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The map label for this gene is algC [H]

Identifier: 148653624

GI number: 148653624

Start: 2268964

End: 2270574

Strand: Direct

Name: algC [H]

Synonym: PsycPRwf_1827

Alternate gene names: 148653624

Gene position: 2268964-2270574 (Clockwise)

Preceding gene: 148653623

Following gene: 148653625

Centisome position: 76.17

GC content: 48.04

Gene sequence:

>1611_bases
TTGCCCAAGACCTCATTTTTAGCACAGCGAGCCTTATTTAAAGCTTACGATATCCGTGGTAATGCTGCTTTATTTACCCC
AGATTTTGTTAAAGCACTGGGCCTCGCCTTTGCTCAGGATTTAGCCGAAACTGCCCAGGCGCGCCAGGTGGTCATAGGCT
ATGATGTGCGTCATGGCAGCAAAAGTATTGCCGAGCAGTTTGTGCAAAGCTTATGCGAGCGAGGCATCGAGGTGATTTGG
CTGGGACTTGTGACCACACCTATCATGGCGTTTTGGGCCAATAGATACCAAGGCCATGGGCTTATTGTCACAGCCAGTCA
TTCTGAGGGTCATATCTTGGGTATTAAATGGCTAATCTCAGGCGAGTCGCCCAGCTATGAGAGGATACAAATGCTGTACC
AGCGCTTAATCTCTCAACAGCCGGCCGATGCTAGCACAGCTACGAGCACAAACCCAGCTGCTACCCCCAAAGTCATTGCG
CCCAACCAAGTGGGGCACACTTATGCCAATAGCGCAGCCATCGCCCTTGACAACATACGTAAGTTTCGCAGCTTAGCGTT
AGTGCAGCATTCGCTTAGCCAAAAAACGCCTGACCGCCTTAAGGTGGTTATCGATAGCTTAAATGGTGCCACTGGCCCCT
ATGTCGCCGCTTTTTTTGAGCCACATCAGAGGTTGTGCGATATTATTTTAATCAATAAAACCCCAGATGGGGACTTCCCT
AAGGGCAACCCTGATCCTATGGAGGATAAGCGCCTTACCGAATTAAGTCAGGCGGTGATTGAACATCAAGCTGACTTAGG
TTTGGCTTTTGATGGTGATGGGGATCGGCTGATGGTGGTGGACAATCAAGGTCACTGCTTGGCGCCAGACCATCTGTTAT
ATCTGTTGGCGCGCGTCTCTATCGAAGACCACCAACCTGTTGAAGCCTGCCTAAATGCACCTGCACCTATCGTACTGTTT
GATGTTAAATGTACCCATCACATGCCGCGACTTATCACAGCACTAGGAGCTGTGCCGCAAATGAGTAAGACCGGCAGTAG
TATCTTGCGCCGTACGCTTCAGACCAAACAAGACAACAATCCTGACCACGCACCCATCTTATTTGCCGGTGAATTGTCGG
GACATTTTTTATTCAATGACGGCTATTTTTTATTACATGATGATGCCATGTATGCAGCGCTGCGCCTACTTAATTGGCTA
CAATATCAAGCGCAACACGCCAAGCCAGCTCAGTTAACTGATATTCTTAAAACTCTGCCGCCCATGGTCAGCACCCCAGA
TGTGTATTTGCCTCTTGATGCCTATGAAGCGTCACCGCTACAGCAAAATACGCCCTTATTAAATAAGCTGATGGCTCTTT
GCGATAAGCTCAGCCAAAGCATTGAGCTGCCTAAAGGTGCGCAGTTGACCTGTATTGATGGCTTGCGTCTAGATTTTGCG
CATGGATTTGGGATCATTAGACCCTCCAATACCAGTAACAGCTTAACCGTACGCTTCGCAGGCGACTCCCTATCTGATTT
AAAAAGCGTGCAAGGCTACTTTGTTAAATTGTGTCACTTTATTAATGATGATTTGGCCAAGCAGGTAGCCAACATTCAGA
TAAAGTCCTAA

Upstream 100 bases:

>100_bases
CTTTGGTCATTCGGGTCGTCAGTAAGCCAGTTTTATTTGTATTTGTTAAAAAAATATAAGATGATGAGACAGAAAAGCAA
TTCTGTTGGAGCCGTCCCTT

Downstream 100 bases:

>100_bases
ACTAACCCTAACCACGATTTATCTTTCACTCACAACCCAGACGAGTCAATCATGTCATTAAATCTTGCTCAAGCCAAAAC
CACTGCTGAAGTCTTAACTA

Product: phosphoglucomutase/phosphomannomutase subunit alpha/beta

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 536; Mature: 535

Protein sequence:

>536_residues
MPKTSFLAQRALFKAYDIRGNAALFTPDFVKALGLAFAQDLAETAQARQVVIGYDVRHGSKSIAEQFVQSLCERGIEVIW
LGLVTTPIMAFWANRYQGHGLIVTASHSEGHILGIKWLISGESPSYERIQMLYQRLISQQPADASTATSTNPAATPKVIA
PNQVGHTYANSAAIALDNIRKFRSLALVQHSLSQKTPDRLKVVIDSLNGATGPYVAAFFEPHQRLCDIILINKTPDGDFP
KGNPDPMEDKRLTELSQAVIEHQADLGLAFDGDGDRLMVVDNQGHCLAPDHLLYLLARVSIEDHQPVEACLNAPAPIVLF
DVKCTHHMPRLITALGAVPQMSKTGSSILRRTLQTKQDNNPDHAPILFAGELSGHFLFNDGYFLLHDDAMYAALRLLNWL
QYQAQHAKPAQLTDILKTLPPMVSTPDVYLPLDAYEASPLQQNTPLLNKLMALCDKLSQSIELPKGAQLTCIDGLRLDFA
HGFGIIRPSNTSNSLTVRFAGDSLSDLKSVQGYFVKLCHFINDDLAKQVANIQIKS

Sequences:

>Translated_536_residues
MPKTSFLAQRALFKAYDIRGNAALFTPDFVKALGLAFAQDLAETAQARQVVIGYDVRHGSKSIAEQFVQSLCERGIEVIW
LGLVTTPIMAFWANRYQGHGLIVTASHSEGHILGIKWLISGESPSYERIQMLYQRLISQQPADASTATSTNPAATPKVIA
PNQVGHTYANSAAIALDNIRKFRSLALVQHSLSQKTPDRLKVVIDSLNGATGPYVAAFFEPHQRLCDIILINKTPDGDFP
KGNPDPMEDKRLTELSQAVIEHQADLGLAFDGDGDRLMVVDNQGHCLAPDHLLYLLARVSIEDHQPVEACLNAPAPIVLF
DVKCTHHMPRLITALGAVPQMSKTGSSILRRTLQTKQDNNPDHAPILFAGELSGHFLFNDGYFLLHDDAMYAALRLLNWL
QYQAQHAKPAQLTDILKTLPPMVSTPDVYLPLDAYEASPLQQNTPLLNKLMALCDKLSQSIELPKGAQLTCIDGLRLDFA
HGFGIIRPSNTSNSLTVRFAGDSLSDLKSVQGYFVKLCHFINDDLAKQVANIQIKS
>Mature_535_residues
PKTSFLAQRALFKAYDIRGNAALFTPDFVKALGLAFAQDLAETAQARQVVIGYDVRHGSKSIAEQFVQSLCERGIEVIWL
GLVTTPIMAFWANRYQGHGLIVTASHSEGHILGIKWLISGESPSYERIQMLYQRLISQQPADASTATSTNPAATPKVIAP
NQVGHTYANSAAIALDNIRKFRSLALVQHSLSQKTPDRLKVVIDSLNGATGPYVAAFFEPHQRLCDIILINKTPDGDFPK
GNPDPMEDKRLTELSQAVIEHQADLGLAFDGDGDRLMVVDNQGHCLAPDHLLYLLARVSIEDHQPVEACLNAPAPIVLFD
VKCTHHMPRLITALGAVPQMSKTGSSILRRTLQTKQDNNPDHAPILFAGELSGHFLFNDGYFLLHDDAMYAALRLLNWLQ
YQAQHAKPAQLTDILKTLPPMVSTPDVYLPLDAYEASPLQQNTPLLNKLMALCDKLSQSIELPKGAQLTCIDGLRLDFAH
GFGIIRPSNTSNSLTVRFAGDSLSDLKSVQGYFVKLCHFINDDLAKQVANIQIKS

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=523, Percent_Identity=27.5334608030593, Blast_Score=132, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17535441, Length=294, Percent_Identity=26.1904761904762, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6323752, Length=300, Percent_Identity=25.3333333333333, Blast_Score=77, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6322722, Length=299, Percent_Identity=24.4147157190635, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17864244, Length=296, Percent_Identity=26.6891891891892, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 58942; Mature: 58811

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKTSFLAQRALFKAYDIRGNAALFTPDFVKALGLAFAQDLAETAQARQVVIGYDVRHGS
CCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCC
KSIAEQFVQSLCERGIEVIWLGLVTTPIMAFWANRYQGHGLIVTASHSEGHILGIKWLIS
HHHHHHHHHHHHHCCHHEEEHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEEEE
GESPSYERIQMLYQRLISQQPADASTATSTNPAATPKVIAPNQVGHTYANSAAIALDNIR
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCCCCCCHHCCCHHHHHHHHH
KFRSLALVQHSLSQKTPDRLKVVIDSLNGATGPYVAAFFEPHQRLCDIILINKTPDGDFP
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEHHHHHHHHCEEEEEEECCCCCCCC
KGNPDPMEDKRLTELSQAVIEHQADLGLAFDGDGDRLMVVDNQGHCLAPDHLLYLLARVS
CCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCCEECHHHHHHHHHHHC
IEDHQPVEACLNAPAPIVLFDVKCTHHMPRLITALGAVPQMSKTGSSILRRTLQTKQDNN
CCCCCHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCC
PDHAPILFAGELSGHFLFNDGYFLLHDDAMYAALRLLNWLQYQAQHAKPAQLTDILKTLP
CCCCCEEEEECCCCEEEEECCEEEEECHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
PMVSTPDVYLPLDAYEASPLQQNTPLLNKLMALCDKLSQSIELPKGAQLTCIDGLRLDFA
CCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEHH
HGFGIIRPSNTSNSLTVRFAGDSLSDLKSVQGYFVKLCHFINDDLAKQVANIQIKS
CCCEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECC
>Mature Secondary Structure 
PKTSFLAQRALFKAYDIRGNAALFTPDFVKALGLAFAQDLAETAQARQVVIGYDVRHGS
CCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCC
KSIAEQFVQSLCERGIEVIWLGLVTTPIMAFWANRYQGHGLIVTASHSEGHILGIKWLIS
HHHHHHHHHHHHHCCHHEEEHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEEEE
GESPSYERIQMLYQRLISQQPADASTATSTNPAATPKVIAPNQVGHTYANSAAIALDNIR
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCCCCCCHHCCCHHHHHHHHH
KFRSLALVQHSLSQKTPDRLKVVIDSLNGATGPYVAAFFEPHQRLCDIILINKTPDGDFP
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEHHHHHHHHCEEEEEEECCCCCCCC
KGNPDPMEDKRLTELSQAVIEHQADLGLAFDGDGDRLMVVDNQGHCLAPDHLLYLLARVS
CCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCCEECHHHHHHHHHHHC
IEDHQPVEACLNAPAPIVLFDVKCTHHMPRLITALGAVPQMSKTGSSILRRTLQTKQDNN
CCCCCHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCC
PDHAPILFAGELSGHFLFNDGYFLLHDDAMYAALRLLNWLQYQAQHAKPAQLTDILKTLP
CCCCCEEEEECCCCEEEEECCEEEEECHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
PMVSTPDVYLPLDAYEASPLQQNTPLLNKLMALCDKLSQSIELPKGAQLTCIDGLRLDFA
CCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEHH
HGFGIIRPSNTSNSLTVRFAGDSLSDLKSVQGYFVKLCHFINDDLAKQVANIQIKS
CCCEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]