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The map label for this gene is 148654089

Identifier: 148654089

GI number: 148654089

Start: 2858343

End: 2860574

Strand: Direct

Name: 148654089

Synonym: PsycPRwf_2292

Alternate gene names: NA

Gene position: 2858343-2860574 (Clockwise)

Preceding gene: 148654087

Following gene: 148654093

Centisome position: 95.95

GC content: 50.04

Gene sequence:

>2232_bases
ATGCTATTAACCTCTTTATGCGCCACCTCCGCTTTGTCTTTATCTTTACAGACAATCAACTGCCGTAACGACTCTAACCC
CATCTCTTTAGCGAGCTCTGCATCGGCCTTCTATGTTAAAGATAATGGCTCATTAGAGAACTCTCAACTAAGCACAAGTG
ACCGAGTAGCACCTATTGCGGCAAGTACTCACACTGGCGCTAGTCATCCTCAGCTTAAACCCAATAAAGCGCCATATTTA
CTCGGTGCAGCTCAAGCTGATATCACAGGCGCTGCGGCAGAGACAGGTATGTTCGGTTATGCCGCGCAGCAAGTGGCTCA
AGGCATCAATGATAGATTGTACGCTCATGCCTTTATTATTGTAGACAATCAGGCAGACAGCGCACAAACTACTCAAAACA
GCGCCCGTATTGTCTATGTATCAGCCGATATGGGTGCCATGTTTAATGCGGTCAGACTCGAAGTGTTAAAACGCTTGCAC
GCCTTGTATGGCCCACTATACACAGATGCCAACGTCATGCTCACGGCTACCCATACCCATGTGGGCAATGCCGGCTACTC
CCATCAAAGATTGTATCAAATTGCCAGTAAAGATGACACCACTGCCGGCTATAGCGAACAGAACTTCACTGCCATAGTGG
ATGGCATCGTACGCGCTATTAGTAAGGCGCATCAAAACTTAACACCCGGCACCTTATCACTAGCGCAAGGCAAGCTCACA
GGCGCGACACGCAACCGCTCAGCCGCCGCTTATAACAATAATCCCGATGCCAAAGCCTATGACAGTAATGTCAATGACAC
CATGACTCAGCTGCGCCTTGATGATCAAAATGGCAAGCCTTTGGGCGCCATTAACTGGTTTGCCATTCACCCAACCAGCT
TTAGCAATCAGTTTATGTACCTAAGTGCTGATAATAAAGGCTATGCTCAGCAAGGCATGCAAGCGGCCATTACCAAAAAA
ACAGGCCAGCCCTTTGTGGCCGCCTTTGCCAACGCTGATGAGGGAGATGTGGTGGCCGCAGGAGGTAATGCCCACTCCTC
GGCAGGCTTCGAGGGAGAAGATGAGGAATGGCATAACGTGGTTCGTGATGGCTCCTTGCAGCTTAATAAAGCACTTGAGC
TATGGGACAAAGCCGAGCCGGTAGTTGGACCCATTGACACACGAGCCCGCTGGATTGATTTAAATGGCTATGTGGTGGAT
GCTCAATACACCCACGGTGCTGGCGAGCAAAGATTATGTGTGCCAGCTCGCGGCTATGCGTTTGCCGCCGGTGCAGAAAA
TGGCCCCTCCGACATACCCGGTATCTATGAAGGTATGACCAAAGACTCTTTGAGTATCACTGACAAGATTAACAAGACCG
ATACTTCGATATTGGGCAGCGCTACTCGAGCCGCTTTTGGTGTGGTGGGCGCTGTCAGTCAAGATCCGTGTCAGGCCGAA
AAGCCGGTGCTCCTACCTACCGGTAAATTGGGCTGGGTCAATAGCAAACAGCCGGTACAATTAATGCGCATTGCCAACCT
AGCCTTAGTGGCCATACCCGGAGAGCCAACCACCATGGTGGGGCGGCGTTTGCAATCTGCGGTGCTGGATGAATTAAAAG
ACAGCGGCGTCAATACTGTCATCGTCAATGGACTGGCCAATAACTATAGCGGCTATGTTGCGACCCGTGAGGAATATGCA
CTGCAACATTATGAGGGCGCCTCTACCGAATATGGCCCATATCAAAGTAATGCCTATGTGCAAGAGTATGTACAACTGGC
TCGGGCACTCAAACACAATCAGCCGCTAAAGAACCATACCGCGCCACCTTCTATAGCAGCTGGCAAATTCGCTGAGCGAC
CCGGCGTCGTATTTGATGACAAACCCTTTAACCAAGCTTGGGGACAGGTACTTATGCAGCCCAAGCAGCATTATCAGAAG
GCCGAGGTGGTTAGTGTGAGCTTCCGCGGTGCCCATCCAAAAAATAACTTACGCACCGAGGACACCTTTTTAAAAGTGCA
GCGCCTAGTGCAAGGTAAATGGGTAGACTACCTGACGGATGCAAGCTTTGATACTCGGTACAGTTGGGCGCGCGAGGGCA
TCACGTATAGCAAAGTTACCATTGATTGGCGCATTGATGAAGACACGCCTTCTGGTACTTACCGTATATTGCATCAAGGA
GATTGGAAAAACGGATGGGACGGTAAAATCACCGCGTATGCGGGTGCGTCTTATGCTTTTGAAGTGAAATAA

Upstream 100 bases:

>100_bases
TACTGAGCTTAGCATAGTATTTGCAGCCACTGCACGCAAGCGCTAACTTAGCGGCCGCTATGTGGTTGTCTTTTATTCAC
TTTTCAATTGGCGAGGCTTT

Downstream 100 bases:

>100_bases
CCTGCATAAAAAAAGCCAGATACACGGGGTATATGGCTTCTTTAATGGGGAGAAAAGTATGAAACAAGTGTGTTGATTGC
AACGCTTAATTTAACCGCAG

Product: neutral/alkaline nonlysosomal ceramidase

Products: NA

Alternate protein names: N-CDase; NCDase; Acylsphingosine deacylase; N-acylsphingosine amidohydrolase [H]

Number of amino acids: Translated: 743; Mature: 743

Protein sequence:

>743_residues
MLLTSLCATSALSLSLQTINCRNDSNPISLASSASAFYVKDNGSLENSQLSTSDRVAPIAASTHTGASHPQLKPNKAPYL
LGAAQADITGAAAETGMFGYAAQQVAQGINDRLYAHAFIIVDNQADSAQTTQNSARIVYVSADMGAMFNAVRLEVLKRLH
ALYGPLYTDANVMLTATHTHVGNAGYSHQRLYQIASKDDTTAGYSEQNFTAIVDGIVRAISKAHQNLTPGTLSLAQGKLT
GATRNRSAAAYNNNPDAKAYDSNVNDTMTQLRLDDQNGKPLGAINWFAIHPTSFSNQFMYLSADNKGYAQQGMQAAITKK
TGQPFVAAFANADEGDVVAAGGNAHSSAGFEGEDEEWHNVVRDGSLQLNKALELWDKAEPVVGPIDTRARWIDLNGYVVD
AQYTHGAGEQRLCVPARGYAFAAGAENGPSDIPGIYEGMTKDSLSITDKINKTDTSILGSATRAAFGVVGAVSQDPCQAE
KPVLLPTGKLGWVNSKQPVQLMRIANLALVAIPGEPTTMVGRRLQSAVLDELKDSGVNTVIVNGLANNYSGYVATREEYA
LQHYEGASTEYGPYQSNAYVQEYVQLARALKHNQPLKNHTAPPSIAAGKFAERPGVVFDDKPFNQAWGQVLMQPKQHYQK
AEVVSVSFRGAHPKNNLRTEDTFLKVQRLVQGKWVDYLTDASFDTRYSWAREGITYSKVTIDWRIDEDTPSGTYRILHQG
DWKNGWDGKITAYAGASYAFEVK

Sequences:

>Translated_743_residues
MLLTSLCATSALSLSLQTINCRNDSNPISLASSASAFYVKDNGSLENSQLSTSDRVAPIAASTHTGASHPQLKPNKAPYL
LGAAQADITGAAAETGMFGYAAQQVAQGINDRLYAHAFIIVDNQADSAQTTQNSARIVYVSADMGAMFNAVRLEVLKRLH
ALYGPLYTDANVMLTATHTHVGNAGYSHQRLYQIASKDDTTAGYSEQNFTAIVDGIVRAISKAHQNLTPGTLSLAQGKLT
GATRNRSAAAYNNNPDAKAYDSNVNDTMTQLRLDDQNGKPLGAINWFAIHPTSFSNQFMYLSADNKGYAQQGMQAAITKK
TGQPFVAAFANADEGDVVAAGGNAHSSAGFEGEDEEWHNVVRDGSLQLNKALELWDKAEPVVGPIDTRARWIDLNGYVVD
AQYTHGAGEQRLCVPARGYAFAAGAENGPSDIPGIYEGMTKDSLSITDKINKTDTSILGSATRAAFGVVGAVSQDPCQAE
KPVLLPTGKLGWVNSKQPVQLMRIANLALVAIPGEPTTMVGRRLQSAVLDELKDSGVNTVIVNGLANNYSGYVATREEYA
LQHYEGASTEYGPYQSNAYVQEYVQLARALKHNQPLKNHTAPPSIAAGKFAERPGVVFDDKPFNQAWGQVLMQPKQHYQK
AEVVSVSFRGAHPKNNLRTEDTFLKVQRLVQGKWVDYLTDASFDTRYSWAREGITYSKVTIDWRIDEDTPSGTYRILHQG
DWKNGWDGKITAYAGASYAFEVK
>Mature_743_residues
MLLTSLCATSALSLSLQTINCRNDSNPISLASSASAFYVKDNGSLENSQLSTSDRVAPIAASTHTGASHPQLKPNKAPYL
LGAAQADITGAAAETGMFGYAAQQVAQGINDRLYAHAFIIVDNQADSAQTTQNSARIVYVSADMGAMFNAVRLEVLKRLH
ALYGPLYTDANVMLTATHTHVGNAGYSHQRLYQIASKDDTTAGYSEQNFTAIVDGIVRAISKAHQNLTPGTLSLAQGKLT
GATRNRSAAAYNNNPDAKAYDSNVNDTMTQLRLDDQNGKPLGAINWFAIHPTSFSNQFMYLSADNKGYAQQGMQAAITKK
TGQPFVAAFANADEGDVVAAGGNAHSSAGFEGEDEEWHNVVRDGSLQLNKALELWDKAEPVVGPIDTRARWIDLNGYVVD
AQYTHGAGEQRLCVPARGYAFAAGAENGPSDIPGIYEGMTKDSLSITDKINKTDTSILGSATRAAFGVVGAVSQDPCQAE
KPVLLPTGKLGWVNSKQPVQLMRIANLALVAIPGEPTTMVGRRLQSAVLDELKDSGVNTVIVNGLANNYSGYVATREEYA
LQHYEGASTEYGPYQSNAYVQEYVQLARALKHNQPLKNHTAPPSIAAGKFAERPGVVFDDKPFNQAWGQVLMQPKQHYQK
AEVVSVSFRGAHPKNNLRTEDTFLKVQRLVQGKWVDYLTDASFDTRYSWAREGITYSKVTIDWRIDEDTPSGTYRILHQG
DWKNGWDGKITAYAGASYAFEVK

Specific function: Hydrolyzes the ceramides into sphingosine and free fatty acid at an optimal pH of 8-9 [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the neutral ceramidase family [H]

Homologues:

Organism=Homo sapiens, GI221218981, Length=739, Percent_Identity=34.6414073071719, Blast_Score=355, Evalue=7e-98,
Organism=Homo sapiens, GI221307475, Length=721, Percent_Identity=34.119278779473, Blast_Score=340, Evalue=3e-93,
Organism=Homo sapiens, GI118442845, Length=133, Percent_Identity=33.8345864661654, Blast_Score=67, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24651405, Length=712, Percent_Identity=31.1797752808989, Blast_Score=315, Evalue=8e-86,
Organism=Drosophila melanogaster, GI24651403, Length=712, Percent_Identity=31.1797752808989, Blast_Score=315, Evalue=8e-86,
Organism=Drosophila melanogaster, GI24651401, Length=712, Percent_Identity=31.1797752808989, Blast_Score=315, Evalue=8e-86,
Organism=Drosophila melanogaster, GI24651397, Length=712, Percent_Identity=31.1797752808989, Blast_Score=315, Evalue=8e-86,
Organism=Drosophila melanogaster, GI24651399, Length=712, Percent_Identity=31.1797752808989, Blast_Score=315, Evalue=8e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006823 [H]

Pfam domain/function: NA

EC number: =3.5.1.23 [H]

Molecular weight: Translated: 80401; Mature: 80401

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00287 CYSTATIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLTSLCATSALSLSLQTINCRNDSNPISLASSASAFYVKDNGSLENSQLSTSDRVAPIA
CCHHHHHHHHHHEEEEEEEECCCCCCCEEEECCCCEEEEECCCCCCCCCCCCCCCEEEEE
ASTHTGASHPQLKPNKAPYLLGAAQADITGAAAETGMFGYAAQQVAQGINDRLYAHAFII
ECCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHCCHHHHHHHHHHHCCCCCEEEEEEEE
VDNQADSAQTTQNSARIVYVSADMGAMFNAVRLEVLKRLHALYGPLYTDANVMLTATHTH
EECCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEE
VGNAGYSHQRLYQIASKDDTTAGYSEQNFTAIVDGIVRAISKAHQNLTPGTLSLAQGKLT
CCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
GATRNRSAAAYNNNPDAKAYDSNVNDTMTQLRLDDQNGKPLGAINWFAIHPTSFSNQFMY
CCCCCCCCEECCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEEEEECCCCCCCEEEE
LSADNKGYAQQGMQAAITKKTGQPFVAAFANADEGDVVAAGGNAHSSAGFEGEDEEWHNV
EECCCCCHHHHCCCEEEHHCCCCCEEEEECCCCCCCEEEECCCCCCCCCCCCCCHHHHHH
VRDGSLQLNKALELWDKAEPVVGPIDTRARWIDLNGYVVDAQYTHGAGEQRLCVPARGYA
HHCCCEEHHHHHHHHHCCCCCCCCCCCCEEEEEECCEEEEEEECCCCCCCEEEEECCCCE
FAAGAENGPSDIPGIYEGMTKDSLSITDKINKTDTSILGSATRAAFGVVGAVSQDPCQAE
EECCCCCCCCCCCHHHHCCCCCCCEEHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
KPVLLPTGKLGWVNSKQPVQLMRIANLALVAIPGEPTTMVGRRLQSAVLDELKDSGVNTV
CCEEEECCCCCCCCCCCCHHHHEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEE
IVNGLANNYSGYVATREEYALQHYEGASTEYGPYQSNAYVQEYVQLARALKHNQPLKNHT
EEECCCCCCCCEEEEHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
APPSIAAGKFAERPGVVFDDKPFNQAWGQVLMQPKQHYQKAEVVSVSFRGAHPKNNLRTE
CCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHCHHHHCCCEEEEEEEEECCCCCCCCCCH
DTFLKVQRLVQGKWVDYLTDASFDTRYSWAREGITYSKVTIDWRIDEDTPSGTYRILHQG
HHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHCCCEEEEEEEEEEECCCCCCCEEEEEECC
DWKNGWDGKITAYAGASYAFEVK
CCCCCCCCEEEEEECCEEEEEEC
>Mature Secondary Structure
MLLTSLCATSALSLSLQTINCRNDSNPISLASSASAFYVKDNGSLENSQLSTSDRVAPIA
CCHHHHHHHHHHEEEEEEEECCCCCCCEEEECCCCEEEEECCCCCCCCCCCCCCCEEEEE
ASTHTGASHPQLKPNKAPYLLGAAQADITGAAAETGMFGYAAQQVAQGINDRLYAHAFII
ECCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHCCHHHHHHHHHHHCCCCCEEEEEEEE
VDNQADSAQTTQNSARIVYVSADMGAMFNAVRLEVLKRLHALYGPLYTDANVMLTATHTH
EECCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEE
VGNAGYSHQRLYQIASKDDTTAGYSEQNFTAIVDGIVRAISKAHQNLTPGTLSLAQGKLT
CCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
GATRNRSAAAYNNNPDAKAYDSNVNDTMTQLRLDDQNGKPLGAINWFAIHPTSFSNQFMY
CCCCCCCCEECCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEEEEECCCCCCCEEEE
LSADNKGYAQQGMQAAITKKTGQPFVAAFANADEGDVVAAGGNAHSSAGFEGEDEEWHNV
EECCCCCHHHHCCCEEEHHCCCCCEEEEECCCCCCCEEEECCCCCCCCCCCCCCHHHHHH
VRDGSLQLNKALELWDKAEPVVGPIDTRARWIDLNGYVVDAQYTHGAGEQRLCVPARGYA
HHCCCEEHHHHHHHHHCCCCCCCCCCCCEEEEEECCEEEEEEECCCCCCCEEEEECCCCE
FAAGAENGPSDIPGIYEGMTKDSLSITDKINKTDTSILGSATRAAFGVVGAVSQDPCQAE
EECCCCCCCCCCCHHHHCCCCCCCEEHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
KPVLLPTGKLGWVNSKQPVQLMRIANLALVAIPGEPTTMVGRRLQSAVLDELKDSGVNTV
CCEEEECCCCCCCCCCCCHHHHEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEE
IVNGLANNYSGYVATREEYALQHYEGASTEYGPYQSNAYVQEYVQLARALKHNQPLKNHT
EEECCCCCCCCEEEEHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
APPSIAAGKFAERPGVVFDDKPFNQAWGQVLMQPKQHYQKAEVVSVSFRGAHPKNNLRTE
CCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHCHHHHCCCEEEEEEEEECCCCCCCCCCH
DTFLKVQRLVQGKWVDYLTDASFDTRYSWAREGITYSKVTIDWRIDEDTPSGTYRILHQG
HHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHCCCEEEEEEEEEEECCCCCCCEEEEEECC
DWKNGWDGKITAYAGASYAFEVK
CCCCCCCCEEEEEECCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10593963; 10984043 [H]