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The map label for this gene is trpC [H]

Identifier: 148653445

GI number: 148653445

Start: 2037011

End: 2037856

Strand: Direct

Name: trpC [H]

Synonym: PsycPRwf_1648

Alternate gene names: 148653445

Gene position: 2037011-2037856 (Clockwise)

Preceding gene: 148653444

Following gene: 148653446

Centisome position: 68.38

GC content: 46.81

Gene sequence:

>846_bases
ATGACGCATGATGCCATCCCCTCAATCCTAAAAAAAATTGTGCTGACCAAAGAGTCTGAAGTGGCCAGTGCCAAAGCACA
ACAAGCGCTGCCTGCGATTAGAGCTGAGGCTGAGCAGCTTGCTGCCTCTCAAGAGGCCCCTCGCCGCGGTTTTGCCCAAG
CGTTATTGGCCAAACAAAGCGCTGGCGTGCCAGGCATCATTGCTGAGGTCAAAAAGGCGTCACCATCAAAGGGGATTATC
TCACCTAACTTTGATCCTAGCCGAGTCGCTAAGCAATATGAGCAAGCTGGTGCTGTCTGTCTGTCTGTACTGACTGATGA
GCAGTATTTTCAAGGCCATAACAGCTACTTACAACAGGCCAAAGCCGCTTGTAGCTTACCCGTACTTCGCAAAGACTTTA
TGATTGATGAGTATCAGATTTATCAGTCCTACCTACTGGGCGCTGACTGTATTTTGTTAATTGTTGCCTGCTTAGATGAC
AAGCAATTACATCATCTACATGAGTTGGCCTGCAAACTTAGCATGGATGTCCTTATCGAAGTGCATACCCTTCATGAGCT
AGAGCGCGCCCTAAAGCTACCGGCGTCTGAGCACAATATTTATGGCATAAATAACCGCGATTTAAACACCTTTAATACTG
ACCTACAAACCTCCATAAAACTCAAAGAATTCCTTGATAATCAGTCAGCCAAACCTCAGCTGTTGGTGACCGAAAGTGGC
ATTCATAGCACTGAGGATATGCAGCTAATGCTCACTCATCACATAAACTGCTTTTTAATTGGCGAGCAGTTTATGAAAAC
TGAGCATCCGGGCGACACCCTAGCCGCCCTACTCAGCTCACTGTAA

Upstream 100 bases:

>100_bases
GGTAAAGCCCTGCAAAAAATGCAGGCATTGGCTGAATATACCCAAACCTTTGATCGCTAGTTTTTGCTAAATTCATTATT
GATAACCCTACGAGCCCAAT

Downstream 100 bases:

>100_bases
GAGCGATAACCTTCTAAATTCATTTAATATAAGTGGTACCTACTACTATGGCAAATTCATTATTTTCAAAAGAGATGCAA
GACCAGCTCAAAGAGCTAAA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MTHDAIPSILKKIVLTKESEVASAKAQQALPAIRAEAEQLAASQEAPRRGFAQALLAKQSAGVPGIIAEVKKASPSKGII
SPNFDPSRVAKQYEQAGAVCLSVLTDEQYFQGHNSYLQQAKAACSLPVLRKDFMIDEYQIYQSYLLGADCILLIVACLDD
KQLHHLHELACKLSMDVLIEVHTLHELERALKLPASEHNIYGINNRDLNTFNTDLQTSIKLKEFLDNQSAKPQLLVTESG
IHSTEDMQLMLTHHINCFLIGEQFMKTEHPGDTLAALLSSL

Sequences:

>Translated_281_residues
MTHDAIPSILKKIVLTKESEVASAKAQQALPAIRAEAEQLAASQEAPRRGFAQALLAKQSAGVPGIIAEVKKASPSKGII
SPNFDPSRVAKQYEQAGAVCLSVLTDEQYFQGHNSYLQQAKAACSLPVLRKDFMIDEYQIYQSYLLGADCILLIVACLDD
KQLHHLHELACKLSMDVLIEVHTLHELERALKLPASEHNIYGINNRDLNTFNTDLQTSIKLKEFLDNQSAKPQLLVTESG
IHSTEDMQLMLTHHINCFLIGEQFMKTEHPGDTLAALLSSL
>Mature_280_residues
THDAIPSILKKIVLTKESEVASAKAQQALPAIRAEAEQLAASQEAPRRGFAQALLAKQSAGVPGIIAEVKKASPSKGIIS
PNFDPSRVAKQYEQAGAVCLSVLTDEQYFQGHNSYLQQAKAACSLPVLRKDFMIDEYQIYQSYLLGADCILLIVACLDDK
QLHHLHELACKLSMDVLIEVHTLHELERALKLPASEHNIYGINNRDLNTFNTDLQTSIKLKEFLDNQSAKPQLLVTESGI
HSTEDMQLMLTHHINCFLIGEQFMKTEHPGDTLAALLSSL

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=258, Percent_Identity=39.1472868217054, Blast_Score=148, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6322638, Length=229, Percent_Identity=36.6812227074236, Blast_Score=128, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 31025; Mature: 30894

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHDAIPSILKKIVLTKESEVASAKAQQALPAIRAEAEQLAASQEAPRRGFAQALLAKQS
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
AGVPGIIAEVKKASPSKGIISPNFDPSRVAKQYEQAGAVCLSVLTDEQYFQGHNSYLQQA
CCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAACSLPVLRKDFMIDEYQIYQSYLLGADCILLIVACLDDKQLHHLHELACKLSMDVLIE
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
VHTLHELERALKLPASEHNIYGINNRDLNTFNTDLQTSIKLKEFLDNQSAKPQLLVTESG
HHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECC
IHSTEDMQLMLTHHINCFLIGEQFMKTEHPGDTLAALLSSL
CCCCHHHHHHHHHCCEEEEECHHHHHCCCCCHHHHHHHHCC
>Mature Secondary Structure 
THDAIPSILKKIVLTKESEVASAKAQQALPAIRAEAEQLAASQEAPRRGFAQALLAKQS
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
AGVPGIIAEVKKASPSKGIISPNFDPSRVAKQYEQAGAVCLSVLTDEQYFQGHNSYLQQA
CCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAACSLPVLRKDFMIDEYQIYQSYLLGADCILLIVACLDDKQLHHLHELACKLSMDVLIE
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
VHTLHELERALKLPASEHNIYGINNRDLNTFNTDLQTSIKLKEFLDNQSAKPQLLVTESG
HHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECC
IHSTEDMQLMLTHHINCFLIGEQFMKTEHPGDTLAALLSSL
CCCCHHHHHHHHHCCEEEEECHHHHHCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA