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The map label for this gene is hemN [H]

Identifier: 148654158

GI number: 148654158

Start: 2942659

End: 2944227

Strand: Direct

Name: hemN [H]

Synonym: PsycPRwf_2361

Alternate gene names: 148654158

Gene position: 2942659-2944227 (Clockwise)

Preceding gene: 148654157

Following gene: 148654167

Centisome position: 98.78

GC content: 46.34

Gene sequence:

>1569_bases
ATGACTCATTCTGCCATTTTTACAGACCAAGCCAGTCTTCCCCCATCTACTGAGCGTCCGGATTTTTCTCCTAGCAATCC
TTATGCCAAAAAACAGTTTGATGCAGCGACCTCTGAGATGCCGCAGTTAGAATATGATCAGGCGTTAATTCATAAATATA
ATCGTTCAGGGCCACGCTATACCTCATACCCTACTGCGCTTGAGTTTAAGCCCATTGAAGCCGGCGTTGAATTAGAGGTT
TTGACCCGCCGCGACCCCAATGCGCCCCTATCGCTTTATTTTCACATTCCCTTTTGTCGCCATCTTTGCTACTACTGTGC
TTGCAATAAGATCATCACCAAAAAGAACAGCGATGCCGGTGACTACCTAGCGTATCTAAAAAATGAAGTAAAACAAAAGC
GTGCCTTATTACAACGTCCTGACTCAGGTGGTAAGCCTTATGTCAAGCAGCTGCATTTGGGTGGGGGTACACCGACTTTC
TTTAGTGATGAGGAACTGACTGAGCTTTGGCAGTTTTTGCAGACCCAGTTTGAATTTGCGCCCACCTCAGTTGAGCAAGT
GAGCGATGAGCACCCAGAAATGGGAGACTATTCTGTAGAGATTGACCCTCGAGAGATTAGAGATACCACGTTGAGCGTGT
TACGCAGTTTGGGCTTTAACCGAGTCAGCTTCGGGGTGCAGGACTTGGATGACAAGGTTCAGATTGCGGTGAACCGAGTG
CAATCTGAAGCGCTTATCCGTAGTGTGATGCAAGAGACCCGCCGCTTAGGCTTTCAGTCGACCAATATTGACTTAATCTA
TGGGCTGCCGCATCAAACGCCGCAGACGTTCGCTAAGACGGTACAGACCATTATTGACATCTCGCCTGATAGATTGTCCA
TCTTTAACTATGCGCACCTGCCCGATCGCTTTAAGTCGCAGCGTCAGATTAAAGAGGAGGATTTACCGACACCAGCCGAG
AAGCTTGAGATGTTCAGTGATACCATAGCCGCGTTGAATACAGCTGGCTACCAGTACATCGGTATCGATCACTTTGCGAA
GCCTGATGACAGCATGGCCATCGCTCAGCGTGATGGTATTTTGCACCGCAACTTCCAAGGCTATACCATCTTAGGTGACT
GCGACTTATTGGGCTTTGGTGTCTCCTCTATCAGTCAAATTAACAGCACCTTGTATGCCAATAAGGGCAATACCTCTACT
CATATTCTACAAAACCACACAGATTTAAAAGAGTATGAGGCCATGGTAGATGCTGGCAAACTACCGGCGGTACGCCATAT
CAAAACCAGCATACAAGACCGTCTGCGTGGTTATGTGATTTCCAATCTGTTGTGCCATGATTACATTGATTTTAAGGACT
TAAATCAAAAATTTGGGATAGATGCCATCACATTTTTTATTGATGAAATTCAGCAGCTCGGTGAGATGCAGCAAGACCGA
CTTATAGATATGGATGCTGCCGGTATCCGTATTTTGCCAAAGGGACGCCTGCTTGCCCGCAACGTGGCCATGGTATTTGA
TAGCTATTTGGCAAGTAAAGAAAAAAACCGCTTCTCTAAAGTGATTTAG

Upstream 100 bases:

>100_bases
GGCAGATTACAGCTACCTTAGGATAATTTGTTATAATTGATTCGATTTTAACCCTCTCCTCATAGCTCCTGTTTATCGGC
TCTCCGATAAGGCCAATCTT

Downstream 100 bases:

>100_bases
TGCTCTAAAAGAGTCGTCATTGCAGCAAAACCTTTAAATAAAGCGGCCAATATAACCCCCTGTTATTGACCTAAAAAAAC
CGACACCACGTTAGATGGTA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 522; Mature: 521

Protein sequence:

>522_residues
MTHSAIFTDQASLPPSTERPDFSPSNPYAKKQFDAATSEMPQLEYDQALIHKYNRSGPRYTSYPTALEFKPIEAGVELEV
LTRRDPNAPLSLYFHIPFCRHLCYYCACNKIITKKNSDAGDYLAYLKNEVKQKRALLQRPDSGGKPYVKQLHLGGGTPTF
FSDEELTELWQFLQTQFEFAPTSVEQVSDEHPEMGDYSVEIDPREIRDTTLSVLRSLGFNRVSFGVQDLDDKVQIAVNRV
QSEALIRSVMQETRRLGFQSTNIDLIYGLPHQTPQTFAKTVQTIIDISPDRLSIFNYAHLPDRFKSQRQIKEEDLPTPAE
KLEMFSDTIAALNTAGYQYIGIDHFAKPDDSMAIAQRDGILHRNFQGYTILGDCDLLGFGVSSISQINSTLYANKGNTST
HILQNHTDLKEYEAMVDAGKLPAVRHIKTSIQDRLRGYVISNLLCHDYIDFKDLNQKFGIDAITFFIDEIQQLGEMQQDR
LIDMDAAGIRILPKGRLLARNVAMVFDSYLASKEKNRFSKVI

Sequences:

>Translated_522_residues
MTHSAIFTDQASLPPSTERPDFSPSNPYAKKQFDAATSEMPQLEYDQALIHKYNRSGPRYTSYPTALEFKPIEAGVELEV
LTRRDPNAPLSLYFHIPFCRHLCYYCACNKIITKKNSDAGDYLAYLKNEVKQKRALLQRPDSGGKPYVKQLHLGGGTPTF
FSDEELTELWQFLQTQFEFAPTSVEQVSDEHPEMGDYSVEIDPREIRDTTLSVLRSLGFNRVSFGVQDLDDKVQIAVNRV
QSEALIRSVMQETRRLGFQSTNIDLIYGLPHQTPQTFAKTVQTIIDISPDRLSIFNYAHLPDRFKSQRQIKEEDLPTPAE
KLEMFSDTIAALNTAGYQYIGIDHFAKPDDSMAIAQRDGILHRNFQGYTILGDCDLLGFGVSSISQINSTLYANKGNTST
HILQNHTDLKEYEAMVDAGKLPAVRHIKTSIQDRLRGYVISNLLCHDYIDFKDLNQKFGIDAITFFIDEIQQLGEMQQDR
LIDMDAAGIRILPKGRLLARNVAMVFDSYLASKEKNRFSKVI
>Mature_521_residues
THSAIFTDQASLPPSTERPDFSPSNPYAKKQFDAATSEMPQLEYDQALIHKYNRSGPRYTSYPTALEFKPIEAGVELEVL
TRRDPNAPLSLYFHIPFCRHLCYYCACNKIITKKNSDAGDYLAYLKNEVKQKRALLQRPDSGGKPYVKQLHLGGGTPTFF
SDEELTELWQFLQTQFEFAPTSVEQVSDEHPEMGDYSVEIDPREIRDTTLSVLRSLGFNRVSFGVQDLDDKVQIAVNRVQ
SEALIRSVMQETRRLGFQSTNIDLIYGLPHQTPQTFAKTVQTIIDISPDRLSIFNYAHLPDRFKSQRQIKEEDLPTPAEK
LEMFSDTIAALNTAGYQYIGIDHFAKPDDSMAIAQRDGILHRNFQGYTILGDCDLLGFGVSSISQINSTLYANKGNTSTH
ILQNHTDLKEYEAMVDAGKLPAVRHIKTSIQDRLRGYVISNLLCHDYIDFKDLNQKFGIDAITFFIDEIQQLGEMQQDRL
IDMDAAGIRILPKGRLLARNVAMVFDSYLASKEKNRFSKVI

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=259, Percent_Identity=27.027027027027, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI87082341, Length=482, Percent_Identity=45.4356846473029, Blast_Score=429, Evalue=1e-121,
Organism=Escherichia coli, GI1789325, Length=260, Percent_Identity=25.7692307692308, Blast_Score=94, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 59284; Mature: 59153

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHSAIFTDQASLPPSTERPDFSPSNPYAKKQFDAATSEMPQLEYDQALIHKYNRSGPRY
CCCCCEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCC
TSYPTALEFKPIEAGVELEVLTRRDPNAPLSLYFHIPFCRHLCYYCACNKIITKKNSDAG
CCCCCEEEEEECCCCCEEEEEECCCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCHH
DYLAYLKNEVKQKRALLQRPDSGGKPYVKQLHLGGGTPTFFSDEELTELWQFLQTQFEFA
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHCC
PTSVEQVSDEHPEMGDYSVEIDPREIRDTTLSVLRSLGFNRVSFGVQDLDDKVQIAVNRV
CCHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHHCCCCEECCCHHCCCHHHHHHHHHH
QSEALIRSVMQETRRLGFQSTNIDLIYGLPHQTPQTFAKTVQTIIDISPDRLSIFNYAHL
HHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEHHEECCC
PDRFKSQRQIKEEDLPTPAEKLEMFSDTIAALNTAGYQYIGIDHFAKPDDSMAIAQRDGI
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCEEHHHHCCC
LHRNFQGYTILGDCDLLGFGVSSISQINSTLYANKGNTSTHILQNHTDLKEYEAMVDAGK
EECCCCCEEEEECCCHHHCCHHHHHHHHHHEEECCCCCCCEEECCCCHHHHHHHHHHCCC
LPAVRHIKTSIQDRLRGYVISNLLCHDYIDFKDLNQKFGIDAITFFIDEIQQLGEMQQDR
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHC
LIDMDAAGIRILPKGRLLARNVAMVFDSYLASKEKNRFSKVI
EEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
THSAIFTDQASLPPSTERPDFSPSNPYAKKQFDAATSEMPQLEYDQALIHKYNRSGPRY
CCCCEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCC
TSYPTALEFKPIEAGVELEVLTRRDPNAPLSLYFHIPFCRHLCYYCACNKIITKKNSDAG
CCCCCEEEEEECCCCCEEEEEECCCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCHH
DYLAYLKNEVKQKRALLQRPDSGGKPYVKQLHLGGGTPTFFSDEELTELWQFLQTQFEFA
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHCC
PTSVEQVSDEHPEMGDYSVEIDPREIRDTTLSVLRSLGFNRVSFGVQDLDDKVQIAVNRV
CCHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHHCCCCEECCCHHCCCHHHHHHHHHH
QSEALIRSVMQETRRLGFQSTNIDLIYGLPHQTPQTFAKTVQTIIDISPDRLSIFNYAHL
HHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEHHEECCC
PDRFKSQRQIKEEDLPTPAEKLEMFSDTIAALNTAGYQYIGIDHFAKPDDSMAIAQRDGI
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCEEHHHHCCC
LHRNFQGYTILGDCDLLGFGVSSISQINSTLYANKGNTSTHILQNHTDLKEYEAMVDAGK
EECCCCCEEEEECCCHHHCCHHHHHHHHHHEEECCCCCCCEEECCCCHHHHHHHHHHCCC
LPAVRHIKTSIQDRLRGYVISNLLCHDYIDFKDLNQKFGIDAITFFIDEIQQLGEMQQDR
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHC
LIDMDAAGIRILPKGRLLARNVAMVFDSYLASKEKNRFSKVI
EEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9767567; 10984043 [H]