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The map label for this gene is bioF [C]

Identifier: 148654167

GI number: 148654167

Start: 2953257

End: 2954486

Strand: Direct

Name: bioF [C]

Synonym: PsycPRwf_2370

Alternate gene names: 148654167

Gene position: 2953257-2954486 (Clockwise)

Preceding gene: 148654158

Following gene: 148654170

Centisome position: 99.14

GC content: 46.26

Gene sequence:

>1230_bases
ATGAGCAGCCCCACAAGCTCAAGCGTTGCGGCGCTACTAGACACTTTAAAATCAAAAGAGCAGTACCGAAAGCTGCCTGG
TATCAGACATGAAAACCAATGGATTGTCTTAGATAATAAGCAGCTATTAAATATTTCAAGTAATGATTATCTGGGGCTTG
GTAATGATACCCAGCTACAATCGCAGTTTTTGAGTGATTTGCAAGCAATGCCAGATAGCCAGAGGCCTAAGATGGGTGCC
ACCTCTTCTCGGCTGTTGACCGGTAATCACAGTCAACTTCCCTTATTAGAAGCGGAGCTGCTAGAGTGGTATACACTTGC
TTTGCCAGAGGCGCAGCGCTCAACGTGTAACAAATCTGTGTTGGTGGTCAATAGCGGCTATCACGCCAATATAGGTATCT
TGCCAGCACTGGCTAAGCTGCCGCTTAATACCTTAATATTGACCGACACGTTAATTCACGCCAGCCTTATAGATGGTGTG
CGCCTTATTGGCAACAAGCACCCACACTGTACCTATCAGCGCTATCGCCATAATGATATGCAGCACCTAGCCACTTTGAT
TGAGCAGGCGGGTGATGAGATACAACGCATTATTGTGGTCACAGAAAGTATCTTTAGTATGGATGGTGATCGAGCCAACT
TAAAAGCCTTAGTCAAGCTCAAGGCCGGCGACCCTCGCATTGAGCTGTATATTGACGAGGCACATGCAGTGGGTGTGCTC
GGATATAATGGACTTGGACTTGCTGAAGAAACTCAGACATTAGAGGATATAGATTATATCGTGGGTACTTTTGGCAAAGC
CTTTGCCTCGATGGGTGCTTATGTGATTTGTGATGCCTCTGTTCGAGAGTGGTTGATTAATCAAATGCGCTCTTTTATCT
TTAGTACAGCGCTACCGCCCATTACCCACTGCTGGACTCGATTTATTTTGGCCAAAATGCCTTCGCTATATCAATCACGC
AGTCACTTAGCCAATATATCACGCCGCGTATCTTACGCCATTCACAATGACTCAGCTGCGCAATATGAGTCGCCCATTAT
TCCTTATATATTAGGCGATAATGCCAGCGCTATAAAAAAAGCTCAGGCGCTGCAGCAAGCAGGATTTTATGCCCTGCCCA
TTCGTCCGCCGACTGTGCCTGTAGGTACCTCACGCATTCGACTGGTCATGAATGCTAAGCTCAGTGATGATGACTGTAGC
CGGCTTATTGAGCAGTTATCTGGTTCATAA

Upstream 100 bases:

>100_bases
CCCCTTTTAGCAATAAAACAGATATATTGTCCATTCTTTTGGACGATTGACGGGCCAAAATAAGCCTTTTATATCAATAA
AAAATCAAGGATGGACATCG

Downstream 100 bases:

>100_bases
GTCAACGAAATCACTAGCCGCTTAACCAGCCATTTAACCAGCCATTTAACCAGTCGCTCAGTAAGTTAAGCCGTTAGATG
ATTGATTATTTAGCTCTTAT

Product: class I/II aminotransferase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MSSPTSSSVAALLDTLKSKEQYRKLPGIRHENQWIVLDNKQLLNISSNDYLGLGNDTQLQSQFLSDLQAMPDSQRPKMGA
TSSRLLTGNHSQLPLLEAELLEWYTLALPEAQRSTCNKSVLVVNSGYHANIGILPALAKLPLNTLILTDTLIHASLIDGV
RLIGNKHPHCTYQRYRHNDMQHLATLIEQAGDEIQRIIVVTESIFSMDGDRANLKALVKLKAGDPRIELYIDEAHAVGVL
GYNGLGLAEETQTLEDIDYIVGTFGKAFASMGAYVICDASVREWLINQMRSFIFSTALPPITHCWTRFILAKMPSLYQSR
SHLANISRRVSYAIHNDSAAQYESPIIPYILGDNASAIKKAQALQQAGFYALPIRPPTVPVGTSRIRLVMNAKLSDDDCS
RLIEQLSGS

Sequences:

>Translated_409_residues
MSSPTSSSVAALLDTLKSKEQYRKLPGIRHENQWIVLDNKQLLNISSNDYLGLGNDTQLQSQFLSDLQAMPDSQRPKMGA
TSSRLLTGNHSQLPLLEAELLEWYTLALPEAQRSTCNKSVLVVNSGYHANIGILPALAKLPLNTLILTDTLIHASLIDGV
RLIGNKHPHCTYQRYRHNDMQHLATLIEQAGDEIQRIIVVTESIFSMDGDRANLKALVKLKAGDPRIELYIDEAHAVGVL
GYNGLGLAEETQTLEDIDYIVGTFGKAFASMGAYVICDASVREWLINQMRSFIFSTALPPITHCWTRFILAKMPSLYQSR
SHLANISRRVSYAIHNDSAAQYESPIIPYILGDNASAIKKAQALQQAGFYALPIRPPTVPVGTSRIRLVMNAKLSDDDCS
RLIEQLSGS
>Mature_408_residues
SSPTSSSVAALLDTLKSKEQYRKLPGIRHENQWIVLDNKQLLNISSNDYLGLGNDTQLQSQFLSDLQAMPDSQRPKMGAT
SSRLLTGNHSQLPLLEAELLEWYTLALPEAQRSTCNKSVLVVNSGYHANIGILPALAKLPLNTLILTDTLIHASLIDGVR
LIGNKHPHCTYQRYRHNDMQHLATLIEQAGDEIQRIIVVTESIFSMDGDRANLKALVKLKAGDPRIELYIDEAHAVGVLG
YNGLGLAEETQTLEDIDYIVGTFGKAFASMGAYVICDASVREWLINQMRSFIFSTALPPITHCWTRFILAKMPSLYQSRS
HLANISRRVSYAIHNDSAAQYESPIIPYILGDNASAIKKAQALQQAGFYALPIRPPTVPVGTSRIRLVMNAKLSDDDCSR
LIEQLSGS

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=403, Percent_Identity=30.0248138957816, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI284448556, Length=370, Percent_Identity=30.8108108108108, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI83977442, Length=370, Percent_Identity=31.0810810810811, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI83977440, Length=370, Percent_Identity=31.0810810810811, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI83977444, Length=370, Percent_Identity=31.0810810810811, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI4758668, Length=382, Percent_Identity=25.130890052356, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI4502025, Length=360, Percent_Identity=27.2222222222222, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI40316939, Length=360, Percent_Identity=27.2222222222222, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI119220554, Length=392, Percent_Identity=23.2142857142857, Blast_Score=92, Evalue=8e-19,
Organism=Escherichia coli, GI1786993, Length=388, Percent_Identity=31.9587628865979, Blast_Score=165, Evalue=6e-42,
Organism=Escherichia coli, GI1790046, Length=378, Percent_Identity=32.010582010582, Blast_Score=159, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI71994529, Length=379, Percent_Identity=28.7598944591029, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI32566772, Length=392, Percent_Identity=22.4489795918367, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17560914, Length=260, Percent_Identity=26.9230769230769, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17560912, Length=260, Percent_Identity=26.9230769230769, Blast_Score=85, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320438, Length=378, Percent_Identity=26.984126984127, Blast_Score=112, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6320267, Length=324, Percent_Identity=27.4691358024691, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6323954, Length=247, Percent_Identity=27.9352226720648, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24662918, Length=374, Percent_Identity=29.4117647058824, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI17137420, Length=371, Percent_Identity=30.4582210242588, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI17136286, Length=382, Percent_Identity=25.3926701570681, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 45239; Mature: 45108

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPTSSSVAALLDTLKSKEQYRKLPGIRHENQWIVLDNKQLLNISSNDYLGLGNDTQLQ
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEECCCCEEECCCCHHHH
SQFLSDLQAMPDSQRPKMGATSSRLLTGNHSQLPLLEAELLEWYTLALPEAQRSTCNKSV
HHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCEE
LVVNSGYHANIGILPALAKLPLNTLILTDTLIHASLIDGVRLIGNKHPHCTYQRYRHNDM
EEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCH
QHLATLIEQAGDEIQRIIVVTESIFSMDGDRANLKALVKLKAGDPRIELYIDEAHAVGVL
HHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEEECCCEEEEE
GYNGLGLAEETQTLEDIDYIVGTFGKAFASMGAYVICDASVREWLINQMRSFIFSTALPP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHCCCH
ITHCWTRFILAKMPSLYQSRSHLANISRRVSYAIHNDSAAQYESPIIPYILGDNASAIKK
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHEEEEECCCHHHHCCCCCCEEECCCHHHHHH
AQALQQAGFYALPIRPPTVPVGTSRIRLVMNAKLSDDDCSRLIEQLSGS
HHHHHHCCCEEECCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
SSPTSSSVAALLDTLKSKEQYRKLPGIRHENQWIVLDNKQLLNISSNDYLGLGNDTQLQ
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEECCCCEEECCCCHHHH
SQFLSDLQAMPDSQRPKMGATSSRLLTGNHSQLPLLEAELLEWYTLALPEAQRSTCNKSV
HHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCEE
LVVNSGYHANIGILPALAKLPLNTLILTDTLIHASLIDGVRLIGNKHPHCTYQRYRHNDM
EEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCH
QHLATLIEQAGDEIQRIIVVTESIFSMDGDRANLKALVKLKAGDPRIELYIDEAHAVGVL
HHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEEECCCEEEEE
GYNGLGLAEETQTLEDIDYIVGTFGKAFASMGAYVICDASVREWLINQMRSFIFSTALPP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHCCCH
ITHCWTRFILAKMPSLYQSRSHLANISRRVSYAIHNDSAAQYESPIIPYILGDNASAIKK
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHEEEEECCCHHHHCCCCCCEEECCCHHHHHH
AQALQQAGFYALPIRPPTVPVGTSRIRLVMNAKLSDDDCSRLIEQLSGS
HHHHHHCCCEEECCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA