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The map label for this gene is pyrC [H]

Identifier: 148653457

GI number: 148653457

Start: 2053483

End: 2054604

Strand: Direct

Name: pyrC [H]

Synonym: PsycPRwf_1660

Alternate gene names: 148653457

Gene position: 2053483-2054604 (Clockwise)

Preceding gene: 148653455

Following gene: 148653458

Centisome position: 68.93

GC content: 49.02

Gene sequence:

>1122_bases
ATGACTCATGATACTGCCCCCACCACTGCGGATACCTCTGACACTGCGGCTGCGACACAAGAGGTCCGTCACATTACGCT
AACTCGCCCAGATGATTGGCACATCCACCTGCGTGATGGACTATCACTGAGTACTACAGTGGCCCATGCGGCGGCTAATT
TTAGCCGAGTTATTTGTATGCCAAACCTTGTGCCACCCGTAAAAAATACTGAGCAAGCCTTGGCTTATCGCAGCCGTATC
ATGCAGGCATTGGCCCACGCGGATATTGATGACACTGCCAAACGCGCTTTTGATCCCCGTATGACCTTATATTTAACCGA
CAGCACCACTGCCGAAGACATCAAGCAGGCCTCAGAGTCAGGTATGATTCAGGCCGTTAAGTTATATCCTGCAGGCGCTA
CGACTAACTCAGCCGATGGTGTCACCAACTTAGGCGGCCGCAGTGCGGTATTTGAAGCGATGCAAAAGTACAAACTGCCT
TTATTAATCCATGGCGAGGTTACCGATGCACACGTCGACATCTTTGATCGTGAAAAGCAGTTTGTCGATACCACTTTGAG
CAACTTGGTGCGTCAATTTCCTGAATTAAAAATTGTGGTTGAACACATTACCACAGGCGATGCAGCAGACTTTGTGCTGT
CACAAAGTGCACTGGTGGCTGCCACCATTACCCCTCAACATTTGTTATTTAACCGAAACCATCTGCTGGTAGGCGGGGTA
AAGCCGCATTTTTATTGTCTGCCAATCTTAAAGCGTCAGCAGCATCAGCAAGTACTGCTTGATGTGGCGACCAGTGGTAA
CCCTAAATTCTTCTTAGGTACAGACTCAGCGCCGCATGCCACCAATGCCAAAGAAAATGCTTGTGGCTGCGCAGGCTGCT
ATTCGGCATCTATTGCACTGCCTTTATATGCGACCGCCTTTGATAGTGTTGGCAAAATTGATCGTTTAGAGGGATTTGCC
AGCCATTTTGGTGCCCAGTTTTATGGCCTACCCCTCAATAACAGCACCATTACCTTAGTCAATGAGCCCATGACTGTGCC
ACAAAGCTACCCATATGTTGACACGCAAAGCCTGACGCCCTTAATGGCCGGTGAGACCCTACCTTGGTCTATCAAAAGCT
AA

Upstream 100 bases:

>100_bases
TTACTGATTCGCTTAGGCCTATCAAAAGCCCAATGATGGCGACAAAGCCAATTCAGGCTGCATGCTTACCTACCCTATTA
AATAACGACGGCGATAACTT

Downstream 100 bases:

>100_bases
TAGATAAGAGAGTAGATGGCCTTATTTTTGAGTTGCTTAATTTTTTATTTACTTAATATGTGATTTTTGATTTATGACTG
ATTTAACTGTACTGGCAGAT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MTHDTAPTTADTSDTAAATQEVRHITLTRPDDWHIHLRDGLSLSTTVAHAAANFSRVICMPNLVPPVKNTEQALAYRSRI
MQALAHADIDDTAKRAFDPRMTLYLTDSTTAEDIKQASESGMIQAVKLYPAGATTNSADGVTNLGGRSAVFEAMQKYKLP
LLIHGEVTDAHVDIFDREKQFVDTTLSNLVRQFPELKIVVEHITTGDAADFVLSQSALVAATITPQHLLFNRNHLLVGGV
KPHFYCLPILKRQQHQQVLLDVATSGNPKFFLGTDSAPHATNAKENACGCAGCYSASIALPLYATAFDSVGKIDRLEGFA
SHFGAQFYGLPLNNSTITLVNEPMTVPQSYPYVDTQSLTPLMAGETLPWSIKS

Sequences:

>Translated_373_residues
MTHDTAPTTADTSDTAAATQEVRHITLTRPDDWHIHLRDGLSLSTTVAHAAANFSRVICMPNLVPPVKNTEQALAYRSRI
MQALAHADIDDTAKRAFDPRMTLYLTDSTTAEDIKQASESGMIQAVKLYPAGATTNSADGVTNLGGRSAVFEAMQKYKLP
LLIHGEVTDAHVDIFDREKQFVDTTLSNLVRQFPELKIVVEHITTGDAADFVLSQSALVAATITPQHLLFNRNHLLVGGV
KPHFYCLPILKRQQHQQVLLDVATSGNPKFFLGTDSAPHATNAKENACGCAGCYSASIALPLYATAFDSVGKIDRLEGFA
SHFGAQFYGLPLNNSTITLVNEPMTVPQSYPYVDTQSLTPLMAGETLPWSIKS
>Mature_372_residues
THDTAPTTADTSDTAAATQEVRHITLTRPDDWHIHLRDGLSLSTTVAHAAANFSRVICMPNLVPPVKNTEQALAYRSRIM
QALAHADIDDTAKRAFDPRMTLYLTDSTTAEDIKQASESGMIQAVKLYPAGATTNSADGVTNLGGRSAVFEAMQKYKLPL
LIHGEVTDAHVDIFDREKQFVDTTLSNLVRQFPELKIVVEHITTGDAADFVLSQSALVAATITPQHLLFNRNHLLVGGVK
PHFYCLPILKRQQHQQVLLDVATSGNPKFFLGTDSAPHATNAKENACGCAGCYSASIALPLYATAFDSVGKIDRLEGFAS
HFGAQFYGLPLNNSTITLVNEPMTVPQSYPYVDTQSLTPLMAGETLPWSIKS

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=348, Percent_Identity=50.8620689655172, Blast_Score=365, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6323452, Length=373, Percent_Identity=32.171581769437, Blast_Score=171, Evalue=1e-43,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 40550; Mature: 40419

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHDTAPTTADTSDTAAATQEVRHITLTRPDDWHIHLRDGLSLSTTVAHAAANFSRVICM
CCCCCCCCCCCCCHHHHHHHHHEEEEEECCCCCEEEEECCCCHHHHHHHHHCCCEEEEEC
PNLVPPVKNTEQALAYRSRIMQALAHADIDDTAKRAFDPRMTLYLTDSTTAEDIKQASES
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCEEEEEECCCCHHHHHHHHHC
GMIQAVKLYPAGATTNSADGVTNLGGRSAVFEAMQKYKLPLLIHGEVTDAHVDIFDREKQ
CCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCEEEEHHHHHH
FVDTTLSNLVRQFPELKIVVEHITTGDAADFVLSQSALVAATITPQHLLFNRNHLLVGGV
HHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHCCCEEEEEECCHHHHEECCCEEEEECC
KPHFYCLPILKRQQHQQVLLDVATSGNPKFFLGTDSAPHATNAKENACGCAGCYSASIAL
CCCEEEEHHHHHHHHHEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHCCEEH
PLYATAFDSVGKIDRLEGFASHFGAQFYGLPLNNSTITLVNEPMTVPQSYPYVDTQSLTP
HHHHHHHHHCCCHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCH
LMAGETLPWSIKS
HHCCCCCCCCCCC
>Mature Secondary Structure 
THDTAPTTADTSDTAAATQEVRHITLTRPDDWHIHLRDGLSLSTTVAHAAANFSRVICM
CCCCCCCCCCCCHHHHHHHHHEEEEEECCCCCEEEEECCCCHHHHHHHHHCCCEEEEEC
PNLVPPVKNTEQALAYRSRIMQALAHADIDDTAKRAFDPRMTLYLTDSTTAEDIKQASES
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCEEEEEECCCCHHHHHHHHHC
GMIQAVKLYPAGATTNSADGVTNLGGRSAVFEAMQKYKLPLLIHGEVTDAHVDIFDREKQ
CCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCEEEEHHHHHH
FVDTTLSNLVRQFPELKIVVEHITTGDAADFVLSQSALVAATITPQHLLFNRNHLLVGGV
HHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHCCCEEEEEECCHHHHEECCCEEEEECC
KPHFYCLPILKRQQHQQVLLDVATSGNPKFFLGTDSAPHATNAKENACGCAGCYSASIAL
CCCEEEEHHHHHHHHHEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHCCEEH
PLYATAFDSVGKIDRLEGFASHFGAQFYGLPLNNSTITLVNEPMTVPQSYPYVDTQSLTP
HHHHHHHHHCCCHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCH
LMAGETLPWSIKS
HHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA