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The map label for this gene is dut

Identifier: 148653623

GI number: 148653623

Start: 2268424

End: 2268888

Strand: Direct

Name: dut

Synonym: PsycPRwf_1826

Alternate gene names: 148653623

Gene position: 2268424-2268888 (Clockwise)

Preceding gene: 148653622

Following gene: 148653624

Centisome position: 76.15

GC content: 46.24

Gene sequence:

>465_bases
ATGAACGCTGTACAAGTTAAAATTTTAAACCCAAAAATTGGTACTGATGCTAATTTTCCTATGCCTACTCGTGCCACCGA
TGGCTCAGCCGGTATCGACTTACGTGCTTGTATCGATGAGCCTATTACCATTAAAGCGGGCGAAACTAAATTAATTGGTA
CCGGTATGGCCATCTATATCGCTGACCCCAATTATGCCGGTATTATCCTACCACGCTCAGGCTTAGGTCATAAGCACGGT
ATCGTTTTGGGCAATCTTGTGGGCCTAATTGATGCCGATTATCAAGGGGAGCTGATGGTGAGTGTATGGAATCGCAGCGA
CACAGATTTTGTACTCAATCCTGCTGAGCGTATGGCGCAATACATGGTAGTGCCCGTAGTACGTCCAAGCTTTCAAGTGG
TCGAAGAATTTAATGAATTAAGTGCTCGTGGTGCCGGCGGCTTTGGTCATTCGGGTCGTCAGTAA

Upstream 100 bases:

>100_bases
CTTTTTTGTGTCTATAGATTAGACTAATTGCGCTTTAACTCAACTGCTCAGTGCCGCCATAGGCGAATTACCCAAACATA
AAATAGATAACGGATAAGTT

Downstream 100 bases:

>100_bases
GCCAGTTTTATTTGTATTTGTTAAAAAAATATAAGATGATGAGACAGAAAAGCAATTCTGTTGGAGCCGTCCCTTTTGCC
CAAGACCTCATTTTTAGCAC

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase

Number of amino acids: Translated: 154; Mature: 154

Protein sequence:

>154_residues
MNAVQVKILNPKIGTDANFPMPTRATDGSAGIDLRACIDEPITIKAGETKLIGTGMAIYIADPNYAGIILPRSGLGHKHG
IVLGNLVGLIDADYQGELMVSVWNRSDTDFVLNPAERMAQYMVVPVVRPSFQVVEEFNELSARGAGGFGHSGRQ

Sequences:

>Translated_154_residues
MNAVQVKILNPKIGTDANFPMPTRATDGSAGIDLRACIDEPITIKAGETKLIGTGMAIYIADPNYAGIILPRSGLGHKHG
IVLGNLVGLIDADYQGELMVSVWNRSDTDFVLNPAERMAQYMVVPVVRPSFQVVEEFNELSARGAGGFGHSGRQ
>Mature_154_residues
MNAVQVKILNPKIGTDANFPMPTRATDGSAGIDLRACIDEPITIKAGETKLIGTGMAIYIADPNYAGIILPRSGLGHKHG
IVLGNLVGLIDADYQGELMVSVWNRSDTDFVLNPAERMAQYMVVPVVRPSFQVVEEFNELSARGAGGFGHSGRQ

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family

Homologues:

Organism=Homo sapiens, GI4503423, Length=132, Percent_Identity=34.0909090909091, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI70906444, Length=132, Percent_Identity=34.0909090909091, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI70906441, Length=132, Percent_Identity=34.0909090909091, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1790071, Length=154, Percent_Identity=59.7402597402597, Blast_Score=199, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI71988561, Length=140, Percent_Identity=37.1428571428571, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319729, Length=152, Percent_Identity=37.5, Blast_Score=84, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19921126, Length=131, Percent_Identity=33.587786259542, Blast_Score=76, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24583610, Length=131, Percent_Identity=33.587786259542, Blast_Score=76, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DUT_PSYWF (A5WGH5)

Other databases:

- EMBL:   CP000713
- RefSeq:   YP_001280716.1
- ProteinModelPortal:   A5WGH5
- SMR:   A5WGH5
- STRING:   A5WGH5
- GeneID:   5204869
- GenomeReviews:   CP000713_GR
- KEGG:   prw:PsycPRwf_1826
- eggNOG:   COG0756
- HOGENOM:   HBG436079
- OMA:   LDLRACI
- ProtClustDB:   PRK00601
- BioCyc:   PSP56811:PSYCPRWF_1826-MONOMER
- HAMAP:   MF_00116
- InterPro:   IPR008180
- InterPro:   IPR008181
- TIGRFAMs:   TIGR00576

Pfam domain/function: PF00692 dUTPase

EC number: =3.6.1.23

Molecular weight: Translated: 16496; Mature: 16496

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: BINDING 85-85 BINDING 99-99

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAVQVKILNPKIGTDANFPMPTRATDGSAGIDLRACIDEPITIKAGETKLIGTGMAIYI
CCEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEECCCEEEEECCEEEEE
ADPNYAGIILPRSGLGHKHGIVLGNLVGLIDADYQGELMVSVWNRSDTDFVLNPAERMAQ
ECCCCEEEEEECCCCCCCCCEEEEEEEEEECCCCCCEEEEEEECCCCCCEEECCHHHHHH
YMVVPVVRPSFQVVEEFNELSARGAGGFGHSGRQ
EEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MNAVQVKILNPKIGTDANFPMPTRATDGSAGIDLRACIDEPITIKAGETKLIGTGMAIYI
CCEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEECCCEEEEECCEEEEE
ADPNYAGIILPRSGLGHKHGIVLGNLVGLIDADYQGELMVSVWNRSDTDFVLNPAERMAQ
ECCCCEEEEEECCCCCCCCCEEEEEEEEEECCCCCCEEEEEEECCCCCCEEECCHHHHHH
YMVVPVVRPSFQVVEEFNELSARGAGGFGHSGRQ
EEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA