| Definition | Psychrobacter sp. PRwf-1 chromosome, complete genome. |
|---|---|
| Accession | NC_009524 |
| Length | 2,978,976 |
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The map label for this gene is aceA [C]
Identifier: 148653250
GI number: 148653250
Start: 1773186
End: 1774769
Strand: Direct
Name: aceA [C]
Synonym: PsycPRwf_1448
Alternate gene names: 148653250
Gene position: 1773186-1774769 (Clockwise)
Preceding gene: 148653243
Following gene: 148653251
Centisome position: 59.52
GC content: 44.51
Gene sequence:
>1584_bases ATGTCAACTTATAAATCAGCTATTGACCATATCCGTGAAATTAAAGCAAAGCATGGCAACTGGCAGAATATCAGCGAATC TGATGCTGCTCGTATGATGGTTCAAAACCGCTTCAAAACCGGTCTTGATATCGCTAAATACACGGCTGCTATCATGCGTA AAGATATGGCAGAGTATGATGCAGATACATCTAAGTACACTCAGTCTCTAGGCGCATGGCATGGTTTTGTTGCACAACAA ACTATGTATGCTAAGAAAAAATACTTCGGTACGACTGCTAAAACCTACATCTACCTATCAGGCTGGATGGTAGCGGCTCT ACGCTCAGAGCTTGGCCCTTTACCTGACCAATCAATGCACGAAAAAACAACGGTTCCTGCGCTAATCGAAGAAATCTACA CCTTCTTACGTCAAGCAGACGCGAAAGTATTAAATGATTATTTCCGTGAGCTTAACGCTGCTAAAGAAGCCGGTCAAGAT ACTTCTGAAATCGAAGAAAAAATCAATAACTTTGATTCACACGTTGTGCCAATCATCGCTGACATCGACGCAGGTTTCGG TAACGAAGAAGCAACTTACTTACTTACTAAAGCCATGATCGAAGCGGGTGCTTGTGCTATCCAGATCGAAAACCAAGTAT CTGATGCAAAACAATGTGGTCACCAAGCCGGTAAAGTCACTGTACCACATGAAGACTTCATCTCTAAGCTTAACGCTATC CGTTATGCATTCTTAGAGCTAGGCGTTGATGATGGTGTTATCGTTGCCCGTACCGACTCAGAAGGTGCATCACTTACTCA AAAGATCCCAGTATCTGAAGAGCCAGGCGACCTTGCTTCTAAATACATCGACTTCATCGACGTTGAAGAAATCGACATCG CTGATGCCAAAGAAAACGACGTACTATTAAAGCGTGACGGTAAATTAGTTCGCCCAGTTCGTCTAGCTAACGGTCTATAC CAGTTCCGTGAAGATACCAACATCGACCGCGTTGTACTTGACTGTGTAACCGCTCTTGAAAATGGTGCTGACCTTCTATG GATCGAAACACCGACTCCAGATGTTGCACACATCAAAATGATGGTTGACCGTATTAAAGAGCAGCAGCCTAAAGCGAAGC TTGTATACAACAACAGCCCATCATTTAACTGGACGCTAAACTTCCGTAAGCAAGTGATTGCTCAGTGGGAAGAAGAAGGC AAAGACATCTCAGCATACGACAAGAACAACTTGATGAGTGCTGATTATGATGGTACTGAGCTTGACGCTGCTGCTGACCA AGCTGCGAAGAACTTCCAGAAAGATGCGTCACGTGAAGCCGGTGTATTCCATCACCTAATCACGCTACCAACTTACCACA CCACAGCACTTAGCGTTCATGAGCTTGCTAAAGGCTACTTCGGTGAAGACGGTATGCTTGCTTATGCAGCTGGCGTACAA CGTAAAGAAATCCGTGAAGGCATCTCTTGCGTTAAGCACCAAGCAATGGCCGGTTCAGACTTAGGTGATGATCACAAAGA GATTTTCTCTGGTGACAACGCACTTAAAGCTGGCGGCGAGAAAAACACAATGAACCAGTTCTAA
Upstream 100 bases:
>100_bases TTAAAGAGAGTTAAATAAAACTTCTTTATCTAACCGTTCAACATCTAGTAGTAAGAAGTATTTATTTCGCCTAACCCATC CTCAATCAAGGAGACAATTG
Downstream 100 bases:
>100_bases GAACTCTTTAGACCAAAGCTCTTTATAAAAGACGCTTCGTTCATCATTAACAAAGTCGCTCTAACCTCGGTTAGGGCGAC TTTTTTTATGAACCTAGGCG
Product: isocitrate lyase
Products: NA
Alternate protein names: ICL; Isocitrase; Isocitratase [H]
Number of amino acids: Translated: 527; Mature: 526
Protein sequence:
>527_residues MSTYKSAIDHIREIKAKHGNWQNISESDAARMMVQNRFKTGLDIAKYTAAIMRKDMAEYDADTSKYTQSLGAWHGFVAQQ TMYAKKKYFGTTAKTYIYLSGWMVAALRSELGPLPDQSMHEKTTVPALIEEIYTFLRQADAKVLNDYFRELNAAKEAGQD TSEIEEKINNFDSHVVPIIADIDAGFGNEEATYLLTKAMIEAGACAIQIENQVSDAKQCGHQAGKVTVPHEDFISKLNAI RYAFLELGVDDGVIVARTDSEGASLTQKIPVSEEPGDLASKYIDFIDVEEIDIADAKENDVLLKRDGKLVRPVRLANGLY QFREDTNIDRVVLDCVTALENGADLLWIETPTPDVAHIKMMVDRIKEQQPKAKLVYNNSPSFNWTLNFRKQVIAQWEEEG KDISAYDKNNLMSADYDGTELDAAADQAAKNFQKDASREAGVFHHLITLPTYHTTALSVHELAKGYFGEDGMLAYAAGVQ RKEIREGISCVKHQAMAGSDLGDDHKEIFSGDNALKAGGEKNTMNQF
Sequences:
>Translated_527_residues MSTYKSAIDHIREIKAKHGNWQNISESDAARMMVQNRFKTGLDIAKYTAAIMRKDMAEYDADTSKYTQSLGAWHGFVAQQ TMYAKKKYFGTTAKTYIYLSGWMVAALRSELGPLPDQSMHEKTTVPALIEEIYTFLRQADAKVLNDYFRELNAAKEAGQD TSEIEEKINNFDSHVVPIIADIDAGFGNEEATYLLTKAMIEAGACAIQIENQVSDAKQCGHQAGKVTVPHEDFISKLNAI RYAFLELGVDDGVIVARTDSEGASLTQKIPVSEEPGDLASKYIDFIDVEEIDIADAKENDVLLKRDGKLVRPVRLANGLY QFREDTNIDRVVLDCVTALENGADLLWIETPTPDVAHIKMMVDRIKEQQPKAKLVYNNSPSFNWTLNFRKQVIAQWEEEG KDISAYDKNNLMSADYDGTELDAAADQAAKNFQKDASREAGVFHHLITLPTYHTTALSVHELAKGYFGEDGMLAYAAGVQ RKEIREGISCVKHQAMAGSDLGDDHKEIFSGDNALKAGGEKNTMNQF >Mature_526_residues STYKSAIDHIREIKAKHGNWQNISESDAARMMVQNRFKTGLDIAKYTAAIMRKDMAEYDADTSKYTQSLGAWHGFVAQQT MYAKKKYFGTTAKTYIYLSGWMVAALRSELGPLPDQSMHEKTTVPALIEEIYTFLRQADAKVLNDYFRELNAAKEAGQDT SEIEEKINNFDSHVVPIIADIDAGFGNEEATYLLTKAMIEAGACAIQIENQVSDAKQCGHQAGKVTVPHEDFISKLNAIR YAFLELGVDDGVIVARTDSEGASLTQKIPVSEEPGDLASKYIDFIDVEEIDIADAKENDVLLKRDGKLVRPVRLANGLYQ FREDTNIDRVVLDCVTALENGADLLWIETPTPDVAHIKMMVDRIKEQQPKAKLVYNNSPSFNWTLNFRKQVIAQWEEEGK DISAYDKNNLMSADYDGTELDAAADQAAKNFQKDASREAGVFHHLITLPTYHTTALSVHELAKGYFGEDGMLAYAAGVQR KEIREGISCVKHQAMAGSDLGDDHKEIFSGDNALKAGGEKNTMNQF
Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]
COG id: COG2224
COG function: function code C; Isocitrate lyase
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]
Homologues:
Organism=Escherichia coli, GI1790445, Length=518, Percent_Identity=28.1853281853282, Blast_Score=155, Evalue=5e-39, Organism=Caenorhabditis elegans, GI71982926, Length=446, Percent_Identity=30.0448430493274, Blast_Score=151, Evalue=6e-37, Organism=Caenorhabditis elegans, GI17561814, Length=446, Percent_Identity=30.0448430493274, Blast_Score=151, Evalue=7e-37, Organism=Saccharomyces cerevisiae, GI6325263, Length=501, Percent_Identity=24.5508982035928, Blast_Score=121, Evalue=3e-28, Organism=Saccharomyces cerevisiae, GI6320908, Length=170, Percent_Identity=35.2941176470588, Blast_Score=99, Evalue=1e-21,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR006254 - InterPro: IPR000918 - InterPro: IPR015813 [H]
Pfam domain/function: PF00463 ICL [H]
EC number: =4.1.3.1 [H]
Molecular weight: Translated: 58685; Mature: 58553
Theoretical pI: Translated: 4.85; Mature: 4.85
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 2.8 %Met (Translated Protein) 3.6 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 2.7 %Met (Mature Protein) 3.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSTYKSAIDHIREIKAKHGNWQNISESDAARMMVQNRFKTGLDIAKYTAAIMRKDMAEYD CCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC ADTSKYTQSLGAWHGFVAQQTMYAKKKYFGTTAKTYIYLSGWMVAALRSELGPLPDQSMH CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHCCCCCCHHH EKTTVPALIEEIYTFLRQADAKVLNDYFRELNAAKEAGQDTSEIEEKINNFDSHVVPIIA HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEE DIDAGFGNEEATYLLTKAMIEAGACAIQIENQVSDAKQCGHQAGKVTVPHEDFISKLNAI ECCCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCCEECCHHHHHHHHHHH RYAFLELGVDDGVIVARTDSEGASLTQKIPVSEEPGDLASKYIDFIDVEEIDIADAKEND HHHHHHCCCCCCEEEEEECCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCC VLLKRDGKLVRPVRLANGLYQFREDTNIDRVVLDCVTALENGADLLWIETPTPDVAHIKM EEEECCCCEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHH MVDRIKEQQPKAKLVYNNSPSFNWTLNFRKQVIAQWEEEGKDISAYDKNNLMSADYDGTE HHHHHHHCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCH LDAAADQAAKNFQKDASREAGVFHHLITLPTYHTTALSVHELAKGYFGEDGMLAYAAGVQ HHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEHHHCCC RKEIREGISCVKHQAMAGSDLGDDHKEIFSGDNALKAGGEKNTMNQF HHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCHHHCCCCCCCCCCC >Mature Secondary Structure STYKSAIDHIREIKAKHGNWQNISESDAARMMVQNRFKTGLDIAKYTAAIMRKDMAEYD CHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC ADTSKYTQSLGAWHGFVAQQTMYAKKKYFGTTAKTYIYLSGWMVAALRSELGPLPDQSMH CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHCCCCCCHHH EKTTVPALIEEIYTFLRQADAKVLNDYFRELNAAKEAGQDTSEIEEKINNFDSHVVPIIA HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEE DIDAGFGNEEATYLLTKAMIEAGACAIQIENQVSDAKQCGHQAGKVTVPHEDFISKLNAI ECCCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCCEECCHHHHHHHHHHH RYAFLELGVDDGVIVARTDSEGASLTQKIPVSEEPGDLASKYIDFIDVEEIDIADAKEND HHHHHHCCCCCCEEEEEECCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCC VLLKRDGKLVRPVRLANGLYQFREDTNIDRVVLDCVTALENGADLLWIETPTPDVAHIKM EEEECCCCEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHH MVDRIKEQQPKAKLVYNNSPSFNWTLNFRKQVIAQWEEEGKDISAYDKNNLMSADYDGTE HHHHHHHCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCH LDAAADQAAKNFQKDASREAGVFHHLITLPTYHTTALSVHELAKGYFGEDGMLAYAAGVQ HHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEHHHCCC RKEIREGISCVKHQAMAGSDLGDDHKEIFSGDNALKAGGEKNTMNQF HHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCHHHCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 10984043 [H]