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The map label for this gene is adh

Identifier: 148661326

GI number: 148661326

Start: 1732890

End: 1733993

Strand: Direct

Name: adh

Synonym: MRA_1542

Alternate gene names: 148661326

Gene position: 1732890-1733993 (Clockwise)

Preceding gene: 148661325

Following gene: 148661327

Centisome position: 39.21

GC content: 68.03

Gene sequence:

>1104_bases
ATGTCGGACGGCGCGGTGGTACGGGCATTGGTATTGGAGGCGCCGCGCAGGCTGGTCGTGCGCCAGTACCGGCTGCCGCG
CATCGGCGATGATGACGCACTAGTGCGAGTAGAGGCCTGCGGGCTGTGCGGCACCGATCACGAGCAATACACGGGCGAGC
TGGCCGGTGGGTTTGCCTTCGTACCTGGCCACGAGACGGTCGGGACGATTGCGGCCATCGGTCCGCGGGCGGAGCAGCGG
TGGGGCGTGTCGGCCGGCGACCGAGTAGCCGTCGAGGTATTCCAGTCGTGTCGGCAGTGCGCTAACTGTCGTGGCGGCGA
GTACCGGCGTTGTGTACGGCATGGCCTCGCTGACATGTACGGGTTCATCCCGGTTGACCGAGAGCCTGGCCTGTGGGGCG
GTTACGCCGAATATCAGTACCTGGCGCCGGATTCGATGGTGTTGCGGGTGGCCGGTGACCTCAGCCCGGAAGTGGCCACC
TTGTTCAACCCGCTGGGGGCGGGAATACGTTGGGGAGTAACGATTCCCGAAACCAAACCGGGCGACGTCGTGGCGGTGCT
GGGTCCAGGAATCCGGGGGCTGTGCGCCGCCGCGGCGGCAAAAGGGGCCGGTGCCGGGTTCGTGATGGTGACCGGGTTGG
GACCCCGTGACGCCGACCGGTTGGCGCTGGCGGCACAGTTCGGAGCCGACCTCGCCGTCGATGTTGCGATCGATGACCCG
GTCGCCGCCCTGACCGAACAGACCGGTGGGCTGGCAGACGTCGTTGTCGACGTGACCGCCAAGGCGCCAGCGGCATTCGC
ACAGGCGATAGCGCTAGCCCGGCCCGCCGGGACCGTTGTTGTCGCCGGCACCCGGGGCGTGGGCAGCGGGGCACCGGGAT
TTTCGCCCGACGTCGTTGTGTTCAAGGAGCTGCGTGTGCTTGGCGCCCTCGGCGTAGACGCCACCGCCTACCGGGCCGCG
CTTGATCTGTTGGTGTCCGGTCGATACCCCTTCGCAAGCCTGCCTCGCCGCTGCGTGCGGCTCGAAGGCGCCGAGGATCT
GCTGGCTACCATGGCCGGTGAACGCGACGGTGTCCCGCCTATCCACGGAGTGCTCACACCATGA

Upstream 100 bases:

>100_bases
TGTTTTCCATTGTGCTACAACCGGTTTGCTGTCTCTGTGGCCCAGTGTTAGTGGGCCGCTCGGCATTGACTGAGCACGAC
ACGATTCCTAGTGTGCTGGT

Downstream 100 bases:

>100_bases
CAACATCCCGCGTGCCCCTGTTGCCGGTCGACGAGGCCAAAGCTGCTGCCGACGAAGCGGGCGTGCCCGACTACATGGCT
GAGCTCAGCATCTTCCAAGT

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MSDGAVVRALVLEAPRRLVVRQYRLPRIGDDDALVRVEACGLCGTDHEQYTGELAGGFAFVPGHETVGTIAAIGPRAEQR
WGVSAGDRVAVEVFQSCRQCANCRGGEYRRCVRHGLADMYGFIPVDREPGLWGGYAEYQYLAPDSMVLRVAGDLSPEVAT
LFNPLGAGIRWGVTIPETKPGDVVAVLGPGIRGLCAAAAAKGAGAGFVMVTGLGPRDADRLALAAQFGADLAVDVAIDDP
VAALTEQTGGLADVVVDVTAKAPAAFAQAIALARPAGTVVVAGTRGVGSGAPGFSPDVVVFKELRVLGALGVDATAYRAA
LDLLVSGRYPFASLPRRCVRLEGAEDLLATMAGERDGVPPIHGVLTP

Sequences:

>Translated_367_residues
MSDGAVVRALVLEAPRRLVVRQYRLPRIGDDDALVRVEACGLCGTDHEQYTGELAGGFAFVPGHETVGTIAAIGPRAEQR
WGVSAGDRVAVEVFQSCRQCANCRGGEYRRCVRHGLADMYGFIPVDREPGLWGGYAEYQYLAPDSMVLRVAGDLSPEVAT
LFNPLGAGIRWGVTIPETKPGDVVAVLGPGIRGLCAAAAAKGAGAGFVMVTGLGPRDADRLALAAQFGADLAVDVAIDDP
VAALTEQTGGLADVVVDVTAKAPAAFAQAIALARPAGTVVVAGTRGVGSGAPGFSPDVVVFKELRVLGALGVDATAYRAA
LDLLVSGRYPFASLPRRCVRLEGAEDLLATMAGERDGVPPIHGVLTP
>Mature_366_residues
SDGAVVRALVLEAPRRLVVRQYRLPRIGDDDALVRVEACGLCGTDHEQYTGELAGGFAFVPGHETVGTIAAIGPRAEQRW
GVSAGDRVAVEVFQSCRQCANCRGGEYRRCVRHGLADMYGFIPVDREPGLWGGYAEYQYLAPDSMVLRVAGDLSPEVATL
FNPLGAGIRWGVTIPETKPGDVVAVLGPGIRGLCAAAAAKGAGAGFVMVTGLGPRDADRLALAAQFGADLAVDVAIDDPV
AALTEQTGGLADVVVDVTAKAPAAFAQAIALARPAGTVVVAGTRGVGSGAPGFSPDVVVFKELRVLGALGVDATAYRAAL
DLLVSGRYPFASLPRRCVRLEGAEDLLATMAGERDGVPPIHGVLTP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family

Homologues:

Organism=Homo sapiens, GI156627571, Length=290, Percent_Identity=28.9655172413793, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI4501929, Length=360, Percent_Identity=21.1111111111111, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI34577061, Length=328, Percent_Identity=23.1707317073171, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI4501933, Length=360, Percent_Identity=20.8333333333333, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI226510992, Length=342, Percent_Identity=28.9473684210526, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790045, Length=342, Percent_Identity=28.3625730994152, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1788073, Length=337, Percent_Identity=25.2225519287834, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1788075, Length=311, Percent_Identity=26.3665594855305, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787863, Length=330, Percent_Identity=25.1515151515152, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87082125, Length=350, Percent_Identity=29.7142857142857, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI87081918, Length=283, Percent_Identity=29.3286219081272, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788407, Length=287, Percent_Identity=25.0871080139373, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=342, Percent_Identity=28.0701754385965, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17562878, Length=344, Percent_Identity=28.1976744186047, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562584, Length=346, Percent_Identity=26.878612716763, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323099, Length=340, Percent_Identity=27.9411764705882, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6322619, Length=349, Percent_Identity=26.0744985673352, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6319955, Length=349, Percent_Identity=26.0744985673352, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6319258, Length=234, Percent_Identity=27.3504273504274, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17137530, Length=255, Percent_Identity=27.0588235294118, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17737897, Length=259, Percent_Identity=28.957528957529, Blast_Score=81, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADH_MYCTU (O53904)

Other databases:

- EMBL:   BX842577
- EMBL:   AE000516
- PIR:   C70820
- RefSeq:   NP_216046.1
- RefSeq:   NP_336034.1
- ProteinModelPortal:   O53904
- SMR:   O53904
- EnsemblBacteria:   EBMYCT00000002218
- EnsemblBacteria:   EBMYCT00000069758
- GeneID:   886426
- GeneID:   924374
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT1581
- KEGG:   mtu:Rv1530
- TIGR:   MT1581
- TubercuList:   Rv1530
- GeneTree:   EBGT00050000015148
- HOGENOM:   HBG753318
- OMA:   VEYPAYR
- ProtClustDB:   CLSK791228
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11695

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N; SSF50129 GroES_like

EC number: =1.1.1.1

Molecular weight: Translated: 37997; Mature: 37866

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDGAVVRALVLEAPRRLVVRQYRLPRIGDDDALVRVEACGLCGTDHEQYTGELAGGFAF
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCEEE
VPGHETVGTIAAIGPRAEQRWGVSAGDRVAVEVFQSCRQCANCRGGEYRRCVRHGLADMY
ECCCCCHHHHEECCCCCHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
GFIPVDREPGLWGGYAEYQYLAPDSMVLRVAGDLSPEVATLFNPLGAGIRWGVTIPETKP
CCEECCCCCCCCCCCCCEEEECCCCEEEEEECCCCHHHHHHHHHHCCCEEECEECCCCCC
GDVVAVLGPGIRGLCAAAAAKGAGAGFVMVTGLGPRDADRLALAAQFGADLAVDVAIDDP
CCEEEEECCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCC
VAALTEQTGGLADVVVDVTAKAPAAFAQAIALARPAGTVVVAGTRGVGSGAPGFSPDVVV
HHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHH
FKELRVLGALGVDATAYRAALDLLVSGRYPFASLPRRCVRLEGAEDLLATMAGERDGVPP
HHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCC
IHGVLTP
CCCCCCC
>Mature Secondary Structure 
SDGAVVRALVLEAPRRLVVRQYRLPRIGDDDALVRVEACGLCGTDHEQYTGELAGGFAF
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCEEE
VPGHETVGTIAAIGPRAEQRWGVSAGDRVAVEVFQSCRQCANCRGGEYRRCVRHGLADMY
ECCCCCHHHHEECCCCCHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
GFIPVDREPGLWGGYAEYQYLAPDSMVLRVAGDLSPEVATLFNPLGAGIRWGVTIPETKP
CCEECCCCCCCCCCCCCEEEECCCCEEEEEECCCCHHHHHHHHHHCCCEEECEECCCCCC
GDVVAVLGPGIRGLCAAAAAKGAGAGFVMVTGLGPRDADRLALAAQFGADLAVDVAIDDP
CCEEEEECCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCC
VAALTEQTGGLADVVVDVTAKAPAAFAQAIALARPAGTVVVAGTRGVGSGAPGFSPDVVV
HHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHH
FKELRVLGALGVDATAYRAALDLLVSGRYPFASLPRRCVRLEGAEDLLATMAGERDGVPP
HHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCC
IHGVLTP
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036