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The map label for this gene is hemX [H]

Identifier: 148358523

GI number: 148358523

Start: 3265344

End: 3266468

Strand: Direct

Name: hemX [H]

Synonym: LPC_0393

Alternate gene names: 148358523

Gene position: 3265344-3266468 (Clockwise)

Preceding gene: 148358524

Following gene: 148358522

Centisome position: 91.3

GC content: 36.98

Gene sequence:

>1125_bases
ATGGCCAATAGCAATGAAGAACAGAAAAAAACAATTCAACCGCAACAACCACCTAAAGTTGAGCCCGACATCAACCAACA
AATGAAAGCCTCTTTCTTCGGTAGTAAATACCTATCCTTAATAATCAGCTTGACATCGCTTTTGGCGTTCCTTGCTATCA
TCGTCTCTATTTATTCCATTCAGTTGGAGAAACAATTTCAAAACCATCAGCTTGTTGAAAACAAAAATTTAACTGATGAA
TTGGGAAGAATAAAAGCAGAGCAAAATACAGTCCAAAAGCTCCTGGATAACAATGCCAATCATCTTCAGCAAATTCAGAG
TGATTTAACAAGCAAAATGGATAGCTTAAATAAAGAATTACAAACAGCTATGAAGCAAAAATTGTATCAAAATAATGATT
GGCTTCTTTTAAAAGCACGTTATTATCTTGAATTAGCGCAAATCAATGTTCATTGGAGTGATAATTTTAATACCTCTGTC
GCCCTTTTACAGCAAGCTGATGCGCTACTGAAAGGCATGAATATCCCCAAAATATTTACCATTCGCCAGATAATCGCCAA
AGAAATTGCCCAATTAAAGTCAATTTCTGTTGTTGATATCACAGGGATATTAAGCCAATTGGATGCGGCTCAAGCGGCTA
TCAATAATCTTTCTATTCAATCCGTAGTAGATCAACAGGAAGTGCTAAACCATATCACCAAGTCTGAAGAGTCTGGCAAA
ATTGGATGGCGAAATCGGTTGCAAGACAGTGTGAATTTTCTGGAGAAATTGGTTGTTATTCGTCGCCACAATGAAAATAT
TCAACCACTTATCTCCCCTCTATATGAATCTGCAATAAAAGAGAATATACGCCTTAACCTTCAGGAAGCGCAGTGGGCTA
TTTTAAATAATAACCCCGCAGTCTACCAGTTTGCTTTAAACCAGGCCATTGCAAATCTTAAAAGAGTATTTAATGAATCT
TCCCAAAACACCGACGCTTTGATTAAGCAATTGTCCACTCTGCAAAATGTAAAATTAACTCAGGAAAAACCTGTCGTAGG
ACAAGCCATCCCGCTAATCAATCAAATGATTGACAATAAAGAATTGCTGGTCGATCAAGCAAACAGCAAGAAAGGAGAAA
ACTAA

Upstream 100 bases:

>100_bases
CCGACTTGCAAAGGTAGCTTCTTTATTTGGAATTAAAAAGATTCTTATTAGCCATCCAGAAAGGATGATAGGTACGTTAT
TTGACTATAAGGATTAATCC

Downstream 100 bases:

>100_bases
GAATGATACGAGTTCTGTTTGCTTTTATTATTTTACTGCTCTCTGTGTTCCTTGGTATTCAACTCAATAAGGATCCAGGT
TATGTCTTAATAGCTATTAA

Product: uroporphyrinogen III methylase

Products: NA

Alternate protein names: Urogen-III methylase; ORF X [H]

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MANSNEEQKKTIQPQQPPKVEPDINQQMKASFFGSKYLSLIISLTSLLAFLAIIVSIYSIQLEKQFQNHQLVENKNLTDE
LGRIKAEQNTVQKLLDNNANHLQQIQSDLTSKMDSLNKELQTAMKQKLYQNNDWLLLKARYYLELAQINVHWSDNFNTSV
ALLQQADALLKGMNIPKIFTIRQIIAKEIAQLKSISVVDITGILSQLDAAQAAINNLSIQSVVDQQEVLNHITKSEESGK
IGWRNRLQDSVNFLEKLVVIRRHNENIQPLISPLYESAIKENIRLNLQEAQWAILNNNPAVYQFALNQAIANLKRVFNES
SQNTDALIKQLSTLQNVKLTQEKPVVGQAIPLINQMIDNKELLVDQANSKKGEN

Sequences:

>Translated_374_residues
MANSNEEQKKTIQPQQPPKVEPDINQQMKASFFGSKYLSLIISLTSLLAFLAIIVSIYSIQLEKQFQNHQLVENKNLTDE
LGRIKAEQNTVQKLLDNNANHLQQIQSDLTSKMDSLNKELQTAMKQKLYQNNDWLLLKARYYLELAQINVHWSDNFNTSV
ALLQQADALLKGMNIPKIFTIRQIIAKEIAQLKSISVVDITGILSQLDAAQAAINNLSIQSVVDQQEVLNHITKSEESGK
IGWRNRLQDSVNFLEKLVVIRRHNENIQPLISPLYESAIKENIRLNLQEAQWAILNNNPAVYQFALNQAIANLKRVFNES
SQNTDALIKQLSTLQNVKLTQEKPVVGQAIPLINQMIDNKELLVDQANSKKGEN
>Mature_373_residues
ANSNEEQKKTIQPQQPPKVEPDINQQMKASFFGSKYLSLIISLTSLLAFLAIIVSIYSIQLEKQFQNHQLVENKNLTDEL
GRIKAEQNTVQKLLDNNANHLQQIQSDLTSKMDSLNKELQTAMKQKLYQNNDWLLLKARYYLELAQINVHWSDNFNTSVA
LLQQADALLKGMNIPKIFTIRQIIAKEIAQLKSISVVDITGILSQLDAAQAAINNLSIQSVVDQQEVLNHITKSEESGKI
GWRNRLQDSVNFLEKLVVIRRHNENIQPLISPLYESAIKENIRLNLQEAQWAILNNNPAVYQFALNQAIANLKRVFNESS
QNTDALIKQLSTLQNVKLTQEKPVVGQAIPLINQMIDNKELLVDQANSKKGEN

Specific function: Siroheme and cobalamin biosynthesis. [C]

COG id: COG2959

COG function: function code H; Uncharacterized enzyme of heme biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790235, Length=229, Percent_Identity=27.5109170305677, Blast_Score=92, Evalue=7e-20,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007470 [H]

Pfam domain/function: PF04375 HemX [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 42440; Mature: 42309

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANSNEEQKKTIQPQQPPKVEPDINQQMKASFFGSKYLSLIISLTSLLAFLAIIVSIYSI
CCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLEKQFQNHQLVENKNLTDELGRIKAEQNTVQKLLDNNANHLQQIQSDLTSKMDSLNKEL
HHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
QTAMKQKLYQNNDWLLLKARYYLELAQINVHWSDNFNTSVALLQQADALLKGMNIPKIFT
HHHHHHHHHCCCCEEEEEHHHHEEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHH
IRQIIAKEIAQLKSISVVDITGILSQLDAAQAAINNLSIQSVVDQQEVLNHITKSEESGK
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCC
IGWRNRLQDSVNFLEKLVVIRRHNENIQPLISPLYESAIKENIRLNLQEAQWAILNNNPA
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCEEEHHHEEEEECCCCC
VYQFALNQAIANLKRVFNESSQNTDALIKQLSTLQNVKLTQEKPVVGQAIPLINQMIDNK
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCH
ELLVDQANSKKGEN
HHHHCCCCCCCCCC
>Mature Secondary Structure 
ANSNEEQKKTIQPQQPPKVEPDINQQMKASFFGSKYLSLIISLTSLLAFLAIIVSIYSI
CCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLEKQFQNHQLVENKNLTDELGRIKAEQNTVQKLLDNNANHLQQIQSDLTSKMDSLNKEL
HHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
QTAMKQKLYQNNDWLLLKARYYLELAQINVHWSDNFNTSVALLQQADALLKGMNIPKIFT
HHHHHHHHHCCCCEEEEEHHHHEEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHH
IRQIIAKEIAQLKSISVVDITGILSQLDAAQAAINNLSIQSVVDQQEVLNHITKSEESGK
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCC
IGWRNRLQDSVNFLEKLVVIRRHNENIQPLISPLYESAIKENIRLNLQEAQWAILNNNPA
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCEEEHHHEEEEECCCCC
VYQFALNQAIANLKRVFNESSQNTDALIKQLSTLQNVKLTQEKPVVGQAIPLINQMIDNK
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCH
ELLVDQANSKKGEN
HHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062586; 3054815; 1379743; 9278503; 9298646 [H]