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The map label for this gene is gltP [H]

Identifier: 148360468

GI number: 148360468

Start: 1065042

End: 1066322

Strand: Direct

Name: gltP [H]

Synonym: LPC_2407

Alternate gene names: 148360468

Gene position: 1065042-1066322 (Clockwise)

Preceding gene: 148360469

Following gene: 148360463

Centisome position: 29.78

GC content: 37.0

Gene sequence:

>1281_bases
ATGTGTGCAGCACACCACCAAAAGAATAAATATATTTTTAGTACCCCACTAATTTATGCAGCGATGATTGGACTTGGGAT
AATAAGTGGATTATCCGATTTGCCTTTTTTAAAAGAAACAGGGCTTTTAATTTCTGATTTGTTTATTAAATTGTTCAAGT
GCATTAGTTTACCTATTATTTCCTTGTCGATTATTGTAACTCTGGCAAACTATCAAACGGATAGTTTGATGAAAAGTGTA
TGGCAAAGAACAATTAAATATACTTTTGCTACAACTTTAGTTGCAGCATTAATCAGCTGTTTTCTATATATTTTGATTCA
TCCAAGCACTGTTCAAGTCAACTTGGATGCGGCGAACCCAAAATCCACCAGCAGTTTGGGATATCTTGGCTATTTGAGTA
ACATGATACCGACTAATTTATTATCTCCATTCCTGGAGCAACAGGTTATGGGGGTATTGTTGCTTAGTATTGTTATCGGT
TTTGCTGTTCGTCAAATACCGGAGACAGAGCCACGTGAAACTATTATTCGATTTTTCCGCGGTGCTCATGGGATGTTTTT
AGTGATGACCAAATGGATAATTAAATTAATACCTTTGGGGTTATTCGGGTTCATTACTTCTACTGTAATTCAGTTGCGAT
CGGGTATGGATATTAAAGGGATAGGTCAATACTTGATGATTATTGTTTTAGCTAATTTGATACAAGGATTAGTCATTCTG
CCTTTATGGCTGAAATCAAATGGTATTAAACCATTCTCTTCGATGCGGGCAATGTTACCTGCGTTATCTGTTGCTTTTTT
TTCCAAGTCATCTGTCGGAACTTTGCCTGTTACAATGAATACTGTAGAGGCTAATTTAAAGGTTAACCCTCAAATCAGTC
GTTTTGTTTTACCATTGTGCACAAGCATTAATATGAATGGATGTGCCGCATTTATTTTTGCCACAGTTATTTATCTTATG
CAAAGTCATGGCATCCAAGTCTCTTATGCTACTATGGGGATATGGGTTTTAGTATCAACTATAGCGGCAATAGGGAATGC
CGGCGTTCCTATGGGCTGCTTTTTCTTAAGCGTTAGTTTGCTCTCCAGTATGAATGTGCCTATCACACTTATGGGAGTTA
TTCTTCCTTTCTATGGTTTGATTGATATGTTGGAAACTGCCTTAAATGTATGGTCTGATGCTTGTGTTACCAAGGTTGTT
AATGATAAAGCAGAAGGTGGTGATGGAGTAGTGGGCATTAGACCAAAAGAGCGTTCATTATTAAATGCCGAGTTAGGTTA
A

Upstream 100 bases:

>100_bases
TTATAATTCCTCATTATTTCACTCCATATATCAAGCCATCTGTTGTTGCTGCTAATCATACTTTGCTTAAATAATTAACT
AAAGTTTTAAGGATTCAGCT

Downstream 100 bases:

>100_bases
AACCAGCAAATCTTCAAGCGCAAATGACTATAGCTTACAAATAAGTCTCCAGAAAGTTTTTTGGAGACTTAATGTCTATG
AAATCAGCTCACTACCTGGA

Product: hypothetical protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MCAAHHQKNKYIFSTPLIYAAMIGLGIISGLSDLPFLKETGLLISDLFIKLFKCISLPIISLSIIVTLANYQTDSLMKSV
WQRTIKYTFATTLVAALISCFLYILIHPSTVQVNLDAANPKSTSSLGYLGYLSNMIPTNLLSPFLEQQVMGVLLLSIVIG
FAVRQIPETEPRETIIRFFRGAHGMFLVMTKWIIKLIPLGLFGFITSTVIQLRSGMDIKGIGQYLMIIVLANLIQGLVIL
PLWLKSNGIKPFSSMRAMLPALSVAFFSKSSVGTLPVTMNTVEANLKVNPQISRFVLPLCTSINMNGCAAFIFATVIYLM
QSHGIQVSYATMGIWVLVSTIAAIGNAGVPMGCFFLSVSLLSSMNVPITLMGVILPFYGLIDMLETALNVWSDACVTKVV
NDKAEGGDGVVGIRPKERSLLNAELG

Sequences:

>Translated_426_residues
MCAAHHQKNKYIFSTPLIYAAMIGLGIISGLSDLPFLKETGLLISDLFIKLFKCISLPIISLSIIVTLANYQTDSLMKSV
WQRTIKYTFATTLVAALISCFLYILIHPSTVQVNLDAANPKSTSSLGYLGYLSNMIPTNLLSPFLEQQVMGVLLLSIVIG
FAVRQIPETEPRETIIRFFRGAHGMFLVMTKWIIKLIPLGLFGFITSTVIQLRSGMDIKGIGQYLMIIVLANLIQGLVIL
PLWLKSNGIKPFSSMRAMLPALSVAFFSKSSVGTLPVTMNTVEANLKVNPQISRFVLPLCTSINMNGCAAFIFATVIYLM
QSHGIQVSYATMGIWVLVSTIAAIGNAGVPMGCFFLSVSLLSSMNVPITLMGVILPFYGLIDMLETALNVWSDACVTKVV
NDKAEGGDGVVGIRPKERSLLNAELG
>Mature_426_residues
MCAAHHQKNKYIFSTPLIYAAMIGLGIISGLSDLPFLKETGLLISDLFIKLFKCISLPIISLSIIVTLANYQTDSLMKSV
WQRTIKYTFATTLVAALISCFLYILIHPSTVQVNLDAANPKSTSSLGYLGYLSNMIPTNLLSPFLEQQVMGVLLLSIVIG
FAVRQIPETEPRETIIRFFRGAHGMFLVMTKWIIKLIPLGLFGFITSTVIQLRSGMDIKGIGQYLMIIVLANLIQGLVIL
PLWLKSNGIKPFSSMRAMLPALSVAFFSKSSVGTLPVTMNTVEANLKVNPQISRFVLPLCTSINMNGCAAFIFATVIYLM
QSHGIQVSYATMGIWVLVSTIAAIGNAGVPMGCFFLSVSLLSSMNVPITLMGVILPFYGLIDMLETALNVWSDACVTKVV
NDKAEGGDGVVGIRPKERSLLNAELG

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI223468564, Length=250, Percent_Identity=29.2, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI223468566, Length=250, Percent_Identity=29.2, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI5032093, Length=253, Percent_Identity=29.2490118577075, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI21314632, Length=252, Percent_Identity=26.984126984127, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI66773030, Length=376, Percent_Identity=24.2021276595745, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI40254478, Length=408, Percent_Identity=22.5490196078431, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI194239697, Length=414, Percent_Identity=23.4299516908213, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI169790839, Length=406, Percent_Identity=21.6748768472906, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4827012, Length=279, Percent_Identity=24.3727598566308, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI301601644, Length=121, Percent_Identity=29.7520661157025, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI262359914, Length=342, Percent_Identity=20.4678362573099, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1790514, Length=366, Percent_Identity=24.8633879781421, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1789473, Length=387, Percent_Identity=25.5813953488372, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788024, Length=368, Percent_Identity=25.2717391304348, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789947, Length=366, Percent_Identity=19.1256830601093, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71983099, Length=404, Percent_Identity=25.990099009901, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71983106, Length=404, Percent_Identity=26.2376237623762, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71996953, Length=416, Percent_Identity=24.7596153846154, Blast_Score=121, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI193206505, Length=455, Percent_Identity=23.956043956044, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17541374, Length=391, Percent_Identity=25.5754475703325, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17537407, Length=409, Percent_Identity=22.2493887530562, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI193206654, Length=405, Percent_Identity=24.1975308641975, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24583025, Length=394, Percent_Identity=22.3350253807107, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI17137668, Length=394, Percent_Identity=22.3350253807107, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24583023, Length=394, Percent_Identity=22.3350253807107, Blast_Score=108, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46390; Mature: 46390

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCAAHHQKNKYIFSTPLIYAAMIGLGIISGLSDLPFLKETGLLISDLFIKLFKCISLPII
CCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHH
SLSIIVTLANYQTDSLMKSVWQRTIKYTFATTLVAALISCFLYILIHPSTVQVNLDAANP
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
KSTSSLGYLGYLSNMIPTNLLSPFLEQQVMGVLLLSIVIGFAVRQIPETEPRETIIRFFR
CCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
GAHGMFLVMTKWIIKLIPLGLFGFITSTVIQLRSGMDIKGIGQYLMIIVLANLIQGLVIL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
PLWLKSNGIKPFSSMRAMLPALSVAFFSKSSVGTLPVTMNTVEANLKVNPQISRFVLPLC
HHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECEEECCHHHHHHHHHH
TSINMNGCAAFIFATVIYLMQSHGIQVSYATMGIWVLVSTIAAIGNAGVPMGCFFLSVSL
HCCCCCHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LSSMNVPITLMGVILPFYGLIDMLETALNVWSDACVTKVVNDKAEGGDGVVGIRPKERSL
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHH
LNAELG
HCCCCC
>Mature Secondary Structure
MCAAHHQKNKYIFSTPLIYAAMIGLGIISGLSDLPFLKETGLLISDLFIKLFKCISLPII
CCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHH
SLSIIVTLANYQTDSLMKSVWQRTIKYTFATTLVAALISCFLYILIHPSTVQVNLDAANP
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
KSTSSLGYLGYLSNMIPTNLLSPFLEQQVMGVLLLSIVIGFAVRQIPETEPRETIIRFFR
CCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
GAHGMFLVMTKWIIKLIPLGLFGFITSTVIQLRSGMDIKGIGQYLMIIVLANLIQGLVIL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
PLWLKSNGIKPFSSMRAMLPALSVAFFSKSSVGTLPVTMNTVEANLKVNPQISRFVLPLC
HHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECEEECCHHHHHHHHHH
TSINMNGCAAFIFATVIYLMQSHGIQVSYATMGIWVLVSTIAAIGNAGVPMGCFFLSVSL
HCCCCCHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LSSMNVPITLMGVILPFYGLIDMLETALNVWSDACVTKVVNDKAEGGDGVVGIRPKERSL
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHH
LNAELG
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]