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The map label for this gene is nuoM [H]

Identifier: 148361090

GI number: 148361090

Start: 3306094

End: 3307599

Strand: Reverse

Name: nuoM [H]

Synonym: LPC_3063

Alternate gene names: 148361090

Gene position: 3307599-3306094 (Counterclockwise)

Preceding gene: 148361091

Following gene: 148361089

Centisome position: 92.48

GC content: 36.85

Gene sequence:

>1506_bases
ATGCATTATTTGCTCAATTTATTAATTTGGTTACCAATATTAGGTGGCGTTTTTGTTTTGCTGACTGGGGATGATAAAAA
TCCAAATGTATCGCGTTATTTAACATTATTCACCATACTCCTCTGTTTAGTGCTCTGCATACCTTTAGTTAAAGGATTTG
ATCTGCAATCTTTTGGAATGCAGTTTATAGAGGAAATCCCCTGGATGCCGGCACTGGGTATTAATTATACTCTTGGTATT
GATGGGTTATCTTTACTATTAATTGTTTTATCCATTTTTACTAATTTAATAGTGATTTTGGCTACTTGGGATAGCATTAG
TAAAAAAGTTTCCCAATATTTATCAGCGTTTTTAATTATGCAAGGGCTTCTGGTTGGTATATTTTCTGCTATGGATGCCA
TAGTATTTTATATTTTCTGGGAAGCAACCTTAATTCCAATGTATCTGATTATAGGTATTTGGGGTTCTGATAATAGAGTA
TATGCGGCAATAAAATTTTTCCTGTATACTTTTTTAGGATCAGTTCTCATGCTGGCCAGTTTCCTGTACATGGGCTACAT
TGCAGGCTCATTTAAGATCGAAACGTTTTATGCCATCAAATTAGGCATGACTGCACAAACATTGATTTTTATTGCCTTTT
TCTTAGGTTTTGCAATAAAAATACCGATGTTTCCAGTCCATACCTGGTTACCAGATGCGCATACCGAAGCCCCTGCTGGT
GGTTCAGTCGTTTTAGCAGCAATTTTGCTAAAACTGGGAGCTTATGGATTTATCCGTTTTTCTTTACCAATAGTCCCTGA
TGCTTGCAGCAAATATGCTCCTCTGATGGTTGCCTTATCTTTGATCGCAGTAGTTTATATAGGACTCATTGCTATTATTC
AGAAGGATATGAAAAAATTGATTGCATATTCTTCAATTTCACATATGGGTTTTGTAACTCTAGGTTGTTTCGCTATATTT
GCAATTGCTCGCCATGGAGGACTAAGCAATGCCGGATTAATCCTTGAGGGTGCAATTGTCGTTATGATATCGCATGCCTT
TGTCTCAAGTGCAATGTTTGCAGGTGTAGGTTTTATATATGATCGTATGCATACAAGACAGCTCGCGGATTTTGGCGGGA
TAGTAAATACCATGCCTATATTTGCTTCTTTTTTTATGCTTTTTGCTATGGCGAATGCCGGCTTGCCAGGAACATCGGGA
TTTGTTGGTGAGTTTATGGTGATATTAGGTAGCATAAAGGCTGGTTTTTGGGTGCATTTTGGGCTGCAAACTACATTGAT
TATTGGAGCAGCATATACGCTATGGATGTACAAAAGAGTTATCTTTGGTCCTGTAGCTAATAAAAAGGTTGCTTTCTTAA
AAGATATATCAGGTTTTGAATTAAGTGCTTATGTATTGCTTGCAATAATGGTCATTGCTCTAGGAGTGTATCCCAAACCC
ATGTTAGAGTTTGTGCATCAAACTGTAAGTCATACTTTGGCATTGGCTGATAAATCTAAACTCTAA

Upstream 100 bases:

>100_bases
GATACAAAGTGGGTACATCTATCATTATGCGACAGTAATGGTGTTTGGATTACTGGCCTTTTTATGCTGGTTAATCCTGG
ACTGAAGATAAGGTGAAGGT

Downstream 100 bases:

>100_bases
CAAAGAACTGCGATAGGCTTAAATTGCAATCAAGTTCCTTAGCAAGGTTAAATATGATGACATTACTAGAAAATATCCAT
GTAGCAATACCAGAAATGAT

Product: NADH dehydrogenase I subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 13; NDH-1, chain 13 [H]

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MHYLLNLLIWLPILGGVFVLLTGDDKNPNVSRYLTLFTILLCLVLCIPLVKGFDLQSFGMQFIEEIPWMPALGINYTLGI
DGLSLLLIVLSIFTNLIVILATWDSISKKVSQYLSAFLIMQGLLVGIFSAMDAIVFYIFWEATLIPMYLIIGIWGSDNRV
YAAIKFFLYTFLGSVLMLASFLYMGYIAGSFKIETFYAIKLGMTAQTLIFIAFFLGFAIKIPMFPVHTWLPDAHTEAPAG
GSVVLAAILLKLGAYGFIRFSLPIVPDACSKYAPLMVALSLIAVVYIGLIAIIQKDMKKLIAYSSISHMGFVTLGCFAIF
AIARHGGLSNAGLILEGAIVVMISHAFVSSAMFAGVGFIYDRMHTRQLADFGGIVNTMPIFASFFMLFAMANAGLPGTSG
FVGEFMVILGSIKAGFWVHFGLQTTLIIGAAYTLWMYKRVIFGPVANKKVAFLKDISGFELSAYVLLAIMVIALGVYPKP
MLEFVHQTVSHTLALADKSKL

Sequences:

>Translated_501_residues
MHYLLNLLIWLPILGGVFVLLTGDDKNPNVSRYLTLFTILLCLVLCIPLVKGFDLQSFGMQFIEEIPWMPALGINYTLGI
DGLSLLLIVLSIFTNLIVILATWDSISKKVSQYLSAFLIMQGLLVGIFSAMDAIVFYIFWEATLIPMYLIIGIWGSDNRV
YAAIKFFLYTFLGSVLMLASFLYMGYIAGSFKIETFYAIKLGMTAQTLIFIAFFLGFAIKIPMFPVHTWLPDAHTEAPAG
GSVVLAAILLKLGAYGFIRFSLPIVPDACSKYAPLMVALSLIAVVYIGLIAIIQKDMKKLIAYSSISHMGFVTLGCFAIF
AIARHGGLSNAGLILEGAIVVMISHAFVSSAMFAGVGFIYDRMHTRQLADFGGIVNTMPIFASFFMLFAMANAGLPGTSG
FVGEFMVILGSIKAGFWVHFGLQTTLIIGAAYTLWMYKRVIFGPVANKKVAFLKDISGFELSAYVLLAIMVIALGVYPKP
MLEFVHQTVSHTLALADKSKL
>Mature_501_residues
MHYLLNLLIWLPILGGVFVLLTGDDKNPNVSRYLTLFTILLCLVLCIPLVKGFDLQSFGMQFIEEIPWMPALGINYTLGI
DGLSLLLIVLSIFTNLIVILATWDSISKKVSQYLSAFLIMQGLLVGIFSAMDAIVFYIFWEATLIPMYLIIGIWGSDNRV
YAAIKFFLYTFLGSVLMLASFLYMGYIAGSFKIETFYAIKLGMTAQTLIFIAFFLGFAIKIPMFPVHTWLPDAHTEAPAG
GSVVLAAILLKLGAYGFIRFSLPIVPDACSKYAPLMVALSLIAVVYIGLIAIIQKDMKKLIAYSSISHMGFVTLGCFAIF
AIARHGGLSNAGLILEGAIVVMISHAFVSSAMFAGVGFIYDRMHTRQLADFGGIVNTMPIFASFFMLFAMANAGLPGTSG
FVGEFMVILGSIKAGFWVHFGLQTTLIIGAAYTLWMYKRVIFGPVANKKVAFLKDISGFELSAYVLLAIMVIALGVYPKP
MLEFVHQTVSHTLALADKSKL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=363, Percent_Identity=34.9862258953168, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI251831117, Length=371, Percent_Identity=23.4501347708895, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1788613, Length=508, Percent_Identity=34.6456692913386, Blast_Score=287, Evalue=1e-78,
Organism=Escherichia coli, GI1788827, Length=278, Percent_Identity=26.2589928057554, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1788831, Length=380, Percent_Identity=27.1052631578947, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1788829, Length=338, Percent_Identity=26.6272189349112, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI145693160, Length=299, Percent_Identity=27.4247491638796, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788614, Length=459, Percent_Identity=23.7472766884532, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI2367154, Length=208, Percent_Identity=26.9230769230769, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 54929; Mature: 54929

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHYLLNLLIWLPILGGVFVLLTGDDKNPNVSRYLTLFTILLCLVLCIPLVKGFDLQSFGM
CHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
QFIEEIPWMPALGINYTLGIDGLSLLLIVLSIFTNLIVILATWDSISKKVSQYLSAFLIM
HHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGLLVGIFSAMDAIVFYIFWEATLIPMYLIIGIWGSDNRVYAAIKFFLYTFLGSVLMLAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHH
FLYMGYIAGSFKIETFYAIKLGMTAQTLIFIAFFLGFAIKIPMFPVHTWLPDAHTEAPAG
HHHHHHHCCCEEEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCC
GSVVLAAILLKLGAYGFIRFSLPIVPDACSKYAPLMVALSLIAVVYIGLIAIIQKDMKKL
HHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAYSSISHMGFVTLGCFAIFAIARHGGLSNAGLILEGAIVVMISHAFVSSAMFAGVGFIY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DRMHTRQLADFGGIVNTMPIFASFFMLFAMANAGLPGTSGFVGEFMVILGSIKAGFWVHF
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCEEEE
GLQTTLIIGAAYTLWMYKRVIFGPVANKKVAFLKDISGFELSAYVLLAIMVIALGVYPKP
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHCCCCHH
MLEFVHQTVSHTLALADKSKL
HHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MHYLLNLLIWLPILGGVFVLLTGDDKNPNVSRYLTLFTILLCLVLCIPLVKGFDLQSFGM
CHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
QFIEEIPWMPALGINYTLGIDGLSLLLIVLSIFTNLIVILATWDSISKKVSQYLSAFLIM
HHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGLLVGIFSAMDAIVFYIFWEATLIPMYLIIGIWGSDNRVYAAIKFFLYTFLGSVLMLAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHH
FLYMGYIAGSFKIETFYAIKLGMTAQTLIFIAFFLGFAIKIPMFPVHTWLPDAHTEAPAG
HHHHHHHCCCEEEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCC
GSVVLAAILLKLGAYGFIRFSLPIVPDACSKYAPLMVALSLIAVVYIGLIAIIQKDMKKL
HHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAYSSISHMGFVTLGCFAIFAIARHGGLSNAGLILEGAIVVMISHAFVSSAMFAGVGFIY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DRMHTRQLADFGGIVNTMPIFASFFMLFAMANAGLPGTSGFVGEFMVILGSIKAGFWVHF
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCEEEE
GLQTTLIIGAAYTLWMYKRVIFGPVANKKVAFLKDISGFELSAYVLLAIMVIALGVYPKP
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHCCCCHH
MLEFVHQTVSHTLALADKSKL
HHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8422400 [H]