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The map label for this gene is cpxA [H]

Identifier: 148358968

GI number: 148358968

Start: 1651401

End: 1652768

Strand: Reverse

Name: cpxA [H]

Synonym: LPC_0853

Alternate gene names: 148358968

Gene position: 1652768-1651401 (Counterclockwise)

Preceding gene: 148358969

Following gene: 148358967

Centisome position: 46.21

GC content: 38.89

Gene sequence:

>1368_bases
ATGCGTAGCCTGTACTGGAAAATATTTGTTTCTTTTTGGCTGGCCACCATTTTAATTATTTTTACTACGGCATGGGTTAC
CAGCCAAATCGCACAAAAATCATCACAACCAGCTCGAGAAGAAATGTTTATGGACAGCTATGCCAATGCAGCTGTCGCAA
CCTATGAGTCAGGCCAACAATCAGCACTTTTGAAATGGCTTGATAAAATAGGCCTTTCTCGTCATATGACACTGTATTTA
CTAACCAGCACCGGTGAAATCATTGGCGCACAGAAACCACCTGACGCCGTAAAAAAAATTTCAGAAAATTTAATAAATGA
TGAACTCCCAAGTGATGGCATATTTAAAACAGGGAAATTAGTCGTTAGCCATGAGATCCTATCAACTTCTGGAAAATATT
ACCGGCTAGCAGCTGTCAGTGAAAAGCCAATCTCTTATTTTGTGCAAATTCCATGGGCTGGACTGACAATACGTTTAACT
CTGGCCATATTCATCAGTGGGCTTATCTGCTATTTACTCTCACGTTATTTAACTCAACCTTTACGCTCATTAGGCATGGC
AGCAAAATCTATCGCTAAAGGAAATTTAAATACCCGGGTTGGTCGCTTCAGAGGTCATAGCAAAGATGAGATTGCGGAGT
TAAGCAATGAATTCGATCGAATGGCCGAGCAATTAGAAGCGCTTGTTCATTCCAAAGAACGATTAATACAGGATATTTCC
CATGAATTACGCTCTCCATTGGCTCGACTTAAAATCGCCATAGAATTGGGGAAAAAGAAAACCAAGCATTTGGCTGATAA
TGAATTTGCCCGCATGGAAATTGAAACATCCAGACTTAATGATTTGATAGGCGAAATTCTCGATTTTGCTCGTTTAGAAA
AATCGACAACAGAACTTCATTTATCCCAAACAAATATCGCGGATTTGCTTGCACAGGTTATAAGTGATGCCAATTATGAG
TTCAGTCACAATTCTATAAGAATACAAGCTGGAATAATTACACCTTGTGAATTAAATATTGACCAACGCCTAATACACAG
AGCTATAGAAAATATTGTTCGTAATGCATCACACTATTCTCCTCCAGATGAAAAGGTCCTGATTTCATCAAGCTATAATA
AAAACAAAGATCAAGTTTATATTGATATTAATGATAAAGGACCTGGGGTTCCCGAAGATCAACTGGAAAAAATATTTAAT
CCTTTCTACCGCGTGGATACCTCCAGAACAAAAAAAACCGGTGGCTATGGGCTTGGGCTCGCAATTGCAGCCAGGGCTGT
AGCATTACACCAAGGAGAAATTATTGCTAAAAATAGAGAGCAAGGTGGTTTGCTTGTTCGTATCATTTTACCTGCTAATG
TTAAATAG

Upstream 100 bases:

>100_bases
AGTATCGATGTTCACATCAGCAATTTACGAAATAAATTAGGCGATAATCCTCAGGGAGAACCTTTAGTCAAAACTGTCCG
CGGGTTTGGGTACATGTTTA

Downstream 100 bases:

>100_bases
AATTTCTATATATCGAGTTCCTCCTTATTGACTAAAATTGATTTTTAACTTGCATTTTTATTATCTAATTTCGCATAAAT
ACAAATAATTATACATTTTG

Product: sensor histidine kinase CpxA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MRSLYWKIFVSFWLATILIIFTTAWVTSQIAQKSSQPAREEMFMDSYANAAVATYESGQQSALLKWLDKIGLSRHMTLYL
LTSTGEIIGAQKPPDAVKKISENLINDELPSDGIFKTGKLVVSHEILSTSGKYYRLAAVSEKPISYFVQIPWAGLTIRLT
LAIFISGLICYLLSRYLTQPLRSLGMAAKSIAKGNLNTRVGRFRGHSKDEIAELSNEFDRMAEQLEALVHSKERLIQDIS
HELRSPLARLKIAIELGKKKTKHLADNEFARMEIETSRLNDLIGEILDFARLEKSTTELHLSQTNIADLLAQVISDANYE
FSHNSIRIQAGIITPCELNIDQRLIHRAIENIVRNASHYSPPDEKVLISSSYNKNKDQVYIDINDKGPGVPEDQLEKIFN
PFYRVDTSRTKKTGGYGLGLAIAARAVALHQGEIIAKNREQGGLLVRIILPANVK

Sequences:

>Translated_455_residues
MRSLYWKIFVSFWLATILIIFTTAWVTSQIAQKSSQPAREEMFMDSYANAAVATYESGQQSALLKWLDKIGLSRHMTLYL
LTSTGEIIGAQKPPDAVKKISENLINDELPSDGIFKTGKLVVSHEILSTSGKYYRLAAVSEKPISYFVQIPWAGLTIRLT
LAIFISGLICYLLSRYLTQPLRSLGMAAKSIAKGNLNTRVGRFRGHSKDEIAELSNEFDRMAEQLEALVHSKERLIQDIS
HELRSPLARLKIAIELGKKKTKHLADNEFARMEIETSRLNDLIGEILDFARLEKSTTELHLSQTNIADLLAQVISDANYE
FSHNSIRIQAGIITPCELNIDQRLIHRAIENIVRNASHYSPPDEKVLISSSYNKNKDQVYIDINDKGPGVPEDQLEKIFN
PFYRVDTSRTKKTGGYGLGLAIAARAVALHQGEIIAKNREQGGLLVRIILPANVK
>Mature_455_residues
MRSLYWKIFVSFWLATILIIFTTAWVTSQIAQKSSQPAREEMFMDSYANAAVATYESGQQSALLKWLDKIGLSRHMTLYL
LTSTGEIIGAQKPPDAVKKISENLINDELPSDGIFKTGKLVVSHEILSTSGKYYRLAAVSEKPISYFVQIPWAGLTIRLT
LAIFISGLICYLLSRYLTQPLRSLGMAAKSIAKGNLNTRVGRFRGHSKDEIAELSNEFDRMAEQLEALVHSKERLIQDIS
HELRSPLARLKIAIELGKKKTKHLADNEFARMEIETSRLNDLIGEILDFARLEKSTTELHLSQTNIADLLAQVISDANYE
FSHNSIRIQAGIITPCELNIDQRLIHRAIENIVRNASHYSPPDEKVLISSSYNKNKDQVYIDINDKGPGVPEDQLEKIFN
PFYRVDTSRTKKTGGYGLGLAIAARAVALHQGEIIAKNREQGGLLVRIILPANVK

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=390, Percent_Identity=31.2820512820513, Blast_Score=149, Evalue=5e-37,
Organism=Escherichia coli, GI1787894, Length=307, Percent_Identity=31.2703583061889, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1788393, Length=277, Percent_Identity=27.4368231046931, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1789808, Length=300, Percent_Identity=28.6666666666667, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1786783, Length=278, Percent_Identity=27.3381294964029, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1786600, Length=243, Percent_Identity=26.7489711934156, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1790551, Length=295, Percent_Identity=25.4237288135593, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790861, Length=245, Percent_Identity=27.3469387755102, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082128, Length=310, Percent_Identity=25.4838709677419, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786912, Length=244, Percent_Identity=27.8688524590164, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI145693157, Length=231, Percent_Identity=27.2727272727273, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI48994928, Length=236, Percent_Identity=25.4237288135593, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1787374, Length=312, Percent_Identity=24.6794871794872, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1789149, Length=408, Percent_Identity=24.5098039215686, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788549, Length=249, Percent_Identity=26.9076305220884, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1790436, Length=247, Percent_Identity=28.7449392712551, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788279, Length=234, Percent_Identity=27.7777777777778, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081816, Length=257, Percent_Identity=27.2373540856031, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789403, Length=250, Percent_Identity=24.4, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790300, Length=236, Percent_Identity=26.271186440678, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51023; Mature: 51023

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSLYWKIFVSFWLATILIIFTTAWVTSQIAQKSSQPAREEMFMDSYANAAVATYESGQQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCCH
SALLKWLDKIGLSRHMTLYLLTSTGEIIGAQKPPDAVKKISENLINDELPSDGIFKTGKL
HHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEECCCE
VVSHEILSTSGKYYRLAAVSEKPISYFVQIPWAGLTIRLTLAIFISGLICYLLSRYLTQP
EEEHHHHHCCCCEEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LRSLGMAAKSIAKGNLNTRVGRFRGHSKDEIAELSNEFDRMAEQLEALVHSKERLIQDIS
HHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HELRSPLARLKIAIELGKKKTKHLADNEFARMEIETSRLNDLIGEILDFARLEKSTTELH
HHHHHHHHHHHHHHHHCCHHHHHCCCCCHHEEEEHHHHHHHHHHHHHHHHHHHCCHHHEE
LSQTNIADLLAQVISDANYEFSHNSIRIQAGIITPCELNIDQRLIHRAIENIVRNASHYS
ECHHHHHHHHHHHHCCCCCEECCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCC
PPDEKVLISSSYNKNKDQVYIDINDKGPGVPEDQLEKIFNPFYRVDTSRTKKTGGYGLGL
CCCCEEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
AIAARAVALHQGEIIAKNREQGGLLVRIILPANVK
HHHHHHHHHHCCCEEECCCCCCCEEEEEEECCCCC
>Mature Secondary Structure
MRSLYWKIFVSFWLATILIIFTTAWVTSQIAQKSSQPAREEMFMDSYANAAVATYESGQQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCCH
SALLKWLDKIGLSRHMTLYLLTSTGEIIGAQKPPDAVKKISENLINDELPSDGIFKTGKL
HHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEECCCE
VVSHEILSTSGKYYRLAAVSEKPISYFVQIPWAGLTIRLTLAIFISGLICYLLSRYLTQP
EEEHHHHHCCCCEEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LRSLGMAAKSIAKGNLNTRVGRFRGHSKDEIAELSNEFDRMAEQLEALVHSKERLIQDIS
HHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HELRSPLARLKIAIELGKKKTKHLADNEFARMEIETSRLNDLIGEILDFARLEKSTTELH
HHHHHHHHHHHHHHHHCCHHHHHCCCCCHHEEEEHHHHHHHHHHHHHHHHHHHCCHHHEE
LSQTNIADLLAQVISDANYEFSHNSIRIQAGIITPCELNIDQRLIHRAIENIVRNASHYS
ECHHHHHHHHHHHHCCCCCEECCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCC
PPDEKVLISSSYNKNKDQVYIDINDKGPGVPEDQLEKIFNPFYRVDTSRTKKTGGYGLGL
CCCCEEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
AIAARAVALHQGEIIAKNREQGGLLVRIILPANVK
HHHHHHHHHHCCCEEECCCCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]