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The map label for this gene is hyuA [H]

Identifier: 148380842

GI number: 148380842

Start: 3073769

End: 3075163

Strand: Reverse

Name: hyuA [H]

Synonym: CBO2886

Alternate gene names: 148380842

Gene position: 3075163-3073769 (Counterclockwise)

Preceding gene: 148380843

Following gene: 148380841

Centisome position: 79.12

GC content: 29.39

Gene sequence:

>1395_bases
ATGGCCACTTTAATAAAAAATGGAATTATTGTTACTTCAGGAGATACCTTTAAAGGAGATATTTATATAGAAAATGGTGT
TATAGCTAAAATAGGTATAGGTTTGATTGAAGAGGCTAATGAAATCATTGATGCTAATGGGAAATATGTAATTCCTGGAG
GGGTAGATGTTCATACTCACCTAAACTTAGATGTAGGAATAGCTGTGGCCACAGATGATTTTTATACTGGAACTGTAGCA
GCTGCATGCGGTGGCACTACAAGTATAGTAGATCATTTAGCATTCGGACCTAAAGGATGTGATTTACACCATCAAATAAA
TTTATATCATAATTATGCTAAGGGGAATGCAGTTATAGACTATGGGTTTCATGGTGTTATACAACATGTAAACGATAATA
TATTACAAGAACTTGAAGAACTCTCCTATGAAGGAATAACAAGCAATAAAGTCTATTTAACTTATGATTATAAATTAAGT
GATTTAGAAGTATTTAAAGTACTTATGAAATCTAAAGAAATTGGTATACTTACAGCTGTACATCCAGAAAATAATGATAT
GGTTAACTATCTTAGAAAATATTATTCAAGCAATGGTTTTACATCTCCTATATATCATGCAAAAAGTAGACCAGTATGTT
GTGAGGGAGAATCTATAAATAAAATGCTAAATATTGCTAATGTGGCAGGAGATTCTCCTCTGTACATAGTACATCTTTCC
TGTAAATTAGGATTAGATTATATAAAAATGGCTATAGATAGAGGACAAAAAAATGTTTTTACAGAAACATGTCCTCAATA
TCTTTTTTTAGATGAAAGCAAATATAATGGTAAAAATAATGAAGGATTAAAATATGTTATGAGTCCTCCCCTAAGAGAAA
AATCTAATCAAGATGCTTTGTGGAAAGGAATTCAAGATGGATATATACAAGTTATTGCTACAGATCATTGTCCATTTAAC
TTTAATATAGAAAAACAATTAGGGAAAGATGATTTTACTAAATGTCCAAGTGGATCACCTGGAATAGAAACTAGAATTCC
TTTAATTTTTTCAGAGGGAGTTATGAAAAAAAGAATATCCTTAAATAAGTTTGTAGATTTAGTAAGTACAAAACCTGCAA
AAATATTTGGATTATATCCCAAAAAAGGAACAATTGCAGTTGGTGCTGATGGAGATATTGTTATAATAGATCCTAATAAA
AAAGTTAAAATTACTAAATCTATGTTACATGAAAATGTTGATTATACTCCTTATGAAGGATTTGAACTTCAGGGTTATCC
AATAATGACAATCTCAAGAGGAAAGATTATAGCAAAAGATAATAAATTCATTGGAGAAAAAGGAGACGGCCAATTTTTAA
AAAGAAAAAAGATAGATTTTTTTAATGTTAAATAA

Upstream 100 bases:

>100_bases
GAAAATAGCTATAAAATAGAAGTAGCTGATAAAGAAACAAAAAATATATAAGTTTAAAATCATTTTTCACAATATTCACA
AAAGGAGATGCGATTTTAAG

Downstream 100 bases:

>100_bases
ATAATAATTTTGTGATTATAAAGAACTTTTTGTAGATTCAAAAGGTTCTTTTTTTCTTAATTTATCATAATGATAAGGTA
TATTAATAAATTTGCAATTA

Product: phenylhydantoinase

Products: NA

Alternate protein names: Hydantoin-utilizing enzyme hyuA [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MATLIKNGIIVTSGDTFKGDIYIENGVIAKIGIGLIEEANEIIDANGKYVIPGGVDVHTHLNLDVGIAVATDDFYTGTVA
AACGGTTSIVDHLAFGPKGCDLHHQINLYHNYAKGNAVIDYGFHGVIQHVNDNILQELEELSYEGITSNKVYLTYDYKLS
DLEVFKVLMKSKEIGILTAVHPENNDMVNYLRKYYSSNGFTSPIYHAKSRPVCCEGESINKMLNIANVAGDSPLYIVHLS
CKLGLDYIKMAIDRGQKNVFTETCPQYLFLDESKYNGKNNEGLKYVMSPPLREKSNQDALWKGIQDGYIQVIATDHCPFN
FNIEKQLGKDDFTKCPSGSPGIETRIPLIFSEGVMKKRISLNKFVDLVSTKPAKIFGLYPKKGTIAVGADGDIVIIDPNK
KVKITKSMLHENVDYTPYEGFELQGYPIMTISRGKIIAKDNKFIGEKGDGQFLKRKKIDFFNVK

Sequences:

>Translated_464_residues
MATLIKNGIIVTSGDTFKGDIYIENGVIAKIGIGLIEEANEIIDANGKYVIPGGVDVHTHLNLDVGIAVATDDFYTGTVA
AACGGTTSIVDHLAFGPKGCDLHHQINLYHNYAKGNAVIDYGFHGVIQHVNDNILQELEELSYEGITSNKVYLTYDYKLS
DLEVFKVLMKSKEIGILTAVHPENNDMVNYLRKYYSSNGFTSPIYHAKSRPVCCEGESINKMLNIANVAGDSPLYIVHLS
CKLGLDYIKMAIDRGQKNVFTETCPQYLFLDESKYNGKNNEGLKYVMSPPLREKSNQDALWKGIQDGYIQVIATDHCPFN
FNIEKQLGKDDFTKCPSGSPGIETRIPLIFSEGVMKKRISLNKFVDLVSTKPAKIFGLYPKKGTIAVGADGDIVIIDPNK
KVKITKSMLHENVDYTPYEGFELQGYPIMTISRGKIIAKDNKFIGEKGDGQFLKRKKIDFFNVK
>Mature_463_residues
ATLIKNGIIVTSGDTFKGDIYIENGVIAKIGIGLIEEANEIIDANGKYVIPGGVDVHTHLNLDVGIAVATDDFYTGTVAA
ACGGTTSIVDHLAFGPKGCDLHHQINLYHNYAKGNAVIDYGFHGVIQHVNDNILQELEELSYEGITSNKVYLTYDYKLSD
LEVFKVLMKSKEIGILTAVHPENNDMVNYLRKYYSSNGFTSPIYHAKSRPVCCEGESINKMLNIANVAGDSPLYIVHLSC
KLGLDYIKMAIDRGQKNVFTETCPQYLFLDESKYNGKNNEGLKYVMSPPLREKSNQDALWKGIQDGYIQVIATDHCPFNF
NIEKQLGKDDFTKCPSGSPGIETRIPLIFSEGVMKKRISLNKFVDLVSTKPAKIFGLYPKKGTIAVGADGDIVIIDPNKK
VKITKSMLHENVDYTPYEGFELQGYPIMTISRGKIIAKDNKFIGEKGDGQFLKRKKIDFFNVK

Specific function: Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives with an aromatic side chains at the 5'-position. Has no activity on dihydropyrimidines. The physiological function is unknown [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503379, Length=457, Percent_Identity=36.7614879649891, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI4503375, Length=463, Percent_Identity=36.2850971922246, Blast_Score=279, Evalue=4e-75,
Organism=Homo sapiens, GI4503051, Length=459, Percent_Identity=37.4727668845316, Blast_Score=278, Evalue=1e-74,
Organism=Homo sapiens, GI4503377, Length=465, Percent_Identity=36.3440860215054, Blast_Score=277, Evalue=2e-74,
Organism=Homo sapiens, GI62422571, Length=459, Percent_Identity=37.4727668845316, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI190194363, Length=465, Percent_Identity=36.5591397849462, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI19923821, Length=455, Percent_Identity=35.3846153846154, Blast_Score=251, Evalue=7e-67,
Organism=Homo sapiens, GI18105007, Length=407, Percent_Identity=24.8157248157248, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI87082175, Length=457, Percent_Identity=52.2975929978118, Blast_Score=508, Evalue=1e-145,
Organism=Escherichia coli, GI1786722, Length=457, Percent_Identity=31.9474835886214, Blast_Score=186, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17539558, Length=460, Percent_Identity=36.5217391304348, Blast_Score=268, Evalue=6e-72,
Organism=Caenorhabditis elegans, GI71989490, Length=458, Percent_Identity=34.2794759825328, Blast_Score=247, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI86575075, Length=455, Percent_Identity=28.7912087912088, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI193204318, Length=408, Percent_Identity=25.7352941176471, Blast_Score=102, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6322218, Length=456, Percent_Identity=29.3859649122807, Blast_Score=130, Evalue=5e-31,
Organism=Drosophila melanogaster, GI221377917, Length=459, Percent_Identity=35.0762527233115, Blast_Score=251, Evalue=9e-67,
Organism=Drosophila melanogaster, GI17137462, Length=456, Percent_Identity=34.2105263157895, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24644287, Length=308, Percent_Identity=33.4415584415584, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24644289, Length=229, Percent_Identity=34.4978165938865, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24642586, Length=412, Percent_Identity=27.1844660194175, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI18859883, Length=256, Percent_Identity=23.828125, Blast_Score=90, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.-.-.- [C]

Molecular weight: Translated: 51498; Mature: 51366

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATLIKNGIIVTSGDTFKGDIYIENGVIAKIGIGLIEEANEIIDANGKYVIPGGVDVHTH
CCCEEECCEEEECCCCEEEEEEEECCEEEEECCHHHHHHHHHCCCCCCEEECCCEEEEEE
LNLDVGIAVATDDFYTGTVAAACGGTTSIVDHLAFGPKGCDLHHQINLYHNYAKGNAVID
EEEEEEEEEEECCCCCCEEHHHCCCHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCEEEE
YGFHGVIQHVNDNILQELEELSYEGITSNKVYLTYDYKLSDLEVFKVLMKSKEIGILTAV
ECHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECEECHHHHHHHHHCCCCCEEEEEE
HPENNDMVNYLRKYYSSNGFTSPIYHAKSRPVCCEGESINKMLNIANVAGDSPLYIVHLS
CCCCCHHHHHHHHHHCCCCCCCCCEECCCCCEEECCHHHHHHHHHHHCCCCCCEEEEEEE
CKLGLDYIKMAIDRGQKNVFTETCPQYLFLDESKYNGKNNEGLKYVMSPPLREKSNQDAL
ECCCHHHHHHHHHCCCCCCHHHHCCCEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCHH
WKGIQDGYIQVIATDHCPFNFNIEKQLGKDDFTKCPSGSPGIETRIPLIFSEGVMKKRIS
HHCCCCCEEEEEEECCCCCCEEHHHHCCCCHHHCCCCCCCCCCEEEEEEECCCHHHHHHH
LNKFVDLVSTKPAKIFGLYPKKGTIAVGADGDIVIIDPNKKVKITKSMLHENVDYTPYEG
HHHHHHHHCCCCCEEEEECCCCCEEEECCCCCEEEECCCCCEEEEHHHHHCCCCCCCCCC
FELQGYPIMTISRGKIIAKDNKFIGEKGDGQFLKRKKIDFFNVK
EEECCEEEEEEECCEEEEECCCCCCCCCCCCHHHHCCCCEECCC
>Mature Secondary Structure 
ATLIKNGIIVTSGDTFKGDIYIENGVIAKIGIGLIEEANEIIDANGKYVIPGGVDVHTH
CCEEECCEEEECCCCEEEEEEEECCEEEEECCHHHHHHHHHCCCCCCEEECCCEEEEEE
LNLDVGIAVATDDFYTGTVAAACGGTTSIVDHLAFGPKGCDLHHQINLYHNYAKGNAVID
EEEEEEEEEEECCCCCCEEHHHCCCHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCEEEE
YGFHGVIQHVNDNILQELEELSYEGITSNKVYLTYDYKLSDLEVFKVLMKSKEIGILTAV
ECHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECEECHHHHHHHHHCCCCCEEEEEE
HPENNDMVNYLRKYYSSNGFTSPIYHAKSRPVCCEGESINKMLNIANVAGDSPLYIVHLS
CCCCCHHHHHHHHHHCCCCCCCCCEECCCCCEEECCHHHHHHHHHHHCCCCCCEEEEEEE
CKLGLDYIKMAIDRGQKNVFTETCPQYLFLDESKYNGKNNEGLKYVMSPPLREKSNQDAL
ECCCHHHHHHHHHCCCCCCHHHHCCCEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCHH
WKGIQDGYIQVIATDHCPFNFNIEKQLGKDDFTKCPSGSPGIETRIPLIFSEGVMKKRIS
HHCCCCCEEEEEEECCCCCCEEHHHHCCCCHHHCCCCCCCCCCEEEEEEECCCHHHHHHH
LNKFVDLVSTKPAKIFGLYPKKGTIAVGADGDIVIIDPNKKVKITKSMLHENVDYTPYEG
HHHHHHHHCCCCCEEEEECCCCCEEEECCCCCEEEECCCCCEEEEHHHHHCCCCCCCCCC
FELQGYPIMTISRGKIIAKDNKFIGEKGDGQFLKRKKIDFFNVK
EEECCEEEEEEECCEEEEECCCCCCCCCCCCHHHHCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA