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The map label for this gene is hemD [H]

Identifier: 148358524

GI number: 148358524

Start: 3264588

End: 3265340

Strand: Direct

Name: hemD [H]

Synonym: LPC_0394

Alternate gene names: 148358524

Gene position: 3264588-3265340 (Clockwise)

Preceding gene: 148358525

Following gene: 148358523

Centisome position: 91.28

GC content: 39.58

Gene sequence:

>753_bases
ATGACCAAATCACTTAATGGTCTTCGCATATTAAACACCAGACCCAGGGAGCAAGCACAAGTACTTAATAAAAAAATTAT
CGAGTCTGGTGGAATACCCATCGACTGCCCCACGATGGAAATAATGGCATCTGAGAACAATTGGATAAATAATTTGCCTG
ATTTGACCTTAGTAAATCAGGCCATTTTTGTCAGTGCAAATGCAGTTCGTTATTTCATGATGGAACTGGCTTCCAAAAGC
ATCAATTGGCCAAATAGCATCCGGGTAGCTGCTATAGGTAAAGGCACCTCCAGAGTACTCAATGAATTCAATATCCAGGT
TAGTGATATCCCCGAATTACCTGACAGCGAGCATTTACTGACTCTCAATTCATTGCAACAAATAAGAAATCAGACGATTC
TGCTTGTGAAAGGAGAAGGAGGCAGGCAACTGATTGAAGAATATTTAATGCTGAAGGGAGCGAAGCTATGTCTTCTGTCA
GTCTATAAACGAGTCATGCCAACCATCGACAAAGAATTTCTTAATTCTCTGTGGCGCGATGACCTGGCGGACATTATACT
GTTAACAAGTGAGCAGTCCATACATAATCTTTTTAAAATGTTTAGCATAGAGGGGCAAATGTGGTTACAAAACAAACCTT
GCCTGGTCATTAGTGACCGACTTGCAAAGGTAGCTTCTTTATTTGGAATTAAAAAGATTCTTATTAGCCATCCAGAAAGG
ATGATAGGTACGTTATTTGACTATAAGGATTAA

Upstream 100 bases:

>100_bases
AGCAACAAGGGAAAATTGCAGAAGCTGAAGTCATTGCAGACAGGTGTACCGAGTCATTAATGACTAAAGGTGCAATGTCC
TTATTGAGTACGATACCATC

Downstream 100 bases:

>100_bases
TCCATGGCCAATAGCAATGAAGAACAGAAAAAAACAATTCAACCGCAACAACCACCTAAAGTTGAGCCCGACATCAACCA
ACAAATGAAAGCCTCTTTCT

Product: uroporphyrinogen III methylase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MTKSLNGLRILNTRPREQAQVLNKKIIESGGIPIDCPTMEIMASENNWINNLPDLTLVNQAIFVSANAVRYFMMELASKS
INWPNSIRVAAIGKGTSRVLNEFNIQVSDIPELPDSEHLLTLNSLQQIRNQTILLVKGEGGRQLIEEYLMLKGAKLCLLS
VYKRVMPTIDKEFLNSLWRDDLADIILLTSEQSIHNLFKMFSIEGQMWLQNKPCLVISDRLAKVASLFGIKKILISHPER
MIGTLFDYKD

Sequences:

>Translated_250_residues
MTKSLNGLRILNTRPREQAQVLNKKIIESGGIPIDCPTMEIMASENNWINNLPDLTLVNQAIFVSANAVRYFMMELASKS
INWPNSIRVAAIGKGTSRVLNEFNIQVSDIPELPDSEHLLTLNSLQQIRNQTILLVKGEGGRQLIEEYLMLKGAKLCLLS
VYKRVMPTIDKEFLNSLWRDDLADIILLTSEQSIHNLFKMFSIEGQMWLQNKPCLVISDRLAKVASLFGIKKILISHPER
MIGTLFDYKD
>Mature_249_residues
TKSLNGLRILNTRPREQAQVLNKKIIESGGIPIDCPTMEIMASENNWINNLPDLTLVNQAIFVSANAVRYFMMELASKSI
NWPNSIRVAAIGKGTSRVLNEFNIQVSDIPELPDSEHLLTLNSLQQIRNQTILLVKGEGGRQLIEEYLMLKGAKLCLLSV
YKRVMPTIDKEFLNSLWRDDLADIILLTSEQSIHNLFKMFSIEGQMWLQNKPCLVISDRLAKVASLFGIKKILISHPERM
IGTLFDYKD

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790236, Length=233, Percent_Identity=26.1802575107296, Blast_Score=75, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 28371; Mature: 28239

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKSLNGLRILNTRPREQAQVLNKKIIESGGIPIDCPTMEIMASENNWINNLPDLTLVNQ
CCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHH
AIFVSANAVRYFMMELASKSINWPNSIRVAAIGKGTSRVLNEFNIQVSDIPELPDSEHLL
HHHEEHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHCCEEECCCCCCCCCCEE
TLNSLQQIRNQTILLVKGEGGRQLIEEYLMLKGAKLCLLSVYKRVMPTIDKEFLNSLWRD
EHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLADIILLTSEQSIHNLFKMFSIEGQMWLQNKPCLVISDRLAKVASLFGIKKILISHPER
HHHHEEEEECCHHHHHHHHHHHCCCCEEECCCCEEEEHHHHHHHHHHHHHHHHHHHCHHH
MIGTLFDYKD
HHHHHHCCCC
>Mature Secondary Structure 
TKSLNGLRILNTRPREQAQVLNKKIIESGGIPIDCPTMEIMASENNWINNLPDLTLVNQ
CCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHH
AIFVSANAVRYFMMELASKSINWPNSIRVAAIGKGTSRVLNEFNIQVSDIPELPDSEHLL
HHHEEHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHCCEEECCCCCCCCCCEE
TLNSLQQIRNQTILLVKGEGGRQLIEEYLMLKGAKLCLLSVYKRVMPTIDKEFLNSLWRD
EHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLADIILLTSEQSIHNLFKMFSIEGQMWLQNKPCLVISDRLAKVASLFGIKKILISHPER
HHHHEEEEECCHHHHHHHHHHHCCCCEEECCCCEEEEHHHHHHHHHHHHHHHHHHHCHHH
MIGTLFDYKD
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8874804 [H]