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The map label for this gene is rnc [H]

Identifier: 148652186

GI number: 148652186

Start: 449067

End: 449846

Strand: Direct

Name: rnc [H]

Synonym: PsycPRwf_0374

Alternate gene names: 148652186

Gene position: 449067-449846 (Clockwise)

Preceding gene: 148652185

Following gene: 148652187

Centisome position: 15.07

GC content: 46.92

Gene sequence:

>780_bases
ATGACAGAAACGGCTGAGATAGCCCATACGAGCAAGCAGTCGCCCAAACAGCGCTATACCAGCTTTGAGCTGGGACTGCT
AAGCTTACAAAAACAGCTCGGTTATAGCTTTAACGACACCAGTTTGGCTAAGCTTGCACTGACGCACCGCTCTTTTGATG
GCAAAATAAACTACGAGCGTTTGGAGTTTTTAGGCGATGCCCTGTTAGGGATGATTATCGGTGAAGCTTTGTACTATCAG
TACCCCAAACAAGATGAAGGCCGTTTGACTCGCATGCGTGCCACTTTGGTGCGCCAAGAATCCTTGGTAGTCGTGGCACA
AAAGCTTAACTTATCGTCGTATTTGATATTGGGTGTGGGTGAGCGAAAAGGCGGTGGCCGAGAGCGTGCCTCAATTTTGG
CAGATACGGTGGAGTCTTTAATTGGCGCCATTTATTTAGACAGTCAAAGCGTGGATACGGTCAAAGCCTGTGTGCTAGAT
TGGTTTGCGGAGCTGATAGACAACGTCAATGATCAACGCGTGCTAAAAGATGCCAAAAGCCGGCTACAAGAATGGTTACA
AGGCTATAAGTTTGAGCTGCCCAATTATGACTTGCTCGAGACGCAAGGCAATGCGCCCAACCAAGTATTTATTGTGCGCT
GTGAGGTAGATGTACCGCACACTACGCCCATTGTAGAGTCTGGTGAAAGCCGCCGAATTGCGGAACAAAAGACGGCTGAA
AAAATGATTAATCAGCTCAATAAATTGGTTAACGACCGCATTATTAAAGTCAAAGCTTAG

Upstream 100 bases:

>100_bases
TTTTATAAGTTTATATAAAAGCTTGAGAGAATAACGGCGGCTAACGTGCCTAATTAATATGCCAAAAGTTTTTAGAAAAG
CCAGTGGTGATAACAGTAAG

Downstream 100 bases:

>100_bases
CTTAGGCTGACTTGATAAAAATCCTCTATTTTTCCTAATTTTATTTTTTATAAATCTTTTATTTTTTATAAATCAACTCA
CATTCAAAGCGCCACTAATA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MTETAEIAHTSKQSPKQRYTSFELGLLSLQKQLGYSFNDTSLAKLALTHRSFDGKINYERLEFLGDALLGMIIGEALYYQ
YPKQDEGRLTRMRATLVRQESLVVVAQKLNLSSYLILGVGERKGGGRERASILADTVESLIGAIYLDSQSVDTVKACVLD
WFAELIDNVNDQRVLKDAKSRLQEWLQGYKFELPNYDLLETQGNAPNQVFIVRCEVDVPHTTPIVESGESRRIAEQKTAE
KMINQLNKLVNDRIIKVKA

Sequences:

>Translated_259_residues
MTETAEIAHTSKQSPKQRYTSFELGLLSLQKQLGYSFNDTSLAKLALTHRSFDGKINYERLEFLGDALLGMIIGEALYYQ
YPKQDEGRLTRMRATLVRQESLVVVAQKLNLSSYLILGVGERKGGGRERASILADTVESLIGAIYLDSQSVDTVKACVLD
WFAELIDNVNDQRVLKDAKSRLQEWLQGYKFELPNYDLLETQGNAPNQVFIVRCEVDVPHTTPIVESGESRRIAEQKTAE
KMINQLNKLVNDRIIKVKA
>Mature_258_residues
TETAEIAHTSKQSPKQRYTSFELGLLSLQKQLGYSFNDTSLAKLALTHRSFDGKINYERLEFLGDALLGMIIGEALYYQY
PKQDEGRLTRMRATLVRQESLVVVAQKLNLSSYLILGVGERKGGGRERASILADTVESLIGAIYLDSQSVDTVKACVLDW
FAELIDNVNDQRVLKDAKSRLQEWLQGYKFELPNYDLLETQGNAPNQVFIVRCEVDVPHTTPIVESGESRRIAEQKTAEK
MINQLNKLVNDRIIKVKA

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=209, Percent_Identity=27.7511961722488, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI155030234, Length=209, Percent_Identity=27.7511961722488, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI1788920, Length=204, Percent_Identity=47.5490196078431, Blast_Score=187, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI193202651, Length=198, Percent_Identity=28.2828282828283, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17506883, Length=198, Percent_Identity=28.2828282828283, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI17137682, Length=197, Percent_Identity=27.9187817258883, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 29259; Mature: 29128

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2 ; PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETAEIAHTSKQSPKQRYTSFELGLLSLQKQLGYSFNDTSLAKLALTHRSFDGKINYER
CCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCHHH
LEFLGDALLGMIIGEALYYQYPKQDEGRLTRMRATLVRQESLVVVAQKLNLSSYLILGVG
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHEEHHHHCCCCEEEEEEEC
ERKGGGRERASILADTVESLIGAIYLDSQSVDTVKACVLDWFAELIDNVNDQRVLKDAKS
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
RLQEWLQGYKFELPNYDLLETQGNAPNQVFIVRCEVDVPHTTPIVESGESRRIAEQKTAE
HHHHHHHCCEECCCCCCEEECCCCCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHH
KMINQLNKLVNDRIIKVKA
HHHHHHHHHHCCCEEEEEC
>Mature Secondary Structure 
TETAEIAHTSKQSPKQRYTSFELGLLSLQKQLGYSFNDTSLAKLALTHRSFDGKINYER
CCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCHHH
LEFLGDALLGMIIGEALYYQYPKQDEGRLTRMRATLVRQESLVVVAQKLNLSSYLILGVG
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHEEHHHHCCCCEEEEEEEC
ERKGGGRERASILADTVESLIGAIYLDSQSVDTVKACVLDWFAELIDNVNDQRVLKDAKS
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
RLQEWLQGYKFELPNYDLLETQGNAPNQVFIVRCEVDVPHTTPIVESGESRRIAEQKTAE
HHHHHHHCCEECCCCCCEEECCCCCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHH
KMINQLNKLVNDRIIKVKA
HHHHHHHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA