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The map label for this gene is hemC [H]

Identifier: 148358525

GI number: 148358525

Start: 3263626

End: 3264591

Strand: Direct

Name: hemC [H]

Synonym: LPC_0395

Alternate gene names: 148358525

Gene position: 3263626-3264591 (Clockwise)

Preceding gene: 148358528

Following gene: 148358524

Centisome position: 91.25

GC content: 42.34

Gene sequence:

>966_bases
ATGATCTTTACCCAAAGAACATATACCGTCTATTCCATGAGCGCAAAAATTATACGAATCGCAACGAGGCAGAGCCCGCT
TGCACTATGGCAGGCTAATCATGTACGGAAAATGCTTGTAAAGCAATGGCCAAATCTAAGCATTGAATTATTACCCATGA
TAACCTCTGGCGATCGGTTTCTTAAAGATAAATTATTATCCGCAGGAGGAAAAGGGTTATTTGTTAAAGAGTTAGAAGAA
GCATTATTGGATAAAAGAGCGGACTTGGCTGTTCATTCGACCAAAGACATGCCAGCACAACTTCCGGATGGCCTCTTGTT
GGCCGCCATTTGCAAAAGAGATAACCCTTTTGACGCTTTAATAAGTCCCCAATTTAAGAGTCTGGATGCTCTCCCCAAAA
ACGCAATTATCGGTACATCAAGCCTTAGACGTCAATCTCAGCTATTGGCTTACAATCCCAATTTGCAAATCAAAACATTA
AGAGGAAACATCCATACAAGACTCAGCAAACTGGAGTCTGGAGAGTATCAAGCCATTATTCTTGCTGCCGCAGGCTTGGA
AAGAATGGGCTTAGCACATCACATCACCCAACTCATACCCGATGACATTATGCTGCCTACTTGTGCTCAGGGCGCTTTAT
GTATTGAGTGCCGAACGGATGATTTGGAAATCCAAGAGCTGATTCATGGCTTAAATGATCCAATTTCTGCCCTTTGTGTC
CATACCGAGCGACGCGTCAACGCAAAATTAGGAGGCAATTGCCATATACCCTTTGCTGTTTATTGTACCATTACTGAGGA
GAAACGCCTCCTTTTGAGAGCAAAAGTACTTAATATGGATGGTTCTCAAATGATTGATGATGAGCAACAAGGGAAAATTG
CAGAAGCTGAAGTCATTGCAGACAGGTGTACCGAGTCATTAATGACTAAAGGTGCAATGTCCTTATTGAGTACGATACCA
TCATGA

Upstream 100 bases:

>100_bases
TTCTCAAACCGATAGGAATGATCATTTATAAATCAATTGCCTGACAAGATTTGCGTACCTATTATCTGAATGGGGTTCTT
TTTAAATTAGAATCAATGTT

Downstream 100 bases:

>100_bases
CCAAATCACTTAATGGTCTTCGCATATTAAACACCAGACCCAGGGAGCAAGCACAAGTACTTAATAAAAAAATTATCGAG
TCTGGTGGAATACCCATCGA

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MIFTQRTYTVYSMSAKIIRIATRQSPLALWQANHVRKMLVKQWPNLSIELLPMITSGDRFLKDKLLSAGGKGLFVKELEE
ALLDKRADLAVHSTKDMPAQLPDGLLLAAICKRDNPFDALISPQFKSLDALPKNAIIGTSSLRRQSQLLAYNPNLQIKTL
RGNIHTRLSKLESGEYQAIILAAAGLERMGLAHHITQLIPDDIMLPTCAQGALCIECRTDDLEIQELIHGLNDPISALCV
HTERRVNAKLGGNCHIPFAVYCTITEEKRLLLRAKVLNMDGSQMIDDEQQGKIAEAEVIADRCTESLMTKGAMSLLSTIP
S

Sequences:

>Translated_321_residues
MIFTQRTYTVYSMSAKIIRIATRQSPLALWQANHVRKMLVKQWPNLSIELLPMITSGDRFLKDKLLSAGGKGLFVKELEE
ALLDKRADLAVHSTKDMPAQLPDGLLLAAICKRDNPFDALISPQFKSLDALPKNAIIGTSSLRRQSQLLAYNPNLQIKTL
RGNIHTRLSKLESGEYQAIILAAAGLERMGLAHHITQLIPDDIMLPTCAQGALCIECRTDDLEIQELIHGLNDPISALCV
HTERRVNAKLGGNCHIPFAVYCTITEEKRLLLRAKVLNMDGSQMIDDEQQGKIAEAEVIADRCTESLMTKGAMSLLSTIP
S
>Mature_321_residues
MIFTQRTYTVYSMSAKIIRIATRQSPLALWQANHVRKMLVKQWPNLSIELLPMITSGDRFLKDKLLSAGGKGLFVKELEE
ALLDKRADLAVHSTKDMPAQLPDGLLLAAICKRDNPFDALISPQFKSLDALPKNAIIGTSSLRRQSQLLAYNPNLQIKTL
RGNIHTRLSKLESGEYQAIILAAAGLERMGLAHHITQLIPDDIMLPTCAQGALCIECRTDDLEIQELIHGLNDPISALCV
HTERRVNAKLGGNCHIPFAVYCTITEEKRLLLRAKVLNMDGSQMIDDEQQGKIAEAEVIADRCTESLMTKGAMSLLSTIP
S

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=282, Percent_Identity=42.1985815602837, Blast_Score=212, Evalue=4e-55,
Organism=Homo sapiens, GI20149500, Length=282, Percent_Identity=42.1985815602837, Blast_Score=212, Evalue=5e-55,
Organism=Escherichia coli, GI48994974, Length=307, Percent_Identity=50.1628664495114, Blast_Score=299, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6319996, Length=325, Percent_Identity=38.7692307692308, Blast_Score=213, Evalue=4e-56,
Organism=Drosophila melanogaster, GI20130425, Length=290, Percent_Identity=37.5862068965517, Blast_Score=179, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 35549; Mature: 35549

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFTQRTYTVYSMSAKIIRIATRQSPLALWQANHVRKMLVKQWPNLSIELLPMITSGDRF
CEEECEEEEEEEECEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHH
LKDKLLSAGGKGLFVKELEEALLDKRADLAVHSTKDMPAQLPDGLLLAAICKRDNPFDAL
HHHHHHHCCCCCEEHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHCCCCCCCHH
ISPQFKSLDALPKNAIIGTSSLRRQSQLLAYNPNLQIKTLRGNIHTRLSKLESGEYQAII
CCCCHHHHHCCCCCCEECCHHHHHHCCEEEECCCEEEEEECCCHHHHHHHHCCCCEEEEE
LAAAGLERMGLAHHITQLIPDDIMLPTCAQGALCIECRTDDLEIQELIHGLNDPISALCV
EEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHCCCCCHHHHHH
HTERRVNAKLGGNCHIPFAVYCTITEEKRLLLRAKVLNMDGSQMIDDEQQGKIAEAEVIA
HHHHHCCCCCCCCCCCCEEEEEEEEHHHHHHHHHHHHCCCCCCCCCCHHCCCHHHHHHHH
DRCTESLMTKGAMSLLSTIPS
HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIFTQRTYTVYSMSAKIIRIATRQSPLALWQANHVRKMLVKQWPNLSIELLPMITSGDRF
CEEECEEEEEEEECEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHH
LKDKLLSAGGKGLFVKELEEALLDKRADLAVHSTKDMPAQLPDGLLLAAICKRDNPFDAL
HHHHHHHCCCCCEEHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHCCCCCCCHH
ISPQFKSLDALPKNAIIGTSSLRRQSQLLAYNPNLQIKTLRGNIHTRLSKLESGEYQAII
CCCCHHHHHCCCCCCEECCHHHHHHCCEEEECCCEEEEEECCCHHHHHHHHCCCCEEEEE
LAAAGLERMGLAHHITQLIPDDIMLPTCAQGALCIECRTDDLEIQELIHGLNDPISALCV
EEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHCCCCCHHHHHH
HTERRVNAKLGGNCHIPFAVYCTITEEKRLLLRAKVLNMDGSQMIDDEQQGKIAEAEVIA
HHHHHCCCCCCCCCCCCEEEEEEEEHHHHHHHHHHHHCCCCCCCCCCHHCCCHHHHHHHH
DRCTESLMTKGAMSLLSTIPS
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA