Click here to switch to the map view.

The map label for this gene is iscA [H]

Identifier: 148653429

GI number: 148653429

Start: 2017356

End: 2017676

Strand: Direct

Name: iscA [H]

Synonym: PsycPRwf_1631

Alternate gene names: 148653429

Gene position: 2017356-2017676 (Clockwise)

Preceding gene: 148653428

Following gene: 148653430

Centisome position: 67.72

GC content: 43.61

Gene sequence:

>321_bases
ATGATTGAACTGACCGAACGTGCTGCCAAACACGTAAAAGATTATCTAGATAACCGTGGTCATGGTGAGGGCATTCGTGT
GGCTATTCGCACCGCTGGATGCTCAGGACTGGCCTACGTGTTAGAATTTGTTGATGATCCCGATTCAAGCGATGAGAAGT
TTGAAAGCAACGGAGTTAATATCTTTGTTGATCCAAAGAGCATGGTATATCTAGATGGACTATTAATGGATTATGTGACT
GAAGGTCTAAACGAGGGCTTCAAATTCACCAACCCTAATCAAAAAGGCGAATGTGGCTGTGGTGAGTCCTTTACCGTTTA
G

Upstream 100 bases:

>100_bases
AGGCACAATGCTGTGACAAGGTGATGGCTTGAAGCTTGATGGATTATCCCCATTAACGTTGAGAACCAATAATAAAATTT
TTAACATTAGGAAAGTCTTA

Downstream 100 bases:

>100_bases
TATGAATACCTTTAAGTCTTCATGCTTATATTGATTGTTGATTGATTACTTTATACTGATTAATCTCTGTCTTATAGCAC
CAGCACTTATCTTATAGTTA

Product: iron-sulfur cluster assembly protein IscA

Products: NA

Alternate protein names: Iron-sulfur cluster assembly protein [H]

Number of amino acids: Translated: 106; Mature: 106

Protein sequence:

>106_residues
MIELTERAAKHVKDYLDNRGHGEGIRVAIRTAGCSGLAYVLEFVDDPDSSDEKFESNGVNIFVDPKSMVYLDGLLMDYVT
EGLNEGFKFTNPNQKGECGCGESFTV

Sequences:

>Translated_106_residues
MIELTERAAKHVKDYLDNRGHGEGIRVAIRTAGCSGLAYVLEFVDDPDSSDEKFESNGVNIFVDPKSMVYLDGLLMDYVT
EGLNEGFKFTNPNQKGECGCGESFTV
>Mature_106_residues
MIELTERAAKHVKDYLDNRGHGEGIRVAIRTAGCSGLAYVLEFVDDPDSSDEKFESNGVNIFVDPKSMVYLDGLLMDYVT
EGLNEGFKFTNPNQKGECGCGESFTV

Specific function: Is able to transfer iron-sulfur clusters to apo- ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that iscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transi

COG id: COG0316

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesB/iscA family [H]

Homologues:

Organism=Homo sapiens, GI52426768, Length=105, Percent_Identity=41.9047619047619, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI1788877, Length=105, Percent_Identity=60.952380952381, Blast_Score=135, Evalue=7e-34,
Organism=Escherichia coli, GI1787974, Length=105, Percent_Identity=42.8571428571429, Blast_Score=100, Evalue=2e-23,
Organism=Escherichia coli, GI1786351, Length=108, Percent_Identity=44.4444444444444, Blast_Score=76, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI193209025, Length=105, Percent_Identity=39.0476190476191, Blast_Score=98, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI25146411, Length=105, Percent_Identity=39.0476190476191, Blast_Score=98, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6323001, Length=106, Percent_Identity=42.4528301886792, Blast_Score=93, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24642263, Length=105, Percent_Identity=40, Blast_Score=92, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000361
- InterPro:   IPR016092
- InterPro:   IPR017870
- InterPro:   IPR011302 [H]

Pfam domain/function: PF01521 Fe-S_biosyn [H]

EC number: NA

Molecular weight: Translated: 11674; Mature: 11674

Theoretical pI: Translated: 4.26; Mature: 4.26

Prosite motif: PS01152 HESB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELTERAAKHVKDYLDNRGHGEGIRVAIRTAGCSGLAYVLEFVDDPDSSDEKFESNGVN
CCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCE
IFVDPKSMVYLDGLLMDYVTEGLNEGFKFTNPNQKGECGCGESFTV
EEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIELTERAAKHVKDYLDNRGHGEGIRVAIRTAGCSGLAYVLEFVDDPDSSDEKFESNGVN
CCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCE
IFVDPKSMVYLDGLLMDYVTEGLNEGFKFTNPNQKGECGCGESFTV
EEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]