Click here to switch to the map view.

The map label for this gene is lepB [H]

Identifier: 148652185

GI number: 148652185

Start: 447733

End: 448878

Strand: Direct

Name: lepB [H]

Synonym: PsycPRwf_0373

Alternate gene names: 148652185

Gene position: 447733-448878 (Clockwise)

Preceding gene: 148652184

Following gene: 148652186

Centisome position: 15.03

GC content: 45.46

Gene sequence:

>1146_bases
ATGGACTTTGATTTTAATGTGATTTTAGTGCCAATAACCTTAATTTTAGGGGTGGTATGGCTGCTGGATAAGCTGTGGCT
AAAGCAACATAAGCGTGGCGGTGATCTGGCAGGCGGCGTTCATAGTAAAGAAAGCCAAGCTGCCCAAGCCAACCTTGCCA
CAAAGAAGCACGCTTATTTGACCGCTTTGGCTGAGCATAATCTTGTGCCTAAAGATAACAGCACGGTAGATGTTGATAAT
ATTGATATCGATGATGCCCCTATGCCCGTTAAACAGGCACATAGAGAATACCGCGAAGCCAAGCGTCAGGCCAGTATCGC
AACCACAGCCAGTTTGCCAAAGCAGTCAAAAAATGAGAATTTCTTGGTACGCTGGGCATATGATTATTTTCCGGTGTTGG
CTGCAGTATTGATTGTGCGCTCTTTTATTGTTGAGCCTTTTAATATTCCGTCATCTTCTATGGTACCGACCTTATATACC
GGTGACTTTGTTGCGGTGAATAAATACGCTTATGGTATTCGTCTGCCGCTCACTTATAATAAAGTTATTGATGTGGGTGA
GCCTGAGCATGGTGATGTGGTTGTGTTTCGCTATCCACAAAACCCGAAGATTTATTACATCAAGCGTATCATTGGCTTGC
CAGGTGATGAGGTCAGCTTTAGCCAAGGCAAGCTTTCAGTAAATGGCCAGGTAGTGCCGAGTGAGCCGGTTAGCTTTACG
GCTGATGAAGCTATGGTTGATCAACTTTATACACCGGTGAAAGGCAGTGACCCAAGCCGTGAGTGGGATTTGTCACCACA
AGATGCGGTGGCGGTGGCGCGCAATGAAGAGCAGGGCGCCCGTTATTTTCAAGAAAATTTGGGTGAGCATCGTTATTTGC
GCCGCTACTTAGCGCCTAATTTACTTGGTTCAGAATATTCTAACTTTTTACAACAGCCCATTACTCATGAGGGCAGTTGG
CAAGTCAAGGTGCCTGAAGGCAACTATTTTGTGATGGGAGATAACTCAGATCGCAGTGAAGATGGTCGCTATTGGGGCTT
TGTCCCTGATGAAAACCTAGCGGGTAAAGCGGTCTACGTGTGGATGCATAAAAAGCCGGGTCTAAGTAATCTACCTACCT
TTAGTCATAACCGTTCTATTGATTAA

Upstream 100 bases:

>100_bases
TATCAACACAGTAAGAAGCATCAGCACAAGCCTGTCGTTAGAACGTGTGACAAATTGCAACGTAGGCTTAGGATGATAAT
GAAGCGGTTAAGGCAGCAGT

Downstream 100 bases:

>100_bases
TCAAGTCTAGAGGTTGATCGATAGAGCGACTGATTTTTAATTTATTTTTTCACTTTATTCAACAAGTGCTGCTGTATTTA
ATCCAAATTTTTATAAGTTT

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MDFDFNVILVPITLILGVVWLLDKLWLKQHKRGGDLAGGVHSKESQAAQANLATKKHAYLTALAEHNLVPKDNSTVDVDN
IDIDDAPMPVKQAHREYREAKRQASIATTASLPKQSKNENFLVRWAYDYFPVLAAVLIVRSFIVEPFNIPSSSMVPTLYT
GDFVAVNKYAYGIRLPLTYNKVIDVGEPEHGDVVVFRYPQNPKIYYIKRIIGLPGDEVSFSQGKLSVNGQVVPSEPVSFT
ADEAMVDQLYTPVKGSDPSREWDLSPQDAVAVARNEEQGARYFQENLGEHRYLRRYLAPNLLGSEYSNFLQQPITHEGSW
QVKVPEGNYFVMGDNSDRSEDGRYWGFVPDENLAGKAVYVWMHKKPGLSNLPTFSHNRSID

Sequences:

>Translated_381_residues
MDFDFNVILVPITLILGVVWLLDKLWLKQHKRGGDLAGGVHSKESQAAQANLATKKHAYLTALAEHNLVPKDNSTVDVDN
IDIDDAPMPVKQAHREYREAKRQASIATTASLPKQSKNENFLVRWAYDYFPVLAAVLIVRSFIVEPFNIPSSSMVPTLYT
GDFVAVNKYAYGIRLPLTYNKVIDVGEPEHGDVVVFRYPQNPKIYYIKRIIGLPGDEVSFSQGKLSVNGQVVPSEPVSFT
ADEAMVDQLYTPVKGSDPSREWDLSPQDAVAVARNEEQGARYFQENLGEHRYLRRYLAPNLLGSEYSNFLQQPITHEGSW
QVKVPEGNYFVMGDNSDRSEDGRYWGFVPDENLAGKAVYVWMHKKPGLSNLPTFSHNRSID
>Mature_381_residues
MDFDFNVILVPITLILGVVWLLDKLWLKQHKRGGDLAGGVHSKESQAAQANLATKKHAYLTALAEHNLVPKDNSTVDVDN
IDIDDAPMPVKQAHREYREAKRQASIATTASLPKQSKNENFLVRWAYDYFPVLAAVLIVRSFIVEPFNIPSSSMVPTLYT
GDFVAVNKYAYGIRLPLTYNKVIDVGEPEHGDVVVFRYPQNPKIYYIKRIIGLPGDEVSFSQGKLSVNGQVVPSEPVSFT
ADEAMVDQLYTPVKGSDPSREWDLSPQDAVAVARNEEQGARYFQENLGEHRYLRRYLAPNLLGSEYSNFLQQPITHEGSW
QVKVPEGNYFVMGDNSDRSEDGRYWGFVPDENLAGKAVYVWMHKKPGLSNLPTFSHNRSID

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=244, Percent_Identity=45.0819672131148, Blast_Score=182, Evalue=3e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 42905; Mature: 42905

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFDFNVILVPITLILGVVWLLDKLWLKQHKRGGDLAGGVHSKESQAAQANLATKKHAYL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
TALAEHNLVPKDNSTVDVDNIDIDDAPMPVKQAHREYREAKRQASIATTASLPKQSKNEN
HHHHHCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
FLVRWAYDYFPVLAAVLIVRSFIVEPFNIPSSSMVPTLYTGDFVAVNKYAYGIRLPLTYN
EEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCEEEEEEEEEEEEECEEHH
KVIDVGEPEHGDVVVFRYPQNPKIYYIKRIIGLPGDEVSFSQGKLSVNGQVVPSEPVSFT
HEEECCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCCEEEECCEECCCCCCCCC
ADEAMVDQLYTPVKGSDPSREWDLSPQDAVAVARNEEQGARYFQENLGEHRYLRRYLAPN
HHHHHHHHHCCCCCCCCCCCCCCCCHHHHEEEECCCHHHHHHHHHHCCHHHHHHHHHCCC
LLGSEYSNFLQQPITHEGSWQVKVPEGNYFVMGDNSDRSEDGRYWGFVPDENLAGKAVYV
HHHHHHHHHHHCCCCCCCCEEEEECCCCEEEECCCCCCCCCCCEEECCCCCCCCCCEEEE
WMHKKPGLSNLPTFSHNRSID
EEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDFDFNVILVPITLILGVVWLLDKLWLKQHKRGGDLAGGVHSKESQAAQANLATKKHAYL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
TALAEHNLVPKDNSTVDVDNIDIDDAPMPVKQAHREYREAKRQASIATTASLPKQSKNEN
HHHHHCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
FLVRWAYDYFPVLAAVLIVRSFIVEPFNIPSSSMVPTLYTGDFVAVNKYAYGIRLPLTYN
EEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCEEEEEEEEEEEEECEEHH
KVIDVGEPEHGDVVVFRYPQNPKIYYIKRIIGLPGDEVSFSQGKLSVNGQVVPSEPVSFT
HEEECCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCCEEEECCEECCCCCCCCC
ADEAMVDQLYTPVKGSDPSREWDLSPQDAVAVARNEEQGARYFQENLGEHRYLRRYLAPN
HHHHHHHHHCCCCCCCCCCCCCCCCHHHHEEEECCCHHHHHHHHHHCCHHHHHHHHHCCC
LLGSEYSNFLQQPITHEGSWQVKVPEGNYFVMGDNSDRSEDGRYWGFVPDENLAGKAVYV
HHHHHHHHHHHCCCCCCCCEEEEECCCCEEEECCCCCCCCCCCEEECCCCCCCCCCEEEE
WMHKKPGLSNLPTFSHNRSID
EEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1546969 [H]