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The map label for this gene is accC [H]

Identifier: 148653455

GI number: 148653455

Start: 2050262

End: 2051611

Strand: Direct

Name: accC [H]

Synonym: PsycPRwf_1658

Alternate gene names: 148653455

Gene position: 2050262-2051611 (Clockwise)

Preceding gene: 148653454

Following gene: 148653457

Centisome position: 68.82

GC content: 47.04

Gene sequence:

>1350_bases
ATGATAAAAAAATTGCTTATCGCCAACCGTGGCGAAATTGCTTTACGCATCGTCCGTGCCTGCAAACAGCTGGGCATTAA
AACGGTAGGGGTTTATTCCACTGCCGATAAGGATTTGATGCACTTACGGTTTGTGGATGAGGCCATCTGTATTGGAAAAC
CCAATGCCAACCAAAGCTACTTGAATATCAATGCGATTATTACTGCCGCAGAGATTACAGGCAGTGATGCCATTCATCCC
GGCTACGGCTTCTTGGCAGAAAATGCTGAATTTGCAGAGAGCATTGAGGATGCGGGCATTATATTTGTCGGCCCCCATCC
CGATCACATCCGCTTAATGGGCAATAAAGTCTCCGCCATTAATGCCATGAAACAGGCTGGGGTACCGACGGTGCCAGGTT
CAGTGGGCACAGTCACTTTAAATAACGCTGAAGAGCAGGCGAAAAATATCGGCTTTCCATTGTTGATTAAAGCAGCTGCC
GGTGGTGGTGGTCGAGGCATGCGCATTGTTGAGCGCTTCGATCAGCTTAATGAACAAGTACAAGCTGCCAAGCAAGAGGC
AGAACTGTGGTTTGGTGATGACAGCGTCTATATGGAGCGTTATCTGCAAAATCCACGCCACATCGAAGTTCAAGTCTTAG
GGGATGGCAATGGTAATGCTATTCACTTATATGACCGTGACTGCTCACTGCAGCGTCGTCATCAAAAAGTGTTAGAGGAA
GCCCCTGCTCCAGATATCCCAGATGACATTCGTGAACCCATTTTACAGGCGTGTGTTAAGGCGTGTGAAACCATTGGCTA
TCGCGGTGCAGGCACGTTTGAATTCTTGTTTGAGGACGGTGAATTCTTCTTTATCGAGATGAACACCAGGGTTCAGGTAG
AGCACCCGATTACTGAAATGGTCACCGGTGTGGATGTGGTGGTAGAACAGCTAAGAATTGCTGCAGGCTATGGCCTATCG
TATCGTCAAAGCGATATCAGCGTTCATGGTCATGCTATTGAATGCCGTATAAATGCCGAGGACCCCAAAACCTTTGCCCC
CTCACCTGGTAAGATTACCCAGTATTTCACGCCTAGTGGGGCCGGTGTGCGCTTTGACTCTCATTTGTACCCCAATTATG
AGATTCCCTCGTACTATGACTCACTTATTGGCAAGCTTATCTGCCATGGTCAGACTCGAGAACAGGCCATTGCTAAGACG
CTTCATGCCCTTGATGAGCTAATCATCGAAGGCATCAAGACCAACATTCCTATGCACCGTGATCTGATTTTAAAAGATCC
CGATTTTGCCTCACGTGCCCAAAATATTCATTATTTAGAAAAATGTCTATTAATGCCAAAGGCTGAATAG

Upstream 100 bases:

>100_bases
TCAAAGTGGTATCGTGGATGCCATCTTGGTGGAAAATGGTGATGTGGTTCAGTTTGGCCAACCCGTAATCCGTTATAGAA
ACTAATATATAGGCACCTTG

Downstream 100 bases:

>100_bases
CACAGCATAGGCTGTTTGGTTACTTATATTAATGATATAAACATAAAAAAAGCAGAAGTGATATCACTTCTGCTTTTTTG
GTGTTAACCGTCACTAATCG

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MIKKLLIANRGEIALRIVRACKQLGIKTVGVYSTADKDLMHLRFVDEAICIGKPNANQSYLNINAIITAAEITGSDAIHP
GYGFLAENAEFAESIEDAGIIFVGPHPDHIRLMGNKVSAINAMKQAGVPTVPGSVGTVTLNNAEEQAKNIGFPLLIKAAA
GGGGRGMRIVERFDQLNEQVQAAKQEAELWFGDDSVYMERYLQNPRHIEVQVLGDGNGNAIHLYDRDCSLQRRHQKVLEE
APAPDIPDDIREPILQACVKACETIGYRGAGTFEFLFEDGEFFFIEMNTRVQVEHPITEMVTGVDVVVEQLRIAAGYGLS
YRQSDISVHGHAIECRINAEDPKTFAPSPGKITQYFTPSGAGVRFDSHLYPNYEIPSYYDSLIGKLICHGQTREQAIAKT
LHALDELIIEGIKTNIPMHRDLILKDPDFASRAQNIHYLEKCLLMPKAE

Sequences:

>Translated_449_residues
MIKKLLIANRGEIALRIVRACKQLGIKTVGVYSTADKDLMHLRFVDEAICIGKPNANQSYLNINAIITAAEITGSDAIHP
GYGFLAENAEFAESIEDAGIIFVGPHPDHIRLMGNKVSAINAMKQAGVPTVPGSVGTVTLNNAEEQAKNIGFPLLIKAAA
GGGGRGMRIVERFDQLNEQVQAAKQEAELWFGDDSVYMERYLQNPRHIEVQVLGDGNGNAIHLYDRDCSLQRRHQKVLEE
APAPDIPDDIREPILQACVKACETIGYRGAGTFEFLFEDGEFFFIEMNTRVQVEHPITEMVTGVDVVVEQLRIAAGYGLS
YRQSDISVHGHAIECRINAEDPKTFAPSPGKITQYFTPSGAGVRFDSHLYPNYEIPSYYDSLIGKLICHGQTREQAIAKT
LHALDELIIEGIKTNIPMHRDLILKDPDFASRAQNIHYLEKCLLMPKAE
>Mature_449_residues
MIKKLLIANRGEIALRIVRACKQLGIKTVGVYSTADKDLMHLRFVDEAICIGKPNANQSYLNINAIITAAEITGSDAIHP
GYGFLAENAEFAESIEDAGIIFVGPHPDHIRLMGNKVSAINAMKQAGVPTVPGSVGTVTLNNAEEQAKNIGFPLLIKAAA
GGGGRGMRIVERFDQLNEQVQAAKQEAELWFGDDSVYMERYLQNPRHIEVQVLGDGNGNAIHLYDRDCSLQRRHQKVLEE
APAPDIPDDIREPILQACVKACETIGYRGAGTFEFLFEDGEFFFIEMNTRVQVEHPITEMVTGVDVVVEQLRIAAGYGLS
YRQSDISVHGHAIECRINAEDPKTFAPSPGKITQYFTPSGAGVRFDSHLYPNYEIPSYYDSLIGKLICHGQTREQAIAKT
LHALDELIIEGIKTNIPMHRDLILKDPDFASRAQNIHYLEKCLLMPKAE

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=443, Percent_Identity=46.0496613995485, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI189095269, Length=428, Percent_Identity=45.7943925233645, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI65506442, Length=428, Percent_Identity=45.7943925233645, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI295821183, Length=428, Percent_Identity=45.7943925233645, Blast_Score=384, Evalue=1e-107,
Organism=Homo sapiens, GI106049528, Length=448, Percent_Identity=44.1964285714286, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI106049295, Length=448, Percent_Identity=44.1964285714286, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI106049292, Length=448, Percent_Identity=44.1964285714286, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI134142062, Length=479, Percent_Identity=31.9415448851775, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI38679960, Length=489, Percent_Identity=32.1063394683027, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI38679974, Length=489, Percent_Identity=32.1063394683027, Blast_Score=222, Evalue=7e-58,
Organism=Homo sapiens, GI38679977, Length=489, Percent_Identity=32.1063394683027, Blast_Score=222, Evalue=7e-58,
Organism=Homo sapiens, GI38679967, Length=489, Percent_Identity=32.1063394683027, Blast_Score=222, Evalue=7e-58,
Organism=Homo sapiens, GI38679971, Length=489, Percent_Identity=32.1063394683027, Blast_Score=221, Evalue=8e-58,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=61.7977528089888, Blast_Score=550, Evalue=1e-158,
Organism=Escherichia coli, GI1786216, Length=243, Percent_Identity=24.2798353909465, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17567343, Length=425, Percent_Identity=45.1764705882353, Blast_Score=374, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI71987519, Length=434, Percent_Identity=44.7004608294931, Blast_Score=369, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17562816, Length=448, Percent_Identity=44.6428571428571, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI133931226, Length=492, Percent_Identity=30.8943089430894, Blast_Score=218, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI71997163, Length=511, Percent_Identity=28.9628180039139, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI71997168, Length=511, Percent_Identity=28.9628180039139, Blast_Score=206, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6319685, Length=437, Percent_Identity=43.0205949656751, Blast_Score=360, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6319695, Length=436, Percent_Identity=45.1834862385321, Blast_Score=340, Evalue=3e-94,
Organism=Saccharomyces cerevisiae, GI6321376, Length=436, Percent_Identity=46.1009174311927, Blast_Score=330, Evalue=3e-91,
Organism=Saccharomyces cerevisiae, GI6324343, Length=514, Percent_Identity=30.7392996108949, Blast_Score=226, Evalue=5e-60,
Organism=Saccharomyces cerevisiae, GI6323863, Length=456, Percent_Identity=33.3333333333333, Blast_Score=221, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24651757, Length=441, Percent_Identity=46.031746031746, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI281363050, Length=426, Percent_Identity=47.4178403755869, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652224, Length=426, Percent_Identity=47.4178403755869, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652222, Length=426, Percent_Identity=47.4178403755869, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652220, Length=426, Percent_Identity=47.4178403755869, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652218, Length=426, Percent_Identity=47.4178403755869, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652212, Length=426, Percent_Identity=47.4178403755869, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652210, Length=426, Percent_Identity=47.4178403755869, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652214, Length=426, Percent_Identity=47.4178403755869, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI19921944, Length=426, Percent_Identity=47.4178403755869, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652216, Length=426, Percent_Identity=47.4178403755869, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24651759, Length=403, Percent_Identity=45.6575682382134, Blast_Score=345, Evalue=2e-95,
Organism=Drosophila melanogaster, GI161076407, Length=472, Percent_Identity=31.3559322033898, Blast_Score=215, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24586460, Length=472, Percent_Identity=31.3559322033898, Blast_Score=215, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24586458, Length=472, Percent_Identity=31.3559322033898, Blast_Score=215, Evalue=5e-56,
Organism=Drosophila melanogaster, GI161076409, Length=472, Percent_Identity=31.3559322033898, Blast_Score=215, Evalue=5e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49639; Mature: 49639

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKLLIANRGEIALRIVRACKQLGIKTVGVYSTADKDLMHLRFVDEAICIGKPNANQSY
CCCCEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCEECCCCCCCCE
LNINAIITAAEITGSDAIHPGYGFLAENAEFAESIEDAGIIFVGPHPDHIRLMGNKVSAI
EEEEEEEEEEEECCCCCCCCCCCEEECCHHHHHHHCCCCEEEECCCCCEEEEECCCHHHH
NAMKQAGVPTVPGSVGTVTLNNAEEQAKNIGFPLLIKAAAGGGGRGMRIVERFDQLNEQV
HHHHHCCCCCCCCCCEEEEECCHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
QAAKQEAELWFGDDSVYMERYLQNPRHIEVQVLGDGNGNAIHLYDRDCSLQRRHQKVLEE
HHHHHHCCEEECCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEEECCCHHHHHHHHHHHH
APAPDIPDDIREPILQACVKACETIGYRGAGTFEFLFEDGEFFFIEMNTRVQVEHPITEM
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHHHH
VTGVDVVVEQLRIAAGYGLSYRQSDISVHGHAIECRINAEDPKTFAPSPGKITQYFTPSG
HHHHHHHHHHHHHHHCCCCCEECCCCEEECEEEEEEECCCCCCCCCCCCCCEEEEECCCC
AGVRFDSHLYPNYEIPSYYDSLIGKLICHGQTREQAIAKTLHALDELIIEGIKTNIPMHR
CCEEECCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DLILKDPDFASRAQNIHYLEKCLLMPKAE
CEEECCCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIKKLLIANRGEIALRIVRACKQLGIKTVGVYSTADKDLMHLRFVDEAICIGKPNANQSY
CCCCEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCEECCCCCCCCE
LNINAIITAAEITGSDAIHPGYGFLAENAEFAESIEDAGIIFVGPHPDHIRLMGNKVSAI
EEEEEEEEEEEECCCCCCCCCCCEEECCHHHHHHHCCCCEEEECCCCCEEEEECCCHHHH
NAMKQAGVPTVPGSVGTVTLNNAEEQAKNIGFPLLIKAAAGGGGRGMRIVERFDQLNEQV
HHHHHCCCCCCCCCCEEEEECCHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
QAAKQEAELWFGDDSVYMERYLQNPRHIEVQVLGDGNGNAIHLYDRDCSLQRRHQKVLEE
HHHHHHCCEEECCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEEECCCHHHHHHHHHHHH
APAPDIPDDIREPILQACVKACETIGYRGAGTFEFLFEDGEFFFIEMNTRVQVEHPITEM
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHHHH
VTGVDVVVEQLRIAAGYGLSYRQSDISVHGHAIECRINAEDPKTFAPSPGKITQYFTPSG
HHHHHHHHHHHHHHHCCCCCEECCCCEEECEEEEEEECCCCCCCCCCCCCCEEEEECCCC
AGVRFDSHLYPNYEIPSYYDSLIGKLICHGQTREQAIAKTLHALDELIIEGIKTNIPMHR
CCEEECCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DLILKDPDFASRAQNIHYLEKCLLMPKAE
CEEECCCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]