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The map label for this gene is nhaA

Identifier: 148652181

GI number: 148652181

Start: 442104

End: 443303

Strand: Direct

Name: nhaA

Synonym: PsycPRwf_0369

Alternate gene names: 148652181

Gene position: 442104-443303 (Clockwise)

Preceding gene: 148652179

Following gene: 148652182

Centisome position: 14.84

GC content: 46.67

Gene sequence:

>1200_bases
GTGTACCAGAAACTAAAAAAATTCTTTGAGTATGAGGCGGCAGGAGGCATTGTGCTGGCACTGGCAGCCATCGCAGCCAT
GATCGTTGCCAACTCTCCCTTACATGATTGGTATGAGTCTTTTATTCACGCCCCTGTGGTGGTTCAGGTGGGCGAGCTAA
TTATCAGCAAAGATGCGCATCATTGGATTAATGATGGTTTGATGGCGGTGTTCTTCTTCTTAGTCGGCTTAGAGCTTAAG
CGCGAGGTATTGATTGGTGAATTATCTAATATCAATCAAATTGTCCTGCCGGCGGCGGCGGCCGTCGGGGGCATGATAGC
GCCAGCTTTGGTCTACGTCGCTTTTAATGCCAGCCACCCCGAGTACTTGGCAGGCTGGGCAATTCCTGCTGCCACAGACA
TCGCTTTTGCCATTGGTATCTTAAGTTTGCTTGGTAGCCGTGTACCGAACTCGTTAAAGATATTTTTAGTGTCAATTGCC
ATCTTTGATGACATTGGCGCCATTTTAATTATCGCTTTGTTTTATACCAGTGACTTGTCGTTGTTATCTTTATTGATAGC
AGGATTGTGCTTGCCGTTTTTATACCTGCTCAATCGCCGTAATGTCACGGCAATTACCCCCTATTTATTTTTTGGGATTA
TCATGTGGATTGCGGTATTAAAATCCGGTATTCATGCCACTTTGGCGGGGGTTATCCTAGCACTATTTATCCCTATGGTG
AATACAGATGACCCTGAGCACTCGCCCCTTGAAGACTTAGAGCACGACCTACATGGCACGGTAGCCTTTGCGATTTTACC
GCTATTTGCCTTTGCAAACGCTGGTATCTCATTGCAAGGTGCTGGATTTGGTCAGCTGTTACACTCAGTGCCCTTTGGTA
TTGCGGCCGGTTTATTTATCGGTAAACAGGTGGGTATTATGCTGATGACTTGGAGCATTATTAAAGCAGGCCTAGCCTCA
TTGCCTAATGGCACCAACTTTAAGCAAATCTATGGTGTTTCTTTGCTGTGCGGTGTGGGCTTTACCATGAGCTTGTTTAT
CAGTGGCCTAGCCTTTGGCGGCGTTACCGAAGGTTTCGATCCGCGCTTGGGTATTATCCTAGGCTCTATCATCTCAGGCA
TTGCCGGCTACATGCTGCTAAAGCGTACTTTAAAAGAAGACACTGCCACTGGCATCACTGCACTGGATTTAACTCGATAG

Upstream 100 bases:

>100_bases
TGCTACCATAAATGCAACTAACTTATTCGTTAAAACAATAAACTAAATCATTTGATGGGCCGATAGAGTTTGCCCATTGG
TAAGAAAGTGAGGATATACG

Downstream 100 bases:

>100_bases
CAGCCATAAGCTAAGGTTGCTGATCCAAGATTCGGTCAGTGGTAGCAGATAACGGTGTTATTTGTATTCATACAAGCCAA
CACAGCCGGCCGGCAAGGGC

Product: pH-dependent sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MYQKLKKFFEYEAAGGIVLALAAIAAMIVANSPLHDWYESFIHAPVVVQVGELIISKDAHHWINDGLMAVFFFLVGLELK
REVLIGELSNINQIVLPAAAAVGGMIAPALVYVAFNASHPEYLAGWAIPAATDIAFAIGILSLLGSRVPNSLKIFLVSIA
IFDDIGAILIIALFYTSDLSLLSLLIAGLCLPFLYLLNRRNVTAITPYLFFGIIMWIAVLKSGIHATLAGVILALFIPMV
NTDDPEHSPLEDLEHDLHGTVAFAILPLFAFANAGISLQGAGFGQLLHSVPFGIAAGLFIGKQVGIMLMTWSIIKAGLAS
LPNGTNFKQIYGVSLLCGVGFTMSLFISGLAFGGVTEGFDPRLGIILGSIISGIAGYMLLKRTLKEDTATGITALDLTR

Sequences:

>Translated_399_residues
MYQKLKKFFEYEAAGGIVLALAAIAAMIVANSPLHDWYESFIHAPVVVQVGELIISKDAHHWINDGLMAVFFFLVGLELK
REVLIGELSNINQIVLPAAAAVGGMIAPALVYVAFNASHPEYLAGWAIPAATDIAFAIGILSLLGSRVPNSLKIFLVSIA
IFDDIGAILIIALFYTSDLSLLSLLIAGLCLPFLYLLNRRNVTAITPYLFFGIIMWIAVLKSGIHATLAGVILALFIPMV
NTDDPEHSPLEDLEHDLHGTVAFAILPLFAFANAGISLQGAGFGQLLHSVPFGIAAGLFIGKQVGIMLMTWSIIKAGLAS
LPNGTNFKQIYGVSLLCGVGFTMSLFISGLAFGGVTEGFDPRLGIILGSIISGIAGYMLLKRTLKEDTATGITALDLTR
>Mature_399_residues
MYQKLKKFFEYEAAGGIVLALAAIAAMIVANSPLHDWYESFIHAPVVVQVGELIISKDAHHWINDGLMAVFFFLVGLELK
REVLIGELSNINQIVLPAAAAVGGMIAPALVYVAFNASHPEYLAGWAIPAATDIAFAIGILSLLGSRVPNSLKIFLVSIA
IFDDIGAILIIALFYTSDLSLLSLLIAGLCLPFLYLLNRRNVTAITPYLFFGIIMWIAVLKSGIHATLAGVILALFIPMV
NTDDPEHSPLEDLEHDLHGTVAFAILPLFAFANAGISLQGAGFGQLLHSVPFGIAAGLFIGKQVGIMLMTWSIIKAGLAS
LPNGTNFKQIYGVSLLCGVGFTMSLFISGLAFGGVTEGFDPRLGIILGSIISGIAGYMLLKRTLKEDTATGITALDLTR

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family

Homologues:

Organism=Escherichia coli, GI1786201, Length=392, Percent_Identity=53.0612244897959, Blast_Score=354, Evalue=6e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAA_PSYWF (A5WCD3)

Other databases:

- EMBL:   CP000713
- RefSeq:   YP_001279274.1
- ProteinModelPortal:   A5WCD3
- SMR:   A5WCD3
- STRING:   A5WCD3
- GeneID:   5205354
- GenomeReviews:   CP000713_GR
- KEGG:   prw:PsycPRwf_0369
- eggNOG:   COG3004
- HOGENOM:   HBG665619
- OMA:   MGLMLRC
- ProtClustDB:   PRK09560
- BioCyc:   PSP56811:PSYCPRWF_0369-MONOMER
- HAMAP:   MF_01844
- InterPro:   IPR023171
- InterPro:   IPR004670
- TIGRFAMs:   TIGR00773

Pfam domain/function: PF06965 Na_H_antiport_1

EC number: NA

Molecular weight: Translated: 42543; Mature: 42543

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x12a8acfc)-; HASH(0x11a1d7ec)-; HASH(0x11d4c868)-; HASH(0x1153e028)-; HASH(0x127c6368)-; HASH(0x12869eec)-; HASH(0x1261210c)-; HASH(0x10808da4)-; HASH(0x11dddea8)-; HASH(0x1150626c)-; HASH(0x11cbba48)-; HASH(0xec09634)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQKLKKFFEYEAAGGIVLALAAIAAMIVANSPLHDWYESFIHAPVVVQVGELIISKDAH
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCH
HWINDGLMAVFFFLVGLELKREVLIGELSNINQIVLPAAAAVGGMIAPALVYVAFNASHP
HHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EYLAGWAIPAATDIAFAIGILSLLGSRVPNSLKIFLVSIAIFDDIGAILIIALFYTSDLS
HHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LLSLLIAGLCLPFLYLLNRRNVTAITPYLFFGIIMWIAVLKSGIHATLAGVILALFIPMV
HHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHC
NTDDPEHSPLEDLEHDLHGTVAFAILPLFAFANAGISLQGAGFGQLLHSVPFGIAAGLFI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHCCHHHHHHHHH
GKQVGIMLMTWSIIKAGLASLPNGTNFKQIYGVSLLCGVGFTMSLFISGLAFGGVTEGFD
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PRLGIILGSIISGIAGYMLLKRTLKEDTATGITALDLTR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCH
>Mature Secondary Structure
MYQKLKKFFEYEAAGGIVLALAAIAAMIVANSPLHDWYESFIHAPVVVQVGELIISKDAH
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCH
HWINDGLMAVFFFLVGLELKREVLIGELSNINQIVLPAAAAVGGMIAPALVYVAFNASHP
HHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EYLAGWAIPAATDIAFAIGILSLLGSRVPNSLKIFLVSIAIFDDIGAILIIALFYTSDLS
HHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LLSLLIAGLCLPFLYLLNRRNVTAITPYLFFGIIMWIAVLKSGIHATLAGVILALFIPMV
HHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHC
NTDDPEHSPLEDLEHDLHGTVAFAILPLFAFANAGISLQGAGFGQLLHSVPFGIAAGLFI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHCCHHHHHHHHH
GKQVGIMLMTWSIIKAGLASLPNGTNFKQIYGVSLLCGVGFTMSLFISGLAFGGVTEGFD
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PRLGIILGSIISGIAGYMLLKRTLKEDTATGITALDLTR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA