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The map label for this gene is cpxR [H]

Identifier: 148358969

GI number: 148358969

Start: 1652761

End: 1653441

Strand: Reverse

Name: cpxR [H]

Synonym: LPC_0854

Alternate gene names: 148358969

Gene position: 1653441-1652761 (Counterclockwise)

Preceding gene: 148358970

Following gene: 148358968

Centisome position: 46.23

GC content: 38.33

Gene sequence:

>681_bases
ATGAGCAGCTCTATTCTCATTATTGATGATGACACAGAACTAACAGATTTATTAACCCAATATTTGGAGCCAGAAGGCTT
TAATGTAGTATGTGTGCATGATGGAGAAAATGGTGTTAAAAAAGCTTTAAATCAGGTATTTGATGCCATTATACTCGACG
TCATGCTGCCCAAGCTTAATGGTTTTGAAGTATTAAAAGCAATAAGAGAGCATTTGGAAACACCTGTATTGATGTTAACT
GCTCGTGGTGATGATATCGATCGCATTGTTGGGTTAGAAATTGGTGCAGATGATTACTTACCTAAACCTTGTAATCCACG
AGAGTTAGTTGCACGTCTGCGTGCTATTTTAAGACGCACTCAAAAAATCCCAACTCCCAAACCAATTATTGAACAACATA
ATATCATTGTGGATTGCTCCAAACGCCACGTGACTATGGGAGGAAAATTCCTTGAATTAACCAATGCGGAATTTAATATT
TTAGAGATGTTAATCAAATCACCAGGACAAGCATTTTCCAAAGAGGAACTCACCGAATATGCTCTGGGAAGAAAATACAC
TGCTTATGACCGCAGTATCGATGTTCACATCAGCAATTTACGAAATAAATTAGGCGATAATCCTCAGGGAGAACCTTTAG
TCAAAACTGTCCGCGGGTTTGGGTACATGTTTAATGCGTAG

Upstream 100 bases:

>100_bases
AAAGTTCTTAATGCCGATTCGAGAAGAATAAAGTTATTAGAATGTCTCGATAAAAGAAGTCCCGAGAAACTAAATTCTAC
TGTTGAAGGATAAGTAATTC

Downstream 100 bases:

>100_bases
CCTGTACTGGAAAATATTTGTTTCTTTTTGGCTGGCCACCATTTTAATTATTTTTACTACGGCATGGGTTACCAGCCAAA
TCGCACAAAAATCATCACAA

Product: transcriptional regulator CpxR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MSSSILIIDDDTELTDLLTQYLEPEGFNVVCVHDGENGVKKALNQVFDAIILDVMLPKLNGFEVLKAIREHLETPVLMLT
ARGDDIDRIVGLEIGADDYLPKPCNPRELVARLRAILRRTQKIPTPKPIIEQHNIIVDCSKRHVTMGGKFLELTNAEFNI
LEMLIKSPGQAFSKEELTEYALGRKYTAYDRSIDVHISNLRNKLGDNPQGEPLVKTVRGFGYMFNA

Sequences:

>Translated_226_residues
MSSSILIIDDDTELTDLLTQYLEPEGFNVVCVHDGENGVKKALNQVFDAIILDVMLPKLNGFEVLKAIREHLETPVLMLT
ARGDDIDRIVGLEIGADDYLPKPCNPRELVARLRAILRRTQKIPTPKPIIEQHNIIVDCSKRHVTMGGKFLELTNAEFNI
LEMLIKSPGQAFSKEELTEYALGRKYTAYDRSIDVHISNLRNKLGDNPQGEPLVKTVRGFGYMFNA
>Mature_225_residues
SSSILIIDDDTELTDLLTQYLEPEGFNVVCVHDGENGVKKALNQVFDAIILDVMLPKLNGFEVLKAIREHLETPVLMLTA
RGDDIDRIVGLEIGADDYLPKPCNPRELVARLRAILRRTQKIPTPKPIIEQHNIIVDCSKRHVTMGGKFLELTNAEFNIL
EMLIKSPGQAFSKEELTEYALGRKYTAYDRSIDVHISNLRNKLGDNPQGEPLVKTVRGFGYMFNA

Specific function: Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=47.3684210526316, Blast_Score=213, Evalue=6e-57,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=40.3508771929825, Blast_Score=171, Evalue=4e-44,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=40.2714932126697, Blast_Score=164, Evalue=3e-42,
Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=36.6812227074236, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1786599, Length=231, Percent_Identity=37.2294372294372, Blast_Score=150, Evalue=7e-38,
Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=36.4444444444444, Blast_Score=137, Evalue=8e-34,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=35.1351351351351, Blast_Score=134, Evalue=3e-33,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=34.6846846846847, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=31.5315315315315, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=31.7180616740088, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1787229, Length=232, Percent_Identity=33.1896551724138, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=36.322869955157, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=30.3418803418803, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=29.7297297297297, Blast_Score=97, Evalue=6e-22,
Organism=Escherichia coli, GI1790437, Length=127, Percent_Identity=32.2834645669291, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1788550, Length=106, Percent_Identity=30.188679245283, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25433; Mature: 25302

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSILIIDDDTELTDLLTQYLEPEGFNVVCVHDGENGVKKALNQVFDAIILDVMLPKLN
CCCCEEEEECCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCC
GFEVLKAIREHLETPVLMLTARGDDIDRIVGLEIGADDYLPKPCNPRELVARLRAILRRT
HHHHHHHHHHHHCCCEEEEEECCCCCHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
QKIPTPKPIIEQHNIIVDCSKRHVTMGGKFLELTNAEFNILEMLIKSPGQAFSKEELTEY
HCCCCCCCHHHCCCEEEECCCCEEECCCEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHH
ALGRKYTAYDRSIDVHISNLRNKLGDNPQGEPLVKTVRGFGYMFNA
HHCCCEECCCCEEEEEHHHHHHHHCCCCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SSSILIIDDDTELTDLLTQYLEPEGFNVVCVHDGENGVKKALNQVFDAIILDVMLPKLN
CCCEEEEECCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCC
GFEVLKAIREHLETPVLMLTARGDDIDRIVGLEIGADDYLPKPCNPRELVARLRAILRRT
HHHHHHHHHHHHCCCEEEEEECCCCCHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
QKIPTPKPIIEQHNIIVDCSKRHVTMGGKFLELTNAEFNILEMLIKSPGQAFSKEELTEY
HCCCCCCCHHHCCCEEEECCCCEEECCCEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHH
ALGRKYTAYDRSIDVHISNLRNKLGDNPQGEPLVKTVRGFGYMFNA
HHCCCEECCCCEEEEEHHHHHHHHCCCCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]