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The map label for this gene is acsA [H]

Identifier: 148652436

GI number: 148652436

Start: 751593

End: 753548

Strand: Direct

Name: acsA [H]

Synonym: PsycPRwf_0624

Alternate gene names: 148652436

Gene position: 751593-753548 (Clockwise)

Preceding gene: 148652434

Following gene: 148652437

Centisome position: 25.23

GC content: 49.85

Gene sequence:

>1956_bases
ATGAAACAGTTTCCAATTAGCCCCGAATTCTCAGCTCAAGCCAACATTACTCCTGAAAAATATGCACAAATCTACCAAGA
GTCAATTGAGTCTCCTGAAAGCAATGAAGCTTTTTGGGCGAAACGAGCAGAGCTAATTGATTGGATCAAAAAACCCACCA
AAATCAAAGACGTCAATTACGACTTAGATAATTTTAGAATTAAGTGGTATGAAGATGGTGAGCTGAACGTTTCGGTGAAC
TGTCTCGACCGTCATCTGGCAGACAACCCTTACAAGCCGGCCATCATCTGGGAAGGCGACCACCCTGCACTACACAAGAT
CATCTCCTTTAAAGAGCTGCATTCAGAAGTATGCCGTCTGGGCAATGCCATGCGCAAAATGGGCGTGGGCAAAGGCGACA
GAGTGGTGTTGTATCTGCCAATGGTGCCAGAAGCTGTGGTGTCTATGCTGGCGTGTGCCCGTATTGGGGCAATTCATACT
GTCGTATTTGGTGGCTTTTCAGCTGAAAGTTTGGCCAGTCGTATTATCGATAGCCAAGCCAAGTTGGTCATCACAGCAGA
TGAAGGGGTGCGTGGCGGCAAATACACGCCGCTAAAAACCAATGTAGACAAAGCGCTCGATGTTGACGGCACAGAATGTG
TGGAGCGAGTGGTTGTGGTACACCGTACCGGCAACTCAGTGCCAATGAGTGGCCGCCGTGATGCTTGGTATCATACGCTC
ATTGATAACTCCAATGAAGACTGCCCACCTGAAACCATGAATGCTGAAGACCCACTGTTCTTACTGTACACCTCAGGGTC
AACCGGTAAGCCTAAGGGCGTGGTACACACCACGGGTGGTTATTTGACCTATGCCTTATCGACCTTTCGAGATGTGTTCG
ATATCAAGCAAGATGATGTGTTCTGGTGTACGGCTGATGTGGGCTGGGTAACCGGTCACAGCTATGTCACTTATGGGCCG
CTGGCCAATGGAACCACCACAGTGATGTTCGAGGGGGTACCGCAATATCCGACTTGGGCGCGTATTGGTCAAATCATCGA
CAAGCATGATGTGAGCATCTTATATACCGCACCGACTGCCATTCGGGCCATGATGAAAGAGGGGGATGCTTATGTACGTG
AGTCAAATCGTGAAAGCTTACGCCTATTAGGTACGGTGGGTGAGCCTATTAACCCTGAAGCTTGGGACTGGTATCACGCT
GTGGTTGGTGAAGGACGTTGTCCTATCGTTGATACTTGGTGGCAGACTGAGACGGGCGGTATCTTGATGGCTCCGCTGCC
AAACTCAGTGGACATGAAGCCAGGTGCTGCTATGAACCCTTTATATGGCATCAAGCCGGCTATTGTTGACTCAGAAGGCG
TGCAACTAGAGGGCTGCTCGACTGCGGGTAACTTAATTATTACTGACGGCTGGCCGGGTCAAATGCGCACCATTTATGGC
GATCATAAGCGCTTCTTAGAGACCTACTATACCACTTATCCTGGCAGCTATTTTACAGGTGATGGCGCAATGCGTGATGA
GGAAGGTCATTACTGGATTACCGGCCGTGTCGATGACGTGCTGAACGTATCGGGCCACCGTATCGGTACCGCTGAGATTG
AAAGCGCCTTGGTGTCGCACCCAGCTGCCGCTGAAACGGCCATTGTCGGAATGCCGCATGAGCTAAAAGGTCAAGGTATC
TGTGCTTATATCATCTTAAGAAACGGGGAAGAAGATACCGAAAGATTGCGTAATGAGCTTAACCGCCATGTGCGTGCAGA
AATCGGCCCGATTGCTAACTTAGATGCCATGTATATTGTTGAGGCGCTACCTAAGACCCGCTCGGGCAAAATCATGCGCC
GCATCTTACGTAAGCTTGCTGCCGGTGAGTTCGATGGTCTAGGCGATACCTCAACGCTTGCAGATGCCAGCGTGGTTGAT
GACTTAATCAATACCGTTAAGGCCGCTCAAGCCTAA

Upstream 100 bases:

>100_bases
TTTATCACGATAACGCAGCAGATTAAGCCTGCTATTAACGGTTTAACACCCGGTGATCTCTAGGACAAGAGTCACAATAA
AATAAAAAGGACTTTATTAT

Downstream 100 bases:

>100_bases
TGCTTAGCGCCAATAGCCCACGGGCAAGGCACGGCTGTTTTTATTAAAAAAATATACGAGTTTATTGACCAGTTTACTGA
TATACCACCGCTTAAGACAT

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 651; Mature: 651

Protein sequence:

>651_residues
MKQFPISPEFSAQANITPEKYAQIYQESIESPESNEAFWAKRAELIDWIKKPTKIKDVNYDLDNFRIKWYEDGELNVSVN
CLDRHLADNPYKPAIIWEGDHPALHKIISFKELHSEVCRLGNAMRKMGVGKGDRVVLYLPMVPEAVVSMLACARIGAIHT
VVFGGFSAESLASRIIDSQAKLVITADEGVRGGKYTPLKTNVDKALDVDGTECVERVVVVHRTGNSVPMSGRRDAWYHTL
IDNSNEDCPPETMNAEDPLFLLYTSGSTGKPKGVVHTTGGYLTYALSTFRDVFDIKQDDVFWCTADVGWVTGHSYVTYGP
LANGTTTVMFEGVPQYPTWARIGQIIDKHDVSILYTAPTAIRAMMKEGDAYVRESNRESLRLLGTVGEPINPEAWDWYHA
VVGEGRCPIVDTWWQTETGGILMAPLPNSVDMKPGAAMNPLYGIKPAIVDSEGVQLEGCSTAGNLIITDGWPGQMRTIYG
DHKRFLETYYTTYPGSYFTGDGAMRDEEGHYWITGRVDDVLNVSGHRIGTAEIESALVSHPAAAETAIVGMPHELKGQGI
CAYIILRNGEEDTERLRNELNRHVRAEIGPIANLDAMYIVEALPKTRSGKIMRRILRKLAAGEFDGLGDTSTLADASVVD
DLINTVKAAQA

Sequences:

>Translated_651_residues
MKQFPISPEFSAQANITPEKYAQIYQESIESPESNEAFWAKRAELIDWIKKPTKIKDVNYDLDNFRIKWYEDGELNVSVN
CLDRHLADNPYKPAIIWEGDHPALHKIISFKELHSEVCRLGNAMRKMGVGKGDRVVLYLPMVPEAVVSMLACARIGAIHT
VVFGGFSAESLASRIIDSQAKLVITADEGVRGGKYTPLKTNVDKALDVDGTECVERVVVVHRTGNSVPMSGRRDAWYHTL
IDNSNEDCPPETMNAEDPLFLLYTSGSTGKPKGVVHTTGGYLTYALSTFRDVFDIKQDDVFWCTADVGWVTGHSYVTYGP
LANGTTTVMFEGVPQYPTWARIGQIIDKHDVSILYTAPTAIRAMMKEGDAYVRESNRESLRLLGTVGEPINPEAWDWYHA
VVGEGRCPIVDTWWQTETGGILMAPLPNSVDMKPGAAMNPLYGIKPAIVDSEGVQLEGCSTAGNLIITDGWPGQMRTIYG
DHKRFLETYYTTYPGSYFTGDGAMRDEEGHYWITGRVDDVLNVSGHRIGTAEIESALVSHPAAAETAIVGMPHELKGQGI
CAYIILRNGEEDTERLRNELNRHVRAEIGPIANLDAMYIVEALPKTRSGKIMRRILRKLAAGEFDGLGDTSTLADASVVD
DLINTVKAAQA
>Mature_651_residues
MKQFPISPEFSAQANITPEKYAQIYQESIESPESNEAFWAKRAELIDWIKKPTKIKDVNYDLDNFRIKWYEDGELNVSVN
CLDRHLADNPYKPAIIWEGDHPALHKIISFKELHSEVCRLGNAMRKMGVGKGDRVVLYLPMVPEAVVSMLACARIGAIHT
VVFGGFSAESLASRIIDSQAKLVITADEGVRGGKYTPLKTNVDKALDVDGTECVERVVVVHRTGNSVPMSGRRDAWYHTL
IDNSNEDCPPETMNAEDPLFLLYTSGSTGKPKGVVHTTGGYLTYALSTFRDVFDIKQDDVFWCTADVGWVTGHSYVTYGP
LANGTTTVMFEGVPQYPTWARIGQIIDKHDVSILYTAPTAIRAMMKEGDAYVRESNRESLRLLGTVGEPINPEAWDWYHA
VVGEGRCPIVDTWWQTETGGILMAPLPNSVDMKPGAAMNPLYGIKPAIVDSEGVQLEGCSTAGNLIITDGWPGQMRTIYG
DHKRFLETYYTTYPGSYFTGDGAMRDEEGHYWITGRVDDVLNVSGHRIGTAEIESALVSHPAAAETAIVGMPHELKGQGI
CAYIILRNGEEDTERLRNELNRHVRAEIGPIANLDAMYIVEALPKTRSGKIMRRILRKLAAGEFDGLGDTSTLADASVVD
DLINTVKAAQA

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=672, Percent_Identity=48.9583333333333, Blast_Score=639, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=685, Percent_Identity=48.1751824817518, Blast_Score=634, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=636, Percent_Identity=48.1132075471698, Blast_Score=629, Evalue=1e-180,
Organism=Homo sapiens, GI13375727, Length=644, Percent_Identity=36.1801242236025, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI115511026, Length=524, Percent_Identity=28.4351145038168, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI38505220, Length=544, Percent_Identity=29.2279411764706, Blast_Score=186, Evalue=8e-47,
Organism=Homo sapiens, GI42544132, Length=517, Percent_Identity=27.852998065764, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI122937307, Length=560, Percent_Identity=26.7857142857143, Blast_Score=174, Evalue=3e-43,
Organism=Homo sapiens, GI31982927, Length=632, Percent_Identity=24.5253164556962, Blast_Score=164, Evalue=4e-40,
Organism=Homo sapiens, GI58082049, Length=560, Percent_Identity=25.8928571428571, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI157311624, Length=562, Percent_Identity=25.6227758007117, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI157311622, Length=562, Percent_Identity=25.6227758007117, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI187761345, Length=558, Percent_Identity=24.910394265233, Blast_Score=115, Evalue=2e-25,
Organism=Homo sapiens, GI187761343, Length=558, Percent_Identity=24.910394265233, Blast_Score=115, Evalue=2e-25,
Organism=Homo sapiens, GI42544134, Length=355, Percent_Identity=24.7887323943662, Blast_Score=90, Evalue=7e-18,
Organism=Homo sapiens, GI195947378, Length=407, Percent_Identity=24.0786240786241, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI156151445, Length=583, Percent_Identity=22.4699828473413, Blast_Score=84, Evalue=4e-16,
Organism=Escherichia coli, GI1790505, Length=633, Percent_Identity=59.2417061611374, Blast_Score=808, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=632, Percent_Identity=35.126582278481, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI221142682, Length=542, Percent_Identity=23.0627306273063, Blast_Score=109, Evalue=6e-25,
Organism=Escherichia coli, GI1788107, Length=572, Percent_Identity=23.7762237762238, Blast_Score=94, Evalue=4e-20,
Organism=Escherichia coli, GI1786810, Length=528, Percent_Identity=23.6742424242424, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI145693145, Length=124, Percent_Identity=32.258064516129, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71983001, Length=656, Percent_Identity=45.7317073170732, Blast_Score=570, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI71982997, Length=656, Percent_Identity=45.7317073170732, Blast_Score=570, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI17569507, Length=607, Percent_Identity=21.7462932454695, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17557194, Length=540, Percent_Identity=22.962962962963, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17558820, Length=494, Percent_Identity=22.2672064777328, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71985884, Length=403, Percent_Identity=22.8287841191067, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI115534440, Length=553, Percent_Identity=21.1573236889693, Blast_Score=82, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17538037, Length=173, Percent_Identity=31.2138728323699, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17560140, Length=522, Percent_Identity=21.0727969348659, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17559526, Length=138, Percent_Identity=28.2608695652174, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6323182, Length=644, Percent_Identity=48.7577639751553, Blast_Score=617, Evalue=1e-177,
Organism=Saccharomyces cerevisiae, GI6319264, Length=643, Percent_Identity=46.9673405909798, Blast_Score=577, Evalue=1e-165,
Organism=Saccharomyces cerevisiae, GI6319699, Length=226, Percent_Identity=28.3185840707965, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24667955, Length=657, Percent_Identity=47.1841704718417, Blast_Score=617, Evalue=1e-177,
Organism=Drosophila melanogaster, GI62472339, Length=560, Percent_Identity=50.3571428571429, Blast_Score=579, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24667959, Length=518, Percent_Identity=51.1583011583012, Blast_Score=543, Evalue=1e-154,
Organism=Drosophila melanogaster, GI21355225, Length=637, Percent_Identity=35.0078492935636, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI21355181, Length=514, Percent_Identity=22.3735408560311, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI18859661, Length=130, Percent_Identity=34.6153846153846, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24656500, Length=374, Percent_Identity=23.7967914438503, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI19922652, Length=378, Percent_Identity=22.7513227513227, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24581924, Length=524, Percent_Identity=21.3740458015267, Blast_Score=74, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24648257, Length=368, Percent_Identity=23.9130434782609, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 71927; Mature: 71927

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQFPISPEFSAQANITPEKYAQIYQESIESPESNEAFWAKRAELIDWIKKPTKIKDVNY
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEECCC
DLDNFRIKWYEDGELNVSVNCLDRHLADNPYKPAIIWEGDHPALHKIISFKELHSEVCRL
CCCCCEEEEEECCCEEEEEEEHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHH
GNAMRKMGVGKGDRVVLYLPMVPEAVVSMLACARIGAIHTVVFGGFSAESLASRIIDSQA
HHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHCCCC
KLVITADEGVRGGKYTPLKTNVDKALDVDGTECVERVVVVHRTGNSVPMSGRRDAWYHTL
EEEEEECCCCCCCCCCCCCCCCHHHCCCCHHHHHHHEEEEEECCCCCCCCCCCCCEEEEE
IDNSNEDCPPETMNAEDPLFLLYTSGSTGKPKGVVHTTGGYLTYALSTFRDVFDIKQDDV
ECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCE
FWCTADVGWVTGHSYVTYGPLANGTTTVMFEGVPQYPTWARIGQIIDKHDVSILYTAPTA
EEEECCCCEEECCCEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCEEEEECHHH
IRAMMKEGDAYVRESNRESLRLLGTVGEPINPEAWDWYHAVVGEGRCPIVDTWWQTETGG
HHHHHHCCCHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHCCCCCCEEECCCCCCCCC
ILMAPLPNSVDMKPGAAMNPLYGIKPAIVDSEGVQLEGCSTAGNLIITDGWPGQMRTIYG
EEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCCEEEECCCCCCCHHHHH
DHKRFLETYYTTYPGSYFTGDGAMRDEEGHYWITGRVDDVLNVSGHRIGTAEIESALVSH
HHHHHHHHHHHCCCCCEEECCCCCCCCCCCEEEEECCCHHHCCCCCEECHHHHHHHHHCC
PAAAETAIVGMPHELKGQGICAYIILRNGEEDTERLRNELNRHVRAEIGPIANLDAMYIV
CCCCCEEEECCCHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
EALPKTRSGKIMRRILRKLAAGEFDGLGDTSTLADASVVDDLINTVKAAQA
HHCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKQFPISPEFSAQANITPEKYAQIYQESIESPESNEAFWAKRAELIDWIKKPTKIKDVNY
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEECCC
DLDNFRIKWYEDGELNVSVNCLDRHLADNPYKPAIIWEGDHPALHKIISFKELHSEVCRL
CCCCCEEEEEECCCEEEEEEEHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHH
GNAMRKMGVGKGDRVVLYLPMVPEAVVSMLACARIGAIHTVVFGGFSAESLASRIIDSQA
HHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHCCCC
KLVITADEGVRGGKYTPLKTNVDKALDVDGTECVERVVVVHRTGNSVPMSGRRDAWYHTL
EEEEEECCCCCCCCCCCCCCCCHHHCCCCHHHHHHHEEEEEECCCCCCCCCCCCCEEEEE
IDNSNEDCPPETMNAEDPLFLLYTSGSTGKPKGVVHTTGGYLTYALSTFRDVFDIKQDDV
ECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCE
FWCTADVGWVTGHSYVTYGPLANGTTTVMFEGVPQYPTWARIGQIIDKHDVSILYTAPTA
EEEECCCCEEECCCEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCEEEEECHHH
IRAMMKEGDAYVRESNRESLRLLGTVGEPINPEAWDWYHAVVGEGRCPIVDTWWQTETGG
HHHHHHCCCHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHCCCCCCEEECCCCCCCCC
ILMAPLPNSVDMKPGAAMNPLYGIKPAIVDSEGVQLEGCSTAGNLIITDGWPGQMRTIYG
EEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCCEEEECCCCCCCHHHHH
DHKRFLETYYTTYPGSYFTGDGAMRDEEGHYWITGRVDDVLNVSGHRIGTAEIESALVSH
HHHHHHHHHHHCCCCCEEECCCCCCCCCCCEEEEECCCHHHCCCCCEECHHHHHHHHHCC
PAAAETAIVGMPHELKGQGICAYIILRNGEEDTERLRNELNRHVRAEIGPIANLDAMYIV
CCCCCEEEECCCHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
EALPKTRSGKIMRRILRKLAAGEFDGLGDTSTLADASVVDDLINTVKAAQA
HHCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA