Click here to switch to the map view.

The map label for this gene is apt

Identifier: 148823779

GI number: 148823779

Start: 2923546

End: 2924217

Strand: Reverse

Name: apt

Synonym: TBFG_12604

Alternate gene names: 148823779

Gene position: 2924217-2923546 (Counterclockwise)

Preceding gene: 148823780

Following gene: 148823778

Centisome position: 66.09

GC content: 68.9

Gene sequence:

>672_bases
GTGTGCCATGGCGGTACATGGGCTGGTGACTACGTGTTGAACGTGATCGCGACGGGGCTCTCCTTAAAGGCACGGGGGAA
GCGCCGCCGGCAGCGTTGGGTCGACGACGGGCGGGTATTGGCGCTCGGTGAGTCCCGCCGGAGCTCAGCCATATCTGTGG
CCGACGTGGTTGCGTCGCTGACCCGGGATGTGGCCGACTTTCCGGTTCCCGGCGTCGAGTTCAAGGACCTCACCCCGCTA
TTCGCCGACCGAAGAGGATTGGCCGCGGTAACCGAAGCGCTGGCCGATCGGGCGTCCGGAGCTGACCTGGTGGCCGGCGT
CGACGCCCGCGGGTTTCTGGTGGCAGCCGCGGTCGCCACCCGGCTCGAAGTGGGTGTGCTGGCCGTTCGCAAGGGCGGCA
AGCTGCCCCGGCCGGTGCTCAGCGAGGAGTACTACAGGGAGTACGGCGCCGCCACTCTGGAGATTCTCGCTGAGGGCATC
GAGGTTGCGGGCCGCCGTGTCGTGATCATTGACGACGTGTTAGCAACCGGCGGCACCATCGGCGCGACGCGACGCCTGCT
TGAGCGCGGTGGCGCCAACGTGGCCGGGGCGGCCGTAGTGGTGGAACTTGCGGGGTTGAGCGGTCGCGCGGCGCTCGCAC
CGCTGCCGGTGCACAGCCTGAGCCGCCTGTGA

Upstream 100 bases:

>100_bases
TGGCCAGTGCCATCTGCAGGTAATTGACAGAATTCCACGACGAGAAGCGGACCTATCGGAGCGTAGTGTCGCAGGTGCTC
CGGGCTGTCTGGGAGAGGAT

Downstream 100 bases:

>100_bases
GGGATATCCTCTAGGTCGGAGGTGACGAACGTGGCCGAGGACCAGCTCACGGCGCAAGCGGTTGCACCGCCCACGGAGGC
TTCTGCGGCTCTCGAGCCCG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MCHGGTWAGDYVLNVIATGLSLKARGKRRRQRWVDDGRVLALGESRRSSAISVADVVASLTRDVADFPVPGVEFKDLTPL
FADRRGLAAVTEALADRASGADLVAGVDARGFLVAAAVATRLEVGVLAVRKGGKLPRPVLSEEYYREYGAATLEILAEGI
EVAGRRVVIIDDVLATGGTIGATRRLLERGGANVAGAAVVVELAGLSGRAALAPLPVHSLSRL

Sequences:

>Translated_223_residues
MCHGGTWAGDYVLNVIATGLSLKARGKRRRQRWVDDGRVLALGESRRSSAISVADVVASLTRDVADFPVPGVEFKDLTPL
FADRRGLAAVTEALADRASGADLVAGVDARGFLVAAAVATRLEVGVLAVRKGGKLPRPVLSEEYYREYGAATLEILAEGI
EVAGRRVVIIDDVLATGGTIGATRRLLERGGANVAGAAVVVELAGLSGRAALAPLPVHSLSRL
>Mature_223_residues
MCHGGTWAGDYVLNVIATGLSLKARGKRRRQRWVDDGRVLALGESRRSSAISVADVVASLTRDVADFPVPGVEFKDLTPL
FADRRGLAAVTEALADRASGADLVAGVDARGFLVAAAVATRLEVGVLAVRKGGKLPRPVLSEEYYREYGAATLEILAEGI
EVAGRRVVIIDDVLATGGTIGATRRLLERGGANVAGAAVVVELAGLSGRAALAPLPVHSLSRL

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=176, Percent_Identity=42.6136363636364, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI71773201, Length=133, Percent_Identity=41.3533834586466, Blast_Score=95, Evalue=4e-20,
Organism=Escherichia coli, GI1786675, Length=169, Percent_Identity=42.0118343195266, Blast_Score=119, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17509087, Length=160, Percent_Identity=40, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6323619, Length=179, Percent_Identity=34.0782122905028, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320649, Length=175, Percent_Identity=29.1428571428571, Blast_Score=62, Evalue=7e-11,
Organism=Drosophila melanogaster, GI17136334, Length=178, Percent_Identity=37.6404494382022, Blast_Score=101, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_MYCBO (P59959)

Other databases:

- EMBL:   BX248343
- RefSeq:   NP_856261.1
- ProteinModelPortal:   P59959
- SMR:   P59959
- EnsemblBacteria:   EBMYCT00000017990
- GeneID:   1092022
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2615c
- GeneTree:   EBGT00050000016328
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   MBOV233413:MB2615C-MONOMER
- BRENDA:   2.4.2.7
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 23246; Mature: 23246

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER; PS00144 ASN_GLN_ASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCHGGTWAGDYVLNVIATGLSLKARGKRRRQRWVDDGRVLALGESRRSSAISVADVVASL
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHH
TRDVADFPVPGVEFKDLTPLFADRRGLAAVTEALADRASGADLVAGVDARGFLVAAAVAT
HHHHHHCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHH
RLEVGVLAVRKGGKLPRPVLSEEYYREYGAATLEILAEGIEVAGRRVVIIDDVLATGGTI
HHHHHHEEEECCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCEEEEEECHHHCCCCH
GATRRLLERGGANVAGAAVVVELAGLSGRAALAPLPVHSLSRL
HHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEECCCCHHHHHCC
>Mature Secondary Structure
MCHGGTWAGDYVLNVIATGLSLKARGKRRRQRWVDDGRVLALGESRRSSAISVADVVASL
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHH
TRDVADFPVPGVEFKDLTPLFADRRGLAAVTEALADRASGADLVAGVDARGFLVAAAVAT
HHHHHHCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHH
RLEVGVLAVRKGGKLPRPVLSEEYYREYGAATLEILAEGIEVAGRRVVIIDDVLATGGTI
HHHHHHEEEECCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCEEEEEECHHHCCCCH
GATRRLLERGGANVAGAAVVVELAGLSGRAALAPLPVHSLSRL
HHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEECCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972