTTTCTGGTGGCAATCCAGGTCGAGGCACTC
GACCGGCACCGGCTGCTGTCGGATGTGACGCGCGCACTGGCCGACGAGAAGGTCAATATCCTGTCCGCGTCGGTCACCAC
TTCGGGGGACCGGGTGGCGATCAGTCGATTCACCTTCGAGATGGGTGACCCCAAGCACCTCGGGCACCTGCTCAACGCCG
TCCGCAACGTCGAAGGTGTCTACGACGTCTACCGGGTGACCTCGGCCGCGTAG

Upstream 100 bases:

>100_bases
GGAACTTGCGGGGTTGAGCGGTCGCGCGGCGCTCGCACCGCTGCCGGTGCACAGCCTGAGCCGCCTGTGAGGGATATCCT
CTAGGTCGGAGGTGACGAAC

Downstream 100 bases:

>100_bases
CGCGCTTTTCTCCGCCGAGCAGACGCAGAATCGCATTGGGCGGGCTGATTTCGTGCGATTCTGTGTCTGCTCGGCGAGCG
TCGGGCTAATCCAGCAGCAC

Product: GTP pyrophosphokinase relA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I

Number of amino acids: Translated: 790; Mature: 789

Protein sequence:

>790_residues
MAEDQLTAQAVAPPTEASAALEPALETPESPVETLKTSISASRRVRARLARRMTAQRSTTNPVLEPLVAVHREIYPKADL
SILQRAYEVADQRHASQLRQSGDPYITHPLAVANILAELGMDTTTLVAALLHDTVEDTGYTLEALTEEFGEEVGHLVDGV
TKLDRVVLGSAAEGETIRKMITAMARDPRVLVIKVADRLHNMRTMRFLPPEKQARKARETLEVIAPLAHRLGMASVKWEL
EDLSFAILHPKKYEEIVRLVAGRAPSRDTYLAKVRAEIVNTLTASKIKATVEGRPKHYWSIYQKMIVKGRDFDDIHDLVG
VRILCDEIRDCYAAVGVVHSLWQPMAGRFKDYIAQPRYGVYQSLHTTVVGPEGKPLEVQIRTRDMHRTAEYGIAAHWRYK
EAKGRNGVLHPHAAAEIDDMAWMRQLLDWQREAADPGEFLESLRYDLAVQEIFVFTPKGDVITLPTGSTPVDFAYAVHTE
VGHRCIGARVNGRLVALERKLENGEVVEVFTSKAPNAGPSRDWQQFVVSPRAKTKIRQWFAKERREEALETGKDAMAREV
RRGGLPLQRLVNGESMAAVARELHYADVSALYTAIGEGHVSAKHVVQRLLAELGGIDQAEEELAERSTPATMPRRPRSTD
DVGVSVPGAPGVLTKLAKCCTPVPGDVIMGFVTRGGGVSVHRTDCTNAASLQQQAERIIEVLWAPSPSSVFLVAIQVEAL
DRHRLLSDVTRALADEKVNILSASVTTSGDRVAISRFTFEMGDPKHLGHLLNAVRNVEGVYDVYRVTSAA

Sequences:

>Translated_790_residues
MAEDQLTAQAVAPPTEASAALEPALETPESPVETLKTSISASRRVRARLARRMTAQRSTTNPVLEPLVAVHREIYPKADL
SILQRAYEVADQRHASQLRQSGDPYITHPLAVANILAELGMDTTTLVAALLHDTVEDTGYTLEALTEEFGEEVGHLVDGV
TKLDRVVLGSAAEGETIRKMITAMARDPRVLVIKVADRLHNMRTMRFLPPEKQARKARETLEVIAPLAHRLGMASVKWEL
EDLSFAILHPKKYEEIVRLVAGRAPSRDTYLAKVRAEIVNTLTASKIKATVEGRPKHYWSIYQKMIVKGRDFDDIHDLVG
VRILCDEIRDCYAAVGVVHSLWQPMAGRFKDYIAQPRYGVYQSLHTTVVGPEGKPLEVQIRTRDMHRTAEYGIAAHWRYK
EAKGRNGVLHPHAAAEIDDMAWMRQLLDWQREAADPGEFLESLRYDLAVQEIFVFTPKGDVITLPTGSTPVDFAYAVHTE
VGHRCIGARVNGRLVALERKLENGEVVEVFTSKAPNAGPSRDWQQFVVSPRAKTKIRQWFAKERREEALETGKDAMAREV
RRGGLPLQRLVNGESMAAVARELHYADVSALYTAIGEGHVSAKHVVQRLLAELGGIDQAEEELAERSTPATMPRRPRSTD
DVGVSVPGAPGVLTKLAKCCTPVPGDVIMGFVTRGGGVSVHRTDCTNAASLQQQAERIIEVLWAPSPSSVFLVAIQVEAL
DRHRLLSDVTRALADEKVNILSASVTTSGDRVAISRFTFEMGDPKHLGHLLNAVRNVEGVYDVYRVTSAA
>Mature_789_residues
AEDQLTAQAVAPPTEASAALEPALETPESPVETLKTSISASRRVRARLARRMTAQRSTTNPVLEPLVAVHREIYPKADLS
ILQRAYEVADQRHASQLRQSGDPYITHPLAVANILAELGMDTTTLVAALLHDTVEDTGYTLEALTEEFGEEVGHLVDGVT
KLDRVVLGSAAEGETIRKMITAMARDPRVLVIKVADRLHNMRTMRFLPPEKQARKARETLEVIAPLAHRLGMASVKWELE
DLSFAILHPKKYEEIVRLVAGRAPSRDTYLAKVRAEIVNTLTASKIKATVEGRPKHYWSIYQKMIVKGRDFDDIHDLVGV
RILCDEIRDCYAAVGVVHSLWQPMAGRFKDYIAQPRYGVYQSLHTTVVGPEGKPLEVQIRTRDMHRTAEYGIAAHWRYKE
AKGRNGVLHPHAAAEIDDMAWMRQLLDWQREAADPGEFLESLRYDLAVQEIFVFTPKGDVITLPTGSTPVDFAYAVHTEV
GHRCIGARVNGRLVALERKLENGEVVEVFTSKAPNAGPSRDWQQFVVSPRAKTKIRQWFAKERREEALETGKDAMAREVR
RGGLPLQRLVNGESMAAVARELHYADVSALYTAIGEGHVSAKHVVQRLLAELGGIDQAEEELAERSTPATMPRRPRSTDD
VGVSVPGAPGVLTKLAKCCTPVPGDVIMGFVTRGGGVSVHRTDCTNAASLQQQAERIIEVLWAPSPSSVFLVAIQVEALD
RHRLLSDVTRALADEKVNILSASVTTSGDRVAISRFTFEMGDPKHLGHLLNAVRNVEGVYDVYRVTSAA

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain

Homologues:

Organism=Homo sapiens, GI38348360, Length=139, Percent_Identity=38.8489208633094, Blast_Score=71, Evalue=4e-12,
Organism=Escherichia coli, GI1790082, Length=728, Percent_Identity=39.4230769230769, Blast_Score=512, Evalue=1e-146,
Organism=Escherichia coli, GI1789147, Length=695, Percent_Identity=37.9856115107914, Blast_Score=487, Evalue=1e-138,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RELA_MYCBO (P66015)

Other databases:

- EMBL:   BX248343
- RefSeq:   NP_856260.1
- ProteinModelPortal:   P66015
- EnsemblBacteria:   EBMYCT00000015834
- GeneID:   1092024
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2614c
- GeneTree:   EBGT00050000015693
- HOGENOM:   HBG594146
- OMA:   HRGQKRK
- ProtClustDB:   CLSK791939
- BioCyc:   MBOV233413:MB2614C-MONOMER
- BRENDA:   2.7.6.5
- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676
- Gene3D:   G3DSA:3.10.20.30
- SMART:   SM00471
- SMART:   SM00954
- TIGRFAMs:   TIGR00691

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS; SSF81271 TGS-like

EC number: =2.7.6.5

Molecular weight: Translated: 87355; Mature: 87224

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEDQLTAQAVAPPTEASAALEPALETPESPVETLKTSISASRRVRARLARRMTAQRSTT
CCCCHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NPVLEPLVAVHREIYPKADLSILQRAYEVADQRHASQLRQSGDPYITHPLAVANILAELG
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHC
MDTTTLVAALLHDTVEDTGYTLEALTEEFGEEVGHLVDGVTKLDRVVLGSAAEGETIRKM
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
ITAMARDPRVLVIKVADRLHNMRTMRFLPPEKQARKARETLEVIAPLAHRLGMASVKWEL
HHHHCCCCCEEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHEEEH
EDLSFAILHPKKYEEIVRLVAGRAPSRDTYLAKVRAEIVNTLTASKIKATVEGRPKHYWS
HHCEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHH
IYQKMIVKGRDFDDIHDLVGVRILCDEIRDCYAAVGVVHSLWQPMAGRFKDYIAQPRYGV
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
YQSLHTTVVGPEGKPLEVQIRTRDMHRTAEYGIAAHWRYKEAKGRNGVLHPHAAAEIDDM
HHHHHHEEECCCCCCEEEEEECCHHHHHHHCCCCEEEEEHHCCCCCCCCCCCHHHHHHHH
AWMRQLLDWQREAADPGEFLESLRYDLAVQEIFVFTPKGDVITLPTGSTPVDFAYAVHTE
HHHHHHHHHHHHCCCHHHHHHHHHHHHEEEHEEEECCCCCEEEECCCCCCCCHHHHHHHH
VGHRCIGARVNGRLVALERKLENGEVVEVFTSKAPNAGPSRDWQQFVVSPRAKTKIRQWF
HCCHHCCCCCCCEEEEEEHHCCCCCEEEEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHH
AKERREEALETGKDAMAREVRRGGLPLQRLVNGESMAAVARELHYADVSALYTAIGEGHV
HHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
SAKHVVQRLLAELGGIDQAEEELAERSTPATMPRRPRSTDDVGVSVPGAPGVLTKLAKCC
CHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHC
TPVPGDVIMGFVTRGGGVSVHRTDCTNAASLQQQAERIIEVLWAPSPSSVFLVAIQVEAL
CCCCHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEHHH
DRHRLLSDVTRALADEKVNILSASVTTSGDRVAISRFTFEMGDPKHLGHLLNAVRNVEGV
HHHHHHHHHHHHHHHCCHHEEEEEEECCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHH
YDVYRVTSAA
HHHHHHHCCC
>Mature Secondary Structure 
AEDQLTAQAVAPPTEASAALEPALETPESPVETLKTSISASRRVRARLARRMTAQRSTT
CCCHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NPVLEPLVAVHREIYPKADLSILQRAYEVADQRHASQLRQSGDPYITHPLAVANILAELG
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHC
MDTTTLVAALLHDTVEDTGYTLEALTEEFGEEVGHLVDGVTKLDRVVLGSAAEGETIRKM
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
ITAMARDPRVLVIKVADRLHNMRTMRFLPPEKQARKARETLEVIAPLAHRLGMASVKWEL
HHHHCCCCCEEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHEEEH
EDLSFAILHPKKYEEIVRLVAGRAPSRDTYLAKVRAEIVNTLTASKIKATVEGRPKHYWS
HHCEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHH
IYQKMIVKGRDFDDIHDLVGVRILCDEIRDCYAAVGVVHSLWQPMAGRFKDYIAQPRYGV
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
YQSLHTTVVGPEGKPLEVQIRTRDMHRTAEYGIAAHWRYKEAKGRNGVLHPHAAAEIDDM
HHHHHHEEECCCCCCEEEEEECCHHHHHHHCCCCEEEEEHHCCCCCCCCCCCHHHHHHHH
AWMRQLLDWQREAADPGEFLESLRYDLAVQEIFVFTPKGDVITLPTGSTPVDFAYAVHTE
HHHHHHHHHHHHCCCHHHHHHHHHHHHEEEHEEEECCCCCEEEECCCCCCCCHHHHHHHH
VGHRCIGARVNGRLVALERKLENGEVVEVFTSKAPNAGPSRDWQQFVVSPRAKTKIRQWF
HCCHHCCCCCCCEEEEEEHHCCCCCEEEEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHH
AKERREEALETGKDAMAREVRRGGLPLQRLVNGESMAAVARELHYADVSALYTAIGEGHV
HHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
SAKHVVQRLLAELGGIDQAEEELAERSTPATMPRRPRSTDDVGVSVPGAPGVLTKLAKCC
CHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHC
TPVPGDVIMGFVTRGGGVSVHRTDCTNAASLQQQAERIIEVLWAPSPSSVFLVAIQVEAL
CCCCHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEHHH
DRHRLLSDVTRALADEKVNILSASVTTSGDRVAISRFTFEMGDPKHLGHLLNAVRNVEGV
HHHHHHHHHHHHHHHCCHHEEEEEEECCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHH
YDVYRVTSAA
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972