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The map label for this gene is purH

Identifier: 148653422

GI number: 148653422

Start: 2009136

End: 2010710

Strand: Direct

Name: purH

Synonym: PsycPRwf_1624

Alternate gene names: 148653422

Gene position: 2009136-2010710 (Clockwise)

Preceding gene: 148653421

Following gene: 148653425

Centisome position: 67.44

GC content: 48.19

Gene sequence:

>1575_bases
ATGTCTGATAAGCCGTACGCTCTTATTTCTGTTTCTGATAAATCACAAATTGAAAGCTTTGCAAAAGGCCTCATCGAAGC
AGGATACGATCTATTATCTACCGGTGGTACGTATCGCCTACTGTCTGACAACGGCATTGCTGTGACTGAAGTGGCCGACT
ATACCGGCTTCGCCGAAATGATGGATGGCCGCGTCAAAACCTTACACCCAAAAATTCATGGTGGTATTCTCGGTCGCCGT
GGTCAAGACGATGCGGTTATGAGCGAACATGGTATTCGCCCTATCGACTTAGTCGTGGTCAACCTTTATCCTTTTGCGCA
AACTGTGGCAAAGCCTGATGTGACCAAAGCTGATGCGATTGAAAACATCGATATCGGTGGCCCAACCATGGTGCGCTCAG
CGGCCAAAAACCACGAACATGTAGCCATCGTAACCAATCCTGCAGACTATGATGTGGTGCTACAAGAGCTAAAAGACACG
GGCAGCATCTCTCAAAAAACCCGTTTTGATTTGGCAGTAAAAGCGTTTGAGCATACCGCTCATTATGATGGCATGATTGC
CAACTTCTTAGGCAGTCGCCTAGAGTCATTTGAAGCGCCAGATAGCTTCGCTCGCACGTTCAACGTACAACTACAAAAAG
CTCAAGATTTGCGCTATGGTGAAAACCCACATCAAAAAGCGGCATTTTATGTAGAAGCCAATGGCTCAGGTGAAGGCAGC
ATCTCTACCGCTCAGCAGCATCAAGGCAAAGAGCTGTCATACAACAACATCGCTGATACTGATGCCGCTTTAGAGTGTGT
CAAATCATTTAGCGAGTCGGCCTGTGTGATTGTGAAGCACGCGAACCCTTGCGGTGTGGCGATCAATGCTGACCAGACTC
AAGCATACAAAACAGCGTTTAGCACAGATCCTGAGTCATCTTTTGGCGGTATCATTGCCTTTAACCGTCCCCTAACTAAG
CAAACGGCGCAAGCGATTGTAGATACGCAGTTCGCTGAAGTGATCATTGCCCCAAGCCTTGAGCAAGGTGTGCTTGACAT
TACTGCCGCCAAAAAGAACGTACGCGTCTTAACCTGTGGTGAGCTACCAAGCCCTGATCAACGTGCCGCGCAATTTGACT
ATAAACGTGTCACAGGCGGTCTATTAATCCAAAACCAAGACTTGGGTCTCATCACTGCCGATGACCTACAAGTGGTGACT
GATCTAAAACCTACTGCTGAGCAGTTAAATGACTTATTGTTCACTTGGACTGTGGCCAAGTATGTTAAGTCAAATGCCAT
TGTTTATGGTAAAGATCAGCGCACCATCGGTATTGGTGCCGGCCAAATGAGCCGTGTGAACTCAGCACGTATCGCAGCCA
TCAAAGCTGAGCATGCCAACCTAGCAACGCAAGGCGCGGTTATGGCCTCAGATGCCTTCTTCCCATTCCGTGATGGTATC
GATAACGCTGCTGAAGTAGGCATTAAAGCCATTATTCAGCCCGGTGGTTCTATTCGTGATGACGAAACCATTGCTGCGGC
GAACGAGCATGGTATCGCTATGGTCTTCACCGGTATGCGTCATTTCCGCCACTAA

Upstream 100 bases:

>100_bases
CTTCCTCGCTTAATTTGCAAAGATTAAGTGTTTTACTAAACCCTGACGATAATCTCAGAATATCATCACCCTTTTTACTG
TCCACACTATGGGAAAAACT

Downstream 100 bases:

>100_bases
GCAACAAGCTTTGTGTATCTGATAGACGCCCATAAAAAAAGACCGCCTCAGTGAGGCGGTCTTTTTTTATGCGTCGTTTA
AGATTGGGTATAAGCTGAGC

Product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase

Number of amino acids: Translated: 524; Mature: 523

Protein sequence:

>524_residues
MSDKPYALISVSDKSQIESFAKGLIEAGYDLLSTGGTYRLLSDNGIAVTEVADYTGFAEMMDGRVKTLHPKIHGGILGRR
GQDDAVMSEHGIRPIDLVVVNLYPFAQTVAKPDVTKADAIENIDIGGPTMVRSAAKNHEHVAIVTNPADYDVVLQELKDT
GSISQKTRFDLAVKAFEHTAHYDGMIANFLGSRLESFEAPDSFARTFNVQLQKAQDLRYGENPHQKAAFYVEANGSGEGS
ISTAQQHQGKELSYNNIADTDAALECVKSFSESACVIVKHANPCGVAINADQTQAYKTAFSTDPESSFGGIIAFNRPLTK
QTAQAIVDTQFAEVIIAPSLEQGVLDITAAKKNVRVLTCGELPSPDQRAAQFDYKRVTGGLLIQNQDLGLITADDLQVVT
DLKPTAEQLNDLLFTWTVAKYVKSNAIVYGKDQRTIGIGAGQMSRVNSARIAAIKAEHANLATQGAVMASDAFFPFRDGI
DNAAEVGIKAIIQPGGSIRDDETIAAANEHGIAMVFTGMRHFRH

Sequences:

>Translated_524_residues
MSDKPYALISVSDKSQIESFAKGLIEAGYDLLSTGGTYRLLSDNGIAVTEVADYTGFAEMMDGRVKTLHPKIHGGILGRR
GQDDAVMSEHGIRPIDLVVVNLYPFAQTVAKPDVTKADAIENIDIGGPTMVRSAAKNHEHVAIVTNPADYDVVLQELKDT
GSISQKTRFDLAVKAFEHTAHYDGMIANFLGSRLESFEAPDSFARTFNVQLQKAQDLRYGENPHQKAAFYVEANGSGEGS
ISTAQQHQGKELSYNNIADTDAALECVKSFSESACVIVKHANPCGVAINADQTQAYKTAFSTDPESSFGGIIAFNRPLTK
QTAQAIVDTQFAEVIIAPSLEQGVLDITAAKKNVRVLTCGELPSPDQRAAQFDYKRVTGGLLIQNQDLGLITADDLQVVT
DLKPTAEQLNDLLFTWTVAKYVKSNAIVYGKDQRTIGIGAGQMSRVNSARIAAIKAEHANLATQGAVMASDAFFPFRDGI
DNAAEVGIKAIIQPGGSIRDDETIAAANEHGIAMVFTGMRHFRH
>Mature_523_residues
SDKPYALISVSDKSQIESFAKGLIEAGYDLLSTGGTYRLLSDNGIAVTEVADYTGFAEMMDGRVKTLHPKIHGGILGRRG
QDDAVMSEHGIRPIDLVVVNLYPFAQTVAKPDVTKADAIENIDIGGPTMVRSAAKNHEHVAIVTNPADYDVVLQELKDTG
SISQKTRFDLAVKAFEHTAHYDGMIANFLGSRLESFEAPDSFARTFNVQLQKAQDLRYGENPHQKAAFYVEANGSGEGSI
STAQQHQGKELSYNNIADTDAALECVKSFSESACVIVKHANPCGVAINADQTQAYKTAFSTDPESSFGGIIAFNRPLTKQ
TAQAIVDTQFAEVIIAPSLEQGVLDITAAKKNVRVLTCGELPSPDQRAAQFDYKRVTGGLLIQNQDLGLITADDLQVVTD
LKPTAEQLNDLLFTWTVAKYVKSNAIVYGKDQRTIGIGAGQMSRVNSARIAAIKAEHANLATQGAVMASDAFFPFRDGID
NAAEVGIKAIIQPGGSIRDDETIAAANEHGIAMVFTGMRHFRH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family

Homologues:

Organism=Homo sapiens, GI20127454, Length=515, Percent_Identity=34.9514563106796, Blast_Score=246, Evalue=3e-65,
Organism=Escherichia coli, GI1790439, Length=524, Percent_Identity=65.4580152671756, Blast_Score=692, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71985564, Length=515, Percent_Identity=34.7572815533981, Blast_Score=261, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI71985574, Length=340, Percent_Identity=27.6470588235294, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71985556, Length=60, Percent_Identity=51.6666666666667, Blast_Score=78, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323056, Length=492, Percent_Identity=34.9593495934959, Blast_Score=249, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6323768, Length=479, Percent_Identity=35.4906054279749, Blast_Score=244, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24649832, Length=511, Percent_Identity=36.0078277886497, Blast_Score=259, Evalue=2e-69,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR9_PSYWF (A5WFX4)

Other databases:

- EMBL:   CP000713
- RefSeq:   YP_001280515.1
- ProteinModelPortal:   A5WFX4
- SMR:   A5WFX4
- STRING:   A5WFX4
- GeneID:   5205092
- GenomeReviews:   CP000713_GR
- KEGG:   prw:PsycPRwf_1624
- eggNOG:   COG0138
- HOGENOM:   HBG498048
- OMA:   ASDGFFP
- ProtClustDB:   PRK00881
- BioCyc:   PSP56811:PSYCPRWF_1624-MONOMER
- HAMAP:   MF_00139
- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607
- Gene3D:   G3DSA:3.40.50.1380
- PANTHER:   PTHR11692
- PIRSF:   PIRSF000414
- SMART:   SM00798
- SMART:   SM00851
- TIGRFAMs:   TIGR00355

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS; SSF53927 Cytidine_deaminase-like; SSF52335 MGS-like_dom

EC number: =2.1.2.3; =3.5.4.10

Molecular weight: Translated: 56499; Mature: 56368

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKPYALISVSDKSQIESFAKGLIEAGYDLLSTGGTYRLLSDNGIAVTEVADYTGFAEM
CCCCCEEEEEECCHHHHHHHHHHHHHCCCHHHCCCCEEEEECCCCEEEEEEHHHCCHHHH
MDGRVKTLHPKIHGGILGRRGQDDAVMSEHGIRPIDLVVVNLYPFAQTVAKPDVTKADAI
HCCCCEEECCHHHCCCCCCCCCCCCHHHHCCCCEEEEEEEEECHHHHHHCCCCCCHHHCC
ENIDIGGPTMVRSAAKNHEHVAIVTNPADYDVVLQELKDTGSISQKTRFDLAVKAFEHTA
CCCCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
HYDGMIANFLGSRLESFEAPDSFARTFNVQLQKAQDLRYGENPHQKAAFYVEANGSGEGS
HHCHHHHHHHHHHHHHCCCCHHHHHEEEEEEEEHHCCCCCCCCCCCEEEEEEECCCCCCC
ISTAQQHQGKELSYNNIADTDAALECVKSFSESACVIVKHANPCGVAINADQTQAYKTAF
CCCHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCEEEECCCHHHHHHHC
STDPESSFGGIIAFNRPLTKQTAQAIVDTQFAEVIIAPSLEQGVLDITAAKKNVRVLTCG
CCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHEEECCCCCCCCEEEEECCCCEEEEEEC
ELPSPDQRAAQFDYKRVTGGLLIQNQDLGLITADDLQVVTDLKPTAEQLNDLLFTWTVAK
CCCCCHHHHHHCCHHHCCCCEEEECCCCCEEEECCEEEEECCCHHHHHHHHHHHHHHHHH
YVKSNAIVYGKDQRTIGIGAGQMSRVNSARIAAIKAEHANLATQGAVMASDAFFPFRDGI
HHHCCCEEEECCCCEEEECCCCHHHCCCCEEEEEEECCCCCHHCCCEEECCCCCCHHCCC
DNAAEVGIKAIIQPGGSIRDDETIAAANEHGIAMVFTGMRHFRH
CHHHHHCCCEEECCCCCCCCCCEEEECCCCCEEEEEECHHHHCC
>Mature Secondary Structure 
SDKPYALISVSDKSQIESFAKGLIEAGYDLLSTGGTYRLLSDNGIAVTEVADYTGFAEM
CCCCEEEEEECCHHHHHHHHHHHHHCCCHHHCCCCEEEEECCCCEEEEEEHHHCCHHHH
MDGRVKTLHPKIHGGILGRRGQDDAVMSEHGIRPIDLVVVNLYPFAQTVAKPDVTKADAI
HCCCCEEECCHHHCCCCCCCCCCCCHHHHCCCCEEEEEEEEECHHHHHHCCCCCCHHHCC
ENIDIGGPTMVRSAAKNHEHVAIVTNPADYDVVLQELKDTGSISQKTRFDLAVKAFEHTA
CCCCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
HYDGMIANFLGSRLESFEAPDSFARTFNVQLQKAQDLRYGENPHQKAAFYVEANGSGEGS
HHCHHHHHHHHHHHHHCCCCHHHHHEEEEEEEEHHCCCCCCCCCCCEEEEEEECCCCCCC
ISTAQQHQGKELSYNNIADTDAALECVKSFSESACVIVKHANPCGVAINADQTQAYKTAF
CCCHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCEEEECCCHHHHHHHC
STDPESSFGGIIAFNRPLTKQTAQAIVDTQFAEVIIAPSLEQGVLDITAAKKNVRVLTCG
CCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHEEECCCCCCCCEEEEECCCCEEEEEEC
ELPSPDQRAAQFDYKRVTGGLLIQNQDLGLITADDLQVVTDLKPTAEQLNDLLFTWTVAK
CCCCCHHHHHHCCHHHCCCCEEEECCCCCEEEECCEEEEECCCHHHHHHHHHHHHHHHHH
YVKSNAIVYGKDQRTIGIGAGQMSRVNSARIAAIKAEHANLATQGAVMASDAFFPFRDGI
HHHCCCEEEECCCCEEEECCCCHHHCCCCEEEEEEECCCCCHHCCCEEECCCCCCHHCCC
DNAAEVGIKAIIQPGGSIRDDETIAAANEHGIAMVFTGMRHFRH
CHHHHHCCCEEECCCCCCCCCCEEEECCCCCEEEEEECHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA