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The map label for this gene is iscS [H]

Identifier: 148653427

GI number: 148653427

Start: 2015474

End: 2016700

Strand: Direct

Name: iscS [H]

Synonym: PsycPRwf_1629

Alternate gene names: 148653427

Gene position: 2015474-2016700 (Clockwise)

Preceding gene: 148653426

Following gene: 148653428

Centisome position: 67.66

GC content: 46.13

Gene sequence:

>1227_bases
ATGAGTAACTTGAACCGCCCTATCTATCTTGACTATGCAGCAACTACCCCTGTAGATCCGCAAGTGGCCAAAAAAATGAC
CGAGTATATGACCTTTGATGGCATGTTCGGTAACCCCGCTTCTCGATCACATGGTTATGGTTGGCAAGCAGAGGAAGCTG
TAGAAAATGCGCGTCAGCAAATCGCTGATCTGGTTAATGCTGATCCTCGTGAAATCGTATTCACCTCAGGGGCTACTGAA
TCAGACAACTTGGCCATTAAAGGCGCCGCTCATTTCTATGCAGGCCGCGGTAAACACATCATTACCAGTAAAATTGAACA
CAAAGCGGTACTAGATACGTGCCGTCAGCTTGAGCAAGAAGGCTATGAAATTACTTATATCGAGCCTCAGCCTAGCACTG
GTCTTATTTTGCCTGAGCAGGTAAAAGATGCGCTTCGTGAAGATACTATTTTAGTATCTCTTATGATGGTGAATAATGAG
CTTGGCACGGTCACTGATGTCAAGGCCATCGGTGAGATCACTCGTGAAGCTGGCGTAGTATTCCACGTGGATGCGGCACA
AGCTGCAGGTAAAGTTGAAATTGATCTTGAAGCGCTAAAAATTGATCTAATGAGCTTCTCAGGTCACAAAATTTATGGCC
CTAAAGGTATCGGCGCTTTATATGTTCGCCGTAAGCCACGCATTCGTTTACGTGCTGAGCAGCATGGCGGTGGCCATGAG
CGTGGTATGCGTTCAGGTACGTTGGCAACGCATCAAATCGTTGGTATGGGTGAAGCCTTTGCTATTGCCGCTGAGCGCTT
AGAGCAAGATCGCGCACATGCACAAAAGCTGCGTGACAAATTATGGGCAGGCGTCCAAGACATCGAAGAGATTTATTTAA
ACGGTGACTCTAATAACAGCGTACCAAACATTGTCAATATCAGCTTTAACTTCGTTGAAGGTGAGTCATTAATGATGTCC
CTAAAAGATATGGCTGTCTCTTCAGGCTCTGCTTGTACATCAGCCACGTTAGAACCCTCTTATGTACTACGAGCTATCGG
CCGCCCTGATGAGTTGGCACACAGCTCAATTCGCTTTAGCTTCGGCCGCTACACCACCGAAGAAGACATCGATATCATCC
TAGCTCAGATTCATGAAGCCGTAGATAAGCTAAGAGATTTATCACCCTTATGGGATATGTATAAAGACGGTGTGGATCTA
ACCTCTGTAGAGTGGACTGAACACTAA

Upstream 100 bases:

>100_bases
TCTCAGACCGTCAACAACTTATTTATGATGTGGCGACAGAAAGCACCACATCTCATTCAAATCCTAATATGATATTCTCA
GCCAGTGAGGTTAATCCAGC

Downstream 100 bases:

>100_bases
GCATAACTGCCATTTTACTGAGTCCGTTTTAGGACAGTAAATGTGCTATGTACGACCCTTTTAGACAGTATTGATTGAAT
ACTGTTCCCTTATTTATCTA

Product: cysteine desulfurase IscS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MSNLNRPIYLDYAATTPVDPQVAKKMTEYMTFDGMFGNPASRSHGYGWQAEEAVENARQQIADLVNADPREIVFTSGATE
SDNLAIKGAAHFYAGRGKHIITSKIEHKAVLDTCRQLEQEGYEITYIEPQPSTGLILPEQVKDALREDTILVSLMMVNNE
LGTVTDVKAIGEITREAGVVFHVDAAQAAGKVEIDLEALKIDLMSFSGHKIYGPKGIGALYVRRKPRIRLRAEQHGGGHE
RGMRSGTLATHQIVGMGEAFAIAAERLEQDRAHAQKLRDKLWAGVQDIEEIYLNGDSNNSVPNIVNISFNFVEGESLMMS
LKDMAVSSGSACTSATLEPSYVLRAIGRPDELAHSSIRFSFGRYTTEEDIDIILAQIHEAVDKLRDLSPLWDMYKDGVDL
TSVEWTEH

Sequences:

>Translated_408_residues
MSNLNRPIYLDYAATTPVDPQVAKKMTEYMTFDGMFGNPASRSHGYGWQAEEAVENARQQIADLVNADPREIVFTSGATE
SDNLAIKGAAHFYAGRGKHIITSKIEHKAVLDTCRQLEQEGYEITYIEPQPSTGLILPEQVKDALREDTILVSLMMVNNE
LGTVTDVKAIGEITREAGVVFHVDAAQAAGKVEIDLEALKIDLMSFSGHKIYGPKGIGALYVRRKPRIRLRAEQHGGGHE
RGMRSGTLATHQIVGMGEAFAIAAERLEQDRAHAQKLRDKLWAGVQDIEEIYLNGDSNNSVPNIVNISFNFVEGESLMMS
LKDMAVSSGSACTSATLEPSYVLRAIGRPDELAHSSIRFSFGRYTTEEDIDIILAQIHEAVDKLRDLSPLWDMYKDGVDL
TSVEWTEH
>Mature_407_residues
SNLNRPIYLDYAATTPVDPQVAKKMTEYMTFDGMFGNPASRSHGYGWQAEEAVENARQQIADLVNADPREIVFTSGATES
DNLAIKGAAHFYAGRGKHIITSKIEHKAVLDTCRQLEQEGYEITYIEPQPSTGLILPEQVKDALREDTILVSLMMVNNEL
GTVTDVKAIGEITREAGVVFHVDAAQAAGKVEIDLEALKIDLMSFSGHKIYGPKGIGALYVRRKPRIRLRAEQHGGGHER
GMRSGTLATHQIVGMGEAFAIAAERLEQDRAHAQKLRDKLWAGVQDIEEIYLNGDSNNSVPNIVNISFNFVEGESLMMSL
KDMAVSSGSACTSATLEPSYVLRAIGRPDELAHSSIRFSFGRYTTEEDIDIILAQIHEAVDKLRDLSPLWDMYKDGVDLT
SVEWTEH

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=404, Percent_Identity=53.960396039604, Blast_Score=476, Evalue=1e-134,
Organism=Homo sapiens, GI156713448, Length=418, Percent_Identity=33.2535885167464, Blast_Score=204, Evalue=1e-52,
Organism=Escherichia coli, GI48994898, Length=402, Percent_Identity=69.6517412935323, Blast_Score=607, Evalue=1e-175,
Organism=Escherichia coli, GI1787970, Length=395, Percent_Identity=27.0886075949367, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789175, Length=219, Percent_Identity=31.9634703196347, Blast_Score=88, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI25143064, Length=405, Percent_Identity=55.8024691358025, Blast_Score=475, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17533177, Length=341, Percent_Identity=34.3108504398827, Blast_Score=165, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6319831, Length=403, Percent_Identity=52.8535980148883, Blast_Score=462, Evalue=1e-131,
Organism=Drosophila melanogaster, GI20129463, Length=404, Percent_Identity=51.980198019802, Blast_Score=452, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 45109; Mature: 44978

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLNRPIYLDYAATTPVDPQVAKKMTEYMTFDGMFGNPASRSHGYGWQAEEAVENARQQ
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHHH
IADLVNADPREIVFTSGATESDNLAIKGAAHFYAGRGKHIITSKIEHKAVLDTCRQLEQE
HHHHHCCCCCEEEEECCCCCCCCEEEEECHHEECCCCCEEEHHHHHHHHHHHHHHHHHHC
GYEITYIEPQPSTGLILPEQVKDALREDTILVSLMMVNNELGTVTDVKAIGEITREAGVV
CCEEEEECCCCCCCCEEHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCEE
FHVDAAQAAGKVEIDLEALKIDLMSFSGHKIYGPKGIGALYVRRKPRIRLRAEQHGGGHE
EEEEHHCCCCEEEEEHEEEEEEEEECCCCEEECCCCCCEEEEECCCCEEEEECCCCCCHH
RGMRSGTLATHQIVGMGEAFAIAAERLEQDRAHAQKLRDKLWAGVQDIEEIYLNGDSNNS
CCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHEECCCCCCC
VPNIVNISFNFVEGESLMMSLKDMAVSSGSACTSATLEPSYVLRAIGRPDELAHSSIRFS
CCCEEEEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHEEE
FGRYTTEEDIDIILAQIHEAVDKLRDLSPLWDMYKDGVDLTSVEWTEH
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEECCCC
>Mature Secondary Structure 
SNLNRPIYLDYAATTPVDPQVAKKMTEYMTFDGMFGNPASRSHGYGWQAEEAVENARQQ
CCCCCCEEEEECCCCCCCHHHHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHHH
IADLVNADPREIVFTSGATESDNLAIKGAAHFYAGRGKHIITSKIEHKAVLDTCRQLEQE
HHHHHCCCCCEEEEECCCCCCCCEEEEECHHEECCCCCEEEHHHHHHHHHHHHHHHHHHC
GYEITYIEPQPSTGLILPEQVKDALREDTILVSLMMVNNELGTVTDVKAIGEITREAGVV
CCEEEEECCCCCCCCEEHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCEE
FHVDAAQAAGKVEIDLEALKIDLMSFSGHKIYGPKGIGALYVRRKPRIRLRAEQHGGGHE
EEEEHHCCCCEEEEEHEEEEEEEEECCCCEEECCCCCCEEEEECCCCEEEEECCCCCCHH
RGMRSGTLATHQIVGMGEAFAIAAERLEQDRAHAQKLRDKLWAGVQDIEEIYLNGDSNNS
CCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHEECCCCCCC
VPNIVNISFNFVEGESLMMSLKDMAVSSGSACTSATLEPSYVLRAIGRPDELAHSSIRFS
CCCEEEEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHEEE
FGRYTTEEDIDIILAQIHEAVDKLRDLSPLWDMYKDGVDLTSVEWTEH
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA